EP0804235A4 - Antikörper gegen p-selectin und ihre verwendungen - Google Patents

Antikörper gegen p-selectin und ihre verwendungen

Info

Publication number
EP0804235A4
EP0804235A4 EP94917301A EP94917301A EP0804235A4 EP 0804235 A4 EP0804235 A4 EP 0804235A4 EP 94917301 A EP94917301 A EP 94917301A EP 94917301 A EP94917301 A EP 94917301A EP 0804235 A4 EP0804235 A4 EP 0804235A4
Authority
EP
European Patent Office
Prior art keywords
selectin
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94917301A
Other languages
English (en)
French (fr)
Other versions
EP0804235A1 (de
Inventor
Robert W Chesnut
Margaret J Polley
James C Paulson
S Tarran Jones
Jose W Saldanha
Mary M Bendig
Michael Kriegler
Carl Perez
Robert Bayer
Michael Nunn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeres Biomedical Ltd
Original Assignee
Aeres Biomedical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1993/004274 external-priority patent/WO1993021956A1/en
Priority claimed from US08/202,047 external-priority patent/US5800815A/en
Application filed by Aeres Biomedical Ltd filed Critical Aeres Biomedical Ltd
Publication of EP0804235A1 publication Critical patent/EP0804235A1/de
Publication of EP0804235A4 publication Critical patent/EP0804235A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP94917301A 1993-05-04 1994-05-04 Antikörper gegen p-selectin und ihre verwendungen Withdrawn EP0804235A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US57292 1987-06-02
PCT/US1993/004274 WO1993021956A1 (en) 1992-05-05 1993-05-04 Antibodies to p-selectin and their uses
WOPCT/US93/04274 1993-05-04
US5729293A 1993-05-05 1993-05-05
US08/202,047 US5800815A (en) 1903-05-05 1994-02-25 Antibodies to P-selectin and their uses
US202047 1994-02-25
PCT/US1994/004935 WO1994025067A1 (en) 1993-05-04 1994-05-04 Antibodies to p-selectin and their uses

Publications (2)

Publication Number Publication Date
EP0804235A1 EP0804235A1 (de) 1997-11-05
EP0804235A4 true EP0804235A4 (de) 2001-09-19

Family

ID=27369213

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94917301A Withdrawn EP0804235A4 (de) 1993-05-04 1994-05-04 Antikörper gegen p-selectin und ihre verwendungen

Country Status (3)

Country Link
EP (1) EP0804235A4 (de)
FI (1) FI955261L (de)
WO (1) WO1994025067A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040942A1 (en) * 1995-06-07 1996-12-19 Cytel Corporation Humanized antibodies to e-selectin
AU6390696A (en) * 1995-06-20 1997-01-22 Trustees Of Boston University Hypoxia-responsive adhesion molecules, specific antibodies, nd their uses
AU9603398A (en) * 1997-10-07 1999-04-27 Centocor Inc. Diagnosis of thrombotic events by detecting p-selectin
PL1737891T3 (pl) * 2004-04-13 2013-08-30 Hoffmann La Roche Przeciwciała przeciw selektynie p
AU2012200852B2 (en) * 2004-04-13 2012-10-18 F. Hoffmann-La Roche Ag Anti-P-selectin antibodies
US8945565B2 (en) 2006-12-01 2015-02-03 Selexys Pharmaceuticals Corporation Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
ES2699273T3 (es) 2006-12-01 2019-02-08 Novartis Ag Anticuerpos anti-P-selectina y métodos de uso de los mismos para tratar enfermedades inflamatorias
US20110212096A1 (en) 2006-12-01 2011-09-01 Scott Rollins Anti-p-selectin antibodies and methods of their use and identification
EP2592147A1 (de) 2007-10-12 2013-05-15 F. Hoffmann-La Roche AG Proteinexpression von mehreren Nukleinsäuren
WO2019025847A1 (en) 2017-08-04 2019-02-07 Novartis Ag TREATMENT DIAGRAMS
JP2021515027A (ja) 2018-03-08 2021-06-17 ノバルティス アーゲー 抗ｐ−セレクチン抗体の使用
CA3142011A1 (en) 2019-06-07 2020-12-10 Novartis Ag Use of an anti-p-selectin antibody
BR112022002282A2 (pt) 2019-08-08 2022-07-19 Novartis Ag Uso do anticorpo anti-p-selectina crizanlizumab para tratar nefropatia de células falciformes e doença renal crônica associada à doença de células falciformes
EP4213878A4 (de) * 2020-09-16 2024-07-03 Ramot at Tel-Aviv University Ltd. Verfahren zur behandlung von glioblastom

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022653A1 (en) * 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
WO1993021956A1 (en) * 1992-05-05 1993-11-11 Cytel Corporation Antibodies to p-selectin and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
DK0496832T3 (da) * 1989-10-20 1996-12-30 New England Medical Center Inc Inhibering af PADGEM-formidlet cellebinding

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022653A1 (en) * 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
WO1993021956A1 (en) * 1992-05-05 1993-11-11 Cytel Corporation Antibodies to p-selectin and their uses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CARLOS T M ET AL: "Membrane proteins involved in phagocyte adherence to endothelium.", IMMUNOLOGICAL REVIEWS, (1990 APR) 114 5-28. REF: 122, XP001008136 *
See also references of WO9425067A1 *
SHARAR S R ET AL: "P - selectin blockade does not impair leukocyte host defense against bacterial peritonitis and soft tissue infection in rabbits.", JOURNAL OF IMMUNOLOGY, (1993 NOV 1) 151 (9) 4982-8., XP000999480 *

Also Published As

Publication number Publication date
EP0804235A1 (de) 1997-11-05
FI955261A7 (fi) 1996-01-03
FI955261L (fi) 1996-01-03
FI955261A0 (fi) 1995-11-02
WO1994025067A1 (en) 1994-11-10

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Legal Events

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