EP0705252A1 - Derives d'aminopyri(mi)dines associes a des acides amines, et leurs activites pharmacologiques - Google Patents
Derives d'aminopyri(mi)dines associes a des acides amines, et leurs activites pharmacologiquesInfo
- Publication number
- EP0705252A1 EP0705252A1 EP94920500A EP94920500A EP0705252A1 EP 0705252 A1 EP0705252 A1 EP 0705252A1 EP 94920500 A EP94920500 A EP 94920500A EP 94920500 A EP94920500 A EP 94920500A EP 0705252 A1 EP0705252 A1 EP 0705252A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- amides according
- group
- amino
- amino acids
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the mechanism for hair regrowth is based on its vasodilatory properties in the peripheral arterioles of the scalp.
- regrowth of hair requires prolonged treatment; the hair formed is fragile and in particular the molecular weight of the keratins formed is smaller than that of normal hair.
- mineral salt preferably designates a salt either of sodium, or of potassium, or of calcium.
- organic salt preferably designates a salt obtained by the action of a primary or secondary or tertiary amine on the carboxylic group; either an ethanolamine salt, a piperidine salt, a pyrrolidine salt or a pyridine salt or their derivatives are preferred.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9307821A FR2706896B1 (en:Method) | 1993-06-23 | 1993-06-23 | |
| FR9307821 | 1993-06-23 | ||
| PCT/FR1994/000753 WO1995000495A1 (fr) | 1993-06-23 | 1994-06-22 | Derives d'aminopyri(mi)dines associes a des acides amines, et leurs activites pharmacologiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0705252A1 true EP0705252A1 (fr) | 1996-04-10 |
Family
ID=9448607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP94920500A Ceased EP0705252A1 (fr) | 1993-06-23 | 1994-06-22 | Derives d'aminopyri(mi)dines associes a des acides amines, et leurs activites pharmacologiques |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5801150A (en:Method) |
| EP (1) | EP0705252A1 (en:Method) |
| FR (1) | FR2706896B1 (en:Method) |
| WO (1) | WO1995000495A1 (en:Method) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732597B1 (fr) * | 1995-04-05 | 1997-05-16 | Oreal | Utilisation dans une composition en tant qu'activateur et/ou stabilisateur de cyclooxygenase d'au moins un derive de pyrimidine substitue en 6 |
| US6596266B2 (en) | 2000-02-18 | 2003-07-22 | Natural Science, Inc. | Compositions containing minoxidil and saw palmetto for treating baldness |
| US20040127502A1 (en) * | 2001-01-31 | 2004-07-01 | Synaptic Pharmaceutical Corporation | Use of GAL3 antagonist for treatment of depression |
| US7081470B2 (en) * | 2001-01-31 | 2006-07-25 | H. Lundbeck A/S | Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods |
| ES2315115B1 (es) * | 2006-07-31 | 2009-12-30 | Desarrollo Biotecnologico, S.L. | Nueva solucion capilar concentrada a base de minoxidil. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT76527B (en) * | 1982-04-19 | 1985-12-09 | Gist Brocades Nv | A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof |
| WO1986000616A1 (en) * | 1984-07-13 | 1986-01-30 | Gail Sansone Bazzano | Substituted pyrimidine oxides useful for hair growth promotion |
| IL78842A0 (en) * | 1985-05-22 | 1986-09-30 | Serono Otc Sa | Piperidino-pyridine derivatives and pharmaceutical and cosmetic compositions containing them |
| JPH02225474A (ja) * | 1989-01-04 | 1990-09-07 | Lonza Ag | ２，４―ジアミノ―６―ピペリジニル―ピリミジン―３―ｎ―オキシドの製造方法 |
| US5124154A (en) * | 1990-06-12 | 1992-06-23 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
| US5328913A (en) * | 1992-12-11 | 1994-07-12 | Duke University | Minoxidil analogs as inhibitors of cell proliferation and lysyl hydroxylase |
-
1993
- 1993-06-23 FR FR9307821A patent/FR2706896B1/fr not_active Expired - Fee Related
-
1994
- 1994-06-22 EP EP94920500A patent/EP0705252A1/fr not_active Ceased
- 1994-06-22 WO PCT/FR1994/000753 patent/WO1995000495A1/fr not_active Application Discontinuation
- 1994-06-22 US US08/571,832 patent/US5801150A/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9500495A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US5801150A (en) | 1998-09-01 |
| WO1995000495A1 (fr) | 1995-01-05 |
| FR2706896A1 (en:Method) | 1994-12-30 |
| FR2706896B1 (en:Method) | 1996-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19960119 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI |
|
| 17Q | First examination report despatched |
Effective date: 19960517 |
|
| APAB | Appeal dossier modified |
Free format text: ORIGINAL CODE: EPIDOS NOAPE |
|
| APAB | Appeal dossier modified |
Free format text: ORIGINAL CODE: EPIDOS NOAPE |
|
| APAD | Appeal reference recorded |
Free format text: ORIGINAL CODE: EPIDOS REFNE |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
| 18R | Application refused |
Effective date: 19991025 |
|
| APAF | Appeal reference modified |
Free format text: ORIGINAL CODE: EPIDOSCREFNE |