EP0807116A4 - Amphiphiles cationiques - Google Patents

Amphiphiles cationiques

Info

Publication number
EP0807116A4
EP0807116A4 EP94924449A EP94924449A EP0807116A4 EP 0807116 A4 EP0807116 A4 EP 0807116A4 EP 94924449 A EP94924449 A EP 94924449A EP 94924449 A EP94924449 A EP 94924449A EP 0807116 A4 EP0807116 A4 EP 0807116A4
Authority
EP
European Patent Office
Prior art keywords
cationic amphiphiles
amphiphiles
cationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94924449A
Other languages
German (de)
English (en)
Other versions
EP0807116A1 (fr
Inventor
Timothy D Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Megabios Corp
Original Assignee
Megabios Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megabios Corp filed Critical Megabios Corp
Publication of EP0807116A1 publication Critical patent/EP0807116A1/fr
Publication of EP0807116A4 publication Critical patent/EP0807116A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94924449A 1994-06-22 1994-06-22 Amphiphiles cationiques Withdrawn EP0807116A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007071 WO1995035301A1 (fr) 1994-06-22 1994-06-22 Amphiphiles cationiques

Publications (2)

Publication Number Publication Date
EP0807116A1 EP0807116A1 (fr) 1997-11-19
EP0807116A4 true EP0807116A4 (fr) 1998-01-07

Family

ID=22242692

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94924449A Withdrawn EP0807116A4 (fr) 1994-06-22 1994-06-22 Amphiphiles cationiques

Country Status (6)

Country Link
EP (1) EP0807116A4 (fr)
JP (1) JPH10506093A (fr)
AU (1) AU696881B2 (fr)
CA (1) CA2194221C (fr)
NO (1) NO970172D0 (fr)
WO (1) WO1995035301A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
ES2231819T3 (es) * 1995-06-07 2005-05-16 Inex Pharmaceuticals Corp Particulas de lipido-acido nucleico preparadas a traves de un intermedio complejo de lipido-acido nucleico hidrofobo y uso para transferir genes.
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
ATE350012T1 (de) 1999-02-22 2007-01-15 Univ Georgetown Immunoliposome mit einem targeting- antikörperfragment zur systemischen genverabreichung
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
DE60228842D1 (de) * 2001-04-02 2008-10-23 Univ Georgetown Vereinfachtes und verbessertes verfahren zur herstellung eines antikörper- oder antikörperfragment-targeted immunoliposoms oder polyplex für die systemische verabreichung eines therapeutischen oder diagnostischen mittels
DE10207178A1 (de) * 2002-02-19 2003-09-04 Novosom Ag Komponenten für die Herstellung amphoterer Liposomen
DK1519714T3 (da) 2002-06-28 2011-01-31 Protiva Biotherapeutics Inc Fremgangsmåde og apparat til fremstilling af liposomer
NZ544637A (en) 2003-07-16 2010-04-30 Protiva Biotherapeutics Inc Lipid encapsulated interfering RNA
EP1664316B1 (fr) 2003-09-15 2012-08-29 Protiva Biotherapeutics Inc. Composes lipidiques modifies avec du polyethyleneglycol et utilisations de ces composes
ATE536418T1 (de) 2004-06-07 2011-12-15 Protiva Biotherapeutics Inc Lipidverkapselte interferenz-rna
EP1781593B1 (fr) 2004-06-07 2011-12-14 Protiva Biotherapeutics Inc. Lipides cationiques et leurs procédés d'utilisation
CA2572439A1 (fr) 2004-07-02 2006-01-12 Protiva Biotherapeutics, Inc. Molecules sirna immunostimulatrices et utilisations de celles-ci
CA2628300C (fr) 2005-11-02 2018-04-17 Protiva Biotherapeutics, Inc. Molecules d'arnsi modifiees et utilisations de celles-ci
WO2007142781A1 (fr) 2006-05-15 2007-12-13 Georgetown University Préparation d'immunoliposomes ciblés sur un anticorps ou sur des fragments d'anticorps, destinée à une administration systémique d'agents thérapeutiques ou diagnostiques et utilisations
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
EP2350043B9 (fr) 2008-10-09 2014-08-20 TEKMIRA Pharmaceuticals Corporation Lipides aminés améliorés et procédés d'administration d'acides nucléiques
JP5766188B2 (ja) 2009-07-01 2015-08-19 プロチバ バイオセラピューティクス インコーポレイティッド 固形腫瘍に治療剤を送達するための脂質製剤
WO2011000106A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Lipides cationiques et procédés améliorés pour l'administration d'agents thérapeutiques
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
JP6557659B2 (ja) 2013-07-16 2019-08-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 骨移植片の骨形成潜在能の増強
KR20230124927A (ko) 2020-11-25 2023-08-28 아카제라 메디신즈, 인크. 핵산 전달을 위한 지질 나노입자, 및 관련 사용 방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (fr) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Dérivés de glycérine pour la synthèse des phospholipides
WO1991016024A1 (fr) * 1990-04-19 1991-10-31 Vical, Inc. Lipides cationiques servant a l'apport intracellulaire de molecules biologiquement actives
WO1994005624A1 (fr) * 1992-08-28 1994-03-17 Life Technologies, Inc. Lipides cationiques
WO1995026356A1 (fr) * 1994-03-29 1995-10-05 Northwestern University Nouveaux phospholipides cationiques destines a la transfection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (fr) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Dérivés de glycérine pour la synthèse des phospholipides
WO1991016024A1 (fr) * 1990-04-19 1991-10-31 Vical, Inc. Lipides cationiques servant a l'apport intracellulaire de molecules biologiquement actives
WO1994005624A1 (fr) * 1992-08-28 1994-03-17 Life Technologies, Inc. Lipides cationiques
WO1995026356A1 (fr) * 1994-03-29 1995-10-05 Northwestern University Nouveaux phospholipides cationiques destines a la transfection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARRIS D J ET AL: "THE DEVELOPMENT OF IMPROVED CATIONIC LIPIDS FOR GENE TRANSFER INTO CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS", PHOSPHORUS, SULPHUR AND SILICON AND THE RELATED ELEMENTS, vol. 109/110, no. 1/04, 1996, pages 289 - 292, XP000676977 *
See also references of WO9535301A1 *
SOLODIN I ET AL: "SYNTHESIS OF PHOSPHOTRIESTER CATIONIC PHOSPHOLIPIDS, CATIONIC LIPIDS 2", SYNLETT, no. 5, May 1996 (1996-05-01), pages 457/458, XP000645321 *

Also Published As

Publication number Publication date
WO1995035301A1 (fr) 1995-12-28
AU696881B2 (en) 1998-09-24
EP0807116A1 (fr) 1997-11-19
JPH10506093A (ja) 1998-06-16
NO970172L (no) 1997-01-15
CA2194221C (fr) 2001-01-02
AU7471194A (en) 1996-01-15
CA2194221A1 (fr) 1995-12-28
NO970172D0 (no) 1997-01-15

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