EP0755405B1 - Phosphonyldipeptides useful in the treatment of cardiovascular diseases - Google Patents

Phosphonyldipeptides useful in the treatment of cardiovascular diseases Download PDF

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Publication number
EP0755405B1
EP0755405B1 EP95916625A EP95916625A EP0755405B1 EP 0755405 B1 EP0755405 B1 EP 0755405B1 EP 95916625 A EP95916625 A EP 95916625A EP 95916625 A EP95916625 A EP 95916625A EP 0755405 B1 EP0755405 B1 EP 0755405B1
Authority
EP
European Patent Office
Prior art keywords
biphenyl
alanine
propylphosphonyl
leucyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95916625A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0755405A1 (en
Inventor
Gabriele Norcini
Gabriele Morazzoni
Francesco Santangelo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Publication of EP0755405A1 publication Critical patent/EP0755405A1/en
Application granted granted Critical
Publication of EP0755405B1 publication Critical patent/EP0755405B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP95916625A 1994-04-14 1995-04-11 Phosphonyldipeptides useful in the treatment of cardiovascular diseases Expired - Lifetime EP0755405B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI940696A IT1274673B (it) 1994-04-14 1994-04-14 Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari
ITMI940696 1994-04-14
PCT/EP1995/001322 WO1995028417A1 (en) 1994-04-14 1995-04-11 Phosphonyldipeptides useful in the treatment of cardiovascular diseases

Publications (2)

Publication Number Publication Date
EP0755405A1 EP0755405A1 (en) 1997-01-29
EP0755405B1 true EP0755405B1 (en) 1999-08-25

Family

ID=11368561

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95916625A Expired - Lifetime EP0755405B1 (en) 1994-04-14 1995-04-11 Phosphonyldipeptides useful in the treatment of cardiovascular diseases

Country Status (8)

Country Link
US (1) US5760285A (it)
EP (1) EP0755405B1 (it)
AT (1) ATE183750T1 (it)
AU (1) AU2305895A (it)
DE (1) DE69511689T2 (it)
ES (1) ES2136848T3 (it)
IT (1) IT1274673B (it)
WO (1) WO1995028417A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276161B1 (it) * 1995-11-23 1997-10-27 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
US6166052A (en) * 1998-03-11 2000-12-26 Warner-Lambert Company Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379146A (en) * 1981-02-17 1983-04-05 Merck & Co., Inc. Substituted phosphonamides as antihypertensives
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5155100A (en) * 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
JPH05105698A (ja) * 1991-06-13 1993-04-27 Takeda Chem Ind Ltd ホスホン酸誘導体、その製造法および用途
IT1254521B (it) * 1992-03-17 1995-09-25 Zambon Spa Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
WO1995028417A1 (en) 1995-10-26
ATE183750T1 (de) 1999-09-15
DE69511689D1 (de) 1999-09-30
ITMI940696A0 (it) 1994-04-14
DE69511689T2 (de) 2000-04-27
ITMI940696A1 (it) 1995-10-14
ES2136848T3 (es) 1999-12-01
AU2305895A (en) 1995-11-10
EP0755405A1 (en) 1997-01-29
IT1274673B (it) 1997-07-24
US5760285A (en) 1998-06-02

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