EP1003521A4 - METHODS OF POTENTIALIZING INTRAVENOUS PHOSPHATE ESTRAMUSTINE - Google Patents
METHODS OF POTENTIALIZING INTRAVENOUS PHOSPHATE ESTRAMUSTINEInfo
- Publication number
- EP1003521A4 EP1003521A4 EP99914884A EP99914884A EP1003521A4 EP 1003521 A4 EP1003521 A4 EP 1003521A4 EP 99914884 A EP99914884 A EP 99914884A EP 99914884 A EP99914884 A EP 99914884A EP 1003521 A4 EP1003521 A4 EP 1003521A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- potentiate
- methods
- estramustine phosphate
- intravenous estramustine
- intravenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229960004750 estramustine phosphate Drugs 0.000 title 1
- ADFOJJHRTBFFOF-RBRWEJTLSA-N estramustine phosphate Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)OP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 ADFOJJHRTBFFOF-RBRWEJTLSA-N 0.000 title 1
- 238000001990 intravenous administration Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000003389 potentiating effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7954298P | 1998-03-27 | 1998-03-27 | |
US79542P | 1998-03-27 | ||
PCT/US1999/004275 WO1999049869A1 (en) | 1998-03-27 | 1999-03-26 | Methods to potentiate intravenous estramustine phosphate |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1003521A1 EP1003521A1 (en) | 2000-05-31 |
EP1003521A4 true EP1003521A4 (en) | 2003-07-23 |
Family
ID=22151209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99914884A Withdrawn EP1003521A4 (en) | 1998-03-27 | 1999-03-26 | METHODS OF POTENTIALIZING INTRAVENOUS PHOSPHATE ESTRAMUSTINE |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1003521A4 (ja) |
JP (1) | JP2001508810A (ja) |
KR (1) | KR20010021656A (ja) |
CN (2) | CN1273530A (ja) |
AU (1) | AU750010B2 (ja) |
BR (1) | BR9906425A (ja) |
CA (1) | CA2295049A1 (ja) |
EA (1) | EA004647B1 (ja) |
HU (1) | HUP0200547A3 (ja) |
ID (1) | ID24504A (ja) |
IL (1) | IL133612A0 (ja) |
NO (1) | NO20002343L (ja) |
NZ (1) | NZ501987A (ja) |
PL (1) | PL342969A1 (ja) |
WO (1) | WO1999049869A1 (ja) |
ZA (1) | ZA997821B (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0003201D0 (en) * | 2000-02-11 | 2000-04-05 | Pharmacia & Upjohn Spa | Method to potentiate the therapeutic efficacy of taxane and derivatives thereof |
US6436913B1 (en) * | 2000-07-25 | 2002-08-20 | Pharmacia & Upjohn Company | Use of estramustine phosphate in the treatment of bone metastasis |
RU2471511C1 (ru) * | 2011-05-04 | 2013-01-10 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНИОИ" Минздравсоцразвития России) | Способ лечения метастазов в печень рака толстой кишки |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4584136A (en) * | 1984-06-20 | 1986-04-22 | Japan Atomic Energy Research Institute | Process for preparing Estracyt compounds having a carcinostatic bound thereto |
US5728687A (en) * | 1992-11-10 | 1998-03-17 | Rhone-Poulenc Rorer, S.A. | Antitumour compositions containing taxane derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
DK0706373T3 (da) * | 1992-03-23 | 2000-09-18 | Univ Georgetown | Liposomindkapslet taxol og en fremgangsmåde til anvendelse heraf |
-
1999
- 1999-03-26 NZ NZ501987A patent/NZ501987A/xx unknown
- 1999-03-26 KR KR1020007000214A patent/KR20010021656A/ko not_active Application Discontinuation
- 1999-03-26 PL PL99342969A patent/PL342969A1/xx unknown
- 1999-03-26 EA EA199901081A patent/EA004647B1/ru not_active IP Right Cessation
- 1999-03-26 EP EP99914884A patent/EP1003521A4/en not_active Withdrawn
- 1999-03-26 IL IL13361299A patent/IL133612A0/xx not_active IP Right Cessation
- 1999-03-26 BR BR9906425-1A patent/BR9906425A/pt not_active IP Right Cessation
- 1999-03-26 HU HU0200547A patent/HUP0200547A3/hu unknown
- 1999-03-26 JP JP54936999A patent/JP2001508810A/ja not_active Ceased
- 1999-03-26 CA CA002295049A patent/CA2295049A1/en not_active Abandoned
- 1999-03-26 ID IDW20000105A patent/ID24504A/id unknown
- 1999-03-26 CN CN99800823A patent/CN1273530A/zh active Pending
- 1999-03-26 AU AU33533/99A patent/AU750010B2/en not_active Ceased
- 1999-03-26 WO PCT/US1999/004275 patent/WO1999049869A1/en not_active Application Discontinuation
- 1999-03-26 CN CNA2004100867183A patent/CN1636598A/zh active Pending
- 1999-12-22 ZA ZA9907821A patent/ZA997821B/xx unknown
-
2000
- 2000-05-04 NO NO20002343A patent/NO20002343L/no not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4584136A (en) * | 1984-06-20 | 1986-04-22 | Japan Atomic Energy Research Institute | Process for preparing Estracyt compounds having a carcinostatic bound thereto |
US5728687A (en) * | 1992-11-10 | 1998-03-17 | Rhone-Poulenc Rorer, S.A. | Antitumour compositions containing taxane derivatives |
Non-Patent Citations (5)
Title |
---|
GARCIA A A ET AL: "PHASE I AND PHARMACOLOGIC STUDY OF ESTRAMUSTINE PHOSPHATE AND SHORTINFUSIONS OF PACLITAXEL IN WOMEN WITH SOLID TUMORS", JOURNAL OF CLINICAL ONCOLOGY, PHILADELPHIA, PA, US, vol. 16, no. 9, September 1998 (1998-09-01), pages 2959 - 2963, XP001000703 * |
GUNNARSSON ET AL: "Pharmacokenetics of estramustine phosphate in prostatic cancer patients", EUR.J.PHARMACOL, vol. 26, 1984, pages 113 - 119 * |
HUDES G R ET AL: "PACLITAXEL PLUS ESTRAMUSTINE IN METASTATIC HORMONE-REFRACTORY PROSTATE CANCER", SEMINARS IN ONCOLOGY, BETHESDA, MD, US, vol. 22, no. 5, SUPPL 12, October 1995 (1995-10-01), pages 41 - 45, XP001000716 * |
NAGEL ET AL: "Treatment of advanced carcinoma of the prostrate with estramustine phopshate", BR.J.UROL., vol. 49, 1977, pages 73 - 79 * |
See also references of WO9949869A1 * |
Also Published As
Publication number | Publication date |
---|---|
HUP0200547A2 (hu) | 2002-07-29 |
AU3353399A (en) | 1999-10-18 |
PL342969A1 (en) | 2001-07-16 |
CN1636598A (zh) | 2005-07-13 |
CN1273530A (zh) | 2000-11-15 |
BR9906425A (pt) | 2000-07-11 |
AU750010B2 (en) | 2002-07-11 |
EA004647B1 (ru) | 2004-06-24 |
CA2295049A1 (en) | 1999-10-07 |
NO20002343D0 (no) | 2000-05-04 |
ID24504A (id) | 2000-07-20 |
EP1003521A1 (en) | 2000-05-31 |
IL133612A0 (en) | 2001-04-30 |
EA199901081A1 (ru) | 2000-12-25 |
HUP0200547A3 (en) | 2003-07-28 |
JP2001508810A (ja) | 2001-07-03 |
WO1999049869A1 (en) | 1999-10-07 |
NO20002343L (no) | 2000-05-04 |
ZA997821B (en) | 2000-08-01 |
KR20010021656A (ko) | 2001-03-15 |
NZ501987A (en) | 2002-10-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000120 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: SI PAYMENT 20000120 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030606 |
|
17Q | First examination report despatched |
Effective date: 20031119 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: PHARMACIA & UPJOHN COMPANY LLC |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20050924 |