EP0881884A4 - System zur verabreichung von bakterien - Google Patents

System zur verabreichung von bakterien

Info

Publication number
EP0881884A4
EP0881884A4 EP96932169A EP96932169A EP0881884A4 EP 0881884 A4 EP0881884 A4 EP 0881884A4 EP 96932169 A EP96932169 A EP 96932169A EP 96932169 A EP96932169 A EP 96932169A EP 0881884 A4 EP0881884 A4 EP 0881884A4
Authority
EP
European Patent Office
Prior art keywords
supply system
bacterial supply
bacterial
supply
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96932169A
Other languages
English (en)
French (fr)
Other versions
EP0881884A1 (de
Inventor
Arthur A Branstrom
Donata R Sizemore
Jerald C Sadoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of the Army
Original Assignee
United States Department of the Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/523,855 external-priority patent/US5824538A/en
Application filed by United States Department of the Army filed Critical United States Department of the Army
Publication of EP0881884A1 publication Critical patent/EP0881884A1/de
Publication of EP0881884A4 publication Critical patent/EP0881884A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0283—Shigella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP96932169A 1995-09-06 1996-09-06 System zur verabreichung von bakterien Withdrawn EP0881884A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US331895P 1995-09-06 1995-09-06
US3318 1995-09-06
US08/523,855 US5824538A (en) 1995-09-06 1995-09-06 Shigella vector for delivering DNA to a mammalian cell
US523855 1995-09-06
US1803596P 1996-05-21 1996-05-21
US18035 1996-05-21
PCT/US1996/014190 WO1997008955A1 (en) 1995-09-06 1996-09-06 Bacterial delivery system

Publications (2)

Publication Number Publication Date
EP0881884A1 EP0881884A1 (de) 1998-12-09
EP0881884A4 true EP0881884A4 (de) 2004-07-14

Family

ID=27357382

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96932169A Withdrawn EP0881884A4 (de) 1995-09-06 1996-09-06 System zur verabreichung von bakterien

Country Status (6)

Country Link
EP (1) EP0881884A4 (de)
JP (1) JP2000500734A (de)
AU (1) AU731061B2 (de)
CA (1) CA2231332C (de)
IL (1) IL123569A (de)
WO (1) WO1997008955A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5756298A (en) 1997-04-18 1998-11-13 Gesellschaft Fur Biotechnologische Forschung Mbh Attenuated salmonella strain used as a vehicle for oral immunization
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
WO1999013053A1 (en) 1997-09-10 1999-03-18 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
EP1021548A1 (de) 1997-10-07 2000-07-26 University Of Maryland Biotechnology Institute Verfahren zür einführung und expression von rna in tierischen zellen
US6825028B1 (en) * 1998-12-11 2004-11-30 Christoph Von Eichel-Streiber Recombinant listeria
DE19754938B4 (de) * 1997-12-11 2006-04-20 Christoph von Dr. Eichel-Streiber TGC-Verfahren zur Induktion einer zielgerichteten, somatischen Transgenität
US6143551A (en) * 1997-12-29 2000-11-07 Schering Aktiengesellschaft Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria
CU22661A1 (es) * 1997-12-30 2001-04-27 Cnic Ct Nac Investigaciones Nuevos candidatos vacunales de vibrio cholerae y método de obtención
US6596477B1 (en) 1998-09-28 2003-07-22 University Of Maryland Biotechnology Institute Treatment and prevention of immunodeficiency virus infection by administration of non-pyrogenic derivatives of lipid A
JP2004500042A (ja) * 1999-10-04 2004-01-08 ヴァイオン　ファーマシューティカルズ、インコーポレーテッド エフェクター分子の腫瘍標的送達のための組成物および方法
US6962696B1 (en) 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
KR20070101854A (ko) * 2004-11-30 2007-10-17 아에라스 글로벌 티비 백신 파운데이션 재조합 이중 가닥 ｒｎａ 뉴클레오캡시드의 생성 및 제조에유용한 세균 패키징 균주 및 그의 용도
DE602005023345D1 (de) * 2004-12-17 2010-10-14 Beth Israel Hospital Zusammensetzungen für bakteriell vermitteltes gen-silencing sowie verfahren zur verwendung davon
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0351322A1 (de) * 1988-07-15 1990-01-17 Institut Pasteur Transformiertes Shigella

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077044A (en) * 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US4632830A (en) * 1981-07-31 1986-12-30 The United States Of America As Represented By The Secretary Of The Army Oral vaccine for immunization against enteric disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0351322A1 (de) * 1988-07-15 1990-01-17 Institut Pasteur Transformiertes Shigella

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HIGH N ET AL: "IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.", THE EMBO JOURNAL. MAY 1992, vol. 11, no. 5, May 1992 (1992-05-01), pages 1991 - 1999, XP000999368, ISSN: 0261-4189 *
LINDBERG A A ET AL: "Development of an auxotrophic oral live Shigella flexneri vaccine.", VACCINE. APR 1988, vol. 6, no. 2, April 1988 (1988-04-01), pages 146 - 150, XP002280511, ISSN: 0264-410X *
MILLS S D ET AL: "ANALYSIS AND GENETIC MANIPULATION OF SHIGELLA VIRULENCE DETERMINANTS FOR VACCINE DEVELOPMENT", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 6, no. 2, 1 April 1988 (1988-04-01), pages 116 - 122, XP000051289, ISSN: 0264-410X *
PHALIPON A ET AL: "Live attenuated Shigella flexneri mutants as vaccine candidates against shigellosis and vectors for antigen delivery.", BIOLOGICALS : JOURNAL OF THE INTERNATIONAL ASSOCIATION OF BIOLOGICAL STANDARDIZATION. JUN 1995, vol. 23, no. 2, June 1995 (1995-06-01), pages 125 - 134, XP002280510, ISSN: 1045-1056 *
See also references of WO9708955A1 *
SIZEMORE D R ET AL: "Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization.", SCIENCE. 13 OCT 1995, vol. 270, no. 5234, 13 October 1995 (1995-10-13), pages 299 - 302, XP002071287, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
CA2231332C (en) 2007-04-17
AU731061B2 (en) 2001-03-22
EP0881884A1 (de) 1998-12-09
IL123569A0 (en) 1998-10-30
CA2231332A1 (en) 1997-03-13
WO1997008955A1 (en) 1997-03-13
AU7105996A (en) 1997-03-27
IL123569A (en) 2006-10-05
JP2000500734A (ja) 2000-01-25

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19980326

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

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17Q First examination report despatched

Effective date: 20061227

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20070508