EP0835106A4 - Verfahren zur behandlung von nierenkrankheiten unter verwendung eines ace inhibitors und eines aii antagonisten - Google Patents

Verfahren zur behandlung von nierenkrankheiten unter verwendung eines ace inhibitors und eines aii antagonisten

Info

Publication number
EP0835106A4
EP0835106A4 EP96921794A EP96921794A EP0835106A4 EP 0835106 A4 EP0835106 A4 EP 0835106A4 EP 96921794 A EP96921794 A EP 96921794A EP 96921794 A EP96921794 A EP 96921794A EP 0835106 A4 EP0835106 A4 EP 0835106A4
Authority
EP
European Patent Office
Prior art keywords
renal disease
ace inhibitor
treating renal
aii antagonist
aii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96921794A
Other languages
English (en)
French (fr)
Other versions
EP0835106A1 (de
Inventor
Giuseppe Remuzzi
Ronald S Eydelloth
Roger A Owen
Shahnaz Shahinfar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratories Merck Sharp and Dohme Chibret SAS
Merck and Co Inc
Original Assignee
Laboratories Merck Sharp and Dohme Chibret SAS
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602854.3A external-priority patent/GB9602854D0/en
Application filed by Laboratories Merck Sharp and Dohme Chibret SAS, Merck and Co Inc filed Critical Laboratories Merck Sharp and Dohme Chibret SAS
Publication of EP0835106A1 publication Critical patent/EP0835106A1/de
Publication of EP0835106A4 publication Critical patent/EP0835106A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP96921794A 1995-06-30 1996-06-26 Verfahren zur behandlung von nierenkrankheiten unter verwendung eines ace inhibitors und eines aii antagonisten Withdrawn EP0835106A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77095P 1995-06-30 1995-06-30
US770P 1995-06-30
GBGB9602854.3A GB9602854D0 (en) 1996-02-13 1996-02-13 Method of treating renal disease using an ace inhibitor and an II antagonist
GB9602854 1996-02-13
PCT/US1996/010942 WO1997002032A1 (en) 1995-06-30 1996-06-26 Method of treating renal disease using an ace inhibitor and an aii antagonist

Publications (2)

Publication Number Publication Date
EP0835106A1 EP0835106A1 (de) 1998-04-15
EP0835106A4 true EP0835106A4 (de) 1998-09-30

Family

ID=26308665

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96921794A Withdrawn EP0835106A4 (de) 1995-06-30 1996-06-26 Verfahren zur behandlung von nierenkrankheiten unter verwendung eines ace inhibitors und eines aii antagonisten

Country Status (5)

Country Link
EP (1) EP0835106A4 (de)
JP (1) JPH11508894A (de)
AU (1) AU716519B2 (de)
CA (1) CA2224451A1 (de)
WO (1) WO1997002032A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2577233C (en) * 1996-04-05 2009-08-18 Takeda Pharmaceutical Company Limited Pharmaceutical composition containing angiotensin ii antagonist
US6833381B2 (en) * 2000-02-18 2004-12-21 Takeda Chemical Industries, Ltd. TNF-α inhibitors
RU2298418C2 (ru) * 2000-04-12 2007-05-10 Новартис Аг Комбинация по меньшей мере двух соединений, выбранных из групп антагонистов at1-рецептора или ингибиторов асе (ангиотензинпревращающий фермент), или ингибиторов hmg-coa-редуктазы (бета-гидрокси-бета-метилглутарил-кофермент-а-редуктаза)
GB0020691D0 (en) * 2000-08-22 2000-10-11 Boehringer Ingelheim Pharma Pharmaceutical combination
PL366419A1 (en) * 2000-08-22 2005-01-24 Boehringer Ingelheim Pharma Bmbh & Co.Kg Pharmaceutical combination of angiotensin ii antagonists and angiotensin i converting enzyme inhibitors
EP1420774B1 (de) 2001-08-31 2008-07-23 Australian Biomedical Company Pty Ltd Herstellung und verwendung von gibberellinen bei diabetes
EP1438027A1 (de) * 2001-10-25 2004-07-21 DepoMed, Inc. Behandlungsmethode unter verwendung einer losartan enthaltenden darreichungsform mit verlängerter magenverweilzeit
AU2002349673A1 (en) * 2001-12-03 2003-06-17 Takeda Chemical Industries, Ltd. Insulin resistance improving agents
JP4484427B2 (ja) * 2001-12-03 2010-06-16 武田薬品工業株式会社 インスリン抵抗性改善剤
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
EP1627638B1 (de) * 2003-05-09 2017-07-12 Toray Industries, Inc. Beraprost und ein inhibitor des renin-angiotensin-systems zur verwendung bei der behandlung von nierenerkrankungen
TR201004754A1 (tr) * 2010-06-11 2012-01-23 Sanovel �La� San. Ve T�C. A.�. Yeni Farmasötik Kombinasyonlar
EP2800738B1 (de) 2012-01-06 2020-04-08 Novartis AG Heterocyclische verbindungen und verfahren zu ihrer verwendung

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017771A1 (en) * 1990-05-11 1991-11-28 Pfizer Inc. Synergistic therapeutic compositions and methods
WO1992010097A1 (en) * 1990-12-14 1992-06-25 Smithkline Beecham Corporation Angiotensin ii receptor blocking compositions
EP0527534A1 (de) * 1991-08-13 1993-02-17 Merck & Co. Inc. Chinolin- und Azachinolin-Derivate als Angiotensin-II-Antagonisten
EP0537937A2 (de) * 1991-10-07 1993-04-21 Merck & Co. Inc. Substituierte Pyrazino (2,3-D)Pyrimidinone als Angiotensin-II Antagoniste
EP0629408A1 (de) * 1993-06-16 1994-12-21 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Kombination von Angiotensin-Converting-Enzyme Hemmern mit A-II-Antagonisten
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
WO1996031234A1 (en) * 1995-04-07 1996-10-10 Novartis Ag Combination compositions containing benazepril or benazeprilat and valsartan
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238924A (en) * 1984-05-03 1993-08-24 Merck & Co., Inc. Treatment of renal diseases with ace inhibitors
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017771A1 (en) * 1990-05-11 1991-11-28 Pfizer Inc. Synergistic therapeutic compositions and methods
WO1992010097A1 (en) * 1990-12-14 1992-06-25 Smithkline Beecham Corporation Angiotensin ii receptor blocking compositions
EP0527534A1 (de) * 1991-08-13 1993-02-17 Merck & Co. Inc. Chinolin- und Azachinolin-Derivate als Angiotensin-II-Antagonisten
EP0537937A2 (de) * 1991-10-07 1993-04-21 Merck & Co. Inc. Substituierte Pyrazino (2,3-D)Pyrimidinone als Angiotensin-II Antagoniste
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
EP0629408A1 (de) * 1993-06-16 1994-12-21 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Kombination von Angiotensin-Converting-Enzyme Hemmern mit A-II-Antagonisten
WO1996031234A1 (en) * 1995-04-07 1996-10-10 Novartis Ag Combination compositions containing benazepril or benazeprilat and valsartan
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURDMANN ET AL: "Prevention of Experimental Cyclosporin-Induced Interstitial Fibrosis by Losartan and Enalapril", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 269, no. 4, October 1995 (1995-10-01), pages f491 - f499, XP002072709 *
POLLOCK ET AL: "Angiotensin II Receptor Blockade Improves Renal Function in Rats with Reduced Renal Mass", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 367, no. 2, 1993, pages 657 - 663, XP002072710 *
See also references of WO9702032A1 *

Also Published As

Publication number Publication date
WO1997002032A1 (en) 1997-01-23
CA2224451A1 (en) 1997-01-23
JPH11508894A (ja) 1999-08-03
AU6291696A (en) 1997-02-05
AU716519B2 (en) 2000-02-24
EP0835106A1 (de) 1998-04-15

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Inventor name: SHAHINFAR, SHAHNAZ

Inventor name: OWEN, ROGER, A.

Inventor name: EYDELLOTH, RONALD, S.

Inventor name: REMUZZI, GIUSEPPE

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Effective date: 19980814

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