EP0959885A4 - Triaryl substituierte imidazole und verfahren zur verwendung - Google Patents
Triaryl substituierte imidazole und verfahren zur verwendungInfo
- Publication number
- EP0959885A4 EP0959885A4 EP97948327A EP97948327A EP0959885A4 EP 0959885 A4 EP0959885 A4 EP 0959885A4 EP 97948327 A EP97948327 A EP 97948327A EP 97948327 A EP97948327 A EP 97948327A EP 0959885 A4 EP0959885 A4 EP 0959885A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- substituted imidazoles
- triaryl substituted
- triaryl
- imidazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3146896P | 1996-11-20 | 1996-11-20 | |
US31468P | 1996-11-20 | ||
GBGB9700559.9A GB9700559D0 (en) | 1997-01-13 | 1997-01-13 | Triaryl substituted imidazoles and methods of use |
GB9700559 | 1997-01-13 | ||
PCT/US1997/020955 WO1998022108A1 (en) | 1996-11-20 | 1997-11-17 | Triaryl substituted imidazoles and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0959885A1 EP0959885A1 (de) | 1999-12-01 |
EP0959885A4 true EP0959885A4 (de) | 2002-07-17 |
Family
ID=26310784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97948327A Withdrawn EP0959885A4 (de) | 1996-11-20 | 1997-11-17 | Triaryl substituierte imidazole und verfahren zur verwendung |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0959885A4 (de) |
JP (1) | JP2001504489A (de) |
AU (1) | AU726311B2 (de) |
CA (1) | CA2271941A1 (de) |
WO (1) | WO1998022108A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6503949B1 (en) | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
JP2003520226A (ja) | 2000-01-21 | 2003-07-02 | ノバルティス アクチエンゲゼルシャフト | ジペプチジルペプチダーゼ−iv阻害剤および抗糖尿病薬剤を含む組合せ物 |
US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
AU2002223500A1 (en) | 2000-11-17 | 2002-05-27 | Novo-Nordisk A/S | Glucagon antagonists/inverse agonists |
US6706744B2 (en) | 2000-11-17 | 2004-03-16 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
US6821960B2 (en) | 2000-11-17 | 2004-11-23 | Noyo Nordisk Pharmaceuticals, Inc. | Glucagon antagonists/inverse agonists |
WO2003024447A1 (en) * | 2001-09-20 | 2003-03-27 | Smithkline Beecham Corporation | Inhibitors of glycogen synthase kinase-3 |
CA2463441A1 (en) * | 2001-10-12 | 2003-05-08 | Bayer Pharmaceuticals Corporation | Phenyl substituted 5-membered nitrogen containing heterocycles for the treatment of obesity |
US6881746B2 (en) | 2001-12-03 | 2005-04-19 | Novo Nordick A/S | Glucagon antagonists/inverse agonists |
US6762318B2 (en) | 2001-12-03 | 2004-07-13 | Novo Nordisk A/S | Glucagon antagonists |
AU2003299791A1 (en) * | 2002-12-20 | 2004-07-22 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
AU2004210127B2 (en) | 2003-01-27 | 2009-10-01 | Merck Sharp & Dohme Corp. | Substituted pyrazoles, compositions containing such compounds and methods of use |
CN1897936A (zh) | 2003-12-19 | 2007-01-17 | 默克公司 | 环状胍、含有这种化合物的组合物及其使用方法 |
ES2306165T3 (es) | 2004-06-04 | 2008-11-01 | MERCK & CO., INC. | Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso. |
CA2572745A1 (en) | 2004-07-07 | 2006-02-16 | Teresa Beeson | Pyrazole amide derivatives, compositions containing such compounds and methods of use |
ATE468853T1 (de) | 2004-07-22 | 2010-06-15 | Merck Sharp & Dohme | Substituierte pyrazole, derartige verbindungen enthaltende zusammensetzungen und verfahren zu ihrer verwendung |
AU2006227435A1 (en) | 2005-03-21 | 2006-09-28 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives |
US7803951B2 (en) | 2005-03-30 | 2010-09-28 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
US7709658B2 (en) | 2005-07-26 | 2010-05-04 | Merck Sharp & Dohme Corp. | Process for synthesizing a substituted pyrazole |
PE20070458A1 (es) | 2005-09-14 | 2007-07-05 | Takeda Pharmaceutical | Composicion farmaceutica que comprende 2-[[6-(3r)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2h)-pirimidinil]metil]-benzonitrilo como inhibidor de dipeptidil peptidasa |
TW200745031A (en) | 2005-10-13 | 2007-12-16 | Merck & Co Inc | Acyl indoles, compositions containing such compounds and methods of use |
CA2645639A1 (en) | 2006-03-23 | 2007-10-04 | Merck & Co. Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
WO2007136577A2 (en) | 2006-05-16 | 2007-11-29 | Merck & Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
TW200821284A (en) | 2006-10-03 | 2008-05-16 | Merck & Co Inc | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
WO2011097079A1 (en) | 2010-02-03 | 2011-08-11 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
EP3065736B1 (de) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon-rezeptor-antagonist-verbindungen, zusammensetzungen daraus und verfahren zur verwendung |
ES2926931T3 (es) * | 2014-02-07 | 2022-10-31 | Agency Science Tech & Res | Inhibidores de caseína quinasa 1 basados en azoles 2,4,5-tri-sustituidos como inductores de la cardiomiogénesis |
US20180044316A1 (en) * | 2015-03-05 | 2018-02-15 | University Of Notre Dame Du Lac | Potentiators of beta-lactam antibiotics |
US11958828B1 (en) | 2023-11-07 | 2024-04-16 | King Faisal University | 4,5-bis(4-bromophenyl)-1-hexyl-2-(3-pyridyl)-1H-imidazole as an antimicrobial compound |
US11970462B1 (en) | 2024-01-03 | 2024-04-30 | King Faisal University | Ethyl 3-[4,4-bis(4-chlorophenyl)-2,5-dioxoimidazolidin-1-yl]propanoate as an antimicrobial compound |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3929807A (en) * | 1971-05-10 | 1975-12-30 | Ciba Geigy Corp | 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles |
US4430326A (en) * | 1981-12-22 | 1984-02-07 | University Patents, Inc. | Method of diminishing glucose levels resulting from endogenous glucagon |
WO1993014081A1 (en) * | 1992-01-13 | 1993-07-22 | Smithkline Beecham Corporation | Imidazole derivatives and their use as cytokine inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
-
1997
- 1997-11-17 CA CA002271941A patent/CA2271941A1/en not_active Abandoned
- 1997-11-17 WO PCT/US1997/020955 patent/WO1998022108A1/en not_active Application Discontinuation
- 1997-11-17 AU AU54414/98A patent/AU726311B2/en not_active Ceased
- 1997-11-17 EP EP97948327A patent/EP0959885A4/de not_active Withdrawn
- 1997-11-17 JP JP52378498A patent/JP2001504489A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3929807A (en) * | 1971-05-10 | 1975-12-30 | Ciba Geigy Corp | 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles |
US4430326A (en) * | 1981-12-22 | 1984-02-07 | University Patents, Inc. | Method of diminishing glucose levels resulting from endogenous glucagon |
WO1993014081A1 (en) * | 1992-01-13 | 1993-07-22 | Smithkline Beecham Corporation | Imidazole derivatives and their use as cytokine inhibitors |
Non-Patent Citations (7)
Title |
---|
ANESTEZIOLOGIIA I REANIMATOLOGIIA. RUSSIA 1996 SEP-OCT, no. 5, September 1996 (1996-09-01), pages 29 - 39, ISSN: 0201-7563 * |
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. UNITED STATES 1 FEB 1993, vol. 300, no. 2, 1 February 1993 (1993-02-01), pages 747 - 750, ISSN: 0003-9861 * |
DATABASE MEDLINE [online] 1 February 1993 (1993-02-01), UNSON C G ET AL: "The role of histidine-1 in glucagon action.", XP002199270, Database accession no. NLM8382034 * |
DATABASE MEDLINE [online] 1996, DEL REY A ET AL: "Metabolic and endocrine effects of interleukin-1 in obese, diabetic Zucker fa/fa rats.", XP002199269, Database accession no. NLM8886749 * |
DATABASE MEDLINE [online] September 1996 (1996-09-01), MAYER N A ET AL: "The utilization of nutrient substances during wound healing", XP002199268, Database accession no. NLM9027251 * |
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES: OFFICIAL JOURNAL, GERMAN SOCIETY OF ENDOCRINOLOGY [AND] GERMAN DIABETES ASSOCIATION. GERMANY 1996, vol. 104, no. 4, 1996, pages 317 - 326, ISSN: 0947-7349 * |
See also references of WO9822108A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2001504489A (ja) | 2001-04-03 |
AU5441498A (en) | 1998-06-10 |
WO1998022108A1 (en) | 1998-05-28 |
AU726311B2 (en) | 2000-11-02 |
EP0959885A1 (de) | 1999-12-01 |
CA2271941A1 (en) | 1998-05-28 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19990621 |
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AK | Designated contracting states |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20020604 |
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GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61P 9/12 B Ipc: 7A 61P 3/10 B Ipc: 7A 61P 3/04 B Ipc: 7A 61K 31/44 A |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20030904 |