WO1997016438A1 - Triterpene derivatives with immunosuppressant activity - Google Patents
Triterpene derivatives with immunosuppressant activity Download PDFInfo
- Publication number
- WO1997016438A1 WO1997016438A1 PCT/US1996/017481 US9617481W WO9716438A1 WO 1997016438 A1 WO1997016438 A1 WO 1997016438A1 US 9617481 W US9617481 W US 9617481W WO 9716438 A1 WO9716438 A1 WO 9716438A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- defined above
- heteroaryl
- aryl
- hydroxy
- Prior art date
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU76663/96A AU700036B2 (en) | 1995-10-31 | 1996-10-28 | Triterpene derivatives with immunosuppressant activity |
EP96939516A EP0891347A4 (en) | 1995-10-31 | 1996-10-28 | Triterpene derivatives with immunosuppressant activity |
JP9517550A JPH11511482A (en) | 1995-10-31 | 1996-10-28 | Triterpene derivatives having immunosuppressive activity |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US710195P | 1995-10-31 | 1995-10-31 | |
US819195P | 1995-10-31 | 1995-10-31 | |
US60/008,191 | 1995-10-31 | ||
US60/007,101 | 1995-10-31 | ||
GBGB9603903.7A GB9603903D0 (en) | 1996-02-23 | 1996-02-23 | Triterpene detivatives with immunosuppressive activity |
GB9603903.7 | 1996-02-23 | ||
GB9605161.0 | 1996-03-12 | ||
GBGB9605161.0A GB9605161D0 (en) | 1996-03-12 | 1996-03-12 | Triterpene derivatives with immunosuppressant activity |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997016438A1 true WO1997016438A1 (en) | 1997-05-09 |
Family
ID=27451412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/017481 WO1997016438A1 (en) | 1995-10-31 | 1996-10-28 | Triterpene derivatives with immunosuppressant activity |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0891347A4 (en) |
JP (1) | JPH11511482A (en) |
AU (1) | AU700036B2 (en) |
CA (1) | CA2236171A1 (en) |
WO (1) | WO1997016438A1 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0877554A1 (en) * | 1995-10-31 | 1998-11-18 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5874594A (en) * | 1996-10-16 | 1999-02-23 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
WO1999032487A1 (en) * | 1997-12-18 | 1999-07-01 | Glaxo Group Limited | Kv2.1 ANTAGONISTS |
US5952371A (en) * | 1996-10-16 | 1999-09-14 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5998408A (en) * | 1996-10-16 | 1999-12-07 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US6022890A (en) * | 1997-11-14 | 2000-02-08 | Merck & Co., Inc. | Immunosuppressant tetracyclic triterpenes |
US6051590A (en) * | 1999-05-13 | 2000-04-18 | Merck & Co., Inc. | Immunosuppressant tricyclic compounds |
US6083980A (en) * | 1997-10-17 | 2000-07-04 | Merck & Co., Inc. | Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity |
US6100293A (en) * | 1997-10-17 | 2000-08-08 | Merck & Co., Inc. | Tetracyclic triterpene derivatives with immunosuppressant activity |
US7507839B2 (en) | 2002-03-20 | 2009-03-24 | The Walter And Eliza Hall Institute Of Medical Research | Therapeutic ion channel blocking agents and methods of use thereof |
US7534770B2 (en) | 2004-03-31 | 2009-05-19 | Morinaga Milk Industry Co., Ltd. | Glycoside having 4-methylergost-7-en-3-ol skeleton and hyperglycemia improving agent |
US7674784B2 (en) | 2004-09-29 | 2010-03-09 | Morinaga Milk Industry Co., Ltd. | Drug and food or drink for improving hyperglycemia |
US7754704B2 (en) | 2004-03-31 | 2010-07-13 | Morinaga Milk Industry Co., Ltd. | Method for treating hyperglycemia |
US8202513B2 (en) | 2007-10-04 | 2012-06-19 | Bionomics Limited | Aryl potassium channel blockers and uses thereof |
US8217189B2 (en) | 2006-10-04 | 2012-07-10 | Bionomics Limited | Chromenone potassium channel blockers and uses thereof |
US8309545B2 (en) | 2006-10-04 | 2012-11-13 | Bionomics Limited | Benzofuran potassium channel blockers and uses thereof |
EP2524912A1 (en) | 2011-05-16 | 2012-11-21 | Bionomics Limited | Amine derivatives |
EP2583678A2 (en) | 2004-06-24 | 2013-04-24 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
US8507539B2 (en) | 2008-06-13 | 2013-08-13 | Bionomics Limited | Potassium channel blockers and uses thereof |
US9493451B2 (en) | 2011-05-16 | 2016-11-15 | Bionomics Limited | Amine derivatives as potassium channel blockers |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4453967A (en) * | 1980-05-16 | 1984-06-12 | Sumitomo Chemical Company, Limited | Homobrassinolide compounds which are steroids having plant growth promoting activity |
-
1996
- 1996-10-28 CA CA002236171A patent/CA2236171A1/en not_active Abandoned
- 1996-10-28 AU AU76663/96A patent/AU700036B2/en not_active Ceased
- 1996-10-28 JP JP9517550A patent/JPH11511482A/en active Pending
- 1996-10-28 WO PCT/US1996/017481 patent/WO1997016438A1/en not_active Application Discontinuation
- 1996-10-28 EP EP96939516A patent/EP0891347A4/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4453967A (en) * | 1980-05-16 | 1984-06-12 | Sumitomo Chemical Company, Limited | Homobrassinolide compounds which are steroids having plant growth promoting activity |
Non-Patent Citations (2)
Title |
---|
PHYTOCHEMISTRY, Vol. 29, No. 7, issued 1990, ABREU et al., "A Nor-triterpenoid from Lophanthera Lactescens", pages 2257-2261. * |
See also references of EP0891347A4 * |
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EP0877554A4 (en) * | 1995-10-31 | 1998-12-02 | ||
US5874594A (en) * | 1996-10-16 | 1999-02-23 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5952371A (en) * | 1996-10-16 | 1999-09-14 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5998408A (en) * | 1996-10-16 | 1999-12-07 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US6083980A (en) * | 1997-10-17 | 2000-07-04 | Merck & Co., Inc. | Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity |
US6100293A (en) * | 1997-10-17 | 2000-08-08 | Merck & Co., Inc. | Tetracyclic triterpene derivatives with immunosuppressant activity |
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Also Published As
Publication number | Publication date |
---|---|
CA2236171A1 (en) | 1997-05-09 |
AU700036B2 (en) | 1998-12-17 |
EP0891347A1 (en) | 1999-01-20 |
JPH11511482A (en) | 1999-10-05 |
EP0891347A4 (en) | 1999-04-07 |
AU7666396A (en) | 1997-05-22 |
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