EP0970054A1 - 1-(isochinolin-1-yl)-4-(1-phenylmethyl)-piperazine; dopamin-rezeptor-subtyp-spezifische liganden - Google Patents

1-(isochinolin-1-yl)-4-(1-phenylmethyl)-piperazine; dopamin-rezeptor-subtyp-spezifische liganden

Info

Publication number
EP0970054A1
EP0970054A1 EP98908854A EP98908854A EP0970054A1 EP 0970054 A1 EP0970054 A1 EP 0970054A1 EP 98908854 A EP98908854 A EP 98908854A EP 98908854 A EP98908854 A EP 98908854A EP 0970054 A1 EP0970054 A1 EP 0970054A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
hydrogen
compound according
halogen
isoquinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98908854A
Other languages
English (en)
French (fr)
Inventor
Xi Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of EP0970054A1 publication Critical patent/EP0970054A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
EP98908854A 1997-03-04 1998-03-03 1-(isochinolin-1-yl)-4-(1-phenylmethyl)-piperazine; dopamin-rezeptor-subtyp-spezifische liganden Withdrawn EP0970054A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81072997A 1997-03-04 1997-03-04
US810729 1997-03-04
PCT/US1998/004051 WO1998039301A1 (en) 1997-03-04 1998-03-03 1-(isoquinolin-1-yl)-4-(1-phenylmethyl)piperazines; dopamine receptor subtype specific ligands

Publications (1)

Publication Number Publication Date
EP0970054A1 true EP0970054A1 (de) 2000-01-12

Family

ID=25204554

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98908854A Withdrawn EP0970054A1 (de) 1997-03-04 1998-03-03 1-(isochinolin-1-yl)-4-(1-phenylmethyl)-piperazine; dopamin-rezeptor-subtyp-spezifische liganden

Country Status (9)

Country Link
EP (1) EP0970054A1 (de)
JP (1) JP2001512491A (de)
KR (1) KR20000075918A (de)
AU (1) AU6678598A (de)
CA (1) CA2283256A1 (de)
HU (1) HUP0001391A3 (de)
IL (1) IL131427A0 (de)
NZ (1) NZ337183A (de)
WO (1) WO1998039301A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008352A (en) * 1997-04-03 1999-12-28 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
CA2308057A1 (en) * 1997-10-24 1999-05-06 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
JP4596792B2 (ja) * 2004-02-24 2010-12-15 あすか製薬株式会社 ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
US7887784B2 (en) 2007-03-21 2011-02-15 University Of Montana 1-[(2′-substituted)-piperazin-1′ -yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3423003A1 (de) * 1984-06-22 1986-01-02 Beiersdorf Ag, 2000 Hamburg Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPS63227570A (ja) * 1987-03-13 1988-09-21 Ss Pharmaceut Co Ltd イソキノリン誘導体
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9839301A1 *

Also Published As

Publication number Publication date
HUP0001391A3 (en) 2001-12-28
IL131427A0 (en) 2001-01-28
JP2001512491A (ja) 2001-08-21
KR20000075918A (ko) 2000-12-26
HUP0001391A2 (hu) 2000-10-28
WO1998039301A1 (en) 1998-09-11
CA2283256A1 (en) 1998-09-11
NZ337183A (en) 2001-05-25
AU6678598A (en) 1998-09-22

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Legal Events

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