EP1001762A4 - METHOD OF USING CARBAMATES AND NEUROTROPHIC UREAS - Google Patents

METHOD OF USING CARBAMATES AND NEUROTROPHIC UREAS

Info

Publication number
EP1001762A4
EP1001762A4 EP98906647A EP98906647A EP1001762A4 EP 1001762 A4 EP1001762 A4 EP 1001762A4 EP 98906647 A EP98906647 A EP 98906647A EP 98906647 A EP98906647 A EP 98906647A EP 1001762 A4 EP1001762 A4 EP 1001762A4
Authority
EP
European Patent Office
Prior art keywords
neurotrophic
ureas
carbamates
neurotrophic carbamates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98906647A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1001762A1 (en
Inventor
Jia-He Li
Gregory S Hamilton
Joseph P Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GPI Nil Holdings Inc
Eisai Corp of North America
Original Assignee
Guilford Pharmaceuticals Inc
GPI Nil Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals Inc, GPI Nil Holdings Inc filed Critical Guilford Pharmaceuticals Inc
Publication of EP1001762A1 publication Critical patent/EP1001762A1/en
Publication of EP1001762A4 publication Critical patent/EP1001762A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP98906647A 1997-02-27 1998-02-26 METHOD OF USING CARBAMATES AND NEUROTROPHIC UREAS Withdrawn EP1001762A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US805646 1985-12-06
US80564697A 1997-02-27 1997-02-27
PCT/US1998/003485 WO1998037882A1 (en) 1997-02-27 1998-02-26 Method of using neurotrophic carbamates and ureas

Publications (2)

Publication Number Publication Date
EP1001762A1 EP1001762A1 (en) 2000-05-24
EP1001762A4 true EP1001762A4 (en) 2002-05-08

Family

ID=25192108

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98906647A Withdrawn EP1001762A4 (en) 1997-02-27 1998-02-26 METHOD OF USING CARBAMATES AND NEUROTROPHIC UREAS

Country Status (9)

Country Link
EP (1) EP1001762A4 (xx)
JP (1) JP2001513772A (xx)
AR (1) AR011869A1 (xx)
AU (1) AU6181698A (xx)
CA (1) CA2281096A1 (xx)
PA (1) PA8447901A1 (xx)
PE (1) PE46599A1 (xx)
WO (1) WO1998037882A1 (xx)
ZA (1) ZA98825B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
AU756912B2 (en) 1998-07-17 2003-01-23 Agouron Pharmaceuticals, Inc. Compounds, compositions, and methods for stimulating neuronal growth and elongation
US6395758B1 (en) * 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6323215B1 (en) 1999-07-09 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
JP2003504367A (ja) 1999-07-09 2003-02-04 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 神経栄養性ピロリジン類およびピペリジン類、並びに関連組成物および方法
WO2001004091A1 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
CA2383086A1 (en) * 1999-09-08 2001-03-15 Joseph P. Steiner Non-peptidic cyclophilin binding compounds and their use
GT200000203A (es) 1999-12-01 2002-05-24 Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas.
EP1339668A2 (en) * 2000-11-28 2003-09-03 Guilford Pharmaceuticals Inc. Bisubstituted carbocyclic cyclophilin binding compounds and theirus
US6656971B2 (en) * 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026337A1 (en) * 1994-03-25 1995-10-05 Vertex Pharmaceuticals Incorporated Novel carbamates and ureas as modifiers of multi-drug resistance
WO1996040633A1 (en) * 1995-06-07 1996-12-19 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme activity
WO1996041609A2 (en) * 1995-06-08 1996-12-27 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
WO1998020893A1 (en) * 1996-11-13 1998-05-22 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620971A (en) * 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026337A1 (en) * 1994-03-25 1995-10-05 Vertex Pharmaceuticals Incorporated Novel carbamates and ureas as modifiers of multi-drug resistance
WO1996040633A1 (en) * 1995-06-07 1996-12-19 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme activity
WO1996041609A2 (en) * 1995-06-08 1996-12-27 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
WO1998020893A1 (en) * 1996-11-13 1998-05-22 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9837882A1 *

Also Published As

Publication number Publication date
AR011869A1 (es) 2000-09-13
CA2281096A1 (en) 1998-09-03
WO1998037882A1 (en) 1998-09-03
PE46599A1 (es) 1999-05-12
EP1001762A1 (en) 2000-05-24
PA8447901A1 (es) 2000-05-24
ZA98825B (en) 1998-10-19
JP2001513772A (ja) 2001-09-04
AU6181698A (en) 1998-09-18

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