EP0877549A4 - Verfahren und zusammenstellungen zur verminderung der xenotransplantation-abstossung - Google Patents

Verfahren und zusammenstellungen zur verminderung der xenotransplantation-abstossung

Info

Publication number
EP0877549A4
EP0877549A4 EP96939544A EP96939544A EP0877549A4 EP 0877549 A4 EP0877549 A4 EP 0877549A4 EP 96939544 A EP96939544 A EP 96939544A EP 96939544 A EP96939544 A EP 96939544A EP 0877549 A4 EP0877549 A4 EP 0877549A4
Authority
EP
European Patent Office
Prior art keywords
transgenic
cells
cell
human
organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96939544A
Other languages
English (en)
French (fr)
Other versions
EP0877549A1 (de
Inventor
Yiannis Ioannou
Robert J Desnick
Mauro S Sandrin
Ian F C Mckenzie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Austin Research Institute
Mount Sinai Medical Center
Original Assignee
Austin Research Institute
Mount Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Austin Research Institute, Mount Sinai Medical Center filed Critical Austin Research Institute
Publication of EP0877549A1 publication Critical patent/EP0877549A1/de
Publication of EP0877549A4 publication Critical patent/EP0877549A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96939544A 1995-11-03 1996-11-01 Verfahren und zusammenstellungen zur verminderung der xenotransplantation-abstossung Withdrawn EP0877549A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US620095P 1995-11-03 1995-11-03
US6200P 1995-11-03
PCT/US1996/017695 WO1997016064A1 (en) 1995-11-03 1996-11-01 Methods and compositions for the reduction of xenotransplantation rejection

Publications (2)

Publication Number Publication Date
EP0877549A1 EP0877549A1 (de) 1998-11-18
EP0877549A4 true EP0877549A4 (de) 2002-01-02

Family

ID=21719767

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96939544A Withdrawn EP0877549A4 (de) 1995-11-03 1996-11-01 Verfahren und zusammenstellungen zur verminderung der xenotransplantation-abstossung

Country Status (5)

Country Link
EP (1) EP0877549A4 (de)
JP (1) JP2000514641A (de)
AU (1) AU7668696A (de)
IL (1) IL124293A0 (de)
WO (1) WO1997016064A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021415A1 (en) * 1997-10-28 1999-05-06 Stem Cell Sciences Pty. Ltd. Nuclear transfer for production of transgenic animal embryo
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
CA2507486A1 (en) 2002-08-14 2004-02-26 Immerge Biotherapeutics, Inc. .alpha.(1,3)-galactosyltransferase null cells, methods of selecting and .alpha.(1,3)-galactosyltransferase null swine produced therefrom
WO2004028243A2 (en) 2002-08-21 2004-04-08 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
CA2548080A1 (en) 2003-11-05 2005-05-26 University Of Pittsburgh Porcine isogloboside 3 synthase protein, cdna, genomic organization, and regulatory region
JP2007529278A (ja) 2004-03-17 2007-10-25 レビビコア， インコーポレイテッド 機能的α１，３ガラクトシルトランスフェラーゼを欠く動物に由来する組織生成物
WO2011012297A1 (en) 2009-07-30 2011-02-03 F. Hoffmann-La Roche Ag Enzymatic antibody processing
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
CA2809632A1 (en) 2010-10-05 2012-04-12 Monika Baehner Antibodies against human tweak and uses thereof
SG2014012470A (en) 2011-10-05 2014-06-27 Hoffmann La Roche Process for antibody g1 glycoform production

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356804A (en) * 1990-10-24 1994-10-18 Mount Sinai School Of Medicine Of The City Of New York Cloning and expression of biologically active human α-galactosidase A
WO1995028412A1 (en) * 1994-04-13 1995-10-26 Biotransplant, Inc. α(1,3) GALACTOSYLTRANSFERASE NEGATIVE SWINE
WO1995034202A1 (en) * 1994-06-15 1995-12-21 Alexion Pharmaceuticals, Inc. Methods for reducing hyperacute rejection of xenografts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356804A (en) * 1990-10-24 1994-10-18 Mount Sinai School Of Medicine Of The City Of New York Cloning and expression of biologically active human α-galactosidase A
WO1995028412A1 (en) * 1994-04-13 1995-10-26 Biotransplant, Inc. α(1,3) GALACTOSYLTRANSFERASE NEGATIVE SWINE
WO1995034202A1 (en) * 1994-06-15 1995-12-21 Alexion Pharmaceuticals, Inc. Methods for reducing hyperacute rejection of xenografts

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
COHNEY N OSMAN ET AL: "Transgenic approaches for the reduction in expression of the xenoepitope Gal-alpha(1,3)Gal by expression of alpha-1,2fucosyltransferase and alpha-Galactosidase.", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 7, no. 9, September 1996 (1996-09-01), 29th Annual Meeting of the American Society of Nephrology;New Orleans, Louisiana, USA; November 3-6, 1996, pages 1884, XP001033732, ISSN: 1046-6673 *
GLINSKY G V: "THE BLOOD GROUP ANTIGENS (BGA)-RELATED GLYCOEPITOPES A KEY STRUCTURAL DETERMINANT IN IMMUNOGENESIS AND CANCER PATHOGENESIS", CRITICAL REVIEWS IN ONCOLOGY / HEMATOLOGY, ELSEVIER SCIENCE IRELAND LTD., LIMERICK, IE, vol. 12, no. 2, 1992, pages 151 - 166, XP001021262, ISSN: 1040-8428 *
LAVECCHIO J A ET AL: "ENZYMATIC REMOVAL OF ALPHA-GALACTOSYL EPITOPES FROM PORCINE ENDOTHELIAL CELLS DIMINISHES THE CYTOTOXIC EFFECT OF NATURAL ANTIBODIES", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 60, no. 8, 27 October 1995 (1995-10-27), pages 841 - 847, XP000579607, ISSN: 0041-1337 *
LOWE J B: "MOLECULAR CLONING, EXPRESSION, AND USES OF MAMMALIAN GLYCOSYLTRANSFERASES", SEMINARS IN CELL BIOLOGY, SAUNDERS SCIENTIFIC PUBLICATIONS, PHILADELPHIA,, US, vol. 2, 1991, pages 289 - 307, XP001018794, ISSN: 1043-4675 *
MCKENZIE I F C ET AL: "Strategies to overcome hyperacute rejection of pig-to-human xenografts.", TRANSPLANTATION PROCEEDINGS, vol. 29, no. 1-2, 1997, Sixteenth International Congress of the Transplantation Society;Barcelona, Spain; August 25-30, 1996, pages 973 - 974, XP000909735, ISSN: 0041-1345 *
ORIOL R ET AL: "CARBOHYDRATE ANTIGENS OF PIG TISSUES REACTING WITH HUMAN NATURAL ANTIBODIES AS POTENTIAL TARGETS FOR HYPERACUTE VASCULAR REJECTION IN PIG-TO-MAN ORGAN XENOTRANSPLANTATION", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 56, no. 6, 1 December 1993 (1993-12-01), pages 1433 - 1442, XP000575421, ISSN: 0041-1337 *
SANDRIN ET AL: "Identification of Gal(alpha1,3)Gal as the major epitope for pig-to-human vacularised xenografts", TRANSPLANTATION REVIEWS, - July 1994 (1994-07-01), pages 134 - 149, XP000999840 *
SANDRIN M S ET AL: "ENZYMATIC REMODELLING OF THE CARBOHYDRATE SURFACE OF A XENOGENIC CELL SUBSTANTIALLY REDUCES HUMAN ANTIBODY BINDING AND COMPLETEMENT-MEDIATED CYTOLYSIS", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 1, no. 12, December 1995 (1995-12-01), pages 1261 - 1267, XP000999070, ISSN: 1078-8956 *
See also references of WO9716064A1 *

Also Published As

Publication number Publication date
JP2000514641A (ja) 2000-11-07
EP0877549A1 (de) 1998-11-18
IL124293A0 (en) 1998-12-06
AU7668696A (en) 1997-05-22
WO1997016064A1 (en) 1997-05-09

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