EP0777741A4 - Biocapteur et procede destines a la detection par luminescence electrophotochimique d'acides nucleiques adsorbes sur une surface solide - Google Patents

Biocapteur et procede destines a la detection par luminescence electrophotochimique d'acides nucleiques adsorbes sur une surface solide

Info

Publication number
EP0777741A4
EP0777741A4 EP95930881A EP95930881A EP0777741A4 EP 0777741 A4 EP0777741 A4 EP 0777741A4 EP 95930881 A EP95930881 A EP 95930881A EP 95930881 A EP95930881 A EP 95930881A EP 0777741 A4 EP0777741 A4 EP 0777741A4
Authority
EP
European Patent Office
Prior art keywords
biosensor
nucleic acid
solid surface
chemiluminescent detection
acid adsorbed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95930881A
Other languages
German (de)
English (en)
Other versions
EP0777741A1 (fr
Inventor
Allen J Bard
Xiao-Hong Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IGEN International Inc
Original Assignee
IGEN Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN Inc filed Critical IGEN Inc
Publication of EP0777741A1 publication Critical patent/EP0777741A1/fr
Publication of EP0777741A4 publication Critical patent/EP0777741A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
EP95930881A 1994-08-26 1995-08-25 Biocapteur et procede destines a la detection par luminescence electrophotochimique d'acides nucleiques adsorbes sur une surface solide Withdrawn EP0777741A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29663094A 1994-08-26 1994-08-26
US296630 1994-08-26
PCT/US1995/010630 WO1996006946A1 (fr) 1994-08-26 1995-08-25 Biocapteur et procede destines a la detection par luminescence electrophotochimique d'acides nucleiques adsorbes sur une surface solide

Publications (2)

Publication Number Publication Date
EP0777741A1 EP0777741A1 (fr) 1997-06-11
EP0777741A4 true EP0777741A4 (fr) 1999-01-13

Family

ID=23142843

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95930881A Withdrawn EP0777741A4 (fr) 1994-08-26 1995-08-25 Biocapteur et procede destines a la detection par luminescence electrophotochimique d'acides nucleiques adsorbes sur une surface solide

Country Status (5)

Country Link
EP (1) EP0777741A4 (fr)
JP (1) JPH10509025A (fr)
AU (1) AU703344B2 (fr)
CA (1) CA2198489A1 (fr)
WO (1) WO1996006946A1 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786141A (en) * 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
HUP9801679A3 (en) * 1995-03-10 2001-01-29 Meso Scale Technologies Llc Co Process and agent for multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
FR2762013B1 (fr) * 1997-04-09 1999-06-04 Cis Bio Int Systemes de detection d'hybridation d'acides nucleiques, leur procede de preparation et leurs utilisations
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
CA2380258C (fr) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Determination de sequences d'acides nucleiques par detection electronique
WO2001042508A2 (fr) * 1999-12-09 2001-06-14 Motorola, Inc. Procedes et compositions se rapportant a la detection electrique des reactions d'acides nucleiques
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6706479B2 (en) * 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
US7138121B2 (en) 2003-01-23 2006-11-21 Spangler Brenda D Biosensors utilizing dendrimer-immobilized ligands and there use thereof
US7741033B2 (en) * 2003-05-13 2010-06-22 Trustees Of Boston College Electrocatalytic nucleic acid hybridization detection
WO2005005952A2 (fr) 2003-05-13 2005-01-20 The Trustees Of Boston College Detection electrocatalytique de l'hybridation d'acides nucleiques
EP1830183A1 (fr) * 2004-12-21 2007-09-05 Kyoto University Sonde, dispositif d'identification de region nucleotidique et procede d'identification de region nucleotidique
JP5712129B2 (ja) 2008-09-02 2015-05-07 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント ナノ構造化微小電極およびそれを組み込んだバイオセンシング装置
ES2704685T3 (es) 2011-01-11 2019-03-19 Governing Council Univ Toronto Método para la detección de proteínas
EP2683822B1 (fr) 2011-03-10 2020-04-22 General Atomics Dispositifs et méthodes de diagnostic et de préparation d'échantillons
WO2017029346A1 (fr) 2015-08-20 2017-02-23 F. Hoffmann-La Roche Ag Dosage immunologique à base de particules utilisant un agent de liaison pégylé spécifique de la substance à analyser
EP3427057A1 (fr) 2016-03-07 2019-01-16 H. Hoffnabb-La Roche Ag Détection d'anticorps anti-p53
EP3577460B1 (fr) 2017-02-02 2021-01-20 Roche Diagnostics GmbH Immunodosage utilisant au moins deux agents de liaison analyte-spécifiques pegylés.
EP3781600A1 (fr) 2018-04-18 2021-02-24 F. Hoffmann-La Roche AG Nouveaux anticorps anti-thymidine kinase
WO2020043868A1 (fr) 2018-08-31 2020-03-05 F. Hoffmann-La Roche Ag Thymidine kinase (tk-1) dans la détermination d'indices de pronostic pour le dlbcl
EP4004554A1 (fr) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a9 utilisée en tant que biomarqueur sanguin pour le diagnostic non invasif de l'endométriose
WO2021013784A1 (fr) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a8 utilisée en tant que biomarqueur sanguin pour le diagnostic non invasif de l'endométriose
KR20220024699A (ko) 2019-07-22 2022-03-03 에프. 호프만-라 로슈 아게 자궁내막증의 비침습적 진단을 위한 혈액 바이오마커로서의 s100a12
EP4004551A1 (fr) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG Substance p en tant que biomarqueur du sang pour le diagnostic non invasif de l'endométriose
CN114144676A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 S100a6作为血液生物标志物用于子宫内膜异位症的非侵入性诊断
KR20220100883A (ko) 2019-11-15 2022-07-18 에프. 호프만-라 로슈 아게 환자 샘플의 질량분석법 측정을 위한 베타-락탐 항생제의 유도체화
CN111272742B (zh) * 2020-03-06 2022-11-08 安徽大学 基于金属有机凝胶复合材料和金属有机框架的电致化学发光传感器及其制备和检测方法
CN116829951A (zh) 2020-11-02 2023-09-29 豪夫迈·罗氏有限公司 SARS-CoV-2核衣壳抗体
WO2022207628A1 (fr) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf comme biomarqueur sanguin pour le diagnostic non invasif de l'endométriose
WO2022207685A1 (fr) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 utilisée en tant que biomarqueur sanguin pour le diagnostic non invasif de l'endométriose
WO2022243210A1 (fr) 2021-05-17 2022-11-24 F. Hoffmann-La Roche Ag Sfrp4 en tant que biomarqueur sanguin pour le diagnostic non invasif de l'adénomyose
WO2023072904A1 (fr) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Anticorps monoclonaux spécifiques du rbd du sars-cov-2
WO2023131594A1 (fr) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Dérivatisation de composés dans des échantillons de patients pour la pharmacovigilance thérapeutique (tdm)
WO2023247752A1 (fr) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Procédé de diagnostic de l'endométriose et de classification du stade de l'endométriose
WO2024017985A1 (fr) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Protéine 1 de liaison au facteur de croissance des fibroblastes (fgfbp1) utilisée en tant que biomarqueur (sanguin) pour le diagnostic du syndrome des ovaires polykystiques
WO2024017983A1 (fr) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Protéine de type météorine (metrnl) utilisée en tant que biomarqueur (sang) pour le diagnostic du syndrome des ovaires polykystiques
WO2024017982A1 (fr) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Leukotriène a4 hydrolase (lta4h) en tant que biomarqueur (sang) pour le diagnostic du syndrome des ovaires polykystiques
CN115414930B (zh) * 2022-08-26 2023-10-31 重庆医科大学 Ru(bpy)32+阳极或阴极共反应物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1258580A (fr) * 1967-12-28 1971-12-30
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5124022A (en) * 1989-08-23 1992-06-23 Aluminum Company Of America Electrolytic capacitor and method of making same
US5019343A (en) * 1989-12-15 1991-05-28 W. R. Grace & Co.-Conn. Control of corrosion in aqueous systems using certain phosphonomethyl amines
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9606946A1 *

Also Published As

Publication number Publication date
AU3410395A (en) 1996-03-22
JPH10509025A (ja) 1998-09-08
EP0777741A1 (fr) 1997-06-11
WO1996006946A1 (fr) 1996-03-07
CA2198489A1 (fr) 1996-03-07
AU703344B2 (en) 1999-03-25

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