EP0960616A2 - Bouchon universel à utilisations multiples - Google Patents

Bouchon universel à utilisations multiples Download PDF

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Publication number
EP0960616A2
EP0960616A2 EP19990103563 EP99103563A EP0960616A2 EP 0960616 A2 EP0960616 A2 EP 0960616A2 EP 19990103563 EP19990103563 EP 19990103563 EP 99103563 A EP99103563 A EP 99103563A EP 0960616 A2 EP0960616 A2 EP 0960616A2
Authority
EP
European Patent Office
Prior art keywords
container
closure assembly
elastomeric
sealing
stopper
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19990103563
Other languages
German (de)
English (en)
Other versions
EP0960616A3 (fr
EP0960616B1 (fr
Inventor
John J. Niedospial Jr.
Mark E. Gabbard
Timothy J. Gabbard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/080,091 external-priority patent/US5971181A/en
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of EP0960616A2 publication Critical patent/EP0960616A2/fr
Publication of EP0960616A3 publication Critical patent/EP0960616A3/fr
Application granted granted Critical
Publication of EP0960616B1 publication Critical patent/EP0960616B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1481—Inlet or outlet ports with connection retaining means, e.g. thread or snap-fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means

Definitions

  • This invention relates to an elastomeric stopper having a self-sealing means so that a pharmaceutical fluid contained in a container closed by the elastomeric stopper can be repeatedly accessed by the use of a luer connector or a syringe having a blunt or sharp needle cannula.
  • the prior art has developed numerous devices to prevent accidental needle strike injuries to practitioners and patients. Such injuries are known to spread infectious diseases including hepatitis and AIDS.
  • One of the main features of these devices is the lack of exposed sharp needles.
  • the closures or stoppers have built in access means to the content of the containers, such as vials, cartridges and bottles. The closures or stoppers in these devices serve the dual function of hermetically sealing the container while allowing access to the content therethrough.
  • Stopper systems for containers such as vials and bottles are made of materials that are resistant to chemicals and pharmaceuticals such as corrosive materials, reagents, parenteral solutions and solid formulations reconstitutable with a solvent prior to use.
  • the most commonly used stopper/container system for such products has been glass or plastic bottles and vials equipped with stoppers made of elastomeric materials.
  • the system provides for good hermetical seal, safe storage and easy access to the content through the elastomeric stopper via the use of an infusion spike or a syringe when withdrawal of the content is desired.
  • the elastomeric stopper used generally comprises an elastomeric base, such as natural or synthetic rubber and an inert coating covering at least some portions of the stopper.
  • the coating used includes chlorobutyl rubber, polymeric fluorocarbon resins such as polytetrafluoroethylene and various thermoplastic films. The coating is intended to insulate the elastomeric stopper base from the contents of the container in order to prevent contact and possible chemical reactions therebetween.
  • the elastomeric stopper is of cylindrical shape and has a flange head portion overlying the open top end of the container. Integral with the head portion is a body portion which extends into the open end and seated in the neck portion of the container, the diameter of the body portion being somewhat larger than the inside diameter of the container so that a tight seal is created between the body portion and the wall of the container.
  • the lower end of the body portion is beveled towards the central, longitudinal axis of the body portion to facilitate the insertion of the body portion into the container.
  • the circular bottom surface that faces the contents of the container is substantially planar and is imperforate, having no recess therein.
  • the head portion of the stopper is provided with a central recess extending downwardly from the top thereof a substantial distance into the body portion so that the central recess and the circular bottom surface define a diaphragm.
  • the walls forming the recess are generally cylindrical but may be provided with one or more circular protuberances extending inwardly to terminate just short of the center line of the stopper.
  • the circular protuberances serve to press against and hold the needle of a syringe when the needle is inserted through the recess to penetrate the diaphragm for removal of the contents of the container.
  • the elastomeric stopper is held in position by a metal ring or cap usually constructed of aluminum.
  • the metal ring or cap has a removable centre opening for allowing insertion of the syringe needle into the container.
  • U.S. Patent No. 5,429,256 pertains to a drug withdrawal system for a vial.
  • the withdrawal system comprises: a vial containing a medicament therein and closed with a rubber gasket; and an apparatus which snap fits on top of the vial.
  • the apparatus comprises: a chassis and a cap which is attached to the cap by a living hinge.
  • the chassis is cylindrical and has vertical grooves on the external sides to facilitate handling.
  • the top of the chassis has a central opening.
  • the chassis includes a removable male luer lock adapter, having external threads thereon, including a ferrule structure the lower end of which has a hollow sharpened lance.
  • the apparatus is used with a syringe having a female luer lock connector which snap fits with the removable male luer lock adapter including the ferrule.
  • the cap cover is opened, and a syringe is screwed onto the outer end of the adapter, then tightened on the adapter which moves the lance downward thereby establishing flow communication with the content of the vial.
  • U.S. Patent No. 5,433,330 relates to a needleless access stopper used on containers with a cannula having a blunt, stopper penetrating tip.
  • the stopper includes a disc and a plug extending from the disc into the container.
  • a diaphragm defined by a target region in the upper face.
  • a centrally located piercing point positioned to pre-slit the diaphragm.
  • This stopper is not suitable for syringe, cartridge or IV tubing having a female luer connector.
  • the pre-slit disc does not assure a complete seal of the contents of the container from the environment and it is not useful for multiple use.
  • the present invention provides a multiple use universal closure assembly allowing repeatedly access to a medical fluid contained in a container with various external access means available to healthcare professionals and emergency practitioners and sometimes to patients requiring self-injections, such as cartridge or iv tubing equipped with a female luer connector or a syringe having sharp or blunt needle cannula or sharp and blunt spikes.
  • the present invention provides a multiple use universal closure assembly allowing access to a medical fluid contained in a container comprising accessing (receiving) and sealing means designed for multiple use so that the medical fluid can be repeatedly accessed. After each withdrawal of the desired amount of the medical fluid, the sealing means self-seals itself thereby preventing contamination of the medical fluid by air-born particles, such as dust and bacteria.
  • the multiple use universal closure assembly comprises:
  • the elastomeric stopper according to the invention having a head portion and a skirt portion is made of an elastomeric base, such as a natural or synthetic rubber preferably having an inert, polymeric coating thereon covering at least the medical fluid contacting portions of the stopper.
  • the coating may be of chlorobutyl rubber, polymeric fluorocarbon resins and thermoplastic films.
  • the elastomeric stopper is of cylindrical shape and has a flange head portion overlying the open top end of the container. Integral with the head portion is a skirt portion which extends into the open end and seated in the neck portion of the container, the diameter of the neck portion of the container being somewhat larger than the inside diameter of the skirt portion so that a tight seal is created between the skirt portion and the wall of the container.
  • the cylindrical opening In the centre portion of the elastomeric stopper there is a cylindrical opening extending through the head and the skirt portions of the stopper.
  • the cylindrical opening through the stopper body would expose the content of the container to the environment allowing contamination therefrom.
  • the cylindrical opening is closed by a sealing means, namely a rupturable sealing membrane.
  • the rupturable sealing membrane may be made separately from the elastomeric stopper, positioned in the opening, and sealed into the elastomeric stopper using thermoplastic or other sealing means known in the art.
  • the elastomeric stopper and the sealing membrane are integral with each other and produced by blow molding or other suitable manufacturing techniques.
  • the sealing membrane is preferably a protuberance residing in the top half of head portion of the elastomeric stopper and is resembling an M-shaped configuration comprising: vertical leg portions or cylindrical side wall; a top surface resembling a cup or U-shaped portion extending downwards and toward the bottom portion of the elastomeric stopper, forming an M-shaped configuration when taken together with the cylindrical side walls.
  • the rupturable sealing membrane is of thin, elastomeric material preferably having a slit in its centre portion which slit does not completely traverse the centre portion of the rupturable sealing membrane.
  • the M-shaped sealing membrane in the elastomeric stopper would collapse, or at least deform when penetrated by a luer connector, sharp or blunt syringe cannula.
  • a rigid, cylindrical housing or male element open at both ends are provided to support the M-shaped sealing membrane and also serving as a receiving (accessing) means for an external access means.
  • Such external access means is preferably female access means, such as a female luer connector.
  • Such external access means are threaded into the male connecting means thereby rupturing the sealing membrane to establish fluid communication with the content of the container.
  • the multiple use universal closure assembly further comprises (3) a cylindrical collar; and further (4) a removable cap.
  • the cylindrical collar preferably made of metal such as aluminum, is fastened over the elastomeric stopper and the neck portion of the container to securely hold the elastomeric stopper in the open end of the container.
  • the cylindrical collar comprises a central opening in its flat top portion to allow access to the cylindrical opening in the stopper and to the sealing membrane and receiving means (male element) located in the cylindrical opening.
  • the removable cap covers the flat top and rim portions of the cylindrical collar and comprises retaining ears which engage the cylindrical collar to maintain the closure assembly in aseptic condition.
  • the present invention provides a multiple use universal closure assembly/container combination comprising:
  • the present invention provides a method for repeatedly accessing a medical fluid contained in a container equipped with the multiple use universal closure assembly of the present invention comprising the steps of:
  • the present invention provides sealing and accessing means for containers such as bottles or vials made of glass or plastic containing medical fluids, such as x-ray contrast media and parenteral liquids.
  • the access means of the closure assembly of the present invention provides for hermetic sealing, safe handling, sterilization and storing.
  • the sealing means are designed for multiple use so that the medical fluid can be accessed repeatedly. After each withdrawal of the desired amount of the medical fluid, the sealing means self-seals itself thereby preventing contamination of the medical fluid by air-born particles, such as dust and bacteria.
  • the invention includes sealing and receiving (accessing) means for containers in general which comprise rigid or semi rigid access ports and are capable of receiving such sealing and access means.
  • the container is preferably made of glass, however, it can also be made of polymeric materials known in the art.
  • the container has a neck portion terminating in an open end to receive the closure assembly which is inserted in the open end to seal the content therein and maintain it in sterile and aseptic condition
  • the access means comprise no “sharps”, such as in sharp needle cannulas, in order to prevent accidental injuries and transmittance of contagious diseases, such as AIDS.
  • the external access means is preferably a syringe, cartridge or IV tubing having a female luer connector.
  • other access means such as a syringe having a sharp or blunt needle cannula or a spike may also be used to rupture the sealing membrane of the closure assembly.
  • the container 10 having an open end in which the multiple use universal stopper is used comprises a neck portion 12, a side portion 14, and a bottom portion 16.
  • the multiple use universal stopper held securely in place by cylindrical collar 70 having an open area 71 in its top centre portion, said open area being defined by the circular rim denoted by the numeral 74.
  • Cylindrical collar further comprises a flat top surface 75 defined by circular rims 74 and 76 and top rim portion 73. Cylindrical collar 70 is crimped at its bottom rim 72 to neck portion 12 of the container.
  • FIG. 1B shows locking ears 50 constituting a part of the universal stopper which is described later in reference to other Figures as the description of the invention proceeds.
  • removable cap 18 covers flat top surface 75 and top rim portion 73 of cylindrical collar to maintain open area in top centre portion 71 of cylindrical collar and locking ears 50 in aseption condition during storage.
  • Removable cap 18 comprises: side rim portion 22, flexible retaining ears 24, and retainer button 26.
  • retaining ears 24 are slid under circular rim 74 in cylindrical collar 70 providing a tight seal between removable cap 18 and flat top surface 75 of cylindrical collar.
  • Retainer button 26 together with retaining ears 24 also serve to limit expansion of the thin elastomeric membrane or seal during sterilisation.
  • the open end of the container 10 is to receive an elastomeric stopper 60 having a top surface 63 and a bottom surface 65 and comprises: a head 62 and a skirt 64 integral therewith.
  • the head comprises a flange 66, extending laterally outwardly from skirt 64 and is designed to cover the transverse end surface of the container.
  • the elastomeric stopper shown in FIGS. 6 and 6A is conventionally used by the prior art. In the present invention, as best seen in FIGS.
  • the elastomeric stopper further comprises: a cylindrical opening 68 in its centre portion defined by cylindrical walls denoted by the numerals 80 and 80'; bottom ring portion denoted by the numerals 82 and 82'; and funnel shaped opening 83 extending downward from the bottom ring portion into the container defined by walls 84 and 84'.
  • Projecting upward towards the top surface 63 of elastomeric stopper 60 is a hollow, vertically-oriented, cylindrical protuberance 85 defined by cylindrical walls 86 and 86' and top surface 120.
  • Top surface 120, along with cylindrical walls 86 and 86', are designed to serve as the elastomeric seal in the elastomeric stopper.
  • the cylindrical protuberance is preferably integral with the stopper body such as produced by blow molding technique or it may be produced separately and sealed into the central opening defined by walls 80 and 80' in the elastomeric stopper 60.
  • the vertically-oriented cylindrical protuberance is of thin, membrane-like material designed to be ruptured by an external force exerted on the protuberance by an external access means, such as a luer connector.
  • the cylindrical protuberance is an M-shaped diaphragm wherein the numerals 86 and 86' denote the leg portions and the numeral 120 denotes the top surface resembling a cup shape. The lowest point in the top surface 120 is denoted by the numeral 121 which is the centre point in the cup-shaped portion.
  • a slit 122 extending from the top surface or inside surface toward the bottom surface 125 of the cup-shaped portion of the M-shaped diaphragm.
  • the slit does not penetrate the bottom surface 125.
  • the thickness between the slit 122 and the intact bottom surface 125 is typically of form about 0.001 to about 2.0 mm.
  • the unpenetrated portion of the membrane denoting its thickness at the centre portion is denoted by the numeral 127 in FIGS. 4B and 4C. The unpenetrated membrane maintains the content of the container in sealed condition.
  • a cylindrical housing or male element (receiving means) generally designated as 100 is provided, located in the upper centre portion 68 of elastomeric stopper 60.
  • Housing 100 comprises: cylindrical wall 102 having a top surface 104 and bottom surface 106.
  • Cylindrical wall 102 comprises an inside wall 108, an outside wall 110, locking ears 50, and horizontally-oriented bottom portion 112.
  • Locking ears 50 is designed to securely hold the female element of a luer connector.
  • Horizontally-oriented bottom portion 112 extends into the skirt 64 and sealed thereto at the bottom ring portion 82 and 82' of elastomeric stopper 60.
  • the cylindrical protuberance serving as a sealing membrane is of inert gas-impermeable polymeric material capable of flexing under internal or external pressures such as exerted during steam sterilisation.
  • the membrane has a thickness of from about 0.001 mm to about 2.00 mm and a durometer of from about 25 to about 80 Shore A.
  • Suitable elastomeric materials for constructing the membrane include:
  • the cylindrical M-shaped protuberance is positioned in elastomeric stopper 60 so that its top surface 120 is spaced about 2 to 3 mm form retainer button 26 of removable cap 18 when the cap is placed on container 10.
  • the spacing allows the membrane to flex outwardly under pressure, such as created under heat sterilisation. However, spacing should not be more than about 2 to 3 mm so that under accidentally high pressures, bursting of the membrane is prevented by the retaining button 26 of removable cap 18.
  • the multiple use universal closure assembly of the present invention may also have a configuration shown in FIGS. 9 and 10.
  • the stopper of this configuration is used when lyophilization of the content of the container is desired. Prior to use the lyophilized content is reconstituted by injecting into the container through the multiple use universal stopper water, saline or other liquids.
  • the universal closure assembly of the present invention is preferably used with an external female luer connector when fluid communication is desired with the content of the container stoppered by the universal stopper.
  • a typical female luer connector 140 is shown in FIG. 11 and comprises: cylindrical outside wall 142 and cylindrical inside wall 143 having an opening in their centre portion for accommodating a tubing within the inside wall. Cylindrical ring 144 located in the top centre portion of cylindrical inside wall 143 tightly holds tubing 160 which has a fluid communicating channel 162.
  • Cylindrical inside wall 143 further comprises integral screw threads 146, 148, 150 and 152 which, upon connecting the female luer connector to the male luer connector, engages locking ears 50 on the housing or male element 100, as shown in FIGS. 7 and 7A.
  • Other type of female luer connectors, such as snap-on connectors may also be used.
  • FIG. 12 shows, in cross-sectional view, a syringe having a female luer connector, which is to engage the multiple use universal stopper in the container 10, wherein the syringe and universal stopper are shown prior to their engagement.
  • removable cap 18 is removed by an upward manual pressure exerted on its rim portion 22 thereby exposing locking ears 50 of the access means housing.
  • the female luer connector of FIG. 11 is used, it is attached to the multiple use universal closure assembly by twisting motion wherein threads 146, 148, 150 and 152 engage locking ears 50 of access means housing 100. Upon turning the female luer connector 140, end portion of tubing 160 ruptures membrane of the universal stopper to establish fluid communication with the content of the container.
  • FIG. 12A shows, in cross-sectional view, the syringe having the female luer connector partially engaging the multiple use universal closure assembly.
  • FIG. 12B shows, in cross-sectional view, the syringe having the female luer connector completely engaging the multiple use universal closure assembly.
  • FIG. 13 shows, in cross-sectional view, the syringe having the female luer connector removed from the multiple use universal closure assembly after their engagement.
  • the multiple use universal closure assembly can be engaged by an external female luer connector having a blunt end which engages and ruptures the cylindrical M-shaped seal in the centre of the multiple use universal closure assembly.
  • the multiple use universal stopper also allows access to the content of the container by a sharp or blunt needle cannula or a spike.
  • the elastomeric stopper used in conjunction with the universal stopper of the present invention is fluid impervious, resilient, and inert without leachable additives therein in order to prevent any alteration of the product contained in the container. It may be of a single component or a blend of components. Examples of materials include synthetic and natural rubbers, such as butyl rubber, isoprene rubber, silicone rubber, halogenated rubber, ethylene propylene therpolymer and the like.
  • a synthetic elastomeric rubber examples include the CH 2 CF 2 -C 3 F 6 (C 3 F 5 H) and the C 2 F 4 -C 2 F 3 OCF 3 series of elastomers made by DuPont under the trade names of VITON® and CARLEZ®; the fluoro-silicone rubbers, such as those made by Dow Corning under the trade name of SILASTIC®; and polyisobutylenes, such as VISTANEX MML-100 and MML-140; and halogenated butyl rubber, such as CHLOROBUTYL 1066, made by Exxon Chemical Company.
  • elastomers may be made into the desired stopper configuration by known methods. Such methods conventionally include the use of a curing agent, a stabilizer and a filler and comprise a primary and a secondary curing step at elevated temperatures.
  • the container used in conjunction with the present invention may be of glass or a polymeric material, i.e., plastic, which are well known in the pharmaceutical industry.
  • the container When the container is made of glass, it is in the shape of a vial or bottle.
  • the vial or bottle is of rigid or semi-flexible polymeric material.
  • the container In all shapes the container is provided with a neck portion which is rigid and retains its configuration so that it is capable of being hermetically sealed by the elastomeric universal stopper of the present invention.
  • the container may have a volume capacity of from 5 ml to 1000 ml or more, preferably about 10 ml to 500 ml.
  • the mouth of the container is to receive the multiple use universal closure assembly.
  • the external diameter of the stopper is slightly larger than the internal diameter of the neck of the container so that on insertion of the multiple use universal stopper into the mouth of the container, a tight, hermetic seal is achieved.
  • the cylindrical collar is preferably made of metal, such as aluminum, while the housing is made of hard plastic known by the prior art and used in conjunction with pharmaceutical fluids.
  • the container and component parts of the closure Prior to use, the container and component parts of the closure are sterilised and the container is filled with a pharmaceutical fluid, such as a parenteral solution.
  • a pharmaceutical fluid such as a parenteral solution.
  • the multiple use universal stopper is inserted, hermetically sealing the content of the container. Cylindrical collar is then crimped onto the container to securely hold the multiple use universal closure assembly in the container. Lastly, the removable cap is snapped onto the cylindrical collar to complete the closing of the container.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
EP19990103563 1998-05-16 1999-02-24 Bouchon universel à utilisations multiples Expired - Lifetime EP0960616B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80091 1987-07-31
US09/080,091 US5971181A (en) 1998-05-04 1998-05-16 Multiple use universal stopper

Publications (3)

Publication Number Publication Date
EP0960616A2 true EP0960616A2 (fr) 1999-12-01
EP0960616A3 EP0960616A3 (fr) 2000-04-26
EP0960616B1 EP0960616B1 (fr) 2004-09-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP19990103563 Expired - Lifetime EP0960616B1 (fr) 1998-05-16 1999-02-24 Bouchon universel à utilisations multiples

Country Status (4)

Country Link
EP (1) EP0960616B1 (fr)
JP (1) JP4288742B2 (fr)
CA (1) CA2262477C (fr)
DE (1) DE69919935T2 (fr)

Cited By (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002056821A2 (fr) * 2000-12-04 2002-07-25 Bracco Diagnostics Inc. Adaptateur d'acces a la fiole a activation axiale
EP1384466A1 (fr) * 2002-07-23 2004-01-28 Fresenius Kabi Deutschland GmbH Bouteille de plastique destinée à recevoir un fluide, notamment une solution de nutrition entérale
FR2939110A1 (fr) * 2008-11-28 2010-06-04 Sarol S A S Di Franzoni Pierfr Bouchon a membrane
EP2546152A2 (fr) * 2002-09-03 2013-01-16 Medical Instill Technologies, Inc. Contenants hermétiques et procédés de fabrication et de remplissage de ceux-ci
WO2014126593A1 (fr) * 2013-02-12 2014-08-21 Abbvie Inc. Seringue avec pression d'étanchéité à deux étages
US8852145B2 (en) 2010-11-14 2014-10-07 Medimop Medical Projects, Ltd. Inline liquid drug medical device having rotary flow control member
US8905994B1 (en) 2011-10-11 2014-12-09 Medimop Medical Projects, Ltd. Valve assembly for use with liquid container and drug vial
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
US8979792B2 (en) 2009-11-12 2015-03-17 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
US9180070B2 (en) 2012-02-02 2015-11-10 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling to a medical container
USD747650S1 (en) 2013-08-05 2016-01-19 Becton Dickinson France Blocking closure for container
US9283324B2 (en) 2012-04-05 2016-03-15 Medimop Medical Projects, Ltd Fluid transfer devices having cartridge port with cartridge ejection arrangement
US9339438B2 (en) 2012-09-13 2016-05-17 Medimop Medical Projects Ltd. Telescopic female drug vial adapter
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
WO2016166197A1 (fr) 2015-04-17 2016-10-20 Centre Hospitalier Universitaire D'amiens-Picardie Dispositif de bouchage pour permettre un prélèvement d'une composition ensemble de conditionnement comprenant un tel dispositif de bouchage, procédés de prélèvement et de conditionnement
US9549873B2 (en) 2012-02-02 2017-01-24 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling to a medical container
US9668939B2 (en) 2012-02-02 2017-06-06 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling with a medical container
US9795536B2 (en) 2012-08-26 2017-10-24 Medimop Medical Projects, Ltd. Liquid drug transfer devices employing manual rotation for dual flow communication step actuations
WO2017147233A3 (fr) * 2016-02-24 2017-10-26 Neomed, Inc. Raccord de transfert de fluide
US9801786B2 (en) 2013-04-14 2017-10-31 Medimop Medical Projects Ltd. Drug container closure for mounting on open-topped drug container to form drug reconstitution assemblage for use with needleless syringe
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
US9815601B2 (en) 2011-09-29 2017-11-14 Ge Healthcare As Package
US9839580B2 (en) 2012-08-26 2017-12-12 Medimop Medical Projects, Ltd. Liquid drug transfer devices
US9943463B2 (en) 2013-05-10 2018-04-17 West Pharma. Services IL, Ltd. Medical devices including vial adapter with inline dry drug module
USD825746S1 (en) 2015-06-18 2018-08-14 Neomed, Inc. Syringe-to-syringe coupler
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
USD833006S1 (en) 2016-11-28 2018-11-06 Neomed, Inc. Fluid transfer connector
US10195350B2 (en) 2011-08-31 2019-02-05 Abbvie Inc. Sealing arrangement for syringe
US10195112B2 (en) 2012-11-26 2019-02-05 Becton Dickinson France Adaptor for multidose medical container
US10278897B2 (en) 2015-11-25 2019-05-07 West Pharma. Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
US10285907B2 (en) 2015-01-05 2019-05-14 West Pharma. Services IL, Ltd. Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
US10576020B2 (en) 2015-06-18 2020-03-03 Neomed, Inc. Syringe-to-syringe coupler
WO2020044106A3 (fr) * 2018-08-29 2020-04-30 СИА Эмтеко Холдинг Forme dosée liquide d'édaravone ou de ses sels pharmaceutiquement acceptables restant stables lors de la conservation, du transport et de l'utilisation
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
US10744317B2 (en) 2015-07-15 2020-08-18 Neomed, Inc. Enteral adaptor couplings
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10772797B2 (en) 2016-12-06 2020-09-15 West Pharma. Services IL, Ltd. Liquid drug transfer devices for use with intact discrete injection vial release tool
US10773067B2 (en) 2014-09-08 2020-09-15 Neomed, Inc. Enteral connectors having coupling features
US10806671B2 (en) 2016-08-21 2020-10-20 West Pharma. Services IL, Ltd. Syringe assembly
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
USD917693S1 (en) 2018-07-06 2021-04-27 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923782S1 (en) 2019-01-17 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
WO2021216821A1 (fr) * 2020-04-24 2021-10-28 West Pharmaceutical Services, Inc. Systèmes de confinement
US11166876B2 (en) 2016-02-24 2021-11-09 Neomed, Inc. Fluid transfer connector
USD954253S1 (en) 2019-04-30 2022-06-07 West Pharma. Services IL, Ltd. Liquid transfer device
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11642285B2 (en) 2017-09-29 2023-05-09 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including twin vented female vial adapters
US11903902B2 (en) 2022-01-03 2024-02-20 Benjamin Martin DAVIS Fluid transfer couplings
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device

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IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
JP6386471B2 (ja) * 2012-12-21 2018-09-05 フレゼニウス カービ ドイチュラント ゲーエムベーハー ミルク瓶アダプター
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Cited By (76)

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WO2002056821A2 (fr) * 2000-12-04 2002-07-25 Bracco Diagnostics Inc. Adaptateur d'acces a la fiole a activation axiale
WO2002056821A3 (fr) * 2000-12-04 2003-01-09 Bracco Diagnostics Inc Adaptateur d'acces a la fiole a activation axiale
EP1384466A1 (fr) * 2002-07-23 2004-01-28 Fresenius Kabi Deutschland GmbH Bouteille de plastique destinée à recevoir un fluide, notamment une solution de nutrition entérale
EP2546152A2 (fr) * 2002-09-03 2013-01-16 Medical Instill Technologies, Inc. Contenants hermétiques et procédés de fabrication et de remplissage de ceux-ci
FR2939110A1 (fr) * 2008-11-28 2010-06-04 Sarol S A S Di Franzoni Pierfr Bouchon a membrane
US9132063B2 (en) 2009-11-12 2015-09-15 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
US8979792B2 (en) 2009-11-12 2015-03-17 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
US8852145B2 (en) 2010-11-14 2014-10-07 Medimop Medical Projects, Ltd. Inline liquid drug medical device having rotary flow control member
US10195350B2 (en) 2011-08-31 2019-02-05 Abbvie Inc. Sealing arrangement for syringe
US9815601B2 (en) 2011-09-29 2017-11-14 Ge Healthcare As Package
US8905994B1 (en) 2011-10-11 2014-12-09 Medimop Medical Projects, Ltd. Valve assembly for use with liquid container and drug vial
US10532005B2 (en) 2012-02-02 2020-01-14 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling to a medical container
US9668939B2 (en) 2012-02-02 2017-06-06 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling with a medical container
US10751252B2 (en) 2012-02-02 2020-08-25 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling with a medical container
US9180070B2 (en) 2012-02-02 2015-11-10 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling to a medical container
US9549873B2 (en) 2012-02-02 2017-01-24 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling to a medical container
US10966903B2 (en) 2012-02-02 2021-04-06 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling to a medical container
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
US9283324B2 (en) 2012-04-05 2016-03-15 Medimop Medical Projects, Ltd Fluid transfer devices having cartridge port with cartridge ejection arrangement
US10299990B2 (en) 2012-08-26 2019-05-28 West Pharma. Services IL, Ltd. Liquid drug transfer devices
US9839580B2 (en) 2012-08-26 2017-12-12 Medimop Medical Projects, Ltd. Liquid drug transfer devices
US9795536B2 (en) 2012-08-26 2017-10-24 Medimop Medical Projects, Ltd. Liquid drug transfer devices employing manual rotation for dual flow communication step actuations
US9339438B2 (en) 2012-09-13 2016-05-17 Medimop Medical Projects Ltd. Telescopic female drug vial adapter
US10195112B2 (en) 2012-11-26 2019-02-05 Becton Dickinson France Adaptor for multidose medical container
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
EP3050586A1 (fr) * 2013-02-12 2016-08-03 AbbVie Inc. Seringue avec une pression d'étanchéité à deux étages
US9669165B2 (en) 2013-02-12 2017-06-06 Abbvie Inc. Syringe with two-stage sealing pressure
WO2014126593A1 (fr) * 2013-02-12 2014-08-21 Abbvie Inc. Seringue avec pression d'étanchéité à deux étages
US9801786B2 (en) 2013-04-14 2017-10-31 Medimop Medical Projects Ltd. Drug container closure for mounting on open-topped drug container to form drug reconstitution assemblage for use with needleless syringe
US9943463B2 (en) 2013-05-10 2018-04-17 West Pharma. Services IL, Ltd. Medical devices including vial adapter with inline dry drug module
USD747650S1 (en) 2013-08-05 2016-01-19 Becton Dickinson France Blocking closure for container
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
US10773067B2 (en) 2014-09-08 2020-09-15 Neomed, Inc. Enteral connectors having coupling features
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
US10285907B2 (en) 2015-01-05 2019-05-14 West Pharma. Services IL, Ltd. Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
US11090226B2 (en) 2015-04-17 2021-08-17 Centre Hospitalier Universitaire D'amiens-Picardie Sealing device for making it possible to collect a composition, packaging assembly comprising such a sealing device, collection and packaging methods
WO2016166197A1 (fr) 2015-04-17 2016-10-20 Centre Hospitalier Universitaire D'amiens-Picardie Dispositif de bouchage pour permettre un prélèvement d'une composition ensemble de conditionnement comprenant un tel dispositif de bouchage, procédés de prélèvement et de conditionnement
US10576020B2 (en) 2015-06-18 2020-03-03 Neomed, Inc. Syringe-to-syringe coupler
US11065181B2 (en) 2015-06-18 2021-07-20 Neomed, Inc. Syringe-to-syringe coupler
USD825746S1 (en) 2015-06-18 2018-08-14 Neomed, Inc. Syringe-to-syringe coupler
US10744317B2 (en) 2015-07-15 2020-08-18 Neomed, Inc. Enteral adaptor couplings
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
US10278897B2 (en) 2015-11-25 2019-05-07 West Pharma. Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
US11166876B2 (en) 2016-02-24 2021-11-09 Neomed, Inc. Fluid transfer connector
US12036183B2 (en) 2016-02-24 2024-07-16 Avent, Inc. Fluid transfer connector
US10857068B2 (en) 2016-02-24 2020-12-08 Neomed, Inc. Fluid transfer connector
WO2017147233A3 (fr) * 2016-02-24 2017-10-26 Neomed, Inc. Raccord de transfert de fluide
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
US10806671B2 (en) 2016-08-21 2020-10-20 West Pharma. Services IL, Ltd. Syringe assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
USD833006S1 (en) 2016-11-28 2018-11-06 Neomed, Inc. Fluid transfer connector
US10772798B2 (en) 2016-12-06 2020-09-15 West Pharma Services Il, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10772797B2 (en) 2016-12-06 2020-09-15 West Pharma. Services IL, Ltd. Liquid drug transfer devices for use with intact discrete injection vial release tool
US11786443B2 (en) 2016-12-06 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
US11642285B2 (en) 2017-09-29 2023-05-09 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including twin vented female vial adapters
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD917693S1 (en) 2018-07-06 2021-04-27 West Pharma. Services IL, Ltd. Medication mixing apparatus
CN112672733A (zh) * 2018-08-29 2021-04-16 新航益泰科股份有限公司 储存、运输稳定且易用的依达拉奉或药学上可接受的盐的液体剂型
WO2020044106A3 (fr) * 2018-08-29 2020-04-30 СИА Эмтеко Холдинг Forme dosée liquide d'édaravone ou de ses sels pharmaceutiquement acceptables restant stables lors de la conservation, du transport et de l'utilisation
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923782S1 (en) 2019-01-17 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11484470B2 (en) 2019-04-30 2022-11-01 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen IV spike
US11786442B2 (en) 2019-04-30 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen IV spike
USD954253S1 (en) 2019-04-30 2022-06-07 West Pharma. Services IL, Ltd. Liquid transfer device
USD1043974S1 (en) 2019-04-30 2024-09-24 West Pharma. Services IL, Ltd. Liquid transfer device
WO2021216821A1 (fr) * 2020-04-24 2021-10-28 West Pharmaceutical Services, Inc. Systèmes de confinement
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11903902B2 (en) 2022-01-03 2024-02-20 Benjamin Martin DAVIS Fluid transfer couplings

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DE69919935D1 (de) 2004-10-14
EP0960616A3 (fr) 2000-04-26
JP4288742B2 (ja) 2009-07-01
CA2262477C (fr) 2008-02-12
CA2262477A1 (fr) 1999-11-16
EP0960616B1 (fr) 2004-09-08
DE69919935T2 (de) 2005-09-15
JPH11321916A (ja) 1999-11-24

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