IL123569A0 - Attenuated shigella strain methods for the production thereof and systems using the same - Google Patents

Attenuated shigella strain methods for the production thereof and systems using the same

Info

Publication number
IL123569A0
IL123569A0 IL12356996A IL12356996A IL123569A0 IL 123569 A0 IL123569 A0 IL 123569A0 IL 12356996 A IL12356996 A IL 12356996A IL 12356996 A IL12356996 A IL 12356996A IL 123569 A0 IL123569 A0 IL 123569A0
Authority
IL
Israel
Prior art keywords
systems
production
same
attenuated shigella
shigella strain
Prior art date
Application number
IL12356996A
Other versions
IL123569A (en
Original Assignee
Us Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/523,855 external-priority patent/US5824538A/en
Application filed by Us Army filed Critical Us Army
Publication of IL123569A0 publication Critical patent/IL123569A0/en
Publication of IL123569A publication Critical patent/IL123569A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0283—Shigella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
IL123569A 1995-09-06 1996-09-06 Attenuated shigella strain for delivering a mamalian expression plasmid into a mammalian cell IL123569A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US331895P 1995-09-06 1995-09-06
US08/523,855 US5824538A (en) 1995-09-06 1995-09-06 Shigella vector for delivering DNA to a mammalian cell
US1803596P 1996-05-21 1996-05-21
PCT/US1996/014190 WO1997008955A1 (en) 1995-09-06 1996-09-06 Bacterial delivery system

Publications (2)

Publication Number Publication Date
IL123569A0 true IL123569A0 (en) 1998-10-30
IL123569A IL123569A (en) 2006-10-05

Family

ID=27357382

Family Applications (1)

Application Number Title Priority Date Filing Date
IL123569A IL123569A (en) 1995-09-06 1996-09-06 Attenuated shigella strain for delivering a mamalian expression plasmid into a mammalian cell

Country Status (6)

Country Link
EP (1) EP0881884A4 (en)
JP (1) JP2000500734A (en)
AU (1) AU731061B2 (en)
CA (1) CA2231332C (en)
IL (1) IL123569A (en)
WO (1) WO1997008955A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2253789T3 (en) * 1997-04-18 2006-06-01 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) DENIMED SALMONELLA CEPA USED AS A VEHICLE FOR ORAL IMMUNIZATION.
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
CA2302866C (en) 1997-09-10 2012-02-21 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
WO1999018221A1 (en) * 1997-10-07 1999-04-15 University Of Maryland Biotechnology Institute Method for introducing and expressing rna in animal cells
DE19754938B4 (en) 1997-12-11 2006-04-20 Christoph von Dr. Eichel-Streiber TGC method for induction of targeted, somatic transgenicity
US6825028B1 (en) * 1998-12-11 2004-11-30 Christoph Von Eichel-Streiber Recombinant listeria
US6143551A (en) * 1997-12-29 2000-11-07 Schering Aktiengesellschaft Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria
CU22661A1 (en) * 1997-12-30 2001-04-27 Cnic Ct Nac Investigaciones NEW VACCINE CANDIDATES OF VIBRIO CHOLERAE AND METHOD OF OBTAINING
US6596477B1 (en) 1998-09-28 2003-07-22 University Of Maryland Biotechnology Institute Treatment and prevention of immunodeficiency virus infection by administration of non-pyrogenic derivatives of lipid A
US6962696B1 (en) 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
NZ518354A (en) * 1999-10-04 2005-02-25 Vion Pharmaceuticals Inc Compositions and methods for tumor-targeted delivery of effector molecules
WO2006060257A2 (en) * 2004-11-30 2006-06-08 Aeras Global Tb Vaccine Foundation Bacterial packaging strains usefuel for generation and production of recombinant double-stranded rna nucleocapsids and uses thereof
EP1838838B1 (en) * 2004-12-17 2010-09-01 Beth Israel Deaconess Medical Center Compositions for bacterial mediated gene silencing and methods of using same
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077044A (en) * 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US4632830A (en) * 1981-07-31 1986-12-30 The United States Of America As Represented By The Secretary Of The Army Oral vaccine for immunization against enteric disease
AR242989A1 (en) * 1988-07-15 1993-06-30 Inst Pasteur I Nat De La Sante A method for modifying a wild strain of a "shigella", in order to produce a modified strain suitable for preparing a vaccine against the wild strain, and a "shigella" strain thus modified.

Also Published As

Publication number Publication date
EP0881884A1 (en) 1998-12-09
WO1997008955A1 (en) 1997-03-13
CA2231332C (en) 2007-04-17
CA2231332A1 (en) 1997-03-13
AU731061B2 (en) 2001-03-22
EP0881884A4 (en) 2004-07-14
IL123569A (en) 2006-10-05
AU7105996A (en) 1997-03-27
JP2000500734A (en) 2000-01-25

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees