EP0711160A4 - Verfahren zur replikationshemmung von hiv-viren mit substituierten azaspiranen - Google Patents

Verfahren zur replikationshemmung von hiv-viren mit substituierten azaspiranen

Info

Publication number
EP0711160A4
EP0711160A4 EP94922685A EP94922685A EP0711160A4 EP 0711160 A4 EP0711160 A4 EP 0711160A4 EP 94922685 A EP94922685 A EP 94922685A EP 94922685 A EP94922685 A EP 94922685A EP 0711160 A4 EP0711160 A4 EP 0711160A4
Authority
EP
European Patent Office
Prior art keywords
replication
inhibiting
human immunodeficiency
immunodeficiency viruses
azaspiranes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94922685A
Other languages
English (en)
French (fr)
Other versions
EP0711160A1 (de
Inventor
Alison Mary Badger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0711160A1 publication Critical patent/EP0711160A1/de
Publication of EP0711160A4 publication Critical patent/EP0711160A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP94922685A 1993-07-23 1994-07-22 Verfahren zur replikationshemmung von hiv-viren mit substituierten azaspiranen Withdrawn EP0711160A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9315340 1993-07-23
GB939315340A GB9315340D0 (en) 1993-07-23 1993-07-23 Methods
PCT/US1994/008276 WO1995003042A1 (en) 1993-07-23 1994-07-22 Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes

Publications (2)

Publication Number Publication Date
EP0711160A1 EP0711160A1 (de) 1996-05-15
EP0711160A4 true EP0711160A4 (de) 1998-09-09

Family

ID=10739357

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94922685A Withdrawn EP0711160A4 (de) 1993-07-23 1994-07-22 Verfahren zur replikationshemmung von hiv-viren mit substituierten azaspiranen

Country Status (9)

Country Link
EP (1) EP0711160A4 (de)
JP (1) JPH09500648A (de)
CN (1) CN1130871A (de)
AU (1) AU7370994A (de)
CA (1) CA2167842A1 (de)
GB (1) GB9315340D0 (de)
NZ (1) NZ269991A (de)
WO (1) WO1995003042A1 (de)
ZA (1) ZA945418B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
SK156698A3 (en) * 1996-05-17 1999-06-11 Anormed Inc Use of substituted azaspirane in the treatment of asthma

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014462A1 (en) * 1991-02-19 1992-09-03 Smithkline Beecham Corporation Cytokine inhibitors
WO1993014760A2 (en) * 1992-01-28 1993-08-05 Smithkline Beecham Corporation Methods
WO1993015735A1 (en) * 1992-01-28 1993-08-19 Smithkline Beecham Corporation (non descriptive)-a method for delaying hiv individual aids by administration of substituted azaspirane compounds
WO1995003048A1 (en) * 1993-07-23 1995-02-02 Smithkline Beecham Corporation Anti-hiv azaspiranes
WO1995003041A1 (en) * 1993-07-23 1995-02-02 Smithkline Beecham Corporation Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes
WO1995003049A1 (en) * 1993-07-23 1995-02-02 Smithkline Beecham Corporation Methods of treating hiv with azaspiranes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014462A1 (en) * 1991-02-19 1992-09-03 Smithkline Beecham Corporation Cytokine inhibitors
WO1993014760A2 (en) * 1992-01-28 1993-08-05 Smithkline Beecham Corporation Methods
WO1993015735A1 (en) * 1992-01-28 1993-08-19 Smithkline Beecham Corporation (non descriptive)-a method for delaying hiv individual aids by administration of substituted azaspirane compounds
WO1995003048A1 (en) * 1993-07-23 1995-02-02 Smithkline Beecham Corporation Anti-hiv azaspiranes
WO1995003041A1 (en) * 1993-07-23 1995-02-02 Smithkline Beecham Corporation Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes
WO1995003049A1 (en) * 1993-07-23 1995-02-02 Smithkline Beecham Corporation Methods of treating hiv with azaspiranes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BADGER A M ET AL: "ANTIARTHRITIC AND SUPPRESSOR CELL INDUCING ACTIVITY OF AZASPIRANES:STRUCTURE-FUNCTION RELATIONSHIPS OF A NOVEL CLASS OF IMMUNOMODULATORY AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 11, November 1990 (1990-11-01), pages 2963 - 2970, XP000605424 *
P.S. SARIN ET AL.: "INHIBITION OF HTLV-III REPLICATION IN CELL CULTURES", NATO ASI SER., SER. A, vol. 120, 1986, pages 329 - 42, XP002069579 *
S. GOODMAN: "THERAPEUTIC EFFECTS OF ORGANIC GERMANIUM", MEDICAL HYPOTHESES, vol. 26, 1988, pages 207 - 215, XP002069578 *
See also references of WO9503042A1 *

Also Published As

Publication number Publication date
JPH09500648A (ja) 1997-01-21
ZA945418B (en) 1995-05-10
CN1130871A (zh) 1996-09-11
WO1995003042A1 (en) 1995-02-02
AU7370994A (en) 1995-02-20
EP0711160A1 (de) 1996-05-15
CA2167842A1 (en) 1995-02-02
GB9315340D0 (en) 1993-09-08
NZ269991A (en) 1999-07-29

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