EP0936888A1 - Systeme pour determiner le debit sanguin pulmonaire effectif - Google Patents
Systeme pour determiner le debit sanguin pulmonaire effectifInfo
- Publication number
- EP0936888A1 EP0936888A1 EP97911114A EP97911114A EP0936888A1 EP 0936888 A1 EP0936888 A1 EP 0936888A1 EP 97911114 A EP97911114 A EP 97911114A EP 97911114 A EP97911114 A EP 97911114A EP 0936888 A1 EP0936888 A1 EP 0936888A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- petco
- rebreathing
- blood flow
- patient
- partial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/029—Measuring or recording blood output from the heart, e.g. minute volume
Definitions
- the invention relates to an arrangement for determining the effective pulmonary blood flow according to the preamble of claim 1.
- the multiple inert gas method with rebreathing of helium, acetylene and carbon monoxide in oxygen and nitrogen from a breathing bag.
- the disadvantage of this measurement is the relatively great effort involved in preparing gas mixtures for rebreathing , the need for special measuring devices which can measure the concentrations of gases in the ventilated air or in the ventilation flow and the need for a person to connect and care for the breathing bag to the patient, so that the measurement of the effective pulmonary blood flow can only be achieved by Specialists are carried out and serves almost exclusively research purposes.
- the partial CO 2 pressure at the end of exhalation is converted into the arterial CO 2 concentration, and the total cardiac output can be calculated from the division of the CO 2 emission difference and the arterial CO 2 concentration difference.
- Disadvantages of this method are the expenditure on equipment for measuring the CO 2 concentration in the ventilated air (mass spectrometer) and the ventilation flow on the endotracheal tube (Fleisch Pneumotacograph).
- the object of the present invention is to provide a clinically applicable arrangement for the non-invasive determination of the effective pulmonary blood flow, with which only the portion of the cardiac output available for gas exchange stands, can be determined.
- This arrangement should not be expensive in terms of equipment, not significantly influence the ventilation pattern and should be able to be automated.
- the signals of a main current CO sensor and a ventilation current sensor are recorded.
- the main flow CO 2 sensor is used to measure the CO 2 concentration in the breathing air and the ventilation flow sensor is used to measure the ventilation flow (Fig. 1).
- the respiratory flow sensor is placed between the endotracheal tube and the CO 2 sensor.
- the measurements of the CO 2 elimination and the end-expiratory partial CO 2 pressure are first carried out during ventilation through the small dead space. This phase lasts approximately 60 seconds and is called the non-rebreathing phase.
- the three-way valve is switched so that the patient is ventilated through the larger dead space (large leg) and breathes back a gas mixture consisting of his own exhaled air and fresh air from the ventilator. This eliminates the need to use a separate CO 2 source for rebreathing.
- the time for switching the three-way valve is recognized by the absence of CO 2 in the inspiratory air. This will not change the breath pressure significantly
- the subsequent phase lasts approx. 30 seconds and is called the rebreathing phase.
- the CO 2 elimination and the end-expiratory partial CO 2 pressure of this phase are measured as mean values of the corresponding variables during a plateau which forms in the range from 15 to 30 seconds during this phase (second half).
- the ventilator With the arrangement according to the invention it is now possible to adjust the patient's ventilation pattern in the ventilator so that the maximum pulmonary blood flow is achieved with the lowest mean and end-expiratory airway pressure. For the patient, this means a reduction in the risk of barotrauma, i.e. Lung damage caused by increased airway pressure is avoided and at the same time an optimization of the oxygen supply to the organs is achieved.
- the solution also offers the option of non-invasively monitoring and automatically documenting the patient's hemodynamics. If measurements of the cardiac output are carried out at the same time, it is possible with the solution found to measure the percentage of the non-ventilated cardiac output (so-called intrapulmonary shunt) without increasing the inspiratory oxygen concentration and taking blood.
- FIG. 1 shows an arrangement of a microprocessor or a controller for measuring the effective pulmonary blood flow.
- FIG. 2 shows an arrangement according to the invention with a microprocessor / controller and respirator.
- FIG. 3 shows an example of a CO 2 measured with the arrangement according to the invention.
- Blood flow 1 shows an arrangement of a microprocessor / controller for measuring the effective pulmonary blood flow, which consists of four parts. The individual parts are connected to each other via cables and plugs. 1, the system consists of a microprocessor / controller 7 and an analog-digital converter card 8, which receives and processes the CO 2 concentration and respiratory flow signals from the CO 2 sensor 3 or from the respiratory flow sensor 1.
- FIG. 2 shows a microprocessor or controller-controlled arrangement according to the invention for measuring the pulmonary blood flow, which consists of seven, optionally fewer or more parts.
- the endotracheal tube of the patient is connected to one side of a ventilation current sensor 1.
- a CO 2 cuvette 2 is connected to the other side of the ventilation current sensor 1.
- a CO 2 sensor 3 is inserted into the CO 2 cuvette 2.
- a controllable three-way valve 4 is connected to the other side of the CO 2 cuvette 2.
- One way from the three-way valve 4 is connected to a Y-piece 5 and the other way is connected to the dead space 6 for rebreathing.
- a ventilator and the dead space 6 for rebreathing are connected to the Y-piece 5.
- the dead space 6 for rebreathing is approx. 200 ml, optionally more or less, depending on the ventilation pattern of the patient.
- the control of the three-way valve 4 and the recording and processing of the CO 2 concentration and ventilation current signals is carried out by the microprocessor / controller 7.
- FIG. 3 shows the courses of the CO 2 concentration in the breathing air and the ventilation flow during a measurement.
- CO 2 is exhaled through the endotracheal tube.
- the CO 2 concentration (FCO 2 ) in the exhaled air which corresponds to the partial CO 2 pressure (PCO) in the air, increases with the exhaled volume and reaches a maximum value at the end of the exhalation.
- the partial CO 2 pressure at this point in time the so-called end-expiratory partial CO 2 pressure (PetCO 2 ), corresponds approximately to the partial CO pressure in the aerated pulmonary capillaries.
- PetCO 2 values are measured, which hardly differ from each other.
- part of the exhaled CO is breathed back.
- the course of the partial CO 2 pressure in the breathing air is modified and the PetCO 2 increases.
- FIG. 4 shows the courses of the end-expiratory partial CO 2 pressure, which corresponds to the highest CO 2 concentration value during exhalation, and the CO 2 elimination per breath, during a measurement with the arrangement according to the invention.
- the CO 2 elimination decreases during the partial CO 2 rebreathing and the end-expiratory partial CO 2 pressure in the breathing air increases until a plateau is reached, usually after about 15 seconds.
- the effective pulmonary blood flow is calculated from the four parameters shown in FIG. 4 according to the following equation:
- VCO 2 (NR) - VCO 2 (R)) PBF f (PetCO 2 (R), PetCO 2 (NR), Hb) x Fs
- VCO 2 (NR) is the CO 2 elimination in ml / min during the non-backhaul phase, measured as the mean value of the CO 2 elimination of complete breaths within 60 seconds to immediately before the start of the backgam phase.
- the CO 2 elimination of a breath is calculated from the product of the ventilation current (nil / min) and CO 2 concentration over time.
- PetCO 2 (R) is the end-expiratory partial CO pressure in mmHg in the breathing air during the non-respiratory phase, measured as the mean of the end-expiratory partial CO 2 pressure values of complete breaths within 60 seconds until immediately before the start of the respiratory phase.
- VCO (R) is understood to mean CO 2 elimination in ml / min during the rebreathing phase, measured as the mean value of CO 2 elimination of complete breaths within 15 to 30 seconds after the patient is ventilated through the larger dead space 6. So after switching the three-way valve 4 to the rebreathing position. The CO 2 elimination of a breath is calculated from the product of the ventilation flow in ml / min and CO 2 concentration in% over time.
- PetCO (R) is the end-expiratory partial CO pressure in mmHg in the breathing air during the recovery phase, measured as the mean of the end-expiratory partial CO 2 pressure values of complete breaths within 15 to 30 seconds after the patient is ventilated through the larger dead space 6 ( after switching the three-way valve 4 to the rebreathing position).
- the function f (PetCO 2 (R), PetCO 2 (NR), Hb) is the standardized CO 2 dissotation curve in the blood. This function, already described in the literature (McHardy, GJR: The relationship between the differences in pressure and content of carbon dioxide in arterial and venous blood, Clin. Sei., 1967 32, 299-309), turns the PetCO (R) and PetCO 2 (NR) values, and also the CO 2 content difference based on the hemoglobin concentration (Hb, g / dl), which has to be measured in a patient's blood sample using another device
- the effective pulmonary blood flow PBF is obtained in 1 / min.
Abstract
L'invention concerne un système permettant de déterminer le débit sanguin pulmonaire effectif (PBF) par réinspiration partielle de CO2. Ce système se caractérise en ce qu'il comprend un tube endotrachéal dont le conduit menant du patient au respirateur est divisé en deux brins, entre une soupape à trois orifices (4) et une pièce en Y (5). Un brin forme un espace mort (6) plus important pour la réinspiration de CO2. Pour la mesure de l'élimination de CO2 et de la pression de CO2 partielle en fin d'expiration, il est prévu un détecteur de CO2 (3) et un détecteur de respiration (1) au niveau du tube endotrachéal du patient. Le calcul du débit sanguin pulmonaire effectif est assuré par un microprocesseur/contrôleur (7) qui pilote également la soupape à trois orifices (4) qui assure la commutation entre les deux brins.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19640152 | 1996-09-28 | ||
DE19640152 | 1996-09-28 | ||
DE19742226 | 1997-09-24 | ||
DE19742226A DE19742226A1 (de) | 1996-09-28 | 1997-09-24 | Anordnung zur Bestimmung des effektiven pulmonalen Blutdurchflusses |
PCT/DE1997/002194 WO1998012963A1 (fr) | 1996-09-28 | 1997-09-26 | Systeme pour determiner le debit sanguin pulmonaire effectif |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0936888A1 true EP0936888A1 (fr) | 1999-08-25 |
Family
ID=26029933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97911114A Withdrawn EP0936888A1 (fr) | 1996-09-28 | 1997-09-26 | Systeme pour determiner le debit sanguin pulmonaire effectif |
Country Status (5)
Country | Link |
---|---|
US (3) | US6106480A (fr) |
EP (1) | EP0936888A1 (fr) |
JP (1) | JP2001506872A (fr) |
AU (1) | AU4861797A (fr) |
WO (1) | WO1998012963A1 (fr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6840906B2 (en) * | 1996-09-28 | 2005-01-11 | Technische Universitaet Dresden | Arrangement for the determination of the effective pulmonary blood flow |
US6306098B1 (en) | 1996-12-19 | 2001-10-23 | Novametrix Medical Systems Inc. | Apparatus and method for non-invasively measuring cardiac output |
US6042550A (en) | 1998-09-09 | 2000-03-28 | Ntc Technology, Inc. | Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output |
US6217524B1 (en) | 1998-09-09 | 2001-04-17 | Ntc Technology Inc. | Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output |
US6238351B1 (en) | 1998-09-09 | 2001-05-29 | Ntc Technology Inc. | Method for compensating for non-metabolic changes in respiratory or blood gas profile parameters |
US6200271B1 (en) | 1998-09-09 | 2001-03-13 | Ntc Technology Inc. | Bi-directional partial re-breathing method |
US6059732A (en) * | 1998-09-09 | 2000-05-09 | Ntc Technology, Inc. | ISO-volumetric method of measuring carbon dioxide elimination |
US6123674A (en) * | 1998-10-15 | 2000-09-26 | Ntc Technology Inc. | Airway valve to facilitate re-breathing, method of operation, and ventilator circuit so equipped |
US6098622A (en) * | 1998-10-15 | 2000-08-08 | Ntc Technology Inc. | Airway valve to facilitate re-breathing, method of operation, and ventilator circuit so equipped |
US6575164B1 (en) * | 1998-10-15 | 2003-06-10 | Ntc Technology, Inc. | Reliability-enhanced apparatus operation for re-breathing and methods of effecting same |
DE19850770C1 (de) * | 1998-11-04 | 2000-01-27 | Draeger Medizintech Gmbh | Vorrichtung und Verfahren zur Steuerung eines Beatmungsgerätes |
JP2002535024A (ja) * | 1999-01-21 | 2002-10-22 | メタセンサーズ,インコーポレイティド | 呼吸ガス分析技術および生理学的モデルを使用した非侵襲的な心拍出量および肺機能のモニタリング |
US6210342B1 (en) | 1999-09-08 | 2001-04-03 | Ntc Technology, Inc. | Bi-directional partial re-breathing method |
US6631717B1 (en) | 1999-10-21 | 2003-10-14 | Ntc Technology Inc. | Re-breathing apparatus for non-invasive cardiac output, method of operation, and ventilator circuit so equipped |
US6413226B1 (en) | 1999-10-22 | 2002-07-02 | Respironics, Inc. | Method and apparatus for determining cardiac output |
US6540689B1 (en) | 2000-02-22 | 2003-04-01 | Ntc Technology, Inc. | Methods for accurately, substantially noninvasively determining pulmonary capillary blood flow, cardiac output, and mixed venous carbon dioxide content |
US7699788B2 (en) | 2000-02-22 | 2010-04-20 | Ric Investments, Llc. | Noninvasive effective lung volume estimation |
US6322514B1 (en) | 2000-03-13 | 2001-11-27 | Instrumentarium Corporation | Method for determining cardiac characteristics of subject |
US7135001B2 (en) * | 2001-03-20 | 2006-11-14 | Ric Investments, Llc | Rebreathing methods including oscillating, substantially equal rebreathing and nonrebreathing periods |
US7112208B2 (en) * | 2001-08-06 | 2006-09-26 | Morris John K | Compact suture punch with malleable needle |
US6951216B2 (en) * | 2002-12-19 | 2005-10-04 | Instrumentarium Corp. | Apparatus and method for use in non-invasively determining conditions in the circulatory system of a subject |
ES2318920B1 (es) * | 2005-05-13 | 2009-12-22 | German Peces-Barba Romero | Dispositivo de medicion no invasiva del valor de presion positiva intratoracica intrinseca existente al final de la espiracion. |
WO2010005343A2 (fr) * | 2008-07-08 | 2010-01-14 | Marat Vadimovich Evtukhov | Détecteur d'anomalie dans une boucle respiratoire de recycleur |
EP2356407A1 (fr) | 2008-09-04 | 2011-08-17 | Nellcor Puritan Bennett LLC | Purge de train d'ondes de pression en dent de scie inverse dans des ventilateurs médicaux |
US8181648B2 (en) | 2008-09-26 | 2012-05-22 | Nellcor Puritan Bennett Llc | Systems and methods for managing pressure in a breathing assistance system |
US8302602B2 (en) | 2008-09-30 | 2012-11-06 | Nellcor Puritan Bennett Llc | Breathing assistance system with multiple pressure sensors |
CA2738212A1 (fr) | 2008-09-30 | 2010-04-08 | Nellcor Puritan Bennett Llc | Detecteur d'inclinaison pneumatique pour une utilisation avec un dispositif de detection de debit respiratoire |
US8776790B2 (en) | 2009-07-16 | 2014-07-15 | Covidien Lp | Wireless, gas flow-powered sensor system for a breathing assistance system |
US8469031B2 (en) | 2009-12-01 | 2013-06-25 | Covidien Lp | Exhalation valve assembly with integrated filter |
US8439037B2 (en) | 2009-12-01 | 2013-05-14 | Covidien Lp | Exhalation valve assembly with integrated filter and flow sensor |
US8469030B2 (en) | 2009-12-01 | 2013-06-25 | Covidien Lp | Exhalation valve assembly with selectable contagious/non-contagious latch |
US8439036B2 (en) | 2009-12-01 | 2013-05-14 | Covidien Lp | Exhalation valve assembly with integral flow sensor |
USD653749S1 (en) | 2010-04-27 | 2012-02-07 | Nellcor Puritan Bennett Llc | Exhalation module filter body |
USD655809S1 (en) | 2010-04-27 | 2012-03-13 | Nellcor Puritan Bennett Llc | Valve body with integral flow meter for an exhalation module |
USD655405S1 (en) | 2010-04-27 | 2012-03-06 | Nellcor Puritan Bennett Llc | Filter and valve body for an exhalation module |
US9629971B2 (en) | 2011-04-29 | 2017-04-25 | Covidien Lp | Methods and systems for exhalation control and trajectory optimization |
WO2013141766A1 (fr) * | 2012-03-21 | 2013-09-26 | Maquet Critical Care Ab | Procédé pour la détermination en continu et non invasive du volume utile des poumons et du débit cardiaque |
US9950135B2 (en) | 2013-03-15 | 2018-04-24 | Covidien Lp | Maintaining an exhalation valve sensor assembly |
CN104941044B (zh) * | 2015-07-14 | 2017-06-13 | 张永庆 | 一种呼吸内科用呼吸器 |
DE102017124256A1 (de) * | 2016-10-29 | 2018-05-03 | Sendsor Gmbh | Sensor und Verfahren zum Messen der Eigenschaften des Atemgas |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE465497B (sv) * | 1989-11-24 | 1991-09-23 | Minco Ab | Anordning foer studium av en persons lungfunktion |
US5005582A (en) * | 1990-06-28 | 1991-04-09 | Vladimir Serikov | Non-invasive method for measuring lung tissue volume and pulmonary blood flow and a probe to carry out the method |
-
1997
- 1997-09-26 AU AU48617/97A patent/AU4861797A/en not_active Abandoned
- 1997-09-26 WO PCT/DE1997/002194 patent/WO1998012963A1/fr not_active Application Discontinuation
- 1997-09-26 US US09/269,458 patent/US6106480A/en not_active Expired - Fee Related
- 1997-09-26 EP EP97911114A patent/EP0936888A1/fr not_active Withdrawn
- 1997-09-26 JP JP51515798A patent/JP2001506872A/ja active Pending
-
2000
- 2000-08-14 US US09/638,996 patent/US6394962B1/en not_active Expired - Fee Related
-
2002
- 2002-03-13 US US10/097,064 patent/US20020128566A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO9812963A1 * |
Also Published As
Publication number | Publication date |
---|---|
US6106480A (en) | 2000-08-22 |
US20020128566A1 (en) | 2002-09-12 |
JP2001506872A (ja) | 2001-05-29 |
WO1998012963A1 (fr) | 1998-04-02 |
AU4861797A (en) | 1998-04-17 |
US6394962B1 (en) | 2002-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0936888A1 (fr) | Systeme pour determiner le debit sanguin pulmonaire effectif | |
DE69737110T2 (de) | Verfahren und vorrichtung zur messung der pulmonaren blutstromung im zuge des austauschs von sauerstoff und einem inerten gas im pulmonaren blut | |
US6540689B1 (en) | Methods for accurately, substantially noninvasively determining pulmonary capillary blood flow, cardiac output, and mixed venous carbon dioxide content | |
EP0131615B1 (fr) | appareil pour la determination du volume-minute du coeur | |
DE60224786T2 (de) | Wiedereinatmungssystem mit oscillatorischen wiedereinatmungs- und nicht-wiedereinatmungsphasen | |
EP0549685B1 (fr) | Dispositif du surveillance du co 2 arteriel et controleur en boucle fermee | |
DE60224964T2 (de) | Beatmungsgerät zur Verwendung in der Untersuchung der Atmungsmechanik eines respiratorischen Systems | |
DE69635677T2 (de) | Künstliches Atmungssystem | |
US6840906B2 (en) | Arrangement for the determination of the effective pulmonary blood flow | |
US20100132710A1 (en) | Apparatus and method for non-invasively measuring caridac output | |
WO2001030234A9 (fr) | Methode et appareil de determination du debit cardiaque | |
DE102007038856A1 (de) | Nicht-Invasive Bestimmung des vom Herzen geförderten Blutvolumens, des Gasaustausches und der Gaskonzentration des arteriellen Blutes | |
EP1237478B1 (fr) | Procede et dispositif de determination, decomposee par respiration, de la pression partielle d'un constituant gazeux dans l'air d'expiration d'un patient | |
DE102021000313A1 (de) | Verfahren zum Betreiben eines Beatmungsgeräts zur künstlichen Beatmung eines Patienten sowie ein solches Beatmungsgerät | |
Mahamed et al. | The contribution of chemoreflex drives to resting breathing in man | |
EP3964253B1 (fr) | Programme d'ordinateur et dispositif de détermination automatique de la fréquence de consigne d'un respirateur | |
DE19742226A1 (de) | Anordnung zur Bestimmung des effektiven pulmonalen Blutdurchflusses | |
US6337895B1 (en) | Method for determining constant in relational expression concerning end-tidal air velocity constant and arterial blood velocity constant and xenon CT apparatus | |
CA2419622A1 (fr) | Nouvelle methode de mesure non invasive de parametres cardiaques par ventilation controlee du spontanee | |
EP0684048B1 (fr) | Dispositif d'oxygénothérapie | |
DE102016015122A1 (de) | Verfahren zur Steuerung einer Vorrichtung zum extrakorporalen Blutgasaustausch, Vorrichtung zum extrakorporalen Blutgasautausch sowie Steuervorrichtung zum Steuern einer Vorrichtung zum extrakorporalen Blutgasaustausch | |
DE10038818A1 (de) | Verfahren und Anordnung zur Bestimmung der funktionellen Residualkapazität der Lungen (FRC) | |
DE2813518B1 (de) | Messgeraet fuer die Lungenfunktionsdiagnostik | |
Schnetzinger | Investigating interactions between heart and lungs-correlation between heartrate variability and respiratory mechanics | |
DE10222176A1 (de) | Verfahren und Vorrichtung zur Einstellung eines Beatmungsgeräts |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990330 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20040608 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20041018 |