EP0888134A1 - Procede pour nettoyer et desinfecter des instruments medicaux sensibles - Google Patents
Procede pour nettoyer et desinfecter des instruments medicaux sensiblesInfo
- Publication number
- EP0888134A1 EP0888134A1 EP97901084A EP97901084A EP0888134A1 EP 0888134 A1 EP0888134 A1 EP 0888134A1 EP 97901084 A EP97901084 A EP 97901084A EP 97901084 A EP97901084 A EP 97901084A EP 0888134 A1 EP0888134 A1 EP 0888134A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cleaning
- weight
- disinfectant
- carbon atoms
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims abstract description 44
- 230000000249 desinfective effect Effects 0.000 title claims abstract description 12
- 239000000645 desinfectant Substances 0.000 claims abstract description 62
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000012459 cleaning agent Substances 0.000 claims abstract description 21
- -1 alkyl propylene diamines Chemical class 0.000 claims abstract description 18
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 6
- 239000001257 hydrogen Substances 0.000 claims abstract description 6
- 150000003839 salts Chemical class 0.000 claims abstract description 4
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims abstract description 3
- 125000005667 alkyl propylene group Chemical group 0.000 claims abstract 2
- 239000012141 concentrate Substances 0.000 claims description 22
- 239000004094 surface-active agent Substances 0.000 claims description 16
- 239000008139 complexing agent Substances 0.000 claims description 12
- 102000035195 Peptidases Human genes 0.000 claims description 9
- 108091005804 Peptidases Proteins 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 238000005187 foaming Methods 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 4
- NYNKJVPRTLBJNQ-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-dodecylpropane-1,3-diamine Chemical compound CCCCCCCCCCCCN(CCCN)CCCN NYNKJVPRTLBJNQ-UHFFFAOYSA-N 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- XMMDVXFQGOEOKH-UHFFFAOYSA-N n'-dodecylpropane-1,3-diamine Chemical compound CCCCCCCCCCCCNCCCN XMMDVXFQGOEOKH-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract description 4
- 150000001412 amines Chemical class 0.000 description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 11
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 7
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 6
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229940088598 enzyme Drugs 0.000 description 6
- 229940050410 gluconate Drugs 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 5
- 150000002191 fatty alcohols Chemical class 0.000 description 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 229960004063 propylene glycol Drugs 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 150000001768 cations Chemical class 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 150000002170 ethers Chemical class 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000003365 glass fiber Substances 0.000 description 3
- 239000000174 gluconic acid Substances 0.000 description 3
- 235000012208 gluconic acid Nutrition 0.000 description 3
- 229950006191 gluconic acid Drugs 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 235000013772 propylene glycol Nutrition 0.000 description 3
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 229940079842 sodium cumenesulfonate Drugs 0.000 description 3
- QEKATQBVVAZOAY-UHFFFAOYSA-M sodium;4-propan-2-ylbenzenesulfonate Chemical compound [Na+].CC(C)C1=CC=C(S([O-])(=O)=O)C=C1 QEKATQBVVAZOAY-UHFFFAOYSA-M 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- YDONNITUKPKTIG-UHFFFAOYSA-N [Nitrilotris(methylene)]trisphosphonic acid Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CP(O)(O)=O YDONNITUKPKTIG-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000012958 reprocessing Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- TYIOVYZMKITKRO-UHFFFAOYSA-N 2-[hexadecyl(dimethyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O TYIOVYZMKITKRO-UHFFFAOYSA-N 0.000 description 1
- SZHQPBJEOCHCKM-UHFFFAOYSA-N 2-phosphonobutane-1,2,4-tricarboxylic acid Chemical compound OC(=O)CCC(P(O)(O)=O)(C(O)=O)CC(O)=O SZHQPBJEOCHCKM-UHFFFAOYSA-N 0.000 description 1
- 241000194108 Bacillus licheniformis Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical group OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 1
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 description 1
- 239000004435 Oxo alcohol Substances 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000187392 Streptomyces griseus Species 0.000 description 1
- 102000005158 Subtilisins Human genes 0.000 description 1
- 108010056079 Subtilisins Proteins 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical class OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000029219 regulation of pH Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- DZCAZXAJPZCSCU-UHFFFAOYSA-K sodium nitrilotriacetate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O DZCAZXAJPZCSCU-UHFFFAOYSA-K 0.000 description 1
- 229940048842 sodium xylenesulfonate Drugs 0.000 description 1
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 1
- KVCGISUBCHHTDD-UHFFFAOYSA-M sodium;4-methylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1 KVCGISUBCHHTDD-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 150000003510 tertiary aliphatic amines Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000012873 virucide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
Definitions
- the present invention relates to a method for cleaning and disinfecting sensitive medical devices, in particular endoscopes, and means for carrying out the method.
- Endoscopes are used in medical diagnostics and therapy as well as in surgical interventions.
- Glass fiber endoscopes in particular are extremely complicated precision instruments that have moving parts and are made from a variety of materials. Cleaning and disinfecting them is extremely problematic for a number of reasons. In this way, not only the external surfaces of the instrument, but also the narrow English channels inside, must be cleaned and disinfected. The devices are usually first cleaned in machine reprocessing processes and then disinfected. The thermal disinfection preferred for medical devices and instruments cannot be used here, since the endoscopes are partly made of temperature-sensitive materials.
- the glass fiber doscopes can be completely inserted into cleaning and disinfection baths, but can withstand temperatures of up to 70 ° C without damage. It must also be taken into account that a number of existing metal parts are susceptible to corrosion and that the connecting elements of the individual parts of the devices can be attacked by the agents. In addition, parts made of rubber-like materials can swell and stick. Finally, the endoscopes should be cleaned and disinfected in a short time so that the instruments are available again for the treatment of the patients as quickly as possible.
- a two-stage cleaning process is known from European patent application EP-A 0 268 227, according to which the surfaces of the devices to be treated are successively (a) brought into contact with a cleaning solution which is heated to 55 to 65 ° C.
- this temperature is maintained and then separated, and which contains at least one low-foaming nonionic surfactant, at least one proteolytic enzyme, at least one complexing agent and, if appropriate, other customary cleaning agent components and has a pH of 6 to 8, and (b) in contact with a disinfectant solution brought, which is heated to 55 to 65 ° C, held at this temperature for 1 to 15 minutes and then separated and which contains at least one aldehyde from the group consisting of formaldehyde and aliphatic dialdehydes having 2 to 8 carbon atoms and at least one complexing agent and one has pH in the range of 6 to 8.
- the endoscope is then rinsed at least twice with water having a pH between 6 and 8, the water being heated to 55 to 65 ° C. in the last rinse, and then dried with sterilized hot air at 55 to 65 ° C. becomes.
- European patent application EP-A 0 342 499 describes a one-step process for cleaning and disinfecting endoscopes, in which the endoscopes are brought into contact with a cleaning disinfectant solution which contains at least one low-foaming nonionic surfactant, at least one proteolytic enzyme, and at least one complexing agent and contains at least one aldehyde from the group consisting of formaldehyde and aliphatic dialdehydes having 2 to 8 carbon atoms and having a pH of between 6 and 8, the solution being heated to 55 to 65 ° C. and at this for 1 to 15 minutes Temperature is maintained and then separated. The surfaces to be treated are then rinsed twice with water, the water being heated to 55 to 65 ° C. at least in the last rinse cycle and then dried with sterilized hot air at 40 to 60 ° C.
- a cleaning disinfectant solution which contains at least one low-foaming nonionic surfactant, at least one proteolytic enzyme, and at least one complexing agent and contains at least one alde
- European patent application EP-A 0 156 275 discloses amine compounds which are obtained by reacting compounds having the formula R 1 NHCH 2 CH 2 CH 2 NH 2 , in which R 1 is a linear alkyl radical having 12 to 14 carbon atoms , with compounds of the formula R 2 OCOCH 2 CH 2 CHNH 2 COOH, in which R 2 is one Alkyl radical with 1 to 4 carbon atoms or a hydrogen atom means, obtained in a molar ratio of 1: 1 to 1: 2 at 60 to 175 ° C., to be used as antimicrobial substances.
- These reaction products have also become known as glucoprotamine.
- German patent application DE-A-40 07 758 describes an aqueous surfactant-containing cleaning and disinfectant concentrate which, as antimicrobial active ingredients, contains the amine compounds mentioned in European patent application EP-A 0 156 275 in combination with selected quaternary ammonium compounds. Furthermore, a method for spray cleaning and disinfection of objects from medical facilities in automatically operated systems is described, which comprises the steps a) spraying an aqueous, disinfectant cleaning agent solution at elevated temperature, which has been prepared by diluting the cleaning agent concentrate described, and if desired b) spraying on an aqueous, optionally surfactant-containing rinse aid and, if desired, c) drying, preferably by means of hot air.
- EP-A-343 605 describes a liquid aldehyde-free tuberculozoid disinfectant which contains N, N-bis- (3-aminopropyl) -laurylamine as active component as active component.
- the European patent application EP-A 620 013 describes a disinfectant for collective toilet systems and similar devices, which is used manually. It contains salts of amines with the formula NR [(CH 2 ) n -NH 2 ] [(CH 2 ) m -NH 2 ] or NRH [(CH 2 ) P -NH 2 ], in which R represents a straight-chain or branched Alkyl or alkenyl radical having 6 to 22 carbon atoms, n and m being a value from 4 to 12 and p being a value from 2 to 12. Because of the corrosive properties to metals such as steel and plastics, the agents are used at low temperatures up to 50 ° C.
- European patent application EP-A-0 551 975 discloses a disinfectant concentrate and a disinfectant based on amine and alcohol and their use, the alcohol component containing at least one aromatic alcohol and the amine component containing at least one secondary and / or tertiary hydroxyl-free Al - comprises kylamine.
- the ready-to-use solution has a pH between 7 and 12.
- the disinfectant is used in particular as a bactericide, in particular as a mycobactericide, fungicide or virucide.
- European patent application EP-A 0-612 170 also relates to an amine and alcohol-containing disinfectant, in which the alcohol component comprises at least one limitedly water-miscible glycol ether and the amine component comprises at least one secondary and / or tertiary, hydroxy group-free alkylamine.
- amine-based disinfectants tend to attack and destroy metals and plastics at higher temperatures above 50 ° C, so that it was expected that they would be used in mechanical reprocessing processes for sensitive medical devices such as e.g. Endoscopes, can not be used (see. EP-A-0 620 013).
- aldehydes fix protein-containing stains if they have not been completely removed by an upstream cleaning step.
- Quaternary ammonium compounds are known to have a good disinfectant effect, but they can spread onto surfaces and cause sticking effects.
- the present invention was based on the object of a method for cleaning and disinfecting sensitive medical devices, in particular endoscopes To make available that a combination of thermal, ie at temperatures above 50 ° C, and chemical treatment enables reliable cleaning and disinfection of these devices in a short time. Even with continuous use, it should not result in damage to the treated devices.
- the method should be designed so that it can be carried out in an automatic dishwasher.
- the present invention relates to a method for cleaning and disinfecting sensitive medical devices, in particular endoscopes, with the aid of aqueous cleaning and disinfectant solutions, in which a) the surfaces of the medical devices to be treated are brought into contact with an aqueous disinfectant solution which a Has temperature between 55 and 65 ° C, held at this temperature for 1 to 15 minutes and then separated, the disinfectant solution at least one disinfectant from the group of alkyl propylenediamines with the general formula I
- R 1 is an alkyl or alkenyl group with 8 to 18 carbon atoms and R 2 hydrogen, an alkyl group with 1 to 4 carbon atoms or an aminoalkyl group with 2 to 4 carbon atoms, and the products known as glucoprotamine, such as those obtained from alkylpropylenediamine of the formula II
- R 3 represents a linear alkyl group having 12 to 14 carbon atoms
- I NH 2 in which R 4 represents hydrogen or an alkyl group with 1 to 4 carbon atoms, are accessible in a molar ratio of 1: 1 to 1: 2 at 60 to 175 ° C., and also contains their salts and has a pH between 4 and 8, b ) the devices are brought into contact with an aqueous cleaning solution before or simultaneously with the treatment with the disinfectant solution, and c) the devices are rinsed with water in a manner known per se and then dried.
- the disinfectant solution of step a) preferably has a pH below 7 and in particular between 4.5 and 6.5.
- the process according to the invention has the advantage that the medical devices are not corroded and that, surprisingly, the amines have a sufficient antimicrobial effect without the workforce being troubled.
- a further surprising effect is that the applied disinfectant solution alone has a clear cleaning effect, which contributes to the removal of any residues still remaining on the surfaces.
- amines present in the disinfectant solution of step a) are glucoprotamine, N, N-bis (3-aminopropyl) laurylamine, N-dodecyl-1, 3-propanediamine or a mixture of the above, with glucoprotamine being particularly preferred.
- the amine used according to the invention is preferably in the disinfectant solution of step a) in amounts of 0.01% by weight to 0.20% by weight, in particular 0.02% by weight to 0.15% by weight , contain.
- the disinfectant solution is preferably prepared by diluting an appropriate concentrate in a ratio of 1:30 to 1: 200 with water.
- the disinfectant solution can contain, as further constituents, surfactants, complexing agents, solvents, corrosion inhibitors, dyes and fragrances and, if appropriate, further antimicrobial agents and agents for pH regulation.
- Nonionic surfactants and amphoteric surfactants are preferably used as surfactants in the process according to the invention, low-foam surfactants being particularly advantageous.
- Non-ionic surfactants in particular are used as low-foam surfactants.
- Alkylene oxide adducts such as those obtained by adding 3 to 30 mol of ethylene oxide (EO) and / or propylene oxide (PO) to fatty alcohols, long-chain oxo alcohols, fatty acids, fatty amines and alkylphenols, each with 8 to 18 carbon atoms, have proven to be particularly suitable. Atoms can be obtained, the terminal hydroxyl groups of these polyglycol ether derivatives also being etherified, esterified or acetalized.
- EO ethylene oxide
- PO propylene oxide
- R 5 is a straight-chain or branched alkyl or alkenyl radical with 8 to 18 carbon atoms
- R 6 is a straight-chain or branched alkyl radical with 4 to 8 carbon atoms and n is a number from 7 to 12
- polyethylene glycol ethers of For ⁇ mel IV are preferred, in which R 5 is a mixture of alkyl and / or alkenyl radicals having 12 to 18 carbon atoms and R 6 is an n-butyl radical originating from a hardened or unhardened tallow alcohol, and R 6 is an n-butyl radical, while n is a number from 9 to 10 means.
- Amphoteric surfactants can be used as further surfactants.
- Suitable amphoteric surfactants include derivatives of tertiary aliphatic amines and quaternary aliphatic ammonium compounds, the aliphatic radicals of which are straight-chain or can be branched and one of which carries a carboxy, sulfo, phosphono, sulfato or phosphato group.
- amphoteric surfactants are N, N-dimethyl-N-tetradecylglycine, N, N-dimethyl-N-hexadecylglycine, NN-dimethyl-N-octadecylglycine, 3- (N; N-Dimethyl-N-dodecylammonium) -1- propane sulfonate.
- complexing agents are alkali metal salts of nitrilotriacetic acid, ethylenediaminotetraacetic acid, 1-hydroxyethane-1, 1-diphosphonic acid, aminotris (methylenephosphonic acid), ethylenediaminotetrakis (methylenephosphonic acid), phosphonobutane tricarboxylic acid, tartaric acid, citric acid and gluconic acid, gluconic acid, gluconic acid, gluconate, gluconate, gluconate, gluconate, gluconate, gluconate, gluconate, gluconate, gluconate, gluconate, gluconate, is particularly preferably used.
- the organic solvents used are preferably those from the group of the alcohols with 1 to 4 carbon atoms, the glycols with 2 to 4 carbon atoms and the diglycols and diglycol ethers derived from these. Such solvents are preferably present in the concentrates in an amount of from 1% by weight to 25% by weight, in particular from 10% by weight to 20% by weight.
- the corresponding application solutions can be prepared in the desired concentrations from the concentrates.
- the disinfectant concentrate contains from 0.5% by weight to 30% by weight, in particular 2% by weight to 15% by weight, of antimicrobial active ingredients, 0.5% by weight to 15% by weight. %, in particular 1% by weight to 10% by weight, surfactants, 1% by weight to 25% by weight, in particular 10% by weight to 20% by weight, organic solvents, up to 10% by weight. -%, in particular 0.5 to 6 wt .-%, complexing agent, and optionally other conventional additives and water.
- the pH of the concentrate is adjusted to preferably 4 to 6 with acid, base or an acid / base mixture.
- the devices Before or simultaneously with the treatment with the disinfectant solution, the devices are brought into contact with a cleaning solution. If the devices are brought into contact with the cleaning solution before the treatment with the disinfectant and the cleaning liquor is removed before the disinfectant solution is added, this constitutes
- the method according to the invention is a two-stage cleaning and disinfection method, similar to that described, for example, in European patent application EP-A-0 268 227. If the devices are treated simultaneously with the cleaning agent and disinfectant solution, the cleaning agent solution and the disinfectant solution can be mixed or separated, preferably successively, into the cleaning apparatus before being brought into contact with the devices. In this case, the process according to the invention is carried out as a one-step process, similar to that described, for example, in European patent application EP-A-0 342 499.
- all cleaning agent solutions are suitable for the cleaning and disinfection method according to the invention in the cleaning step, as are customary for cleaning sensitive medical devices, provided that they do not impair the advantages of the amine active ingredients used for disinfection.
- Quaternary ammonium compounds and all other active substances which negatively influence the effect of the process according to the invention are preferably dispensed with both in the disinfectant solution and in the cleaning solution.
- the cleaning agent solution from step b) preferably contains at least one low-foaming nonionic surfactant and at least one proteolytic enzyme, and, if appropriate, further conventional cleaning agent components, for example complexing agents. It has proven particularly expedient to use a cleaning agent solution which
- the surfactants in the cleaning agent solution used are preferably in amounts of from 0.01% by weight to 0.08% by weight, in particular from 0.02% by weight to 0.05% by weight .-% contain.
- a corresponding concentrate preferably contains from 2 to 15% by weight, in particular from 4 to 10% by weight, of surfactants.
- Suitable proteolytic enzymes for the cleaning agent solution of step b) are, in particular, proteases obtained from bacterial strains. Suitable are e.g. the enzymes obtained from Bacillus Subtilis, Bacillus Licheniformis and Streptomyces Griseus. Corresponding commercial preparations are either in the form of solutions of the enzyme in a mixture of water or an organic solvent, for example 1, 2-propanediol, or as solid granules.
- the detergent concentrate may contain enzyme stabilizers as a further constituent, for example triethanolamine, morpholine, ⁇ -pyrrolidone, ethylene glycol, propylene glycol, glycerol, water-soluble calcium salts or mixtures of these compounds. Glycerol and / or propylene glycol are preferably used as the enzyme stabilizer.
- the pH of the cleaning agent solution is preferably in the same range as that of the disinfectant solution, namely between 4 and 8, preferably below 7 and in particular between 4.5 and 6.5.
- water with a hardness in the range from 3 to 8 ° d is preferably used. This applies both to the preparation of the cleaning and disinfectant solution and to the rinse cycles.
- the setting of the above-mentioned degrees of hardness is expediently carried out by passing tap water at least partly over a cation exchanger which removes the hardness-forming cations from the water. This cation exchange results in a shift in the pH in the weakly alkaline areas.
- the cleaning solution and the disinfectant solution are preferably produced from concentrates which have proven to be advantageous from an economic point of view. Such concentrates can be formulated in such a way that when diluted with the tap water treated in the cation exchanger they give solutions with a pH in the required range.
- the devices treated with the cleaning agent solution and the disinfectant solution are then rinsed with water in a manner known per se and dried.
- the devices are expediently rinsed with water at least twice, the water being heated to 55 to 65 ° C. at least in the last rinse cycle, and then dried.
- the drying step is preferably carried out with sterilized hot air at about 40 to 65 ° C., preferably 55 to 60 ° C.
- sterilized hot air at about 40 to 65 ° C., preferably 55 to 60 ° C.
- air which has been sterilized by suction through a microfilter before being heated.
- the method according to the invention can be carried out in practice, for example, in commercially available apparatus for disinfecting laboratory equipment and medical equipment, automatic dishwashers, as are known and customary for cleaning and disinfecting medical instruments, in particular endoscopes, being preferred.
- the cleaning solution is expediently prepared from a storable concentrate.
- low-foaming surfactant 7.1 to 77 AU / I proteolytic enzyme
- 1 to 5% by weight of complexing agent 10 to 50% by weight of enzyme stabilizer, 1 to 5% by weight of packaging aid and 0, 05 to 0.5% by weight preservative.
- the pH of the concentrate is adjusted to 4 to 6 with acid, base or an acid / base mixture.
- Assembly aids (solubilizers) suitable for the aqueous cleaning agent concentrate are, for example, sodium cumene sulfonate, sodium toluenesulfonate, sodium xylene sulfonate, urea, polyethylene glycols and methyl acetamide; sodium cumene sulfonate is preferably used as a packaging aid.
- the mixture was adjusted to pH 5 with 37% strength by weight NaOH solution.
- the endoscopes were cleaned and disinfected in a closable, heated stainless steel vessel (diameter approx. 60 cm; height approx. 65 cm), the supply and discharge lines for the cleaning and disinfectant solution and the water used in the rinse cycles as well as for had the hot air needed to dry the equipment.
- the apparatus was equipped with a circulation pump, with the help of which the liquid present could be pumped through the channels of the fiber endoscopes.
- a ready-to-use cleaning and disinfectant solution was prepared by diluting the appropriate proportions of cleaning agent concentrate and disinfectant concentrate.
- the cleaning solution contained 0.40 g surfactant / l and 0.05 g enzyme / l in the application solution.
- the disinfectant solution contained 0.84 g glucoprotamine / l in the application solution.
- the air used for drying was sucked in via a microfilter and passed through a heating section before being introduced into the stainless steel vessel, where it was heated to 60 ° C.
- the endoscope When performing the cleaning process, the endoscope was placed in a wire basket in the stainless steel container. The channels of the endoscope were connected to the circulation pump. In the individual steps of the process, so much liquid was supplied to the stainless steel container that the endoscope was completely covered. During the individual process steps, the liquid present was continuously pumped through the channels of the endoscope. The cleaner was dosed at 0.5% at 30 ° C, the cleaning solution was pumped through the endoscope channels and heated to 45 ° C. After reaching its temperature, it was rinsed through the endoscope for a further 2 minutes, at the same time the endoscope was also cleaned on the outside by the cleaning solution.
- the solutions used in the disinfection step for experiments 1 and 2 were heated to 60 ° C.
- the solutions were brought into contact with the gastroscope both on the inside and outside for 5 minutes.
- the stainless steel vessel was then filled again with water, which was then heated to 60 ° C. and then removed. Filtered hot air was finally introduced for 5 minutes to dry the endoscope.
- the channels of the endoscope were separately contaminated with germ suspensions which contained the following germs:
- the germ suspensions contained an addition of 20% by weight of defibrinated mutton blood to simulate practical conditions.
- the channels of the endoscope were filled with the germ suspensions. After briefly standing, the germ suspensions were drained off again. One hour after contamination, the endoscope was cleaned and disinfected according to the invention. Then 0.5 l of a solution containing 3% by weight of Tween® 80, 0.3% by weight of lecithin, 0.1% by weight of histidine, 0.1% by weight of tryptone and 0.05% by weight .-% Sodium chloride contained, sucked through the channels of the endoscope. Samples of 1 ml each of this solution was inoculated on Aggarplatten, a C incubated subsequently at least 48 hours at 37 ° C and 72 hours, and 35 were then tested for existing microbial growth.
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Abstract
L'invention concerne un procédé pour nettoyer et désinfecter des instruments médicaux sensibles, notamment des endoscopes, à l'aide de solutions aqueuses d'agents nettoyants et désinfectants. Au cours de ce procédé, (a) les surfaces des instruments médicaux à traiter sont mises en contact avec une solution aqueuse d'agent désinfectant qui se trouve à une température comprise entre 55 et 65 °C, est maintenue à ladite température pendant 1 à 15 minutes et est ensuite évacuée, cette solution d'agent désinfectant contenant au moins une substance désinfectante du groupe des alkylpropylènediamines ayant la formule (I), dans laquelle R1 est un groupe alkyle ou alcényle avec 8 à 18 atomes de carbone, et R2 est hydrogène, un groupe alkyle avec 1 à 4 atomes de carbone ou un groupe aminoalkyle avec 2 à 4 atomes de carbone, et des produits connus sous la désignation glucoprotamine, tels qu'ils peuvent être obtenus, dans le rapport molaire 1 : 1 à 1 : 2 à une température comprise entre 60 et 175 °C, à partir d'alkylpropylènediamine de la formule (II) R3-NH-CH¿2?-CH2-CH2-NH2, dans laquelle R?3¿ est un groupe alkyle linéaire avec 12 à 14 atomes de carbone, par réaction avec des composés de la formule (III) dans laquelle R4 est hydrogène ou un groupe alkyle avec 1 à 4 atomes de carbone, ainsi que leurs sels, ladite solution présentant une valeur pH comprise entre 4 et 8; (b) les instruments sont mis en contact avec une solution aqueuse nettoyante avant ou en même temps que le traitement avec la solution d'agent désinfectant; et (c) les instruments sont rincés à l'eau et ensuite séchés de manière connue en soi.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1996103977 DE19603977A1 (de) | 1996-02-05 | 1996-02-05 | Verfahren zur Reinigung und Desinfektion von empfindlichen medizinischen Geräten |
DE19603977 | 1996-02-05 | ||
PCT/EP1997/000351 WO1997028829A1 (fr) | 1996-02-05 | 1997-01-27 | Procede pour nettoyer et desinfecter des instruments medicaux sensibles |
Publications (1)
Publication Number | Publication Date |
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EP0888134A1 true EP0888134A1 (fr) | 1999-01-07 |
Family
ID=7784474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97901084A Withdrawn EP0888134A1 (fr) | 1996-02-05 | 1997-01-27 | Procede pour nettoyer et desinfecter des instruments medicaux sensibles |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0888134A1 (fr) |
JP (1) | JP2000506516A (fr) |
AU (1) | AU703790B2 (fr) |
BR (1) | BR9707348A (fr) |
CA (1) | CA2245726A1 (fr) |
DE (1) | DE19603977A1 (fr) |
NZ (1) | NZ326367A (fr) |
WO (1) | WO1997028829A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19717329A1 (de) * | 1997-04-24 | 1998-10-29 | Henkel Ecolab Gmbh & Co Ohg | Flüssige Enzymzubereitung und ihre Verwendung |
DE19722757C5 (de) † | 1997-05-31 | 2010-01-21 | Bode Chemie Gmbh | Aldehydfreie Desinfektionsmittel für Flächen und Instrumente |
DE19741910A1 (de) * | 1997-09-25 | 1999-04-29 | Henkel Ecolab Gmbh & Co Ohg | Verfahren zur Reinigung und Desinfektion von medizinischen Instrumenten |
DE19918475A1 (de) * | 1999-04-23 | 2000-10-26 | Henkel Ecolab Gmbh & Co Ohg | Verfahren zur desinfizierenden Pflege von Fußböden |
ATE284946T1 (de) * | 2000-02-17 | 2005-01-15 | Bode Chemie Gmbh & Co | Reinigungs- und desinfektionssysteme für medizinische instrumente |
DE10007323A1 (de) * | 2000-02-17 | 2001-08-23 | Bode Chemie Gmbh & Co Kg | Reinigunsmittel für medizinische Instrumente |
DE10028998A1 (de) * | 2000-02-17 | 2001-08-23 | Bode Chemie Gmbh & Co Kg | Reinigungs- und Desinfektionssysteme für medizinische Instrumente |
DE10163845A1 (de) * | 2001-12-22 | 2003-07-03 | Ecolab Gmbh & Co Ohg | Desinfektion für Absauganlagen im medizinischen Bereich |
DE102004053141A1 (de) * | 2004-11-03 | 2006-05-04 | Schülke & Mayr GmbH | Desinfektionsmittel mit verbesserter Wirksamkeit gegen Mykobakterien |
CA2533950C (fr) | 2005-01-28 | 2013-10-22 | B. Braun Medical Ag | Desinfectant virocide |
EP1685854B2 (fr) * | 2005-01-28 | 2020-06-10 | B. Braun Medical AG | Composition virucidal en désinfection |
AR061906A1 (es) | 2006-07-18 | 2008-10-01 | Novapharm Res Australia | Limpiador de baja espuma |
WO2012028196A1 (fr) * | 2010-09-02 | 2012-03-08 | Ecolab Inc. | Désinfectants à base de glucoprotamine efficaces contre les prions |
JP5789488B2 (ja) * | 2011-11-10 | 2015-10-07 | ライオン株式会社 | 衣料用液体洗浄剤 |
DE102014110783A1 (de) | 2014-07-30 | 2016-02-04 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Zusammensetzung zur Modulation der Aktivität von Nicht-Strukturproteinen |
JP7068895B2 (ja) * | 2018-04-02 | 2022-05-17 | ライオン株式会社 | 食器洗い機用洗浄剤組成物 |
JP6956671B2 (ja) * | 2018-04-02 | 2021-11-02 | ライオン株式会社 | 食器洗い機用洗浄剤組成物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3410956A1 (de) * | 1984-03-24 | 1985-09-26 | Henkel KGaA, 4000 Düsseldorf | Antimikrobiell wirksame substanzen, ihre herstellung und ihre verwendung |
DE3639322A1 (de) * | 1986-11-17 | 1988-05-26 | Henkel Kgaa | Verfahren zur reinigung und desinfektion von endoskopen und mittel zur durchfuehrung des verfahrens |
DE3816734A1 (de) * | 1988-05-17 | 1989-11-30 | Henkel Kgaa | Verfahren zur reinigung und desinfektion von hitze- und korrosionsempfindlichen medizinischen geraeten, insbesondere von endoskopen und mittel zur durchfuehrung des verfahrens |
DE4201038C2 (de) * | 1992-01-17 | 1996-03-28 | Schuelke & Mayr Gmbh | Desinfektionsmittelkonzentrat und Desinfektionsmittel auf Amin- und Alkoholbasis und deren Verwendung |
DE4234070A1 (de) * | 1992-10-09 | 1994-04-14 | Henkel Ecolab Gmbh & Co Ohg | Reinigendes Desinfektionsmittel |
DE4311840C2 (de) * | 1993-04-15 | 1999-04-01 | Bode Chemie Gmbh & Co | Desinfektionsmittel für Sammeltoilettensysteme und ähnliche Anlagen |
WO1996009763A1 (fr) * | 1994-09-26 | 1996-04-04 | Henkel Kommanditgesellschaft Auf Aktien | Utilisation de tensioactifs en vue d'augmenter l'activite antimicrobienne d'un amide d'acide carboxylique |
-
1996
- 1996-02-05 DE DE1996103977 patent/DE19603977A1/de not_active Withdrawn
-
1997
- 1997-01-27 EP EP97901084A patent/EP0888134A1/fr not_active Withdrawn
- 1997-01-27 NZ NZ326367A patent/NZ326367A/xx unknown
- 1997-01-27 BR BR9707348A patent/BR9707348A/pt not_active Application Discontinuation
- 1997-01-27 JP JP9528099A patent/JP2000506516A/ja active Pending
- 1997-01-27 AU AU14453/97A patent/AU703790B2/en not_active Ceased
- 1997-01-27 CA CA 2245726 patent/CA2245726A1/fr not_active Abandoned
- 1997-01-27 WO PCT/EP1997/000351 patent/WO1997028829A1/fr not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO9728829A1 * |
Also Published As
Publication number | Publication date |
---|---|
BR9707348A (pt) | 1999-07-27 |
DE19603977A1 (de) | 1997-08-07 |
AU703790B2 (en) | 1999-04-01 |
WO1997028829A1 (fr) | 1997-08-14 |
NZ326367A (en) | 2000-01-28 |
CA2245726A1 (fr) | 1997-08-14 |
JP2000506516A (ja) | 2000-05-30 |
AU1445397A (en) | 1997-08-28 |
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