EP0891347A4 - Triterpene derivatives with immunosuppressant activity - Google Patents

Triterpene derivatives with immunosuppressant activity

Info

Publication number
EP0891347A4
EP0891347A4 EP96939516A EP96939516A EP0891347A4 EP 0891347 A4 EP0891347 A4 EP 0891347A4 EP 96939516 A EP96939516 A EP 96939516A EP 96939516 A EP96939516 A EP 96939516A EP 0891347 A4 EP0891347 A4 EP 0891347A4
Authority
EP
European Patent Office
Prior art keywords
immunosuppressant activity
triterpene derivatives
triterpene
derivatives
immunosuppressant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96939516A
Other languages
German (de)
French (fr)
Other versions
EP0891347A1 (en
Inventor
Robert K Baker
Jianming Bao
Frank Kayser
William H Parsons
Kathleen M Rupprecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603903.7A external-priority patent/GB9603903D0/en
Priority claimed from GBGB9605161.0A external-priority patent/GB9605161D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0891347A1 publication Critical patent/EP0891347A1/en
Publication of EP0891347A4 publication Critical patent/EP0891347A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
EP96939516A 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity Withdrawn EP0891347A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US819195P 1995-10-31 1995-10-31
US710195P 1995-10-31 1995-10-31
US8191P 1995-10-31
US7101P 1995-10-31
GBGB9603903.7A GB9603903D0 (en) 1996-02-23 1996-02-23 Triterpene detivatives with immunosuppressive activity
GB9603903 1996-02-23
GBGB9605161.0A GB9605161D0 (en) 1996-03-12 1996-03-12 Triterpene derivatives with immunosuppressant activity
GB9605161 1996-03-12
PCT/US1996/017481 WO1997016438A1 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Publications (2)

Publication Number Publication Date
EP0891347A1 EP0891347A1 (en) 1999-01-20
EP0891347A4 true EP0891347A4 (en) 1999-04-07

Family

ID=27451412

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96939516A Withdrawn EP0891347A4 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Country Status (5)

Country Link
EP (1) EP0891347A4 (en)
JP (1) JPH11511482A (en)
AU (1) AU700036B2 (en)
CA (1) CA2236171A1 (en)
WO (1) WO1997016438A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU712015B2 (en) * 1995-10-31 1999-10-28 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5998408A (en) * 1996-10-16 1999-12-07 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5952371A (en) * 1996-10-16 1999-09-14 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5874594A (en) * 1996-10-16 1999-02-23 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US6083980A (en) * 1997-10-17 2000-07-04 Merck & Co., Inc. Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity
US6100293A (en) * 1997-10-17 2000-08-08 Merck & Co., Inc. Tetracyclic triterpene derivatives with immunosuppressant activity
US6022890A (en) * 1997-11-14 2000-02-08 Merck & Co., Inc. Immunosuppressant tetracyclic triterpenes
GB9726630D0 (en) 1997-12-18 1998-02-18 Glaxo Group Ltd Kv2.1 Antagonists
US6051590A (en) * 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
AUPS127202A0 (en) 2002-03-20 2002-04-18 Walter And Eliza Hall Institute Of Medical Research, The Therapeutic ion channel blocking agents and methods of use thereof
EP1731158B1 (en) 2004-03-31 2014-10-08 Morinaga Milk Industry Co., Ltd. Drug and food or drink for improving hyperglycemia
US7534770B2 (en) 2004-03-31 2009-05-19 Morinaga Milk Industry Co., Ltd. Glycoside having 4-methylergost-7-en-3-ol skeleton and hyperglycemia improving agent
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
WO2006035525A1 (en) 2004-09-29 2006-04-06 Morinaga Milk Industry Co., Ltd. Medicine and food/beverage for ameliorating hyperglycemia
AU2007304881B2 (en) 2006-10-04 2013-03-07 Bionomics Limited Novel chromenone potassium channel blockers and uses thereof
WO2008040057A1 (en) 2006-10-04 2008-04-10 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
NZ584480A (en) 2007-10-04 2011-08-26 Bionomics Ltd Novel aryl potassium channel blockers and uses thereof
CN102112453A (en) 2008-06-13 2011-06-29 生态有限公司 Novel potassium channel blockers and uses thereof
AU2012255690B2 (en) 2011-05-16 2015-06-11 Bionomics Limited Amine derivatives as potassium channel blockers
EP2524912A1 (en) 2011-05-16 2012-11-21 Bionomics Limited Amine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6017794B2 (en) * 1980-05-16 1985-05-07 ア−ス製薬株式会社 New steroids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9716438A1 *

Also Published As

Publication number Publication date
WO1997016438A1 (en) 1997-05-09
JPH11511482A (en) 1999-10-05
CA2236171A1 (en) 1997-05-09
AU7666396A (en) 1997-05-22
EP0891347A1 (en) 1999-01-20
AU700036B2 (en) 1998-12-17

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