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EP0881884A4 - Bacterial delivery system - Google Patents

Bacterial delivery system

Info

Publication number
EP0881884A4
EP0881884A4 EP19960932169 EP96932169A EP0881884A4 EP 0881884 A4 EP0881884 A4 EP 0881884A4 EP 19960932169 EP19960932169 EP 19960932169 EP 96932169 A EP96932169 A EP 96932169A EP 0881884 A4 EP0881884 A4 EP 0881884A4
Authority
EP
Grant status
Application
Patent type
Prior art keywords
bacterial
delivery
system
bacterial delivery
delivery system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19960932169
Other languages
German (de)
French (fr)
Other versions
EP0881884A1 (en )
Inventor
Arthur A Branstrom
Donata R Sizemore
Jerald C Sadoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Secretary of Army
Original Assignee
US Secretary of Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0283Shigella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
EP19960932169 1995-09-06 1996-09-06 Bacterial delivery system Withdrawn EP0881884A4 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US331895 true 1995-09-06 1995-09-06
US08523855 US5824538A (en) 1995-09-06 1995-09-06 Shigella vector for delivering DNA to a mammalian cell
US3318 1995-09-06
US523855 1995-09-06
US1803596 true 1996-05-21 1996-05-21
US18035 1996-05-21
PCT/US1996/014190 WO1997008955A1 (en) 1995-09-06 1996-09-06 Bacterial delivery system

Publications (2)

Publication Number Publication Date
EP0881884A1 true EP0881884A1 (en) 1998-12-09
EP0881884A4 true true EP0881884A4 (en) 2004-07-14

Family

ID=27357382

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19960932169 Withdrawn EP0881884A4 (en) 1995-09-06 1996-09-06 Bacterial delivery system

Country Status (4)

Country Link
EP (1) EP0881884A4 (en)
JP (1) JP2000500734A (en)
CA (1) CA2231332C (en)
WO (1) WO1997008955A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2286210A1 (en) * 1997-04-18 1998-10-29 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Attenuated salmonella strain used as a vehicle for oral immunization
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
JP2002500001A (en) 1997-09-10 2002-01-08 イエール ユニバーシティー Genetically modified tumor targeting bacteria having reduced toxicity
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
US6596477B1 (en) 1998-09-28 2003-07-22 University Of Maryland Biotechnology Institute Treatment and prevention of immunodeficiency virus infection by administration of non-pyrogenic derivatives of lipid A
JP2001519162A (en) 1997-10-07 2001-10-23 ユニバーシティ・オブ・メリーランド・バイオテクノロジー・インスティチュート Methods of expressing by introducing rna in animal cells
US6825028B1 (en) * 1998-12-11 2004-11-30 Christoph Von Eichel-Streiber Recombinant listeria
DE19754938B4 (en) 1997-12-11 2006-04-20 Christoph von Dr. Eichel-Streiber TGC method for inducing a targeted somatic transgenesis
US6143551A (en) * 1997-12-29 2000-11-07 Schering Aktiengesellschaft Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria
DK1099759T3 (en) * 1997-12-30 2008-06-23 Cnic Ct Nac Investigaciones Vibrio cholerae vaccine candidates and the method for the construction thereof
CA2386465A1 (en) * 1999-10-04 2001-04-12 Vion Pharmaceuticals, Inc. Compositions and methods for tumor-targeted delivery of effector molecules
US6962696B1 (en) 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
JP2008521434A (en) * 2004-11-30 2008-06-26 エーラス グローバル ティービー ワクチン ファウンデーション Recombinant double-stranded RNA nucleocapsids such product and useful bacterial packaging strains and their use in the production of (rdsRNs)
JP5601756B2 (en) * 2004-12-17 2014-10-08 ベス イスラエル デアコネス メディカル センター, インコーポレイテッド The composition for gene silencing mediated by bacteria and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0351322A1 (en) * 1988-07-15 1990-01-17 Institut Pasteur Transformed Shigella

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077044A (en) * 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US4632830A (en) * 1981-07-31 1986-12-30 The United States Of America As Represented By The Secretary Of The Army Oral vaccine for immunization against enteric disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0351322A1 (en) * 1988-07-15 1990-01-17 Institut Pasteur Transformed Shigella

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HIGH N ET AL: "IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.", THE EMBO JOURNAL. MAY 1992, vol. 11, no. 5, May 1992 (1992-05-01), pages 1991 - 1999, XP000999368, ISSN: 0261-4189 *
LINDBERG A A ET AL: "Development of an auxotrophic oral live Shigella flexneri vaccine.", VACCINE. APR 1988, vol. 6, no. 2, April 1988 (1988-04-01), pages 146 - 150, XP002280511, ISSN: 0264-410X *
MILLS S D ET AL: "ANALYSIS AND GENETIC MANIPULATION OF SHIGELLA VIRULENCE DETERMINANTS FOR VACCINE DEVELOPMENT", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 6, no. 2, 1 April 1988 (1988-04-01), pages 116 - 122, XP000051289, ISSN: 0264-410X *
PHALIPON A ET AL: "Live attenuated Shigella flexneri mutants as vaccine candidates against shigellosis and vectors for antigen delivery.", BIOLOGICALS : JOURNAL OF THE INTERNATIONAL ASSOCIATION OF BIOLOGICAL STANDARDIZATION. JUN 1995, vol. 23, no. 2, June 1995 (1995-06-01), pages 125 - 134, XP002280510, ISSN: 1045-1056 *
See also references of WO9708955A1 *
SIZEMORE D R ET AL: "Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization.", SCIENCE. 13 OCT 1995, vol. 270, no. 5234, 13 October 1995 (1995-10-13), pages 299 - 302, XP002071287, ISSN: 0036-8075 *

Also Published As

Publication number Publication date Type
EP0881884A1 (en) 1998-12-09 application
JP2000500734A (en) 2000-01-25 application
CA2231332C (en) 2007-04-17 grant
WO1997008955A1 (en) 1997-03-13 application
CA2231332A1 (en) 1997-03-13 application

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