EP0746365A1 - Dispositif d'injection - Google Patents
Dispositif d'injectionInfo
- Publication number
- EP0746365A1 EP0746365A1 EP94927453A EP94927453A EP0746365A1 EP 0746365 A1 EP0746365 A1 EP 0746365A1 EP 94927453 A EP94927453 A EP 94927453A EP 94927453 A EP94927453 A EP 94927453A EP 0746365 A1 EP0746365 A1 EP 0746365A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- injection device
- syringe
- needle
- base surface
- barrel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
Definitions
- the present invention relates to an injection device having a locating means causing a needle to be inserted into the skin of a subject at a predetermined angle and depth. Whilst the invention is according to one embodiment directed towards and primarily described with reference to skin testing for allergy, it is considered that the invention is suitable for use for injecting other substances into or under skin. Background
- Skin testing for allergy is conventionally performed by placing a small drop of a solution of the test material (allergen) on the skin (usually forearm or back) of the subject and passing a hypodermic needle or lancet through the drop into the first layer of skin without drawing blood.
- An inflammatory response in the form of a wheal and flare reaction occurring within about 15 minutes indicates allergy to the suspected allergen.
- This test commonly called the "skin prick test” has been used for many years chiefly by specialist allergists as it is labour-intensive and takes a valuable consultation time in a surgery.
- it is costly to provide this form of testing especially if only done occasionally, and requires some technical skill.
- the method is, however, the most reliable diagnostic procedure for allergies and is sensitive, rapid, specific and relatively inexpensive.
- Testing for delayed, or cell-mediated hypersensitive reactions may also be performed by skin testing wherein the needle is used to penetrate the skin to a greater depth allowing the test material (antigen) greater access to the tissues underlying the dermal layer.
- This skin reaction which is an index of the patient's ability to mount a cellular immune response to the test antigen is usually measured over hours or even days.
- the present invention seeks to provide an injection device which readily allows the controlled and accurate injection of substances into skin of patients and in particular for the use in allergen and delayed-type hypersensitivity testing.
- the present invention consists in an injection device comprising a housing defining a base surface, a syringe slidable with respect to the housing and having a syringe barrel defining a chamber, a hollow needle mounted at one end of the barrel and being in fluid communication with the chamber, a plunger slidingly disposed in the barrel for urging fluid from the chamber through the hollow needle arid, wherein in use, the needle of the syringe projects from the base surface at a distance no greater than the depth of skin to be injected and at a predetermined angle with respect to the base surface to ensure optimum injection into the skin.
- the syringe is preferably slidable in a passage in the housing to an extended position wherein the needle projects from the base surface, the passage extending through the base surface, and wherein the extended position is determined by a stop located within the passage of the housing which, in use, engages with a locating portion of the syringe barrel.
- the syringe is slidable between the extended position and a retracted position wherein the needle is positioned so as not to project from the base surface.
- the locating portion of the syringe barrel is in the form of an annular ridge of enlarged diameter located on the outer surface of the syringe barrel which is slidably received in an enlarged diameter portion of the passage of the housing, the enlarged diameter portion having proximal and distal end stops which determine the retracted and extended positions of the syringe respectively.
- the injection device is further provided with a spring bias means to urge the syringe into its retracted position.
- the spring bias means is a coil spring located within the enlarged diameter portion of the passage and acting between the locating portion of the syringe barrel and the distal end stop, and wherein, in use the coil spring and the distal end stop determines the extended position of the syringe.
- the syringe contains within the chamber a substance to be injected and most preferably the substance is in a fluid form.
- the injection device is provided for use in a sterile container with the substance to be injected preloaded in the chamber.
- the substance to be injected may comprise a composition, an active ingredient, an allergen, an antigen, a drug or any combination thereof.
- the chamber of the syringe is divided into a distal and a proximal part by means of the seal and, wherein, in use actuation of the plunger causes the seal to be broken and causes the contents within the distal and proximal parts to combine and be urged out through the needle.
- the plunger has a pin extending from its distal end and wherein in use the pin penetrates and breaks the seal causing the contents of the distal and proximal parts to combine.
- the distal part of the chamber contains a substance to be injected and the proximal part contains a diluent.
- the substance is in a non-liquid form.
- the injection device is suitable for injecting substances into skin and the angle of the needle with respect to the base surface will be determined by the type of injection to be made by the device.
- the injection device of the present invention has the needle defining an angle of less than about 45 degrees relative to the base surface and more preferably the angle of the needle is between 10-30 degrees.
- the needle of the syringe defines an angle of about 20 degrees relative to the base surface.
- the distance that the needle projects from the base surface is determined by the type of injection to be made by the device.
- the needle projects from the base surface so the end of the needle is 0.5 to 1.5 mm from the base surface.
- the injection device is suitable for injecting micro-volumes (approximately 5 to 25 microlitres), small volumes (25-100 microlitres) and larger volumes of up to approximately 250 microlitres.
- the volume of substance to be injected will be determined by the type of injection to be made by the device.
- the base surface can be substantially flat, or can be curved so as to conform with the curvature of the site of injection.
- the injection device is suitable for injecting substances into or within layers of the skin. Injections may be made to the epidermis (ectodern), dermis (mesoderm) or the subcutaneous fat (adipose tissue).
- the device may be adapted for different types of injection by varying the angle of the needle to the base surface, the distance that the needle projects from the base and the volume to be injected.
- Figure 1 depicts a perspective view of an injection device in accordance with the present invention with the syringe in its extended position;
- Figure 2 is a longitudinal-sectional view of an injection device with the syringe in its retracted position and showing one embodiment of the mounting of the syringe on the housing;
- Figure 3 is a longitudinal-sectional view of an injection device showing embodiment of the mounting of the syringe in the housing;
- Figure 4 is a longitudinal-sectional view of the injection device similar to that shown in Figure 2 with an alternative arrangement for containing the substance to be injected. Best Mode for Carrying out the Invention
- the injection device 10 includes a housing 11, a syringe 15 and a needle 20.
- the housing 11 includes a base surface 12 and a passage 13.
- a syringe 15 is slidable in the passage 13 of the housing 11.
- the syringe 15 includes a barrel 16 and a syringe barrel head 17.
- a plunger 18 including a plunger head 19.
- the plunger 18 is slidingly disposed within, and is in sealing engagement with the barrel 16 so as to form a chamber 21 towards the distal end of barrel 16.
- a hollow needle 20 is mounted at the distal end of the barrel 16 and is in fluid communication with the chamber 21.
- the syringe 15 is slidable in the passage 13 of the housing 11 to an extended position (as represented by the arrow), wherein the end of the needle 20 is positioned a distance A from the base surface 12.
- the extended position of the syringe 15 is determined by a stop 22 located within the passage 13 of the housing 11 so as to engage with a portion 26 of the syringe barrel 16 when in use. Stop 22 ensures that needle 20 projects from the base surface 12 at a distance A which is no greater than the thickness of skin to be injected.
- the positioning of the passage 13 in the housing 11 determines the angle of the needle with respect to the base surface 12 ensuring optimum entry and subsequent injection into the skin.
- the base surface 12 of injection device 10 is placed on the surface of the skin of a patient and syringe 15 is pushed via pressure on barrel head 17 and/or plunger head 19 through the passage 13 until the barrel 16 is in contact with the stop 22.
- the needle 20 penetrates the skin of the patient to the desired depth A.
- Plunger head 19 is further pressed so as to move the plunger 18 towards the needle 20 and move the contents in chamber 21 through needle 20 into the site of injection.
- the resistance of the sliding movement of the syringe 15 in the passage 13 is significantly less than the resistance to the movement of the plunger 18 in the barrel 16.
- FIG 3 Another embodiment of the mounting of the syringe 15 in the housing 11 is shown in Fig 3 in which the injection device 10 is arranged so that the syringe 15 is slidable between a retracted position and an extended position.
- the needle 20 In the retracted position the needle 20 is positioned so as not to project from base surface 12 and the positioning of the needle 20 is by a locating means 32 comprising an annular ridge 27 of enlarged diameter located on the outer surface of syringe barrel 16 adapted to be slidably received in an enlarged diameter portion 30 of passage 13 of housing 11.
- the enlarged diameter portion 30 has end stops 28, 29 which determine the extended and retracted positions respectively of the syringe 15.
- a coil spring 31 is provided within the enlarged diameter portion 30 to urge syringe 16 into its retracted position.
- the substance to be injected is preferably in a liquid form and is contained in the chamber 21.
- the chamber 21 is divided into a proximal part 14 and distal part 25 by a seal 24.
- Mounted on the distal end of the plunger 18 is a pin 23 extending towards the seal 24 such that, during actuation of the plunger 18, the seal 24 is broken by the pin 23 and the contents within the distal 25 and proximal 14 parts combine and are urged out through the needle 20.
- the needle 20 is positioned defining angle of less than 45 degrees relative to base surface 12 to ensure that needle 20 penetrates the skin at the required angle.
- the angle is 10 to 30 degrees and most preferably the angle is about 20 degrees relative to base surface 12 to ensure optimum entry and injection into the skin of the patient.
- the distance A that the end of the needle 20 is spaced from base surface 12 between 0.5 and 1.5 mm.
- the injection device 10 may be supplied for use preloaded with the substance to be injected and provided in a suitable sterile container.
- the injection device 10 is easy to use and may be disposable and suitable for the use in skin testing of patients for immediate hypersensitivity (allergic) or delayed hypersensitivity (delayed or cell-mediated) immune reactions.
- the injection device 10 may contain substances to be injected in liquid form.
- the substance to be injected may contain suitably formulated and preserved allergen solutions or extracts, antigens, drugs or any combination thereof.
- the device may be used with a labile or unstable substances which are dissolved or mixed in a liquid diluent in the device immediately before testing.
- An embodiment as shown in Figure 4 having a chamber 21 divided into two parts enables this form of the invention to be utilised.
- the injection device 10 may be made of any suitable material such as moulded plastic and needle 20 may be plastic, metal or any other suitable material known to the art.
- the present invention is also suitable for use in injecting any materials in the skin where a predetermined entry angle of a needle and depth is required for administration of a desired substance.
Abstract
Un dispositif d'injection (10) comprend un boîtier (11) qui définit une surface de base (12), une seringue (15) pouvant coulisser dans ce boîtier (11) et doté d'un corps (16) qui définit une chambre (21), une aiguille creuse (20) montée à une extrémité du corps (16) et en communication fluide avec la chambre (21), et un piston plongeur (18) disposé de façon à pouvoir coulisser dans le corps (16) pour chasser un fluide hors de la chambre (21) au travers de l'aiguille creuse (20). Pendant l'utilisation, l'aiguille (20) de la seringue (15) fait saillie depuis la surface de base (12) sur une distance ne dépassant pas la profondeur de la peau recevant l'injection et sous un angle, par rapport à la surface de base (12), propre à assurer une injection optimum dans la peau.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPM117993 | 1993-09-14 | ||
AUPM1179/93 | 1993-09-14 | ||
PCT/AU1994/000549 WO1995007722A1 (fr) | 1993-09-14 | 1994-09-14 | Dispositif d'injection |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0746365A1 true EP0746365A1 (fr) | 1996-12-11 |
EP0746365A4 EP0746365A4 (fr) | 1997-05-21 |
Family
ID=3777192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94927453A Withdrawn EP0746365A4 (fr) | 1993-09-14 | 1994-09-14 | Dispositif d'injection |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0746365A4 (fr) |
CA (1) | CA2171563A1 (fr) |
WO (1) | WO1995007722A1 (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6309374B1 (en) * | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
GB9900166D0 (en) * | 1999-01-06 | 1999-02-24 | Zeneca Ltd | Pharmaceutical device |
AU5614199A (en) * | 1999-04-14 | 2000-11-14 | Thomas Randall Inkpen | Needle injection-facilitating device |
WO2002074336A2 (fr) | 2001-02-23 | 2002-09-26 | Glaxosmithkline Biologicals S.A. | Vaccin |
GB0109297D0 (en) * | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US7833189B2 (en) | 2005-02-11 | 2010-11-16 | Massachusetts Institute Of Technology | Controlled needle-free transport |
GB2436526B (en) | 2006-03-29 | 2010-01-27 | Arash Bakhtyari-Nejad-Esfahani | Syringe |
GB0610553D0 (en) | 2006-05-26 | 2006-07-05 | Bakhtyari Nejad Esfahani Arash | Dressing |
KR20090051246A (ko) | 2006-09-01 | 2009-05-21 | 메사추세츠 인스티튜트 오브 테크놀로지 | 자동 장입 성능을 갖는 무침 주사기 장치 |
CN104606745B (zh) | 2009-07-23 | 2017-07-28 | 适宜卫生科技项目公司 | 皮内注射适配器、皮内注射组件和皮内注射输送的注射器组件 |
WO2011028719A2 (fr) | 2009-09-01 | 2011-03-10 | Massachusetts Institute Of Technology | Techniques d'identification de systèmes non linéaires et dispositifs pour découvrir des propriétés de tissu dynamiques et statiques |
WO2011075545A1 (fr) | 2009-12-15 | 2011-06-23 | Massachusetts Institute Of Technogy | Dispositif de nettoyage actionné par la force de lorentz |
DE102010001506A1 (de) * | 2010-02-02 | 2011-08-04 | Vosseler, Michael, 78073 | Dermale Zugangsvorrichtung |
US9327086B2 (en) | 2010-03-12 | 2016-05-03 | Sid Technologies, Llc | Needle shield and adapter fixedly attached to syringe |
EP2489379B1 (fr) | 2011-01-21 | 2020-09-23 | SID Technologies, LLC | Adaptateur de stylo intradermique |
GB2487899A (en) | 2011-02-01 | 2012-08-15 | Olberon Ltd | Needle holder with grip means |
GB201112933D0 (en) | 2011-07-27 | 2011-09-14 | Olberon Ltd | Improvements relating to needle insertion or cannulation |
US9474865B2 (en) | 2013-04-25 | 2016-10-25 | West Pharmaceutical Services, Inc. | Needle shield for disposable syringe with annular ring |
GB2563027B (en) * | 2017-05-30 | 2022-04-06 | Janssen Pharmaceuticals Inc | Grip accessory for a manual injection device |
USD888941S1 (en) | 2017-11-30 | 2020-06-30 | Janssen Pharmacauticals, Inc. | Grip accessory for a manual injection device |
GB2563029B (en) * | 2017-05-30 | 2022-06-08 | Janssen Pharmaceuticals Inc | Grip accessory for a manual injection device |
USD946750S1 (en) | 2018-07-11 | 2022-03-22 | Janssen Pharmaceuticals, Inc. | Grip accessory for an injection device |
CN113633850B (zh) * | 2021-07-08 | 2023-04-25 | 中国科学院大学宁波华美医院 | 一种胰岛素自动化注射装置 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB743789A (en) * | 1953-02-22 | 1956-01-25 | Hubert Percival Schofield | Improvements in or relating to cartridges and the like tubular containers for use in dispensing liquids |
DE1055760B (de) * | 1956-10-10 | 1959-04-23 | Robert Behringer | Selbsttaetiger Injektionsapparat |
GB1206340A (en) * | 1966-06-13 | 1970-09-23 | Secr Defence | Improvements in or relating to hypodermic injection apparatus |
US4059109A (en) * | 1976-07-27 | 1977-11-22 | Tischlinger Edward A | Mixing and dispensing disposable medicament injector |
DE3012851A1 (de) * | 1980-04-02 | 1981-10-08 | Edwin 8633 Rödental Wolf | Vorrichtung zum exakten und weitergehend schmerzfreien einstechen der kanuele eines einmal-spritzensets, insbesondere zum subkutanen injizieren von insulin in den menschlichen koerper |
EP0369972A1 (fr) * | 1988-11-14 | 1990-05-23 | Fluidics International, Inc. | Ensemble de cathéter composé |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2314367A1 (de) * | 1973-03-22 | 1974-09-26 | Siemens Ag | Ultraschall-dopplerapplikator |
SE9102652D0 (sv) * | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
-
1994
- 1994-09-14 WO PCT/AU1994/000549 patent/WO1995007722A1/fr not_active Application Discontinuation
- 1994-09-14 EP EP94927453A patent/EP0746365A4/fr not_active Withdrawn
- 1994-09-14 CA CA 2171563 patent/CA2171563A1/fr not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB743789A (en) * | 1953-02-22 | 1956-01-25 | Hubert Percival Schofield | Improvements in or relating to cartridges and the like tubular containers for use in dispensing liquids |
DE1055760B (de) * | 1956-10-10 | 1959-04-23 | Robert Behringer | Selbsttaetiger Injektionsapparat |
GB1206340A (en) * | 1966-06-13 | 1970-09-23 | Secr Defence | Improvements in or relating to hypodermic injection apparatus |
US4059109A (en) * | 1976-07-27 | 1977-11-22 | Tischlinger Edward A | Mixing and dispensing disposable medicament injector |
DE3012851A1 (de) * | 1980-04-02 | 1981-10-08 | Edwin 8633 Rödental Wolf | Vorrichtung zum exakten und weitergehend schmerzfreien einstechen der kanuele eines einmal-spritzensets, insbesondere zum subkutanen injizieren von insulin in den menschlichen koerper |
EP0369972A1 (fr) * | 1988-11-14 | 1990-05-23 | Fluidics International, Inc. | Ensemble de cathéter composé |
Non-Patent Citations (1)
Title |
---|
See also references of WO9507722A1 * |
Also Published As
Publication number | Publication date |
---|---|
CA2171563A1 (fr) | 1995-03-23 |
EP0746365A4 (fr) | 1997-05-21 |
WO1995007722A1 (fr) | 1995-03-23 |
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