EP0989062B1 - Device for filling a pressurized pharmaceutical liquid in a package - Google Patents

Device for filling a pressurized pharmaceutical liquid in a package Download PDF

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Publication number
EP0989062B1
EP0989062B1 EP99116465A EP99116465A EP0989062B1 EP 0989062 B1 EP0989062 B1 EP 0989062B1 EP 99116465 A EP99116465 A EP 99116465A EP 99116465 A EP99116465 A EP 99116465A EP 0989062 B1 EP0989062 B1 EP 0989062B1
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EP
European Patent Office
Prior art keywords
liquid
distributor
filling
temperature
line
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Expired - Lifetime
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EP99116465A
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German (de)
French (fr)
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EP0989062A1 (en
Inventor
Werner Mayer
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Robert Bosch GmbH
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Robert Bosch GmbH
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B63/00—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged
    • B65B63/08—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged for heating or cooling articles or materials to facilitate packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67D—DISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D1/00—Apparatus or devices for dispensing beverages on draught
    • B67D1/08—Details
    • B67D1/0857—Cooling arrangements
    • B67D1/0858—Cooling arrangements using compression systems
    • B67D1/0861—Cooling arrangements using compression systems the evaporator acting through an intermediate heat transfer means
    • B67D1/0865—Cooling arrangements using compression systems the evaporator acting through an intermediate heat transfer means by circulating a cooling fluid along beverage supply lines, e.g. pythons
    • B67D1/0867—Cooling arrangements using compression systems the evaporator acting through an intermediate heat transfer means by circulating a cooling fluid along beverage supply lines, e.g. pythons the cooling fluid being a liquid

Definitions

  • the invention relates to a device for filling a pressurized pharmaceutical liquid in packaging container according to the preamble of claim 1, such as it is known from DE 43 41 934 A1.
  • the filling time for the liquid if necessary, taking into account the Distributor arranged temperature sensor detected temperature to calculate.
  • the device according to the invention for filling a Pressurized pharmaceutical liquid in packaging container with the characterizing features of claim 1 has the advantage that the filling accuracy also with a strongly temperature-dependent flow behavior of the to be filled Liquid is very high. This is achieved that the liquid according to the invention with a certain and in particular constant temperature of the filling valves is supplied so that the otherwise detectable Temperature fluctuations in the liquid, for example in the event of a batch change, after a break in production or when filling starts due to the heating of the Components of the filling device can be avoided can.
  • the device 10 shown in FIG. 1 is used for filling a pressurized pharmaceutical liquid 1 in packaging containers such as vials 2, ampoules or similar.
  • the device 10 has a product container 11, which by means of a quick release device 12 is replaceably attachable to a feed line 13.
  • a connector 14 which is connected to a pressure source, not shown.
  • the feed line 13 opens into a tubular in the filling area Distributor 15, from which fill lines 17 branch off, that lead directly to the individual vials 2.
  • a filling valve 18 is arranged, that can be controlled by the control device 20 of the device 10 is.
  • the ends of the filling lines facing the vials 2 17, which are designed as filling needles 21, are more common Arranged movable up and down to in one Standstill phase of the cycle by means of a conveyor pumped vials 2 for dispensing the liquid 1 in to be able to immerse the head openings of the vials 2.
  • the one required facilities are known per se and not essential to the invention, not shown.
  • the essential opening time with regard to the exact filling quantity the filling valve 18 is controlled by the control device 20 taking into account that of one arranged in the distributor 15 Pressure sensor 22 calculated pressure that with the control device 20 is connected. Furthermore, a first temperature sensor 23 is provided in the distributor 15, which is also connected to the control device 20.
  • the device To incorrect dosing of the liquid 1 due to temperature fluctuations the liquid 1, which is in a changed Expressing viscosity, the device is to be avoided 10 specially furnished.
  • the basic idea is there in that the liquid 1 when filling, that is Passing through the filling valves 18 always a very specific one Should have temperature, the thus known viscosity from the control device 20 when calculating the opening times the filling valve 18 is taken into account.
  • the distributor 15 and a section of each Filling lines 17 integrated in a block-shaped housing 24, which in turn is arranged on a console 25 of the device 10 is.
  • the housing 24 has an inlet connector 26 and an outlet port 27 for a coolant that by the housing 24 is passed.
  • the housing 24 is as Hollow housing formed, the interior 28 of a in Loops laid cooling line 29 is penetrated.
  • the cooling line 29 surrounds the distributor 15 in the housing 24, so that it is cooled by convection.
  • the temperature prevailing in the housing 24 can be determined by means of a second temperature sensor 31 can be detected with a Temperature control loop is coupled to the temperature in the housing to keep constant.
  • the distributor 15 is still at least part of the feed line 13 double-walled with an inlet 32 and an outlet 33 for coolant educated. Furthermore, the product container 11 can also be double-walled formed with an inlet 34 and an outlet 35 be to allow coolant to flow through.
  • the basic idea of the invention exists in the pharmaceutical liquid 1 with a possible constant temperature, here the one achieved by the coolant Liquid 1 temperature to be filled.
  • This means of the second temperature sensor 31 arranged in the housing 24 is monitored by means of the temperature control loop mentioned above kept consistent.
  • the goal is that Liquid 1 in the distributor 15 to a very specific temperature, their viscosity when calculating the opening time of the filling valves 18 on the basis of the control device 20 will cool down, and this during the filling processes to keep as constant as possible.
  • the volume the distributor 15 with respect to the number of filling lines 17 and that to be dispensed into the vials 2 with each filling operation Filling volume and the target temperature of the liquid 1 decisive.
  • the liquid 1 tends to nucleate at a higher temperature, so that the trend basically goes to the total product volume and thus to cool the entire device 10.
  • the filling accuracy of the device 10 can be increased if the software the control device 20 is able to adjust the opening time the filling valves 18 with slight temperature fluctuations the liquid 1 in the distributor 15, which from the first Temperature sensor 23 are detected to adapt. To do this corresponding temperature / viscosity characteristics of the liquid 1 stored in the control device 20. Because the temperature fluctuations the liquid 1 in relation to devices, which have no means of keeping the temperature constant the liquid, are less, are Fluctuations in filling times compared to conventional devices lower.

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  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Basic Packing Technique (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

Die Erfindung betrifft eine Vorrichtung zum Abfüllen einer unter Druck stehenden pharmazeutischen Flüssigkeit in Verpackungsbehälter nach dem Oberbegriff des Anspruchs 1, wie sie aus der DE 43 41 934 A1 bekannt ist. Bei der bekannten Vorrichtung ist vorgesehen, die Abfüllzeit für die Flüssigkeit gegebenenfalls unter Berücksichtigung der von einem im Verteiler angeordneten Temperatursensor erfaßten Temperatur zu berechnen. Es hat sich jedoch herausgestellt, daß die Messung der Flüssigkeitstemperatur und die Anpassung der Füllzeit mittels die Flüssigkeitstemperatur berücksichtigender Softwareprogramme insbesondere bei Produkten mit einem stark temperaturabhängigen Fließverhalten keine zufriedenstellenden Ergebnisse bezüglich der Abfüllgenauigkeit ergibt.The invention relates to a device for filling a pressurized pharmaceutical liquid in packaging container according to the preamble of claim 1, such as it is known from DE 43 41 934 A1. With the known Device is provided, the filling time for the liquid if necessary, taking into account the Distributor arranged temperature sensor detected temperature to calculate. However, it has been found that the Measuring the liquid temperature and adjusting the Filling time by taking the liquid temperature into account Software programs, especially for products with one strongly temperature-dependent flow behavior not satisfactory Results regarding the filling accuracy results.

Vorteile der ErfindungAdvantages of the invention

Die erfindungsgemäße Vorrichtung zum Abfüllen einer unter Druck stehenden pharmazeutischen Flüssigkeit in Verpackungsbehälter mit den kennzeichnenden Merkmalen des Anspruchs 1 hat demgegenüber den Vorteil, daß die Abfüllgenauigkeit auch bei einem stark temperaturabhängigen Fließverhalten der abzufüllenden Flüssigkeit sehr hoch ist. Dies wird dadurch erreicht, daß die Flüssigkeit erfindungsgemäß mit einer bestimmten und insbesondere konstanten Temperatur den Füllventilen zugeführt wird, so daß die ansonsten feststellbaren Temperaturschwankungen der Flüssigkeit, die sich beispielsweise bei einem Chargenwechsel, nach einer Produktionspause oder beim Starten des Abfüllens aufgrund der Erwärmung der Bauteile der Abfüllvorrichtung ergeben, vermieden werden können.The device according to the invention for filling a Pressurized pharmaceutical liquid in packaging container with the characterizing features of claim 1 has the advantage that the filling accuracy also with a strongly temperature-dependent flow behavior of the to be filled Liquid is very high. This is achieved that the liquid according to the invention with a certain and in particular constant temperature of the filling valves is supplied so that the otherwise detectable Temperature fluctuations in the liquid, for example in the event of a batch change, after a break in production or when filling starts due to the heating of the Components of the filling device can be avoided can.

Weitere Vorteile und vorteilhafte Weiterbildungen der erfindungsgemäßen Vorrichtung zum Abfüllen einer unter Druck stehenden pharmazeutischen Flüssigkeit in Verpackungsbehälter ergeben sich aus den Unteransprüchen und der Beschreibung.Further advantages and advantageous developments of the invention Device for filling a pressurized pharmaceutical liquid in packaging container result from the subclaims and the description.

Zeichnungdrawing

Ein Ausführungsbeispiel der Erfindung ist in der Zeichnung dargestellt und wird nachfolgend näher erläutert. Die einzige Figur zeigt einen Teil einer Vorrichtung zum Abfüllen einer unter Druck stehenden pharmazeutischen Flüssigkeit in Verpackungsbehälter in einer schematischen Darstellung.An embodiment of the invention is in the drawing shown and will be explained in more detail below. The only Figure shows part of a device for filling a pressurized pharmaceutical liquid in Packaging container in a schematic representation.

Beschreibung des AusführunqsbeispielsDescription of the execution example

Die in der Figur 1 dargestellte Vorrichtung 10 dient zum Abfüllen einer unter Druck stehenden pharmazeutischen Flüssigkeit 1 in Verpackungsbehälter wie Vials 2, Ampullen oder ähnlichen. Dazu weist die Vorrichtung 10 einen Produktbehälter 11 auf, der mittels einer Schnellspannvorrichtung 12 austauschbar an einer Zuführleitung 13 befestigbar ist. Zur Beaufschlagung der Flüssigkeit 1 mit Überdruck ist an dem Produktbehälter 11 ferner ein Anschluß 14 ausgebildet, der mit einer nicht dargestellten Druckquelle verbunden ist.The device 10 shown in FIG. 1 is used for filling a pressurized pharmaceutical liquid 1 in packaging containers such as vials 2, ampoules or similar. For this purpose, the device 10 has a product container 11, which by means of a quick release device 12 is replaceably attachable to a feed line 13. to Application of liquid 1 with overpressure is on the Product container 11 also formed a connector 14 which is connected to a pressure source, not shown.

Die Zuführleitung 13 mündet im Abfüllbereich in einem rohrförmigen Verteiler 15, von dem Fülleitungen 17 abzweigen, die unmittelbar zu den einzelnen Vials 2 führen. Am Ende jeder Fülleitung 17 ist jeweils ein Füllventil 18 angeordnet, das von der Steuereinrichtung 20 der Vorrichtung 10 ansteuerbar ist. Die den Vials 2 zugewandten Enden der Fülleitungen 17, die als Füllnadeln 21 ausgebildet sind, sind in üblicher Weise auf- und abbewegbar angeordnet, um in einer Stillstandsphase der mittels einer Fördereinrichtung taktweise geförderten Vials 2 zum Abgeben der Flüssigkeit 1 in die Kopföffnungen der Vials 2 eintauchen zu können. Die dazu erforderlichen Einrichtungen sind, da an sich bekannt und nicht erfindungswesentlich, nicht dargestellt.The feed line 13 opens into a tubular in the filling area Distributor 15, from which fill lines 17 branch off, that lead directly to the individual vials 2. In the end everyone Filling line 17, a filling valve 18 is arranged, that can be controlled by the control device 20 of the device 10 is. The ends of the filling lines facing the vials 2 17, which are designed as filling needles 21, are more common Arranged movable up and down to in one Standstill phase of the cycle by means of a conveyor pumped vials 2 for dispensing the liquid 1 in to be able to immerse the head openings of the vials 2. The one required facilities are known per se and not essential to the invention, not shown.

Die bezüglich der genauen Abfüllmenge wesentliche Öffnungszeit der Füllventile 18 wird von der Steuereinrichtung 20 unter Berücksichtigung des von einem im Verteiler 15 angeordneten Drucksensor 22 erfaßten Drucks berechnet, der mit der Steuereinrichtung 20 verbunden ist. Weiterhin ist ggf. ein erster Temperatursensor 23 im Verteiler 15 vorgesehen, der ebenfalls mit der Steuereinrichtung 20 verbunden ist.The essential opening time with regard to the exact filling quantity the filling valve 18 is controlled by the control device 20 taking into account that of one arranged in the distributor 15 Pressure sensor 22 calculated pressure that with the control device 20 is connected. Furthermore, a first temperature sensor 23 is provided in the distributor 15, which is also connected to the control device 20.

Um Fehldosierungen der Flüssigkeit 1 aufgrund von Temperaturschwankungen der Flüssigkeit 1, die sich in einer geänderten Viskosität äußert, zu vermeiden, ist die Vorrichtung 10 besonders eingerichtet. Der Grundgedanke besteht dabei darin, daß die Flüssigkeit 1 beim Abfüllen, das heißt beim Durchtritt durch die Füllventile 18 stets eine ganz bestimmte Temperatur aufweisen soll, deren somit bekannte Viskosität von der Steuereinrichtung 20 bei der Berechnung der Öffnungszeiten der Füllventile 18 berücksichtigt wird.To incorrect dosing of the liquid 1 due to temperature fluctuations the liquid 1, which is in a changed Expressing viscosity, the device is to be avoided 10 specially furnished. The basic idea is there in that the liquid 1 when filling, that is Passing through the filling valves 18 always a very specific one Should have temperature, the thus known viscosity from the control device 20 when calculating the opening times the filling valve 18 is taken into account.

Dazu ist der Verteiler 15 sowie jeweils ein Abschnitt der Fülleitungen 17 in ein blockförmiges Gehäuse 24 integriert, das seinerseits auf einer Konsole 25 der Vorrichtung 10 angeordnet ist. Das Gehäuse 24 hat einen Eintrittsstutzen 26 und einen Austrittsstutzen 27 für ein Kühlmittel, daß durch das Gehäuse 24 geleitet wird.For this purpose, the distributor 15 and a section of each Filling lines 17 integrated in a block-shaped housing 24, which in turn is arranged on a console 25 of the device 10 is. The housing 24 has an inlet connector 26 and an outlet port 27 for a coolant that by the housing 24 is passed.

Im dargestellten Ausführungsbeispiel ist das Gehäuse 24 als Hohlgehäuse ausgebildet, dessen Innenraum 28 von einer in Schlingen verlegten Kühlleitung 29 durchsetzt ist. Die Kühlleitung 29 umgibt den Verteiler 15 in dem Gehäuse 24, so daß dieser durch Konvektion gekühlt wird.In the illustrated embodiment, the housing 24 is as Hollow housing formed, the interior 28 of a in Loops laid cooling line 29 is penetrated. The cooling line 29 surrounds the distributor 15 in the housing 24, so that it is cooled by convection.

Die im Gehäuse 24 herrschende Temperatur kann mittels eines zweiten Temperatursensors 31 erfaßt werden, der mit einem Temperaturregelkreis gekoppelt ist, um die Temperatur im Gehäuse konstant zu halten.The temperature prevailing in the housing 24 can be determined by means of a second temperature sensor 31 can be detected with a Temperature control loop is coupled to the temperature in the housing to keep constant.

Um eine zusätzliche Kühlung der Flüssigkeit 1 erzielen zu können, bevor diese in den Verteiler 15 eintritt, ist weiterhin zumindest ein Teil der Zuführleitung 13 doppelwandig mit einem Eintritt 32 und einem Austritt 33 für Kühlmittel ausgebildet. Ferner kann auch der Produktbehälter 11 doppelwandig mit einem Eintritt 34 und einem Austritt 35 ausgebildet sein, um ein Durchströmen von Kühlmittel zu ermöglichen.To achieve additional cooling of the liquid 1 can before it enters the distributor 15 is still at least part of the feed line 13 double-walled with an inlet 32 and an outlet 33 for coolant educated. Furthermore, the product container 11 can also be double-walled formed with an inlet 34 and an outlet 35 be to allow coolant to flow through.

Wie bereits erwähnt besteht der Grundgedanke der Erfindung darin, die pharmazeutische Flüssigkeit 1 mit einer möglichst konstanten Temperatur, hier die durch das Kühlmittel erzielte Temperatur der Flüssigkeit 1, abzufüllen. Diese mittels des im Gehäuse 24 angeordneten zweiten Temperatursensors 31 überwachte Temperatur wird mittels des oben erwähnten Temperaturregelkreises konsant gehalten. Das Ziel ist es, die Flüssigkeit 1 im Verteiler 15 auf eine ganz bestimmte Temperatur, deren Viskosität bei der Berechnung der Öffnungszeit der Füllventile 18 von der Steuereinrichtung 20 zugrunde gelegt wird, herunterzukühlen, und diese während der Abfüllvorgänge möglichst konstant zu halten.As already mentioned, the basic idea of the invention exists in the pharmaceutical liquid 1 with a possible constant temperature, here the one achieved by the coolant Liquid 1 temperature to be filled. This means of the second temperature sensor 31 arranged in the housing 24 is monitored by means of the temperature control loop mentioned above kept consistent. The goal is that Liquid 1 in the distributor 15 to a very specific temperature, their viscosity when calculating the opening time of the filling valves 18 on the basis of the control device 20 will cool down, and this during the filling processes to keep as constant as possible.

Ob dabei neben dem Verteiler 15 auch noch die Zuführleitung 13 bzw. der Produktbehälter 11 gekühlt werden muß, ist von mehreren Faktoren abhängig. Insbesondere ist dabei das Volumen des Verteilers 15 in bezug auf die Anzahl der Fülleitungen 17 und das bei jedem Abfüllvorgang in die Vials 2 abzugebende Füllvolumen sowie die Solltemperatur der Flüssigkeit 1 maßgebend. Je rascher das im Verteiler 15 befindliche Flüssigkeitsvolumen durch neue Flüssigkeit 1 aus der Zuführleitung 13 und dem Produktbehälter 11 ersetzt wird, und desto niedriger die Temperatur der Flüssigkeit 1 im Verteiler 15 im Verhältnis zur Flüssigkeitstemperatur in der Zuführleitung 13 und dem Produktbehälter 11 ist, desto eher müssen auch die Zuführleitung 13 und der Produktbehälter 11 gekühlt werden. Ferner ist zu berücksichtigen, daß die Flüssigkeit 1 bei höherer Temperatur eher zur Keimbildung neigt, so daß die Tendenz grundsätzlich dahin geht, das gesamte Produktvolumen und somit die gesamte Vorrichtung 10 zu kühlen.Whether in addition to the distributor 15 also the feed line 13 or the product container 11 must be cooled is from depending on several factors. In particular, the volume the distributor 15 with respect to the number of filling lines 17 and that to be dispensed into the vials 2 with each filling operation Filling volume and the target temperature of the liquid 1 decisive. The faster that is in the distributor 15 Liquid volume due to new liquid 1 from the supply line 13 and the product container 11 is replaced, and the more lower the temperature of liquid 1 in the distributor 15 in relation to the liquid temperature in the feed line 13 and the product container 11, the sooner must also the supply line 13 and the product container 11 cooled become. It should also be borne in mind that the liquid 1 tends to nucleate at a higher temperature, so that the trend basically goes to the total product volume and thus to cool the entire device 10.

Die Wahl der der Berechnung der Abfüllzeit und der Auslegung des Kühlkreislaufes zugrundegelegten Temperatur der Flüssigkeit 1 ist stark von der Art der Flüssigkeit 1 abhängig. Dazu ist anzumerken, daß viele pharmazeutische Produkte aus Gründen der Haltbarkeit kalt abgefüllt werden sollten. Obwohl der Erfindungsgedanke lediglich von einer Konstanthaltung der Flüssigkeitstemperatur an den Füllventilen 18 ausgeht, so daß es auch durchaus denkbar wäre, die Flüssigkeit 1 nicht auf eine bestimmte Temperatur herabzukühlen sondern zu erwärmen, wird man aus o.g. Grund bei den allermeisten pharmazeutischen Flüssigkeiten 1 eine Absenkung der Temperatur gegenüber der Umgebungstemperatur wählen.The choice of the calculation of the filling time and the design the temperature of the liquid on which the cooling circuit is based 1 is strongly dependent on the type of liquid 1. To It should be noted that many pharmaceutical products are made from Bottled cold for durability. Even though the idea of the invention is only of keeping it constant the liquid temperature at the filling valves 18 runs out, so that it would also be quite conceivable for the liquid 1 not to cool down to a certain temperature but to heat, you will from the above The reason for most of them pharmaceutical liquids 1 a drop in temperature choose against the ambient temperature.

Insbesondere bei längeren Maschinenstillstandszeiten muß aus Gründen der Produktionssicherheit bei den genannten haltbarkeitsempfindlichen Flüssigkeiten 1 neben einer Kühlung des Verteilers 15, die ansonsten ausreichen würde, auch eine Kühlung der Produktwege, d.h. der Zuführleitung 13 und des Produkttanks 11 in Betracht ziehen.Especially with longer machine downtimes, Production safety reasons for the above-mentioned durability-sensitive Liquids 1 in addition to cooling the Distributor 15, which would otherwise be sufficient, also one Cooling the product paths, i.e. the feed line 13 and the Consider product tanks 11.

Ergänzend wird erwähnt, daß die Abfüllgenauigkeit der Vorrichtung 10 zusätzlich erhöht werden kann, wenn die Software der Steuereinrichtung 20 in der Lage ist, die Öffnungszeit der Füllventile 18 bei geringfügigen Temperaturschwankungen der Flüssigkeit 1 in dem Verteiler 15, welche von dem ersten Temperatursensor 23 erfasst werden, anzupassen. Dazu sind entsprechende Temperatur/Viskositätskennlinien der Flüssigkeit 1 in der Steuereinrichtung 20 abgelegt. Da die Temperaturschwankungen der Flüssigkeit 1 im Verhältnis zu Vorrichtungen, die keinerlei Mittel zum Konstanthalten der Temperatur der Flüssigkeit aufweisen, geringer sind, sind die Schwankungen der Füllzeiten gegenüber herkömmlichen Vorrichtungen geringer.In addition, it is mentioned that the filling accuracy of the device 10 can be increased if the software the control device 20 is able to adjust the opening time the filling valves 18 with slight temperature fluctuations the liquid 1 in the distributor 15, which from the first Temperature sensor 23 are detected to adapt. To do this corresponding temperature / viscosity characteristics of the liquid 1 stored in the control device 20. Because the temperature fluctuations the liquid 1 in relation to devices, which have no means of keeping the temperature constant the liquid, are less, are Fluctuations in filling times compared to conventional devices lower.

Weiterhin wurde im Ausführungsbeispiel davon ausgegangen, daß sich die Temperatur der Flüssigkeit 1 auf ihrem Weg vom Verteiler 15 bzw. vom Gehäuse 24 bis hin zu den Füllventilen 18 nahezu nicht ändert. Sollten die spezifischen Bedingungen der Vorrichtung 10 oder der Umgebung dies nicht gewährleisten, so sollten auch noch die aus dem Gehäuse 24 herausragenden Abschnitte der Fulleitungen 17 und ggf. auch die Füllventile 18 gekühlt werden.Furthermore, it was assumed in the exemplary embodiment that that the temperature of the liquid 1 on its way from Distributor 15 or from the housing 24 to the filling valves 18 almost does not change. Should the specific conditions the device 10 or the surroundings do not guarantee this, so should protrude from the housing 24 Sections of the Fulleitung 17 and possibly also the Filling valves 18 are cooled.

Claims (6)

  1. Device (10) for decanting a pressurized pharmaceutical liquid (1) into packaging containers, such as ampoules, phials (2) or the like, with a first line (13) feeding the liquid (1) out of a product container (11) to a distributor (15), with decanting lines (17) which branch off from the distributor (15), are assigned to the individual packaging containers and are provided with decanting valves (18), and with a pressure sensor (22) for the liquid (1), said pressure sensor being disposed in the distributor (15) and being connected to a control arrangement (20) in order to calculate the activation times of the decanting valves (18), characterized in that means for keeping the temperature of the liquid (1) constant in the distributor (15) are provided.
  2. Device according to Claim 1, characterized in that the means comprise a housing (24) which at least partially surrounds the distributor (15) and in the interior (28) of which is disposed at least one coolant line (29) which is connected to a coolant circuit and surrounds the distributor (15).
  3. Device according to Claim 1, characterized in that the means comprise a housing (24) which at least partially surrounds the distributor (15) and in the interior (28) of which is formed at least one coolant duct.
  4. Device according to one of Claims 1 to 3, characterized in that additional means for keeping the temperature constant in at least one portion of the first line (13) are provided.
  5. Device according to Claim 4, characterized in that the additional means comprise a double-walled first line (13) through which coolant flows and which has a first inlet (32) and a first outlet (33).
  6. Device according to one of Claims 1 to 5, characterized in that, furthermore, additional means for keeping the temperature constant in the product container (11) are provided, which comprise a double-walled product container (11) through which coolant flows and which has a second inlet (34) and a second outlet (35).
EP99116465A 1998-09-25 1999-08-21 Device for filling a pressurized pharmaceutical liquid in a package Expired - Lifetime EP0989062B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19844011A DE19844011C1 (en) 1998-09-25 1998-09-25 Pressurized pharmaceutical filling apparatus comprises primary pipe, distribution unit, filling valves, pressure sensor and housing
DE19844011 1998-09-25

Publications (2)

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EP0989062A1 EP0989062A1 (en) 2000-03-29
EP0989062B1 true EP0989062B1 (en) 2003-03-12

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EP99116465A Expired - Lifetime EP0989062B1 (en) 1998-09-25 1999-08-21 Device for filling a pressurized pharmaceutical liquid in a package

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US (1) US6176277B1 (en)
EP (1) EP0989062B1 (en)
JP (1) JP2000109190A (en)
DE (2) DE19844011C1 (en)

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US6176277B1 (en) 2001-01-23
DE59904519D1 (en) 2003-04-17
DE19844011C1 (en) 2000-03-09
JP2000109190A (en) 2000-04-18
EP0989062A1 (en) 2000-03-29

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