EP0912193A1 - Vaccin visant a prevenir l'endocardite streptococcique - Google Patents
Vaccin visant a prevenir l'endocardite streptococciqueInfo
- Publication number
- EP0912193A1 EP0912193A1 EP97932373A EP97932373A EP0912193A1 EP 0912193 A1 EP0912193 A1 EP 0912193A1 EP 97932373 A EP97932373 A EP 97932373A EP 97932373 A EP97932373 A EP 97932373A EP 0912193 A1 EP0912193 A1 EP 0912193A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- fima
- endocarditis
- parasanguis
- protein
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Abstract
Les protéines Fim A provenant des streptocoques et des entérocoques, qui sont responsables de l'adhérence bactérienne aux tissus cardiaques endommagés, sont de puissants vaccins contre l'endocardite, empêchant cette maladie de se développer chez un patient. Des protéines Fim A produites par recombinaison et provenant de S. parasanguis confèrent une protection contre l'endocardite dérivée de S. parasanguis ainsi que l'endocardite dérivée de plusieurs autres streptocoques. Des régions d'ADN préservées dans les entérocoques et les streptocoques viridians suggèrent que les protéines Fim A provenant de ces souches seront applicables de manière généralisée comme un vaccin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2017496P | 1996-06-21 | 1996-06-21 | |
| US20174P | 1996-06-21 | ||
| PCT/US1997/011329 WO1997048417A1 (fr) | 1996-06-21 | 1997-06-20 | Vaccin visant a prevenir l'endocardite streptococcique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0912193A1 true EP0912193A1 (fr) | 1999-05-06 |
| EP0912193A4 EP0912193A4 (fr) | 2000-11-02 |
Family
ID=21797134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97932373A Withdrawn EP0912193A4 (fr) | 1996-06-21 | 1997-06-20 | Vaccin visant a prevenir l'endocardite streptococcique |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0912193A4 (fr) |
| JP (1) | JP2000514790A (fr) |
| AU (1) | AU3584897A (fr) |
| CA (1) | CA2258011A1 (fr) |
| WO (1) | WO1997048417A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5882871A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
| DK1140157T3 (da) | 1998-12-21 | 2009-06-08 | Medimmune Inc | Streptococcus pneumoniae-proteiner og immunogene fragmenter til vacciner |
| LT6214B (lt) * | 2013-10-07 | 2015-08-25 | Uab "Bioseka" | Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993010238A1 (fr) * | 1991-11-14 | 1993-05-27 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Vaccins a base de proteine a de pili pneumococcique |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422427A (en) * | 1991-09-17 | 1995-06-06 | The United States Of America As Represented By The United States Department Of Health And Human Services | Pneumococcal fimbrial protein A |
| EP0707651A1 (fr) * | 1993-04-26 | 1996-04-24 | University Of Victoria Innovation And Development Corporation | PROCEDES ET COMPOSITIONS DE DETECTION DE LA $i(SALMONELLE) |
-
1997
- 1997-06-20 AU AU35848/97A patent/AU3584897A/en not_active Abandoned
- 1997-06-20 JP JP10503584A patent/JP2000514790A/ja active Pending
- 1997-06-20 EP EP97932373A patent/EP0912193A4/fr not_active Withdrawn
- 1997-06-20 WO PCT/US1997/011329 patent/WO1997048417A1/fr not_active Application Discontinuation
- 1997-06-20 CA CA002258011A patent/CA2258011A1/fr not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993010238A1 (fr) * | 1991-11-14 | 1993-05-27 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Vaccins a base de proteine a de pili pneumococcique |
Non-Patent Citations (4)
| Title |
|---|
| BURNETTE-CURLEY D ET AL: "FimA, a major virulence factor associated with Streptococcus parasanguis endocarditis." INFECTION AND IMMUNITY, vol. 63, no. 12, December 1995 (1995-12), pages 4669-4674, XP002145681 * |
| DATABASE CHEMABS [Online] CHEMICAL ABSTRACTS SERVICE; 1996 VISCOUNT, HELEN BRAFF: "Pathogenesis and immunology of streptococcal endocarditis (Streptococcus parasanguis)" retrieved from STN Database accession no. 126:168903 XP002145683 & DISSERTATION 120 PP. AVAIL.: UNIV. MICROFILMS INT., ORDER NO. DA9703883 FROM: DISS. ABSTR. INT., B 1997, 57(9), 5475, * |
| See also references of WO9748417A1 * |
| VISCOUNT H B ET AL: "Immunization with FimA protects against Streptococcus parasanguis endocarditis in rats." INFECTION AND IMMUNITY, vol. 65, no. 3, March 1997 (1997-03), pages 994-1002, XP002145682 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2258011A1 (fr) | 1997-12-24 |
| AU3584897A (en) | 1998-01-07 |
| JP2000514790A (ja) | 2000-11-07 |
| WO1997048417A1 (fr) | 1997-12-24 |
| EP0912193A4 (fr) | 2000-11-02 |
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