CA2258011A1 - Vaccin visant a prevenir l'endocardite streptococcique - Google Patents
Vaccin visant a prevenir l'endocardite streptococcique Download PDFInfo
- Publication number
- CA2258011A1 CA2258011A1 CA002258011A CA2258011A CA2258011A1 CA 2258011 A1 CA2258011 A1 CA 2258011A1 CA 002258011 A CA002258011 A CA 002258011A CA 2258011 A CA2258011 A CA 2258011A CA 2258011 A1 CA2258011 A1 CA 2258011A1
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- Prior art keywords
- fima
- endocarditis
- streptococci
- parasanguis
- protein
- Prior art date
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- 150000002894 organic compounds Chemical class 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000014493 regulation of gene expression Effects 0.000 description 1
- 238000004153 renaturation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 208000004124 rheumatic heart disease Diseases 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Les protéines Fim A provenant des streptocoques et des entérocoques, qui sont responsables de l'adhérence bactérienne aux tissus cardiaques endommagés, sont de puissants vaccins contre l'endocardite, empêchant cette maladie de se développer chez un patient. Des protéines Fim A produites par recombinaison et provenant de S. parasanguis confèrent une protection contre l'endocardite dérivée de S. parasanguis ainsi que l'endocardite dérivée de plusieurs autres streptocoques. Des régions d'ADN préservées dans les entérocoques et les streptocoques viridians suggèrent que les protéines Fim A provenant de ces souches seront applicables de manière généralisée comme un vaccin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2017496P | 1996-06-21 | 1996-06-21 | |
| US60/020,174 | 1996-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2258011A1 true CA2258011A1 (fr) | 1997-12-24 |
Family
ID=21797134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002258011A Abandoned CA2258011A1 (fr) | 1996-06-21 | 1997-06-20 | Vaccin visant a prevenir l'endocardite streptococcique |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0912193A4 (fr) |
| JP (1) | JP2000514790A (fr) |
| AU (1) | AU3584897A (fr) |
| CA (1) | CA2258011A1 (fr) |
| WO (1) | WO1997048417A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5882871A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
| EP2050464B1 (fr) | 1998-12-21 | 2019-08-07 | Medimmune, Inc. | Protéines de streptococcus pneumoniae et fragments immunogènes pour vaccins |
| LT6214B (lt) * | 2013-10-07 | 2015-08-25 | Uab "Bioseka" | Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422427A (en) * | 1991-09-17 | 1995-06-06 | The United States Of America As Represented By The United States Department Of Health And Human Services | Pneumococcal fimbrial protein A |
| WO1993010238A1 (fr) * | 1991-11-14 | 1993-05-27 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Vaccins a base de proteine a de pili pneumococcique |
| AU7008494A (en) * | 1993-04-26 | 1994-11-21 | King, Joshua | Methods and compositions for (salmonella)-based vaccines |
-
1997
- 1997-06-20 AU AU35848/97A patent/AU3584897A/en not_active Abandoned
- 1997-06-20 CA CA002258011A patent/CA2258011A1/fr not_active Abandoned
- 1997-06-20 WO PCT/US1997/011329 patent/WO1997048417A1/fr not_active Application Discontinuation
- 1997-06-20 EP EP97932373A patent/EP0912193A4/fr not_active Withdrawn
- 1997-06-20 JP JP10503584A patent/JP2000514790A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0912193A4 (fr) | 2000-11-02 |
| JP2000514790A (ja) | 2000-11-07 |
| EP0912193A1 (fr) | 1999-05-06 |
| WO1997048417A1 (fr) | 1997-12-24 |
| AU3584897A (en) | 1998-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |