EP0957913A4 - N-BONDED SULPHONAMIDES OF HETEROCYCLIC THIOESTERS - Google Patents
N-BONDED SULPHONAMIDES OF HETEROCYCLIC THIOESTERSInfo
- Publication number
- EP0957913A4 EP0957913A4 EP97950991A EP97950991A EP0957913A4 EP 0957913 A4 EP0957913 A4 EP 0957913A4 EP 97950991 A EP97950991 A EP 97950991A EP 97950991 A EP97950991 A EP 97950991A EP 0957913 A4 EP0957913 A4 EP 0957913A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- heterocyclic thioesters
- linked sulfonamides
- sulfonamides
- linked
- thioesters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Lubricants (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/775,584 US5874449A (en) | 1996-12-31 | 1996-12-31 | N-linked sulfonamides of heterocyclic thioesters |
US775584 | 1996-12-31 | ||
US08/996,342 US6121273A (en) | 1996-12-31 | 1997-12-22 | N-linked sulfonamides of heterocyclic thioesters |
PCT/US1997/023526 WO1998029116A1 (en) | 1996-12-31 | 1997-12-22 | N-linked sulfonamides of heterocyclic thioesters |
US996342 | 2001-11-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0957913A1 EP0957913A1 (en) | 1999-11-24 |
EP0957913A4 true EP0957913A4 (en) | 2002-05-02 |
Family
ID=25104856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97950991A Withdrawn EP0957913A4 (en) | 1996-12-31 | 1997-12-22 | N-BONDED SULPHONAMIDES OF HETEROCYCLIC THIOESTERS |
Country Status (18)
Country | Link |
---|---|
US (1) | US5874449A (ko) |
EP (1) | EP0957913A4 (ko) |
KR (1) | KR20000057489A (ko) |
CN (1) | CN1246792A (ko) |
AR (1) | AR011320A1 (ko) |
AU (1) | AU741100B2 (ko) |
BG (1) | BG103407A (ko) |
BR (1) | BR9713732A (ko) |
CA (1) | CA2239926A1 (ko) |
CZ (1) | CZ154599A3 (ko) |
GT (1) | GT199800013A (ko) |
HU (1) | HUP0002974A2 (ko) |
IL (1) | IL129697A0 (ko) |
MX (1) | MXPA99006120A (ko) |
PL (1) | PL334214A1 (ko) |
SK (1) | SK57799A3 (ko) |
WO (1) | WO1998029116A1 (ko) |
ZA (1) | ZA9711703B (ko) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5945441A (en) * | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
GB9804426D0 (en) * | 1998-03-02 | 1998-04-29 | Pfizer Ltd | Heterocycles |
PL348661A1 (en) * | 1998-06-03 | 2002-06-03 | Gpi Nil Holdings | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
WO2000004020A1 (en) | 1998-07-17 | 2000-01-27 | Agouron Pharmaceuticals, Inc. | Compounds, compositions, and methods for stimulating neuronal growth and elongation |
US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6506788B1 (en) * | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
US7265150B1 (en) * | 1998-08-14 | 2007-09-04 | Gpi Nil Holdings Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders |
US6376517B1 (en) * | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US7410995B1 (en) * | 1998-08-14 | 2008-08-12 | Gpi Nil Holdings Inc. | N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
US6323215B1 (en) | 1999-07-09 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
US6544976B1 (en) | 1999-07-09 | 2003-04-08 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods |
CN1382140A (zh) | 1999-07-09 | 2002-11-27 | 奥索-麦克尼尔药品公司 | 具有神经营养活性的吡咯烷和哌啶、以及含有它们的相关组合物 |
EP1214293A1 (en) | 1999-09-08 | 2002-06-19 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
US20040152745A1 (en) * | 1999-11-12 | 2004-08-05 | Guilford Pharmaceuticals, Inc. | Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors |
GT200000203A (es) | 1999-12-01 | 2002-05-24 | Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas. | |
US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
CA2393466C (en) | 1999-12-21 | 2010-01-19 | Gpi Nil Holdings, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
MXPA03006666A (es) | 2001-01-25 | 2004-05-31 | Guilford Pharm Inc | Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. |
US6593362B2 (en) | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
FI120057B (fi) | 2007-07-13 | 2009-06-15 | Andritz Oy | Laite ja menetelmä lipeäruiskun puhdistamiseksi ja jäähdyttämiseksi |
PT2935222T (pt) | 2012-12-21 | 2018-12-10 | Epizyme Inc | Inibidores de prmt5 e seus usos |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040140A1 (en) * | 1995-06-07 | 1996-12-19 | Guilford Pharmaceuticals Inc. | Inhibitors of rotamase enzyme activity |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070361A (en) * | 1977-04-21 | 1978-01-24 | E. R. Squibb & Sons, Inc. | Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof |
US5274097A (en) * | 1988-04-19 | 1993-12-28 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
US5356890A (en) * | 1988-06-15 | 1994-10-18 | Brigham And Women's Hospital | S-nitroso derivatives of ace inhibitors and the use thereof |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
JP3599287B2 (ja) * | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | スルホンアミド誘導体 |
EP0749421B1 (en) * | 1994-03-07 | 1999-09-15 | Vertex Pharmaceuticals Incorporated | Sulphonamide derivatives as aspartyl protease inhibitors |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5717092A (en) * | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
-
1996
- 1996-12-31 US US08/775,584 patent/US5874449A/en not_active Expired - Fee Related
-
1997
- 1997-12-22 HU HU0002974A patent/HUP0002974A2/hu unknown
- 1997-12-22 PL PL97334214A patent/PL334214A1/xx unknown
- 1997-12-22 MX MXPA99006120A patent/MXPA99006120A/es unknown
- 1997-12-22 CA CA002239926A patent/CA2239926A1/en not_active Abandoned
- 1997-12-22 BR BR9713732-4A patent/BR9713732A/pt unknown
- 1997-12-22 EP EP97950991A patent/EP0957913A4/en not_active Withdrawn
- 1997-12-22 CZ CZ991545A patent/CZ154599A3/cs unknown
- 1997-12-22 IL IL12969797A patent/IL129697A0/xx unknown
- 1997-12-22 CN CN97181164A patent/CN1246792A/zh active Pending
- 1997-12-22 KR KR1019990705163A patent/KR20000057489A/ko not_active Application Discontinuation
- 1997-12-22 WO PCT/US1997/023526 patent/WO1998029116A1/en not_active Application Discontinuation
- 1997-12-22 SK SK577-99A patent/SK57799A3/sk unknown
- 1997-12-22 AU AU53854/98A patent/AU741100B2/en not_active Ceased
- 1997-12-30 ZA ZA9711703A patent/ZA9711703B/xx unknown
- 1997-12-30 AR ARP970106252A patent/AR011320A1/es unknown
-
1998
- 1998-01-19 GT GT199800013A patent/GT199800013A/es unknown
-
1999
- 1999-05-17 BG BG103407A patent/BG103407A/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040140A1 (en) * | 1995-06-07 | 1996-12-19 | Guilford Pharmaceuticals Inc. | Inhibitors of rotamase enzyme activity |
Non-Patent Citations (2)
Title |
---|
MOSS, WILLIAM O. ET AL: "2-Amino ketene S,S-acetals as.alpha.-amino acid homoenolate equivalents. Synthesis of 3-substituted prolines and molecular structure of 2-(N-pivaloylpyrrolidin-2-ylidene)-1,3-dithiane", J. CHEM. SOC., PERKIN TRANS. 1 (1992), (20), 2615-24, XP001057718 * |
See also references of WO9829116A1 * |
Also Published As
Publication number | Publication date |
---|---|
BR9713732A (pt) | 2000-01-25 |
CA2239926A1 (en) | 1998-06-30 |
IL129697A0 (en) | 2000-02-29 |
GT199800013A (es) | 1999-07-13 |
ZA9711703B (en) | 1999-02-10 |
SK57799A3 (en) | 2000-08-14 |
WO1998029116A1 (en) | 1998-07-09 |
AR011320A1 (es) | 2000-08-16 |
MXPA99006120A (es) | 2004-08-31 |
CZ154599A3 (cs) | 1999-11-17 |
PL334214A1 (en) | 2000-02-14 |
BG103407A (en) | 2000-01-31 |
CN1246792A (zh) | 2000-03-08 |
US5874449A (en) | 1999-02-23 |
KR20000057489A (ko) | 2000-09-15 |
AU5385498A (en) | 1998-07-31 |
EP0957913A1 (en) | 1999-11-24 |
AU741100B2 (en) | 2001-11-22 |
HUP0002974A2 (hu) | 2001-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA9711703B (en) | N-linked sulfonamides of heterocyclic thioesters | |
ZA975675B (en) | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one | |
PL339551A1 (en) | Derivatives of rezorcin | |
EG24291A (en) | Novel form of s-omeprazole | |
PL331856A1 (en) | Heterocyclic inhibitors of metaloprotease | |
PL329875A1 (en) | Derivatives of carbolin | |
PL329195A1 (en) | Derivatives of 6-phenylpyridol-2-amine | |
IL134871A0 (en) | Polymeric derivatives of campothecins | |
IL134086A0 (en) | Novel spiroazabicyclic heterocyclic compounds | |
PL327998A1 (en) | Novel derivatives of 19-nor-pregnene | |
HUP9904239A3 (en) | High level expression of proteins | |
PL338075A1 (en) | Derivatives of piperazine | |
AU3039995A (en) | Heterocyclic derivatives of N-phenylamides | |
IL140509A0 (en) | Expression of functional eukaryotic proteins | |
PL340461A1 (en) | Derivatives of isothiazocarboxylic acid | |
PL326604A1 (en) | Derivatives of 5"-dezoxy-cytidin | |
PL342817A1 (en) | Novel derivatives of dihydroxyhexanic acid | |
ZA955753B (en) | Heterocyclic derivatives of azolones | |
ZA981920B (en) | Novel heterocyclic compounds | |
NO992268D0 (no) | N-bundne sulfonamider av heterocykliske tioestere | |
PL325687A1 (en) | Derivatives of phenyloxymethyl piperidine | |
PL334769A1 (en) | Derivatives of 5-aroylnaphtene | |
ZA985064B (en) | Derivatives of pentaerythrits | |
PL333323A1 (en) | Derivatives of piperidine | |
PL338777A1 (en) | Derivative of piperidinylmethyloxazolydinone |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990616 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: GPI NIL HOLDINGS, INC. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020319 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/40 A, 7C 07D 207/46 B, 7C 07D 207/48 B, 7C 07D 211/96 B |
|
17Q | First examination report despatched |
Effective date: 20020719 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20021203 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1021327 Country of ref document: HK |