EP0765317A1 - Procede de preparation de derives de benzothiophene - Google Patents

Procede de preparation de derives de benzothiophene

Info

Publication number
EP0765317A1
EP0765317A1 EP95921831A EP95921831A EP0765317A1 EP 0765317 A1 EP0765317 A1 EP 0765317A1 EP 95921831 A EP95921831 A EP 95921831A EP 95921831 A EP95921831 A EP 95921831A EP 0765317 A1 EP0765317 A1 EP 0765317A1
Authority
EP
European Patent Office
Prior art keywords
formula
thionyl chloride
acid
reaction
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95921831A
Other languages
German (de)
English (en)
Inventor
Hermann Uhr
Jörg-Dietrich Jentsch
Eberhard Zirngiebl
Reinhard Lantzsch
Hans-Ludwig Elbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of EP0765317A1 publication Critical patent/EP0765317A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Definitions

  • Suitable solvents are all solvents which do not themselves react with the 3-chlorobenzothiophene-2-carboxylic acid, preferably hydrocarbons such as benzene, toluene or hexane, halogenated hydrocarbons such as carbon tetrachloride, chloroform, methylene chloride, ethers such as diethyl ether, dipropyl ether, dibutyl ether , Methyl tert-butyl ether, dioxane, tetrahydrofuran, and also ethyl acetate, dimethylformamide, acetonitrile or DMSO.
  • hydrocarbons such as benzene, toluene or hexane
  • halogenated hydrocarbons such as carbon tetrachloride, chloroform, methylene chloride
  • ethers such as diethyl ether, dipropyl ether, dibutyl ether , Methyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation de dérivés de benzothiophène substitués de manière spéciale, de la formule générale (I), par réaction de dérivés d'acide cinnamique avec a) du chlorure de thionyle, b) des amines et c) de l'hydrogène, selon un processus se déroulant en un seul pot.
EP95921831A 1994-06-16 1995-06-06 Procede de preparation de derives de benzothiophene Withdrawn EP0765317A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19944420926 DE4420926A1 (de) 1994-06-16 1994-06-16 Verfahren zur Herstellung von Benzthiophenderivaten
DE4420926 1994-06-16
PCT/EP1995/002140 WO1995034551A1 (fr) 1994-06-16 1995-06-06 Procede de preparation de derives de benzothiophene

Publications (1)

Publication Number Publication Date
EP0765317A1 true EP0765317A1 (fr) 1997-04-02

Family

ID=6520657

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95921831A Withdrawn EP0765317A1 (fr) 1994-06-16 1995-06-06 Procede de preparation de derives de benzothiophene

Country Status (5)

Country Link
EP (1) EP0765317A1 (fr)
JP (1) JPH10501543A (fr)
AU (1) AU2674595A (fr)
DE (1) DE4420926A1 (fr)
WO (1) WO1995034551A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115184A1 (de) * 1991-05-09 1992-11-12 Bayer Ag Benzothiophen-2-carboxamid-s,s-dioxide
DE4317076A1 (de) * 1993-05-21 1994-11-24 Bayer Ag Benzthiophencarbonsäureamid-S-oxide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9534551A1 *

Also Published As

Publication number Publication date
DE4420926A1 (de) 1995-12-21
JPH10501543A (ja) 1998-02-10
WO1995034551A1 (fr) 1995-12-21
AU2674595A (en) 1996-01-05

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19980324