EP0858456A4 - Triterpene derivatives with immunosuppressant activity - Google Patents

Triterpene derivatives with immunosuppressant activity

Info

Publication number
EP0858456A4
EP0858456A4 EP96939514A EP96939514A EP0858456A4 EP 0858456 A4 EP0858456 A4 EP 0858456A4 EP 96939514 A EP96939514 A EP 96939514A EP 96939514 A EP96939514 A EP 96939514A EP 0858456 A4 EP0858456 A4 EP 0858456A4
Authority
EP
European Patent Office
Prior art keywords
immunosuppressant activity
triterpene derivatives
triterpene
derivatives
immunosuppressant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96939514A
Other languages
German (de)
French (fr)
Other versions
EP0858456A1 (en
Inventor
Robert K Baker
Jianming Bao
Frank Kayser
William H Parsons
Kathleen M Rupprecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603850.0A external-priority patent/GB9603850D0/en
Priority claimed from GBGB9605159.4A external-priority patent/GB9605159D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0858456A1 publication Critical patent/EP0858456A1/en
Publication of EP0858456A4 publication Critical patent/EP0858456A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96939514A 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity Withdrawn EP0858456A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US711695P 1995-10-31 1995-10-31
US819095P 1995-10-31 1995-10-31
US8190P 1995-10-31
US7116P 1995-10-31
GBGB9603850.0A GB9603850D0 (en) 1996-02-23 1996-02-23 Triterpene derivatives with immunosuppressant activity
GB9603850 1996-02-23
GBGB9605159.4A GB9605159D0 (en) 1996-03-12 1996-03-12 Triterpene derivatives with immunosuppressant activity
GB9605159 1996-03-12
PCT/US1996/017478 WO1997016437A1 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Publications (2)

Publication Number Publication Date
EP0858456A1 EP0858456A1 (en) 1998-08-19
EP0858456A4 true EP0858456A4 (en) 1998-12-30

Family

ID=27451411

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96939514A Withdrawn EP0858456A4 (en) 1995-10-31 1996-10-28 Triterpene derivatives with immunosuppressant activity

Country Status (4)

Country Link
EP (1) EP0858456A4 (en)
JP (1) JPH11511481A (en)
AU (1) AU708667B2 (en)
WO (1) WO1997016437A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952371A (en) * 1996-10-16 1999-09-14 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5998408A (en) * 1996-10-16 1999-12-07 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5874594A (en) * 1996-10-16 1999-02-23 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US6100293A (en) * 1997-10-17 2000-08-08 Merck & Co., Inc. Tetracyclic triterpene derivatives with immunosuppressant activity
US6083980A (en) * 1997-10-17 2000-07-04 Merck & Co., Inc. Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity
US6022890A (en) * 1997-11-14 2000-02-08 Merck & Co., Inc. Immunosuppressant tetracyclic triterpenes
US6051590A (en) * 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
AUPS127202A0 (en) 2002-03-20 2002-04-18 Walter And Eliza Hall Institute Of Medical Research, The Therapeutic ion channel blocking agents and methods of use thereof
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
AU2007304880B9 (en) 2006-10-04 2012-11-08 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
WO2008040058A1 (en) 2006-10-04 2008-04-10 Bionomics Limited Novel chromenone potassium channel blockers and uses thereof
WO2009043117A1 (en) 2007-10-04 2009-04-09 Bionomics Limited Novel aryl potassium channel blockers and uses thereof
JP2011522843A (en) 2008-06-13 2011-08-04 バイオノミクス リミテッド Novel potassium channel blockers and their use
WO2012155199A1 (en) 2011-05-16 2012-11-22 Bionomics Limited Amine derivatives as potassium channel blockers
EP2524912A1 (en) 2011-05-16 2012-11-21 Bionomics Limited Amine derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483191A (en) * 1963-09-13 1969-12-09 Squibb & Sons Inc Steroids
WO1996040688A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. Triterpenes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6017794B2 (en) * 1980-05-16 1985-05-07 ア−ス製薬株式会社 New steroids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483191A (en) * 1963-09-13 1969-12-09 Squibb & Sons Inc Steroids
WO1996040688A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. Triterpenes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9716437A1 *

Also Published As

Publication number Publication date
WO1997016437A1 (en) 1997-05-09
EP0858456A1 (en) 1998-08-19
AU7666196A (en) 1997-05-22
AU708667B2 (en) 1999-08-12
JPH11511481A (en) 1999-10-05

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Legal Events

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