EP0807116A4 - Kationische amphiphile - Google Patents

Kationische amphiphile

Info

Publication number
EP0807116A4
EP0807116A4 EP94924449A EP94924449A EP0807116A4 EP 0807116 A4 EP0807116 A4 EP 0807116A4 EP 94924449 A EP94924449 A EP 94924449A EP 94924449 A EP94924449 A EP 94924449A EP 0807116 A4 EP0807116 A4 EP 0807116A4
Authority
EP
European Patent Office
Prior art keywords
cationic amphiphiles
amphiphiles
cationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94924449A
Other languages
English (en)
French (fr)
Other versions
EP0807116A1 (de
Inventor
Timothy D Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Megabios Corp
Original Assignee
Megabios Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megabios Corp filed Critical Megabios Corp
Publication of EP0807116A1 publication Critical patent/EP0807116A1/de
Publication of EP0807116A4 publication Critical patent/EP0807116A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94924449A 1994-06-22 1994-06-22 Kationische amphiphile Withdrawn EP0807116A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007071 WO1995035301A1 (en) 1994-06-22 1994-06-22 Cationic amphiphiles

Publications (2)

Publication Number Publication Date
EP0807116A1 EP0807116A1 (de) 1997-11-19
EP0807116A4 true EP0807116A4 (de) 1998-01-07

Family

ID=22242692

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94924449A Withdrawn EP0807116A4 (de) 1994-06-22 1994-06-22 Kationische amphiphile

Country Status (6)

Country Link
EP (1) EP0807116A4 (de)
JP (1) JPH10506093A (de)
AU (1) AU696881B2 (de)
CA (1) CA2194221C (de)
NO (1) NO970172L (de)
WO (1) WO1995035301A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69634084T2 (de) * 1995-06-07 2005-12-08 Inex Pharmaceuticals Corp. Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
ES2366100T3 (es) 1999-02-22 2011-10-17 Georgetown University Inmunoliposomas dirigidos mediante un fragmento de anticuerpo para la administración sistémica de genes.
DE60228842D1 (de) * 2001-04-02 2008-10-23 Univ Georgetown Vereinfachtes und verbessertes verfahren zur herstellung eines antikörper- oder antikörperfragment-targeted immunoliposoms oder polyplex für die systemische verabreichung eines therapeutischen oder diagnostischen mittels
DE10207178A1 (de) * 2002-02-19 2003-09-04 Novosom Ag Komponenten für die Herstellung amphoterer Liposomen
DE60334618D1 (de) 2002-06-28 2010-12-02 Protiva Biotherapeutics Inc Verfahren und vorrichtung zur herstellung von liposomen
SG190613A1 (en) 2003-07-16 2013-06-28 Protiva Biotherapeutics Inc Lipid encapsulated interfering rna
JP4842821B2 (ja) 2003-09-15 2011-12-21 プロチバ バイオセラピューティクス インコーポレイティッド ポリエチレングリコール修飾脂質化合物およびその使用
EP1766035B1 (de) 2004-06-07 2011-12-07 Protiva Biotherapeutics Inc. Lipidverkapselte interferenz-rna
JP4764426B2 (ja) 2004-06-07 2011-09-07 プロチバ バイオセラピューティクス インコーポレイティッド カチオン性脂質および使用方法
EP1773857A4 (de) 2004-07-02 2009-05-13 Protiva Biotherapeutics Inc Das immunsystem stimulierende sirna-moleküle und anwendungen davon
AU2006308765B2 (en) 2005-11-02 2013-09-05 Arbutus Biopharma Corporation Modified siRNA molecules and uses thereof
CA2652222A1 (en) 2006-05-15 2007-12-13 Georgetown University Preparation of antibody- or antibody-fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
AU2009303345B2 (en) 2008-10-09 2015-08-20 Arbutus Biopharma Corporation Improved amino lipids and methods for the delivery of nucleic acids
JP5766188B2 (ja) 2009-07-01 2015-08-19 プロチバ バイオセラピューティクス インコーポレイティッド 固形腫瘍に治療剤を送達するための脂質製剤
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
KR102307174B1 (ko) 2013-07-16 2021-10-01 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 골 이식편의 골형성 잠재력 강화
US11591544B2 (en) 2020-11-25 2023-02-28 Akagera Medicines, Inc. Ionizable cationic lipids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (de) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Neue Glycerinderivate zur Synthese von Phospholipiden
WO1991016024A1 (en) * 1990-04-19 1991-10-31 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1994005624A1 (en) * 1992-08-28 1994-03-17 Life Technologies, Inc. Cationic lipids
WO1995026356A1 (en) * 1994-03-29 1995-10-05 Northwestern University Novel cationic phospholipids for transfection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (de) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Neue Glycerinderivate zur Synthese von Phospholipiden
WO1991016024A1 (en) * 1990-04-19 1991-10-31 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1994005624A1 (en) * 1992-08-28 1994-03-17 Life Technologies, Inc. Cationic lipids
WO1995026356A1 (en) * 1994-03-29 1995-10-05 Northwestern University Novel cationic phospholipids for transfection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARRIS D J ET AL: "THE DEVELOPMENT OF IMPROVED CATIONIC LIPIDS FOR GENE TRANSFER INTO CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS", PHOSPHORUS, SULPHUR AND SILICON AND THE RELATED ELEMENTS, vol. 109/110, no. 1/04, 1996, pages 289 - 292, XP000676977 *
See also references of WO9535301A1 *
SOLODIN I ET AL: "SYNTHESIS OF PHOSPHOTRIESTER CATIONIC PHOSPHOLIPIDS, CATIONIC LIPIDS 2", SYNLETT, no. 5, May 1996 (1996-05-01), pages 457/458, XP000645321 *

Also Published As

Publication number Publication date
NO970172D0 (no) 1997-01-15
EP0807116A1 (de) 1997-11-19
CA2194221A1 (en) 1995-12-28
JPH10506093A (ja) 1998-06-16
WO1995035301A1 (en) 1995-12-28
AU7471194A (en) 1996-01-15
NO970172L (no) 1997-01-15
CA2194221C (en) 2001-01-02
AU696881B2 (en) 1998-09-24

Similar Documents

Publication Publication Date Title
EP0714954A3 (de) Kationische Imidazolazofarbstoffe
EP0807116A4 (de) Kationische amphiphile
DE69530493D1 (en) Ablationsgerät
DE69531947D1 (en) Ausbreitbare ringprothese
DE69512030D1 (en) Cerebral-dilator
EP0696731A3 (de) Zytoanalysator
DE59503739D1 (en) Polymer-sensor
DE69529159D1 (en) Hüftgelenkprothese
DE69502271D1 (en) Afterabtrennung
DE69511086D1 (en) Pyrimidinderivate
DE69429543D1 (en) Koagulationszange
DE69504528D1 (en) Quenchkühler
HU9503015D0 (en) Ketoprofene liposomes
DE59503634D1 (en) Friercontainer
EP0701109A3 (de) Wasserzähler
DE69512382D1 (en) Deodorierte thermoplaste
DE59509661D1 (en) Heterocyclylbenzonitrile
EP0801076A4 (de) Thrombozytotischer faktor
EP0711710A3 (de) Palettenbehälter
DE69517588D1 (en) Gekühlter transportcontainer
DE69517886D1 (en) Spiropyranverbindung
AU122938S (en) Breadbox
DE69508761D1 (en) Haloalkylierungsverfahren
GB2289889B (en) Spiles
DE59508136D1 (en) Phenylthio-oxazolin-derivate

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19970121

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19971121

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

RHK1 Main classification (correction)

Ipc: C07F 9/10

17Q First examination report despatched

Effective date: 20010220

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20031223