EP0668500A3 - Chemical microanalyser - Google Patents

Chemical microanalyser Download PDF

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Publication number
EP0668500A3
EP0668500A3 EP95101811A EP95101811A EP0668500A3 EP 0668500 A3 EP0668500 A3 EP 0668500A3 EP 95101811 A EP95101811 A EP 95101811A EP 95101811 A EP95101811 A EP 95101811A EP 0668500 A3 EP0668500 A3 EP 0668500A3
Authority
EP
European Patent Office
Prior art keywords
chemical
microanalyser
construction
microfluidic
microsensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95101811A
Other languages
German (de)
French (fr)
Other versions
EP0668500A2 (en
Inventor
Minh Tan Dr. Pham
Steffen Dr. Howitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Dresden Rossendorf eV
Original Assignee
Forschungszentrum Dresden Rossendorf eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Dresden Rossendorf eV filed Critical Forschungszentrum Dresden Rossendorf eV
Publication of EP0668500A2 publication Critical patent/EP0668500A2/en
Publication of EP0668500A3 publication Critical patent/EP0668500A3/en
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

Abstract

Die Erfindung betrifft einen chemischen Mikro-Analysator zur Multiionendetektion in Fluidmedien unter Verwendung von chemischen Mikrosensoren auf der Basis der Differenzmessung.
Die derzeitig bei chemischen Mikroanalysesystemen erkennbaren Probleme bezüglich Membranpumpen und mikromechanischer Ventile werden bei der Konstruktion des erfindungsgemäßen Mikroanalysators dadurch gelöst, daß zur Bewältigung des Fluidhandlings ausschließlich Mikrofluidmanipulatoren, das sind Mikrotropfen-Emitter und Mikro-Fluiddioden, eingesetzt sind, welche mittels mikrotechnischer Verfahren und mikrosystemtechnischer Aufbau- und Verbindungstechniken herstellbar und als modulare Komponenten flexibel koppelbar an Mikrofluidiksystem und Mikrosensoren zum Systemaufbau sind. Der erfindungsgemäße Mikroanalysator mit einem neu konzipierten Fluid-Handlingsystem zeichnet sich in besonderer Weise durch eine absolute Leckfreiheit, eine einfache Konstruktion, einen geringen Platzbedarf und eine kostengünstige Herstellung aus.

Figure 00000001
The invention relates to a chemical micro-analyzer for multi-ion detection in fluid media using chemical microsensors based on the difference measurement.
The problems with diaphragm pumps and micromechanical valves currently recognizable in chemical microanalysis systems are solved in the construction of the microanalyser according to the invention in that only microfluid manipulators, that is, microdrop emitters and microfluidic diodes, which are used by means of microtechnical methods and microsystem technology, are used to handle the fluid handling and connection technologies can be produced and can be flexibly coupled as modular components to the microfluidic system and microsensors for system construction. The microanalyser according to the invention with a newly designed fluid handling system is characterized in a particular way by an absolutely leak-free design, a simple construction, a small space requirement and an inexpensive manufacture.
Figure 00000001
EP95101811A 1994-02-17 1995-02-10 Chemical microanalyser Withdrawn EP0668500A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19944405004 DE4405004A1 (en) 1994-02-17 1994-02-17 Chemical micro-analyzer
DE4405004 1994-02-17

Publications (2)

Publication Number Publication Date
EP0668500A2 EP0668500A2 (en) 1995-08-23
EP0668500A3 true EP0668500A3 (en) 1998-06-17

Family

ID=6510441

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95101811A Withdrawn EP0668500A3 (en) 1994-02-17 1995-02-10 Chemical microanalyser

Country Status (2)

Country Link
EP (1) EP0668500A3 (en)
DE (1) DE4405004A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9502251D0 (en) 1995-06-21 1995-06-21 Pharmacia Ab Flow-through sampling cell and use thereof
DE19546535C2 (en) * 1995-12-13 2000-02-03 Karl Cammann Measuring cartridge for liquid or gaseous samples, process for their operation and their use
US5879632A (en) * 1996-04-09 1999-03-09 Sarnoff Corporation Apportioning system
DE19648458C1 (en) 1996-11-22 1998-07-09 Evotec Biosystems Gmbh Micromechanical ejection pump for separating the smallest fluid volumes from a flowing sample fluid
GB9708587D0 (en) * 1997-04-29 1997-06-18 Eastman Kodak Co Device for electrochemical detection or measurement
JP3582316B2 (en) * 1997-08-20 2004-10-27 株式会社日立製作所 Chemical analyzer
NL1008315C2 (en) * 1998-02-16 1999-08-25 Stichting Fund Ond Material Microdialysis probe integrated with Si chip.
DE10001116C2 (en) * 2000-01-13 2002-11-28 Meinhard Knoll Device and method for the optical or electrochemical quantitative determination of chemical or biochemical substances in liquid samples
DE10002500A1 (en) * 2000-01-21 2001-07-26 Univ Albert Ludwigs Freiburg Capillary action mixer for mixing components which are analyzed during reaction, e.g. in DNA sequencing, uses capillary action to feed the reactants into the mixer
US6649078B2 (en) 2000-12-06 2003-11-18 The Regents Of The University Of California Thin film capillary process and apparatus
GB0306163D0 (en) * 2003-03-18 2003-04-23 Univ Cambridge Tech Embossing microfluidic sensors
GB0326049D0 (en) * 2003-11-07 2003-12-10 Qinetiq Ltd Fluid analysis apparatus
IT1403791B1 (en) * 2010-12-30 2013-10-31 St Microelectronics Srl METHOD FOR CALIBRATING A TEMPERATURE SENSOR OF A CHEMICAL MICROREACTOR AND ANALYZER FOR BIOCHEMICAL ANALYSIS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025005A1 (en) * 1979-08-18 1981-03-11 Schaldach, Max, Prof. Dr. Ing. Device for delivering and dosing very small quantities of liquid
US5121132A (en) * 1989-09-29 1992-06-09 Hewlett-Packard Company Ink delivery system for printers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915920A1 (en) * 1989-05-16 1990-11-22 Messerschmitt Boelkow Blohm Micro-mechanical structures for storing and testing substances - e.g. for disease diagnosis, is made of inert material, e.g. glass, and has defined pattern of depressions, cavities, etc.
EP0637996B1 (en) * 1992-05-01 1997-07-23 The Trustees Of The University Of Pennsylvania Microfabricated detection structures
DE4227323A1 (en) * 1992-08-18 1994-02-24 Ekf Ind Elektronik Gmbh Semi-automatic liquid analysis - involves passing measurement liquid, air and cleaning and/or buffer soln. past biosensor in defined repeated sequence

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025005A1 (en) * 1979-08-18 1981-03-11 Schaldach, Max, Prof. Dr. Ing. Device for delivering and dosing very small quantities of liquid
US5121132A (en) * 1989-09-29 1992-06-09 Hewlett-Packard Company Ink delivery system for printers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EFFENHAUSER C S ET AL: "GLASS CHIPS FOR HIGH-SPEED CAPILLARY ELECTROPHORESIS SEPARATIONS WITH SUBMICROMETER PLATE HEIGHTS", ANALYTICAL CHEMISTRY, vol. 65, no. 19, 1 October 1993 (1993-10-01), pages 2637 - 2642, XP000413548 *
MANZ A ET AL: "Miniaturized total chemical analysis systems: a novel concept for chemical sensing", 5TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS AND ACTUATORS AND EUROSENSORS III, MONTREUX, SWITZERLAND, 25-30 JUNE 1989, vol. B1, no. 1-6, ISSN 0925-4005, SENSORS AND ACTUATORS B (CHEMICAL), JAN. 1990, SWITZERLAND, pages 244 - 248, XP002062625 *
VAN DER SCHOOT B H ET AL: "A SILICON INTEGRATED MINIATURE CHEMICAL ANALYSIS SYSTEM", SENSORS AND ACTUATORS B, vol. B06, no. 1 / 03, 1 January 1992 (1992-01-01), pages 57 - 60, XP000276297 *

Also Published As

Publication number Publication date
DE4405004A1 (en) 1995-08-24
EP0668500A2 (en) 1995-08-23

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