EP0735821A4 - Procedes permettant de traiter ou de prevenir les pathologies associees aux peptides amylo dogenes - Google Patents
Procedes permettant de traiter ou de prevenir les pathologies associees aux peptides amylo dogenesInfo
- Publication number
- EP0735821A4 EP0735821A4 EP95906018A EP95906018A EP0735821A4 EP 0735821 A4 EP0735821 A4 EP 0735821A4 EP 95906018 A EP95906018 A EP 95906018A EP 95906018 A EP95906018 A EP 95906018A EP 0735821 A4 EP0735821 A4 EP 0735821A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- reptides
- amyloidogenic
- prevention
- treatment
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17154693A | 1993-12-21 | 1993-12-21 | |
US171546 | 1993-12-21 | ||
PCT/US1994/014655 WO1995017095A1 (fr) | 1993-12-21 | 1994-12-14 | Procedes permettant de traiter ou de prevenir les pathologies associees aux peptides amyloïdogenes |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0735821A1 EP0735821A1 (fr) | 1996-10-09 |
EP0735821A4 true EP0735821A4 (fr) | 1998-04-01 |
Family
ID=22624148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95906018A Withdrawn EP0735821A4 (fr) | 1993-12-21 | 1994-12-14 | Procedes permettant de traiter ou de prevenir les pathologies associees aux peptides amylo dogenes |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0735821A4 (fr) |
JP (1) | JPH09507071A (fr) |
AU (1) | AU1440395A (fr) |
CA (1) | CA2176127A1 (fr) |
WO (1) | WO1995017095A1 (fr) |
ZA (1) | ZA9410036B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL115582A0 (en) * | 1994-10-14 | 1996-01-19 | Lilly Co Eli | Methods for treating resistant tumors |
EP0716854A3 (fr) * | 1994-10-20 | 1996-08-28 | Lilly Co Eli | Compositions pour inhiber le récepteur de la neuropeptide Y |
CA2206752A1 (fr) * | 1996-07-02 | 1998-01-02 | George Joseph Cullinan | Composes de benzothiophene,intermediaires, procedes et methodes d'utilisation |
EP0944580A2 (fr) * | 1996-11-22 | 1999-09-29 | Elan Pharmaceuticals, Inc. | Esters de n-(aryl/heteroaryl) aminoacide, compositions pharmaceutiques et methodes pour inhiber la liberation du peptide beta-amyloide et/ou sa synthese |
US5965614A (en) | 1996-11-22 | 1999-10-12 | Athena Neurosciences, Inc. | N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6271227B1 (en) | 1997-04-30 | 2001-08-07 | Eli Lilly And Company | Antithrombotic Agents |
CA2287993A1 (fr) | 1997-04-30 | 1998-11-05 | Mary George Johnson | Agents antithrombotiques |
JP2002514217A (ja) | 1997-04-30 | 2002-05-14 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
DE69828522T2 (de) | 1997-04-30 | 2005-12-15 | Eli Lilly And Co., Indianapolis | Antithrombotische mittel |
WO1998055454A2 (fr) * | 1997-06-05 | 1998-12-10 | Takeda Chemical Industries, Ltd. | Composes heterocycliques, leur preparation et leur utilisation |
US5994396A (en) * | 1997-08-18 | 1999-11-30 | Centaur Pharmaceuticals, Inc. | Furansulfonic acid derivatives and pharmaceutical compositions containing the same |
AU3171099A (en) * | 1998-04-17 | 1999-11-08 | Senga Pharmaceutical Laboratory Inc. | 1-heteroindene derivatives and medicinal composition containing the same |
US6284756B1 (en) | 1998-04-30 | 2001-09-04 | Eli Lilly And Company | Antithrombotic agents |
HUP0103834A2 (hu) * | 1998-06-16 | 2002-05-29 | Eli Lilly And Co. | Eljárás az acetil-kolin-szint növelésére |
CN1305377A (zh) | 1998-06-16 | 2001-07-25 | 伊莱利利公司 | 提高乙酰胆碱水平的方法 |
US6288108B1 (en) | 1998-06-16 | 2001-09-11 | Eli Lilly And Company | Methods for increasing levels of acetylcholine |
DE69904427T2 (de) * | 1998-10-28 | 2003-07-17 | Eli Lilly And Co., Indianapolis | Benzothiophenderivate als antithrombotische Mitteln und Zwischenprodukte |
NZ544687A (en) * | 2003-06-23 | 2009-06-26 | Bellus Health Int Ltd | Treatment of amyloid- and epileptogenesis-associated diseases |
TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
KR100858357B1 (ko) * | 2006-10-02 | 2008-09-11 | (주) 디지탈바이오텍 | 벤조퓨란계 유도체 화합물을 유효성분으로 함유하는인지기능 장애의 예방 및 치료용 조성물 |
JP2008231102A (ja) * | 2007-02-23 | 2008-10-02 | Hiroaki Okuno | アミロイドベータ凝集阻害作用を有するフェノール誘導体 |
TW200901998A (en) * | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
US8193363B2 (en) | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
EP0617030A1 (fr) * | 1993-03-19 | 1994-09-28 | Eli Lilly And Company | Dérivés de sulphonate et carbamate de aroyl-3-benzo(bêta)thiophènes |
WO1994023708A1 (fr) * | 1993-04-10 | 1994-10-27 | Altramed Holdings Ltd. | Utilisation d'antagonistes steroïdiens pour le traitement et la prophylaxie de maladies du type demence |
WO1995017382A1 (fr) * | 1993-12-21 | 1995-06-29 | Eli Lilly And Company | Antagonistes non peptidiques des recepteurs des tachykinines |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4024273A (en) * | 1974-06-20 | 1977-05-17 | Smithkline Corporation | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity |
GB8704572D0 (en) * | 1987-02-26 | 1987-04-01 | Lundbeck & Co As H | Organic compounds |
US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
-
1994
- 1994-12-14 AU AU14403/95A patent/AU1440395A/en not_active Abandoned
- 1994-12-14 CA CA002176127A patent/CA2176127A1/fr not_active Abandoned
- 1994-12-14 WO PCT/US1994/014655 patent/WO1995017095A1/fr not_active Application Discontinuation
- 1994-12-14 EP EP95906018A patent/EP0735821A4/fr not_active Withdrawn
- 1994-12-14 JP JP7517547A patent/JPH09507071A/ja active Pending
- 1994-12-15 ZA ZA9410036A patent/ZA9410036B/xx unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
EP0617030A1 (fr) * | 1993-03-19 | 1994-09-28 | Eli Lilly And Company | Dérivés de sulphonate et carbamate de aroyl-3-benzo(bêta)thiophènes |
WO1994023708A1 (fr) * | 1993-04-10 | 1994-10-27 | Altramed Holdings Ltd. | Utilisation d'antagonistes steroïdiens pour le traitement et la prophylaxie de maladies du type demence |
WO1995017382A1 (fr) * | 1993-12-21 | 1995-06-29 | Eli Lilly And Company | Antagonistes non peptidiques des recepteurs des tachykinines |
Non-Patent Citations (1)
Title |
---|
See also references of WO9517095A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU1440395A (en) | 1995-07-10 |
ZA9410036B (en) | 1996-06-18 |
WO1995017095A1 (fr) | 1995-06-29 |
EP0735821A1 (fr) | 1996-10-09 |
JPH09507071A (ja) | 1997-07-15 |
CA2176127A1 (fr) | 1995-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19960621 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: LT PAYMENT 960621;SI PAYMENT 960621 |
|
RAX | Requested extension states of the european patent have changed |
Free format text: LT PAYMENT 960621;SI PAYMENT 960621 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19980216 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19990708 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20000219 |