EP0874754A1 - Vorrichtung zum abfüllen einer unter druck stehenden flüssigkeit - Google Patents
Vorrichtung zum abfüllen einer unter druck stehenden flüssigkeitInfo
- Publication number
- EP0874754A1 EP0874754A1 EP97938759A EP97938759A EP0874754A1 EP 0874754 A1 EP0874754 A1 EP 0874754A1 EP 97938759 A EP97938759 A EP 97938759A EP 97938759 A EP97938759 A EP 97938759A EP 0874754 A1 EP0874754 A1 EP 0874754A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- distributor
- liquid
- gas pressure
- filling
- pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 40
- 238000004806 packaging method and process Methods 0.000 claims description 10
- 239000000047 product Substances 0.000 description 6
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 239000003708 ampul Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
Definitions
- the invention relates to a device for filling a liquid under pressure into packaging containers, as has become known for example from EP 0 430 897 B1.
- This device has a storage container for a liquid under gas pressure, which is connected via a supply line to a distributor, to which, in turn, filling valves assigned to the packaging containers are connected.
- the sterile filter Pass liquid through a sterile filter before filling. So that no further germs can get into the liquid after passing through the sterile filter, the sterile filter is as close as possible to the filling elements or the Filling valves arranged. For reasons of space and handling, however, in most cases it is not possible to arrange the sterile filter in the flow path between the distributor and the filling valves, rather it is located directly in front of the distributor.
- the commonly used sterile filters containing ceramics have the disadvantage that as soon as they are only subjected to a gas pressure in the direction of flow, i.e. that there is no longer any liquid in the sterile filter, they have a blocking effect. Only when the gas pressure is much higher, for which the operation of the device is not otherwise designed, is the shut-off effect released again.
- the storage container can be completely emptied, but due to the above-mentioned blocking effect of the sterile filter, liquid remains in the distributor, which due to the there only low liquid pressure can no longer be filled. In the case of expensive pharmaceutical products in particular, this liquid remaining in the distributor represents a considerable cost factor which burdens the operation of the device and thus the price of the end product.
- claim 1 has the advantage that the amount of liquid remaining in the distributor when emptying the storage container can also be used for filling the packaging container. This makes the operation of the device less expensive.
- the distributor has a separate pressure connection, so that the liquid in the distributor is acted upon by a second gas pressure which is independent of the pressure of the storage container.
- FIG. 1 shows a first device for filling a pressurized liquid in a schematic representation
- Figure 2 shows a distributor of a second embodiment, also in a schematic representation.
- the device 10 shown in FIG. 1 for filling a liquid 1 has a product container 11 for the liquid 1.
- a first is on the product container 11
- Pressure line 12 connected, which is connected to a pressure source, not shown, and which acts on the liquid 1 in the product container 11 with a first gas pressure Pl.
- a supply line 14 extends from the bottom 13 of the product container 11 and opens into a distributor 15. When viewed in the direction of flow of the liquid 1, a shut-off valve 17 and a sterile filter 18 are interposed in the supply line 14, the sterile filter 18 being arranged in the immediate area in front of the distributor 15.
- a second pressure line 19 opens, via which the liquid 1 in the distributor 15 is acted upon by a second gas pressure P2.
- a first fill level sensor 22 for detecting an upper liquid level and a second fill level sensor 23 for detecting a lower liquid level are arranged in a side or jacket wall 21 of the distributor 15. The two level sensors 22, 23 are with the
- a pressure sensor 24 is also connected to the distributor 15 and detects the total pressure p in the liquid 1 prevailing in the distributor 15, consisting of the hydrostatic pressure component of the liquid 1 and the gas pressure component P2.
- Filling hoses 25 are connected to the distributor 15, each of which is connected to a filling valve 26 that can be moved up and down.
- Each filling valve 26 is assigned to a packaging container (not shown), for example a vial, an ampoule or the like.
- the packaging containers are cyclically fed to the filling valves 26 for filling with a certain amount of liquid in a manner known per se, and further conveyed after the filling.
- the metering of the amount of liquid is regulated by means of the control device of the device 10, taking into account the total pressure P of the liquid 1 detected by the pressure sensor 24.
- the control device of the device 10 opens the shut-off valve 17 so that liquid 1 can flow from the product container 11 into the distributor 15.
- the gas pressure P 1 together with the hydrostatic liquid pressure present up to the mouth at the distributor 15 is greater than the gas pressure P2 prevailing in the distributor 15. This condition must also be met to completely empty the product container 11. Despite the pressure loss through the sterile filter 18, these conditions can generally be achieved when the gas pressure Pl is greater than the gas pressure P2.
- the distributor 15a of a second embodiment of the invention shown in FIG. 2 differs from
- Distributor 15 of Figure 1 in that the distributor 15a is now tubular, the main direction of extension of the distributor 15a is horizontal. Furthermore, the distributor 15a has a vertically upwardly projecting one that starts from one end face
- the second pressure line 19a opens in the top of the pipe section 27, whereas the supply line 14a opens at the distributor 15a on the same side as the pipe section 27 in the distributor 15a.
- the filling hoses 25a can be made shorter than in the distributor 15, since the filling hoses 25a can be arranged directly above the packaging containers. It follows that the length of the distributor 15a is based on the space required for the packaging containers which are fed in at intervals. In contrast, in the case of the distributor 15 in the first exemplary embodiment according to FIG. 1, longer or curved filling hoses 25 are required as a result of the cylindrical (with a vertical main direction of extension) distributor 15.
- the distributor 15a enables advantages with regard to cleaning with CIP (Clean in place) or SIP (Sterile in place).
- CIP Cylean in place
- SIP Sterile in place
- Forming the distributor 15a is particularly useful in the case of small filling quantities in the packaging containers, in which only a small total volume of the distributor 15 is required.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Basic Packing Technique (AREA)
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19640664 | 1996-10-02 | ||
DE19640664A DE19640664C1 (de) | 1996-10-02 | 1996-10-02 | Vorrichtung zum Abfüllen einer unter Druck stehenden Flüssigkeit |
PCT/DE1997/001727 WO1998014372A1 (de) | 1996-10-02 | 1997-08-14 | Vorrichtung zum abfüllen einer unter druck stehenden flüssigkeit |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0874754A1 true EP0874754A1 (de) | 1998-11-04 |
Family
ID=7807687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97938759A Withdrawn EP0874754A1 (de) | 1996-10-02 | 1997-08-14 | Vorrichtung zum abfüllen einer unter druck stehenden flüssigkeit |
Country Status (7)
Country | Link |
---|---|
US (1) | US6024251A (zh) |
EP (1) | EP0874754A1 (zh) |
JP (1) | JP2000501363A (zh) |
KR (1) | KR19990064097A (zh) |
CN (1) | CN1106320C (zh) |
DE (1) | DE19640664C1 (zh) |
WO (1) | WO1998014372A1 (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6685823B2 (en) * | 2000-10-16 | 2004-02-03 | Uniroyal Chemical Company, Inc. | C-nitrosoaniline compounds and their blends as polymerization inhibitors |
US20020138216A1 (en) * | 2001-02-16 | 2002-09-26 | Merit Medical Systems, Inc., | Systems and methods for accurately measuring fluid |
DE60206215T2 (de) | 2001-06-27 | 2006-05-04 | Matsushita Electric Industrial Co., Ltd., Kadoma | Metall-Halogen-Lampe |
EP1620347A4 (en) * | 2003-02-24 | 2007-08-29 | Millipore Corp | FLUID DISPENSER WITH MEANS FOR CONTINUOUS MEASUREMENT OF FLUID VOLUMES |
US7118011B2 (en) * | 2003-06-17 | 2006-10-10 | Millipore Corporation | Fluid dispensing apparatus |
DE10335680B3 (de) * | 2003-08-03 | 2004-12-09 | Quiel, Joachim, Dipl.-Ing. | Portioniereinrichtung für faserige Güter |
JP4665136B2 (ja) * | 2003-09-22 | 2011-04-06 | バッテル メモリアル インスティテュート | コンテナ充填アッセンブリ |
JP4518918B2 (ja) * | 2003-11-20 | 2010-08-04 | ミリポア・コーポレイション | 流体分注デバイス |
US7757891B2 (en) * | 2007-03-14 | 2010-07-20 | Chemflow Systems, Inc. | Method and apparatus for providing constant liquid rates and dispensing precisely repeatable liquid volumes |
GB0802216D0 (en) * | 2008-02-07 | 2008-03-12 | Hammersmith Imanet Ltd | GMP dispenser for non-controlled environments |
DE102010060469B3 (de) * | 2010-11-10 | 2011-11-10 | Sartorius Ag | Behälteranordnung und Verfahren zum Füllen von flexiblen Einwegbeuteln |
US8863986B2 (en) | 2011-03-09 | 2014-10-21 | Acertacorp LLC | Time volumetric fluid dispensing apparatus |
DE102011001584B4 (de) | 2011-03-28 | 2018-11-08 | Sartorius Lab Instruments Gmbh & Co. Kg | Abfüllsystem und Abfüllverfahren |
CN103288028A (zh) * | 2013-05-08 | 2013-09-11 | 深圳市华星光电技术有限公司 | 一种供液系统及其供液方法 |
CN103318436A (zh) * | 2013-05-30 | 2013-09-25 | 常熟市喆宏机械科技有限公司 | 外桶填充式灌装装置 |
US9051066B1 (en) | 2014-02-07 | 2015-06-09 | Tinnus Enterprises, Llc | System and method for filling containers with fluids |
PL3340846T3 (pl) | 2015-08-27 | 2020-01-31 | Deb Ip Limited | Wąż napełniający |
US10493370B2 (en) | 2016-06-21 | 2019-12-03 | Tinnus Enterprises, Llc | System and method for filling containers with fluids and sealing the filled containers |
CN106115005B (zh) * | 2016-08-18 | 2018-05-04 | 无锡市稼宝药业有限公司 | 一种便于拆卸的农药生产用液体分装机 |
TW202144236A (zh) * | 2020-02-14 | 2021-12-01 | 瑞士商赫孚孟拉羅股份公司 | 用於液體藥物產物之時間-壓力-充填系統 |
CN112678225A (zh) * | 2020-12-15 | 2021-04-20 | 长沙君成包装机械有限公司 | 一种恒压灌装系统及灌装方法 |
CN114259917A (zh) * | 2021-12-21 | 2022-04-01 | 开封市儿童医院 | 一种临床营养科用营养液调配装置 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE414385B (sv) * | 1977-03-09 | 1980-07-28 | Ake Andersson | Fyllningsmaskin for flytande produkter |
WO1980001797A1 (en) * | 1979-02-22 | 1980-09-04 | D Haig | Precision material filling systems |
IT1236158B (it) * | 1989-11-23 | 1993-01-11 | Farmomac Srl | Metodo per il riempimento di contenitori con prodotti liquidi e/o gelatinosi,e/o corrosivi,o collanti,o sospensioni abrasive e macchina che attua tale metodo. |
US5148945B1 (en) * | 1990-09-17 | 1996-07-02 | Applied Chemical Solutions | Apparatus and method for the transfer and delivery of high purity chemicals |
US5680960A (en) * | 1993-03-05 | 1997-10-28 | Keyes; Denis E. | Volumetric fluid dispensing apparatus |
DE4341934A1 (de) * | 1993-12-09 | 1995-06-14 | Bosch Gmbh Robert | Verfahren und Vorrichtung zum Dosieren und Abfüllen einer Flüssigkeit in Verpackungsbehälter |
-
1996
- 1996-10-02 DE DE19640664A patent/DE19640664C1/de not_active Revoked
-
1997
- 1997-08-14 KR KR1019980702577A patent/KR19990064097A/ko not_active Application Discontinuation
- 1997-08-14 WO PCT/DE1997/001727 patent/WO1998014372A1/de not_active Application Discontinuation
- 1997-08-14 EP EP97938759A patent/EP0874754A1/de not_active Withdrawn
- 1997-08-14 JP JP10516093A patent/JP2000501363A/ja not_active Ceased
- 1997-08-14 CN CN97191325A patent/CN1106320C/zh not_active Expired - Fee Related
- 1997-08-14 US US09/068,792 patent/US6024251A/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO9814372A1 * |
Also Published As
Publication number | Publication date |
---|---|
CN1204992A (zh) | 1999-01-13 |
KR19990064097A (ko) | 1999-07-26 |
JP2000501363A (ja) | 2000-02-08 |
US6024251A (en) | 2000-02-15 |
DE19640664C1 (de) | 1998-02-05 |
CN1106320C (zh) | 2003-04-23 |
WO1998014372A1 (de) | 1998-04-09 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): CH DE ES FR GB IT LI SE |
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17P | Request for examination filed |
Effective date: 19981009 |
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GRAG | Despatch of communication of intention to grant |
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|
17Q | First examination report despatched |
Effective date: 19990916 |
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GRAG | Despatch of communication of intention to grant |
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GRAH | Despatch of communication of intention to grant a patent |
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GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20000522 |