EP0733042A4 - Verfahren zur herstellung von spirocyclischen lactamen - Google Patents

Verfahren zur herstellung von spirocyclischen lactamen

Info

Publication number
EP0733042A4
EP0733042A4 EP19950904839 EP95904839A EP0733042A4 EP 0733042 A4 EP0733042 A4 EP 0733042A4 EP 19950904839 EP19950904839 EP 19950904839 EP 95904839 A EP95904839 A EP 95904839A EP 0733042 A4 EP0733042 A4 EP 0733042A4
Authority
EP
European Patent Office
Prior art keywords
spirocyclic lactams
preparing
preparing spirocyclic
lactams
spirocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19950904839
Other languages
English (en)
French (fr)
Other versions
EP0733042A1 (de
Inventor
David Ryckman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anormed Inc
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0733042A4 publication Critical patent/EP0733042A4/de
Publication of EP0733042A1 publication Critical patent/EP0733042A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C19/00—Acyclic saturated compounds containing halogen atoms
    • C07C19/07—Acyclic saturated compounds containing halogen atoms containing iodine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP95904839A 1993-12-17 1994-12-07 Verfahren zur herstellung von spirocyclischen lactamen Withdrawn EP0733042A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9325854 1993-12-17
GB939325854A GB9325854D0 (en) 1993-12-17 1993-12-17 Porcess
PCT/US1994/014083 WO1995016657A1 (en) 1993-12-17 1994-12-07 Process for preparing spirocyclic lactams

Publications (2)

Publication Number Publication Date
EP0733042A4 true EP0733042A4 (de) 1996-07-30
EP0733042A1 EP0733042A1 (de) 1996-09-25

Family

ID=10746789

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95904839A Withdrawn EP0733042A1 (de) 1993-12-17 1994-12-07 Verfahren zur herstellung von spirocyclischen lactamen

Country Status (5)

Country Link
EP (1) EP0733042A1 (de)
JP (1) JPH09506618A (de)
AU (1) AU1337095A (de)
GB (1) GB9325854D0 (de)
WO (1) WO1995016657A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354178A (en) * 1965-04-09 1967-11-21 Sterling Drug Inc Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides
DE2114251A1 (de) * 1970-03-30 1971-10-14 Gaf Corp Tertiaere Aminomethylderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
ES447346A1 (es) * 1976-04-26 1977-10-01 Lepori Farma Sa Procedimiento para la obtencion de un compuesto lactamico, denominado 2-oxo-1-pirrolidinilacetamida.
EP0241050A2 (de) * 1986-04-08 1987-10-14 Hisamitsu Pharmaceutical Co., Inc. Azacycloalkanderivate, Absorptionspromotoren, die die Derivate als effektiven Inhaltsstoff enthalten und äusserlich anzuwendende Präparate, die Absorptionspromotoren enthalten
WO1989010358A1 (en) * 1988-04-29 1989-11-02 Gaf Chemicals Corporation Heat stable quaternized lactams having oxylated sulfur anions
EP0459133A2 (de) * 1990-05-31 1991-12-04 American Cyanamid Company Herbizide Aryloxyspiroalkylindolinone

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US5049680A (en) * 1990-05-03 1991-09-17 Lce Partnership Novel cationic lactam polymers and 1-(3-alkyl amino propyl)pyrrolidone-2 intermediates therefor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354178A (en) * 1965-04-09 1967-11-21 Sterling Drug Inc Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides
DE2114251A1 (de) * 1970-03-30 1971-10-14 Gaf Corp Tertiaere Aminomethylderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
ES447346A1 (es) * 1976-04-26 1977-10-01 Lepori Farma Sa Procedimiento para la obtencion de un compuesto lactamico, denominado 2-oxo-1-pirrolidinilacetamida.
EP0241050A2 (de) * 1986-04-08 1987-10-14 Hisamitsu Pharmaceutical Co., Inc. Azacycloalkanderivate, Absorptionspromotoren, die die Derivate als effektiven Inhaltsstoff enthalten und äusserlich anzuwendende Präparate, die Absorptionspromotoren enthalten
WO1989010358A1 (en) * 1988-04-29 1989-11-02 Gaf Chemicals Corporation Heat stable quaternized lactams having oxylated sulfur anions
EP0459133A2 (de) * 1990-05-31 1991-12-04 American Cyanamid Company Herbizide Aryloxyspiroalkylindolinone

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BAILEY, W. F. ET. AL.: "Reactions of tert-Butyllithium with .alpha.,.omega.Dihaloalkanes.", J. ORG. CHEM., vol. 49, no. 12, 1984, pages 2098 - 2107, XP002009098 *
BRIT. J. PHARMACOL. CHEMOTHERAPY, vol. 26, no. 1, 1966, pages 68 - 78, XP000575454 *
BRIT. J. PHARMCOL. CHEMOTHERAPY, vol. 26, no. 1, 1966, pages 56 - 67, XP000575179 *
CHEMICAL ABSTRACTS, vol. 88, no. 23, 5 June 1978, Columbus, Ohio, US; abstract no. 169962, XP002009100 *
GREENHOW ET. AL., J. CHEM. SOC., 1951, pages 2848 - 2851, XP000574825 *
MALAWSKA, B.; GORCZYCA, M., ACTA POL. PHARM., vol. 42, no. 4, 1985, pages 359 - 366, XP000575466 *
RICE, LEONARD M. ET AL: "Spirans. XX. Synthesis of 8,8-dialkylazaspiro[4.5]decanes and 9,9-dialkylazaspiro[5.5]undecanes", J. HETEROCYCL. CHEM. (1973), 10(5), 731-5 CODEN: JHTCAD, 1973, XP002009099 *
See also references of WO9516657A1 *

Also Published As

Publication number Publication date
EP0733042A1 (de) 1996-09-25
AU1337095A (en) 1995-07-03
JPH09506618A (ja) 1997-06-30
GB9325854D0 (en) 1994-02-23
WO1995016657A1 (en) 1995-06-22

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