EP0900086A4 - Stimulation du sommeil avec un secretagogue d'hormone de croissance - Google Patents
Stimulation du sommeil avec un secretagogue d'hormone de croissanceInfo
- Publication number
- EP0900086A4 EP0900086A4 EP97924576A EP97924576A EP0900086A4 EP 0900086 A4 EP0900086 A4 EP 0900086A4 EP 97924576 A EP97924576 A EP 97924576A EP 97924576 A EP97924576 A EP 97924576A EP 0900086 A4 EP0900086 A4 EP 0900086A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- sleep
- enhancement
- growth hormone
- hormone secretagogue
- secretagogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102100033367 Appetite-regulating hormone Human genes 0.000 title 1
- 101710111255 Appetite-regulating hormone Proteins 0.000 title 1
- 239000003324 growth hormone secretagogue Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1678796P | 1996-05-07 | 1996-05-07 | |
US16787P | 1996-05-07 | ||
GB9611002 | 1996-05-24 | ||
GBGB9611002.8A GB9611002D0 (en) | 1996-05-24 | 1996-05-24 | Enhancement of sleep with a growth hormone secreragogue |
PCT/US1997/007516 WO1997041879A1 (fr) | 1996-05-07 | 1997-05-05 | Stimulation du sommeil avec un secretagogue d'hormone de croissance |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0900086A1 EP0900086A1 (fr) | 1999-03-10 |
EP0900086A4 true EP0900086A4 (fr) | 2000-01-12 |
Family
ID=26309399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97924576A Withdrawn EP0900086A4 (fr) | 1996-05-07 | 1997-05-05 | Stimulation du sommeil avec un secretagogue d'hormone de croissance |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0900086A4 (fr) |
JP (1) | JP2000511885A (fr) |
AU (1) | AU711884B2 (fr) |
CA (1) | CA2253390A1 (fr) |
WO (1) | WO1997041879A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3220097A (en) | 1996-05-22 | 1997-12-09 | Arch Development Corporation | Sleep quality improvement using a growth hormone secretagogue |
AU759022B2 (en) | 1999-02-18 | 2003-04-03 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
IL143690A0 (en) * | 2000-06-19 | 2002-04-21 | Pfizer Prod Inc | The use of growth hormone secretagogues to treat systemic lupus erythematosus and inflammatory bowel disease |
IL144468A0 (en) * | 2000-07-27 | 2002-05-23 | Pfizer Prod Inc | Use of growth hormone secretagogues for improvement of functional health status |
JP4731031B2 (ja) * | 2001-03-30 | 2011-07-20 | 株式会社デンソー | 睡眠解析装置及びプログラム並びに記録媒体 |
JP2006520371A (ja) * | 2003-03-14 | 2006-09-07 | メルク シャープ エンド ドーム リミテッド | 軽症の認識損傷の治療方法及びアルツハイマー病の予防又は遅延方法 |
WO2004108120A1 (fr) * | 2003-06-11 | 2004-12-16 | Pfizer Products Inc. | Utilisation de sécrétagogues de l'hormone de croissance pour le traitement de la fibromyalgie |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
US7786141B2 (en) | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
EP2374455A3 (fr) | 2004-08-19 | 2012-03-28 | Vertex Pharmaceuticals Incorporated | Modulateurs des recepteurs muscariniques |
RU2007124373A (ru) | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
RU2008130094A (ru) | 2005-12-22 | 2010-01-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
CN101426499A (zh) | 2006-02-22 | 2009-05-06 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
WO2007100670A1 (fr) | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Modulateurs des recepteurs muscariniques |
CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
EP2040706A2 (fr) | 2006-06-29 | 2009-04-01 | Vertex Pharmceuticals Incorporated | Modulateurs des récepteurs muscariniques |
JP2010500412A (ja) | 2006-08-15 | 2010-01-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
CN101573121A (zh) | 2006-08-18 | 2009-11-04 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
KR20090107088A (ko) | 2007-02-09 | 2009-10-12 | 트랜자임 파르마 인크 | 거대고리 그렐린 수용체 조절제 및 이의 사용 방법 |
WO2009045519A1 (fr) | 2007-10-03 | 2009-04-09 | Vertex Pharmaceuticals Incorporated | Modulateurs des récepteurs muscariniques |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0662481A1 (fr) * | 1992-12-11 | 1995-07-12 | Merck & Co. Inc. | Spiro piperidines et ses homologues favorisants la libération de l'hormone de croissance. |
WO1996040105A1 (fr) * | 1995-06-07 | 1996-12-19 | Arch Development Corporation | UTILISATION DE η-HYDROXYBUTYRATE POUR STIMULER LA SECRETION DE L'HORMONE DE CROISSANCE ASSOCIEE AU SOMMEIL |
WO1997034604A1 (fr) * | 1996-03-21 | 1997-09-25 | Merck & Co., Inc. | 4-spiroindoline piperidines favorisant la liberation de l'hormone de croissance |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
US5578593A (en) * | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
US5284841A (en) * | 1993-02-04 | 1994-02-08 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
-
1997
- 1997-05-05 EP EP97924576A patent/EP0900086A4/fr not_active Withdrawn
- 1997-05-05 CA CA002253390A patent/CA2253390A1/fr not_active Abandoned
- 1997-05-05 JP JP09540091A patent/JP2000511885A/ja active Pending
- 1997-05-05 WO PCT/US1997/007516 patent/WO1997041879A1/fr not_active Application Discontinuation
- 1997-05-05 AU AU29963/97A patent/AU711884B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0662481A1 (fr) * | 1992-12-11 | 1995-07-12 | Merck & Co. Inc. | Spiro piperidines et ses homologues favorisants la libération de l'hormone de croissance. |
WO1996040105A1 (fr) * | 1995-06-07 | 1996-12-19 | Arch Development Corporation | UTILISATION DE η-HYDROXYBUTYRATE POUR STIMULER LA SECRETION DE L'HORMONE DE CROISSANCE ASSOCIEE AU SOMMEIL |
WO1997034604A1 (fr) * | 1996-03-21 | 1997-09-25 | Merck & Co., Inc. | 4-spiroindoline piperidines favorisant la liberation de l'hormone de croissance |
Non-Patent Citations (8)
Title |
---|
BIOLOGICAL ABSTRACTS, vol. 1994, 1994, Philadelphia, PA, US; abstract no. 75188, M L HARTMAN ET AL.: "Normal control of growth hormone secretion" XP002122541 * |
DATABASE MEDLINE 1 January 1900 (1900-01-01), XP002122540, Database accession no. 96320058 * |
G COPINSCHI ET AL.: "Effects of a 7-day treatment with a novel, orally active, growth hormone secretagogue, MK-677,on 24-hour GH profiles, insulin-like growth factor I, amd adrenocortical function in normal young men", J. CLIN. ENDOCRINOL. METABOLISM, vol. 81, no. 8, August 1996 (1996-08-01), pages 2776 - 2782 * |
HORMONE RESEARCH, vol. 40, no. 1-3, 1993, Basel, pages 37 - 47 * |
J TAKAHARA ET AL.: "Inhibitory effects of substance P on the gamma-aminobutyric acid and gamma-hydroxybutyric acid-induced growth hormone and prolactin release in male rats", LIFE SCIENCES, vol. 29, no. 12, 1981, UK, pages 1229 - 1233, XP000600046 * |
J TAKAHARA ET AL.: "Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans", J CLIN. ENDOCRIN. METAB., vol. 44, no. 5, 1977, USA, pages 1014 - 1017, XP000600031 * |
M MAMELAK ET AL.: "The effects of gamma-hydroxybutyrate on sleep", BIOLOGICAL PSYCHIATRY, vol. 12, no. 2, 1977, USA, pages 273 - 288, XP000600034 * |
See also references of WO9741879A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU711884B2 (en) | 1999-10-21 |
WO1997041879A1 (fr) | 1997-11-13 |
CA2253390A1 (fr) | 1997-11-13 |
EP0900086A1 (fr) | 1999-03-10 |
AU2996397A (en) | 1997-11-26 |
JP2000511885A (ja) | 2000-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19981207 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19991129 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20000620 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20010102 |