EP0835106A4 - Method of treating renal disease using an ace inhibitor and an aii antagonist - Google Patents

Method of treating renal disease using an ace inhibitor and an aii antagonist

Info

Publication number
EP0835106A4
EP0835106A4 EP96921794A EP96921794A EP0835106A4 EP 0835106 A4 EP0835106 A4 EP 0835106A4 EP 96921794 A EP96921794 A EP 96921794A EP 96921794 A EP96921794 A EP 96921794A EP 0835106 A4 EP0835106 A4 EP 0835106A4
Authority
EP
European Patent Office
Prior art keywords
renal disease
ace inhibitor
treating renal
aii antagonist
aii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96921794A
Other languages
German (de)
French (fr)
Other versions
EP0835106A1 (en
Inventor
Giuseppe Remuzzi
Ronald S Eydelloth
Roger A Owen
Shahnaz Shahinfar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratories Merck Sharp and Dohme Chibret SAS
Merck and Co Inc
Original Assignee
Laboratories Merck Sharp and Dohme Chibret SAS
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602854.3A external-priority patent/GB9602854D0/en
Application filed by Laboratories Merck Sharp and Dohme Chibret SAS, Merck and Co Inc filed Critical Laboratories Merck Sharp and Dohme Chibret SAS
Publication of EP0835106A1 publication Critical patent/EP0835106A1/en
Publication of EP0835106A4 publication Critical patent/EP0835106A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP96921794A 1995-06-30 1996-06-26 Method of treating renal disease using an ace inhibitor and an aii antagonist Withdrawn EP0835106A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77095P 1995-06-30 1995-06-30
US770P 1995-06-30
GBGB9602854.3A GB9602854D0 (en) 1996-02-13 1996-02-13 Method of treating renal disease using an ace inhibitor and an II antagonist
GB9602854 1996-02-13
PCT/US1996/010942 WO1997002032A1 (en) 1995-06-30 1996-06-26 Method of treating renal disease using an ace inhibitor and an aii antagonist

Publications (2)

Publication Number Publication Date
EP0835106A1 EP0835106A1 (en) 1998-04-15
EP0835106A4 true EP0835106A4 (en) 1998-09-30

Family

ID=26308665

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96921794A Withdrawn EP0835106A4 (en) 1995-06-30 1996-06-26 Method of treating renal disease using an ace inhibitor and an aii antagonist

Country Status (5)

Country Link
EP (1) EP0835106A4 (en)
JP (1) JPH11508894A (en)
AU (1) AU716519B2 (en)
CA (1) CA2224451A1 (en)
WO (1) WO1997002032A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT914158E (en) * 1996-04-05 2002-11-29 Takeda Chemical Industries Ltd A PHARMACEUTICAL COMBINATION THAT INCORPORATES A COMPOUND THAT HAS AN ANTGONIST ACTIVITY OF ANGIOTENSIN II AND A COMPOUND THAT INCREASES INSULIN SENSITIVITY
KR20030016229A (en) * 2000-02-18 2003-02-26 다케다 야쿠힌 고교 가부시키가이샤 TNF-αINHIBITORS
PL365696A1 (en) * 2000-04-12 2005-01-10 Novartis Ag Combination of organic compounds
EP1671632A1 (en) * 2000-08-22 2006-06-21 Boehringer Ingelheim Pharma GmbH & Co. KG Pharmaceutical combination of angiotensin II antagonists and ACE inhibitors
GB0020691D0 (en) * 2000-08-22 2000-10-11 Boehringer Ingelheim Pharma Pharmaceutical combination
DK1420774T3 (en) 2001-08-31 2008-11-24 Australian Biomedical Company Preparation and Diabetic Use of Gibberellins
CA2464561A1 (en) 2001-10-25 2003-05-01 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
JP4484427B2 (en) * 2001-12-03 2010-06-16 武田薬品工業株式会社 Insulin resistance improving agent
EP1452176A4 (en) * 2001-12-03 2009-01-21 Takeda Pharmaceutical Insulin resistance improving agents
DE10229180A1 (en) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Use of vasopeptidase inhibitors in the treatment of metabolic disorders, nephropathy and AGE-associated disorders
KR101187693B1 (en) * 2003-05-09 2012-10-05 도레이 카부시키가이샤 Agent for treating or preventing renal disease
TR201004754A1 (en) * 2010-06-11 2012-01-23 Sanovel �La� San. Ve T�C. A.�. New Pharmaceutical Combinations
NZ626973A (en) 2012-01-06 2016-09-30 Novartis Ag Heterocyclic compounds and methods for their use

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017771A1 (en) * 1990-05-11 1991-11-28 Pfizer Inc. Synergistic therapeutic compositions and methods
WO1992010097A1 (en) * 1990-12-14 1992-06-25 Smithkline Beecham Corporation Angiotensin ii receptor blocking compositions
EP0527534A1 (en) * 1991-08-13 1993-02-17 Merck & Co. Inc. Quinoline and azaquinoline angiotensin II antagonists
EP0537937A2 (en) * 1991-10-07 1993-04-21 Merck & Co. Inc. Substituted pyrazino 2,3-D pyrimidinones as angiotensin II antagonists
EP0629408A1 (en) * 1993-06-16 1994-12-21 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Combination of angiotensin converting enzyme inhibitors and AII antagonists
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
WO1996031234A1 (en) * 1995-04-07 1996-10-10 Novartis Ag Combination compositions containing benazepril or benazeprilat and valsartan
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238924A (en) * 1984-05-03 1993-08-24 Merck & Co., Inc. Treatment of renal diseases with ace inhibitors
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017771A1 (en) * 1990-05-11 1991-11-28 Pfizer Inc. Synergistic therapeutic compositions and methods
WO1992010097A1 (en) * 1990-12-14 1992-06-25 Smithkline Beecham Corporation Angiotensin ii receptor blocking compositions
EP0527534A1 (en) * 1991-08-13 1993-02-17 Merck & Co. Inc. Quinoline and azaquinoline angiotensin II antagonists
EP0537937A2 (en) * 1991-10-07 1993-04-21 Merck & Co. Inc. Substituted pyrazino 2,3-D pyrimidinones as angiotensin II antagonists
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
EP0629408A1 (en) * 1993-06-16 1994-12-21 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Combination of angiotensin converting enzyme inhibitors and AII antagonists
WO1996031234A1 (en) * 1995-04-07 1996-10-10 Novartis Ag Combination compositions containing benazepril or benazeprilat and valsartan
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURDMANN ET AL: "Prevention of Experimental Cyclosporin-Induced Interstitial Fibrosis by Losartan and Enalapril", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 269, no. 4, October 1995 (1995-10-01), pages f491 - f499, XP002072709 *
POLLOCK ET AL: "Angiotensin II Receptor Blockade Improves Renal Function in Rats with Reduced Renal Mass", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 367, no. 2, 1993, pages 657 - 663, XP002072710 *
See also references of WO9702032A1 *

Also Published As

Publication number Publication date
WO1997002032A1 (en) 1997-01-23
AU716519B2 (en) 2000-02-24
AU6291696A (en) 1997-02-05
EP0835106A1 (en) 1998-04-15
JPH11508894A (en) 1999-08-03
CA2224451A1 (en) 1997-01-23

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19980130

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SHAHINFAR, SHAHNAZ

Inventor name: OWEN, ROGER, A.

Inventor name: EYDELLOTH, RONALD, S.

Inventor name: REMUZZI, GIUSEPPE

A4 Supplementary search report drawn up and despatched

Effective date: 19980814

AK Designated contracting states

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STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20010103