EP0858332A4 - Triterpene derivatives with immunosuppressant activity - Google Patents

Triterpene derivatives with immunosuppressant activity

Info

Publication number
EP0858332A4
EP0858332A4 EP96938708A EP96938708A EP0858332A4 EP 0858332 A4 EP0858332 A4 EP 0858332A4 EP 96938708 A EP96938708 A EP 96938708A EP 96938708 A EP96938708 A EP 96938708A EP 0858332 A4 EP0858332 A4 EP 0858332A4
Authority
EP
European Patent Office
Prior art keywords
immunosuppressant activity
triterpene derivatives
triterpene
derivatives
immunosuppressant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96938708A
Other languages
German (de)
French (fr)
Other versions
EP0858332A1 (en
Inventor
Robert K Baker
Jianming Bao
Frank Kayser
William H Parsons
Kathleen M Rupprecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603842.7A external-priority patent/GB9603842D0/en
Priority claimed from GBGB9609665.6A external-priority patent/GB9609665D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0858332A1 publication Critical patent/EP0858332A1/en
Publication of EP0858332A4 publication Critical patent/EP0858332A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96938708A 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity Withdrawn EP0858332A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US608595P 1995-10-31 1995-10-31
US609295P 1995-10-31 1995-10-31
US6085P 1995-10-31
US6092P 1995-10-31
GBGB9603842.7A GB9603842D0 (en) 1996-02-23 1996-02-23 Triterpene derivatives with immunosuppresent activity
GB9603842 1996-02-23
GB9609665 1996-05-09
GBGB9609665.6A GB9609665D0 (en) 1996-05-09 1996-05-09 Triterpine derivatives with immunosuppressant activity
PCT/US1996/017482 WO1997016182A1 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Publications (2)

Publication Number Publication Date
EP0858332A1 EP0858332A1 (en) 1998-08-19
EP0858332A4 true EP0858332A4 (en) 2001-02-28

Family

ID=27451410

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96938708A Withdrawn EP0858332A4 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Country Status (5)

Country Link
EP (1) EP0858332A4 (en)
JP (1) JP2002503201A (en)
AU (1) AU707991B2 (en)
CA (1) CA2237607A1 (en)
WO (1) WO1997016182A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016068A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5874594A (en) * 1996-10-16 1999-02-23 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5998408A (en) * 1996-10-16 1999-12-07 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5952371A (en) * 1996-10-16 1999-09-14 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US6083980A (en) * 1997-10-17 2000-07-04 Merck & Co., Inc. Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity
US6100293A (en) * 1997-10-17 2000-08-08 Merck & Co., Inc. Tetracyclic triterpene derivatives with immunosuppressant activity
US6022890A (en) * 1997-11-14 2000-02-08 Merck & Co., Inc. Immunosuppressant tetracyclic triterpenes
US6482857B1 (en) 1998-07-17 2002-11-19 The University Of Texas Southwestern Medical Center Compositions which contain triterpenes for regulating hair growth
US6124362A (en) 1998-07-17 2000-09-26 The Procter & Gamble Company Method for regulating hair growth
US6051590A (en) * 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03240495A (en) * 1990-02-16 1991-10-25 Microbial Chem Res Found New physiologically active substance cyclooctatin, production and use thereof
JPH07138156A (en) * 1993-11-18 1995-05-30 Kobe Steel Ltd Immunosuppressive agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03240495A (en) * 1990-02-16 1991-10-25 Microbial Chem Res Found New physiologically active substance cyclooctatin, production and use thereof
JPH07138156A (en) * 1993-11-18 1995-05-30 Kobe Steel Ltd Immunosuppressive agent

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ISAO KITAGAWA ET AL.: "Indonesian Medicinal Plants. XI. Chemical Structures of Caesaldekarins a and b, Two New Cassane-Type Furanoditerpenes from the Roots of Caesalpinia major", CHEM. PHARM. BULL., vol. 42, no. 9, 1994, japan, pages 1798 - 1802, XP002156009 *
PATENT ABSTRACTS OF JAPAN vol. 016, no. 025 (C - 0903) 22 January 1992 (1992-01-22) *
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 08 29 September 1995 (1995-09-29) *
See also references of WO9716182A1 *

Also Published As

Publication number Publication date
JP2002503201A (en) 2002-01-29
EP0858332A1 (en) 1998-08-19
CA2237607A1 (en) 1997-05-09
AU7602096A (en) 1997-05-22
WO1997016182A1 (en) 1997-05-09
AU707991B2 (en) 1999-07-29

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Legal Events

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