EP0663241A1 - Buse de pulverisation - Google Patents

Buse de pulverisation Download PDF

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Publication number
EP0663241A1
EP0663241A1 EP93120417A EP93120417A EP0663241A1 EP 0663241 A1 EP0663241 A1 EP 0663241A1 EP 93120417 A EP93120417 A EP 93120417A EP 93120417 A EP93120417 A EP 93120417A EP 0663241 A1 EP0663241 A1 EP 0663241A1
Authority
EP
European Patent Office
Prior art keywords
nozzle
channels
atomizer
mixing chamber
diameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP93120417A
Other languages
German (de)
English (en)
Other versions
EP0663241B1 (fr
Inventor
Ales Dr.-Ing. Blaha-Schnabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PARI GmbH Spezialisten fuer Effektive Inhalation
Original Assignee
PAUL RITZAU PARI-WERK GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE59308788T priority Critical patent/DE59308788D1/de
Priority to ES93120417T priority patent/ES2120471T3/es
Priority to AT93120417T priority patent/ATE168289T1/de
Priority to DK93120417T priority patent/DK0663241T3/da
Priority to EP93120417A priority patent/EP0663241B1/fr
Application filed by PAUL RITZAU PARI-WERK GmbH filed Critical PAUL RITZAU PARI-WERK GmbH
Priority to CA002138234A priority patent/CA2138234A1/fr
Publication of EP0663241A1 publication Critical patent/EP0663241A1/fr
Priority to US08/760,911 priority patent/US5740966A/en
Application granted granted Critical
Publication of EP0663241B1 publication Critical patent/EP0663241B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
    • B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
    • B05B7/0807—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form intersecting jets
    • B05B7/0861—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form intersecting jets with one single jet constituted by a liquid or a mixture containing a liquid and several gas jets

Definitions

  • the present invention relates to an atomizing nozzle for inhalation purposes, with which a powdery or liquid atomizing material is atomized, preferably in the form of a solution or suspension.
  • a first group of atomizing nozzles works on the Venturi principle.
  • a nozzle of this type is known for example from DE 32 38 149 A1.
  • Compressed air is fed through a central compressed gas duct, which emerges from an opening of the central duct in a mouth plane.
  • several suction channels are usually provided, which extend from the mouth level into a container for the atomizing material.
  • the atomizing material is sucked in by the escaping compressed gas through the suction channels and exits from openings of the suction channels in the mouth plane.
  • the openings of the compressed gas duct and the intake ducts are arranged adjacent to one another, so that compressed gas and atomizing material mix intensively and the turbulence that occurs for to provide atomization.
  • Aerosols with a primary distribution containing aerosol particles with a diameter of up to 40 ⁇ m are generated with this type of atomizer nozzle.
  • a post-treatment of the aerosol is required; this includes, for example, separating oversized particles from the aerosol by means of design measures.
  • the separated atomization material is returned to the container and can be atomized again.
  • the circulation of the atomized material is unproblematic.
  • numerous medications are not or only poorly suited for this type of atomization, since the effectiveness of the medication must be expected to be impaired.
  • Atomizer nozzles of this type are known for example from DE 26 46 251 A1 and DE 28 23 643 A1.
  • the basic structure of atomizing nozzles in this group also results from "Atomization and Sprays" by Arthur H. Lefebvre.
  • distinctive designs are distinguished on the basis of the type and location of the atomization process that occurs, specifically on the one hand so-called “air-assist” nozzles with a mixture inside or outside the Nozzle body and so-called “prefilming” nozzles.
  • These atomizing nozzles follow a common construction principle in that annular channels are arranged concentrically around a central channel.
  • the atomizing nozzles can only be dismantled to a limited extent or only with great effort.
  • the nozzle body known from DE 26 46 251 A1
  • the atomizing nozzle which is a "prefilming" nozzle, is not suitable for repeated disassembly and cleaning due to the problems associated with the alignment of the elements.
  • this known atomizer nozzle has a considerable dead space, since the gap space producing the thin liquid film is surrounded on all sides by a much larger annular space, which also applies to the nozzle known from DE 28 23 643 A1.
  • this structure is necessary in order to feed the atomization material through the gap in such a way that a thin film of liquid enters the centrally guided gas stream on all sides.
  • the invention has for its object to provide an atomizer nozzle for inhalation purposes, with which an aerosol with the largest possible proportion of respirable particles can be generated and which is still easy to use, especially disassemble and clean, and simple and is inexpensive to manufacture (bulk items).
  • the atomizer nozzle according to the invention consists of several parts, which are shown in FIG. 3. What is important is the configuration of the nozzle body, which consists of two parts, the nozzle insert 1 and the nozzle holder 2.
  • FIG. 1 the nozzle insert is shown;
  • Figure A shows the nozzle insert 1 in a perspective view,
  • Figure B in a sectional view.
  • the basic shape of the nozzle insert 1 is composed of two flat circular cylinders with different diameters and a circular cone, the maximum diameter of which corresponds to that of the smaller circular cylinder.
  • the circular cone defines a contact surface 11 of the nozzle insert 1.
  • the two circular cylinders and the circular cone are arranged axially to one another.
  • the larger circular cylinder is flattened on its circumference at two opposite points 12, only one of which is visible in FIG. 1A.
  • a channel 13 for the atomizing material is provided centrally in the nozzle insert 1 extends in the longitudinal direction of the basic shape of the nozzle insert 1, so that the outlet opening 14 lies in the tip of the contact surface 11.
  • the outlet opening 14 defines the smallest diameter d of the channel 13 and thus its outlet cross-sectional area A Z ; the channel 13 has a gradually increasing diameter.
  • FIGS. 2A and 2B show the nozzle holder 2 in a perspective or sectional representation.
  • the basic shape of the nozzle holder is formed by two flat circular cylinders which are arranged axially to each other.
  • the free end face of the larger circular cylinder has a central circular-conical depression which defines a receiving surface 21 which is adapted to the shape of the bearing surface 11 of the nozzle insert 1.
  • three channels 22 for the compressed gas are formed, which run radially to the center of the flat circular cylinder and thereby follow the inclined receiving surface 21 of the circular-conical depression.
  • the channels 22 are evenly distributed over the circumference of the nozzle holder 2, so that there is an angle of 120 ° between them, and taper towards the center of the nozzle holder.
  • the channels 22 for the compressed gas are grooves in the receiving surface 21 with a rectangular or trapezoidal cross-section and with a minimal cross-sectional area A D at the mouth end.
  • the channels 22 for the compressed gas end in a cylindrical mixing chamber 23 which runs coaxially with the flat circular cylinders of the nozzle holder 2.
  • the orifice chamber 23 opens into a circular conical outlet funnel 24.
  • FIG. 3 shows further parts of the exemplary embodiment of the atomizing nozzle according to the invention.
  • a cylindrical housing 3 serves to receive the nozzle body, ie the nozzle insert 1 and the nozzle holder 2 in the order shown in FIG. 3.
  • the inside diameter of the housing 3 corresponds to the diameter of the larger, flat circular cylinder of the two Parts 1 and 2 forming the nozzle body, which can be introduced into the interior of the housing 3 through a completely open end face.
  • the opposite end face of the housing 3 has only an opening 31 for receiving the smaller, flat circular cylinder of the nozzle holder 2.
  • a groove 34 is provided for receiving a further O-ring 35 on the end face of the housing 3 which is open for receiving the nozzle body in the housing wall.
  • An external thread 36 is formed on the housing 3 on this side.
  • a cover 4 serves on the one hand to close the housing 3 and on the other hand has connections for the supply of the atomizing material and the compressed gas.
  • the cover 4 has a cylindrical basic shape with an axially arranged bore 41 for the supply of the atomizing material and an eccentrically arranged bore 42 for the supply of compressed air.
  • a portion of the cover 4 has a diameter that is sufficient to seal the interior of the housing 3 in cooperation with the O-ring 35.
  • the three O-rings 33, 35, 44 completely separate the gas and liquid parts within the nozzle.
  • a union nut 5 serves to secure the parts inserted into the housing 3 and for this purpose has a thread 51 on an inner peripheral surface. In the opposite end face an opening 52 is provided, which ensures access to the connection bores 41 and 42 in the cover 4.
  • Fig. 4 shows the embodiment of the atomizer nozzle according to the invention in the assembled state.
  • the nozzle body, ie the nozzle insert 1 and the nozzle holder 2 are arranged in the housing 3.
  • the circular conical bearing surface 11 of the Nozzle insert 1 rests on the complementarily shaped receiving surface 21 of the nozzle holder 2.
  • the two parts forming the nozzle body are clamped against one another via the cover 4, the union nut 5 and the housing 3, which ensures a good fit of the nozzle insert in the nozzle receptacle and an alignment of the outlet opening 14 with respect to the mixing chamber 23.
  • the channels 22 formed as grooves in the receiving surface 21 are closed on their originally opened upper side by the contact surface 11 of the nozzle insert 1.
  • the compressed air supplied through the eccentric connection bore 42 in the cover 4 passes through the space 6 resulting at the flattened points 12 of the nozzle insert 1 in the housing 3 into the annular space 7, which is formed around the flat circular cylinder with a smaller diameter of the nozzle insert 1. From there, the compressed air flows through the three channels 22 into the mixing chamber 23.
  • FIG. 5 shows a further exemplary embodiment of the atomizer nozzle according to the invention in the assembled state.
  • the structure corresponds in many points to the exemplary embodiment described above, so that reference can be made to the description thereof. The differences by which the two exemplary embodiments are distinguished are explained below.
  • the nozzle insert 1 has a channel 13 with a diameter that is constant except for a section in the region of the outlet opening 14. This diameter is selected so that a flattened cannula is inserted and the dead space can thereby be minimized.
  • the spout with the smallest diameter d is kept as short as possible for cleaning reasons.
  • the axial bore 41 is designed such that a rubber washer 43 with a central hole for the cannula 8 can be inserted.
  • An intermediate ring 44 is arranged above it, which is slightly conical on the side of the rubber washer 43, preferably at an angle of 160 ° is trained.
  • the diameter of the mixing chamber 23 is dimensioned such that its free cross section gives approximately the sum of the free cross sections of the channels 22 for the compressed gas at the outlet into the mixing chamber 23 in order to optimally use the energy of the compressed air supplied. If the cross-section of the mixing chamber 23 is too large, there is premature relaxation, and if the cross-section is too small, the compressed air is blocked. The aim is to optimize the conversion of the pressure difference between compressed gas and ambient pressure into kinetic energy in the area of the outlet openings of the channels 22. The distance between the liquid emerging from the channel 13 and the outlet openings of the channels 22 for the compressed air plays a decisive role. The length of the mixing chamber corresponds approximately to its diameter. Too short a mixing chamber would cause manufacturing difficulties in terms of the required channel depth in the mouth area. If the mixing chamber is too long, the atomization efficiency may deteriorate due to impaction and friction, as well as the tendency to clog.
  • the cross-sectional area A M of the mixing chamber 23 corresponds essentially to the sum of the minimum cross-sectional areas A D of the channels 22.
  • the smallest diameter d of the channel 13 for the atomizing material at the outlet opening 14 is approximately 55% to 85%, preferably 60% to 70% of the Diameter D of the mixing chamber 23.
  • the angle of the conical bearing surface 11 or the complementary receiving surface 21 should be about 120 °. Angles smaller than 120 ° not only have an unfavorable effect in this context, but also lead to problems in the manufacture and cleaning of the nozzle body (formation of degrees at the outlet in the nozzle insert during spray production, risk of damage to the edge of the bore in the nozzle insert, poor accessibility of the mixing chamber during cleaning ).
  • the channels 22 for the compressed air can also be formed in the contact surface 11 of the nozzle insert 1.
  • the configuration described above is preferred since the risk of mechanical damage to the channels is reduced, in particular in the area of the mixing chamber 23.
  • the cross-sectional shape of the channels 22 for the compressed air is also not limited to a rectangular shape or the shape of an isosceles trapezoid. With regard to simple injection molding, the cross-sectional shapes described are advantageous and are also particularly suitable with regard to the reduction in cross-section towards the center of the nozzle body, which serves to accelerate the compressed air while increasing the kinetic energy.
  • three channels 22 are provided for the compressed air in the receiving surface 21.
  • the channel depth should correspond to about half the length of the mixing chamber. From geometrical considerations and with regard to the possible manufacturing accuracy in injection molding, the number of three channels for the supply of compressed air seems to be optimal.
  • a tangential can also support this Arrangement of the channels 22 based on the mixing chamber 23 act.
  • a flat design of the channels 22 for the compressed air is also preferred, since this not only simplifies cleaning of the channels but also of the mixing chamber.
  • the channel 13 for the atomizing material in the nozzle insert 1 can be cleaned with a wire or a nylon cord.
  • the atomized material Since there is an overpressure due to the supply of compressed air to the mixing chamber 23, the atomized material must be added under pressure through the channel 13 in the nozzle insert 1. This offers the possibility of varying the ratio of the mass flows to the quantity of atomization material supplied. Practically any amount of the atomized material can be atomized, since a much larger amount (> 250 ⁇ l / min) than the amount of up to 50 ⁇ l / min that is useful for therapeutic purposes can be added. With an air flow of 4.5 to 5 l / min and a pressure difference of 2 bar, the therapeutically useful amount can also be dried off without any problems. As a result, particles of the primary aerosol with a diameter of up to 16 ⁇ m are reduced to such an extent by drying alone that an aerosol which contains 100% respirable particles is produced by the atomizing nozzle according to the invention without further aftertreatment.
  • the advantages of the atomizer nozzle according to the invention lie in the ease of manufacture (mass article), in the simple structure (easy cleaning), in the possibility of metering the liquid phase (different formulations), in the fine primary droplet spectrum (relatively high initial concentration of the medicament solution possible, i.e. short inhalation times) and in the low pneumatic power requirement ( ⁇ p ⁇ 2 bar, air volume flow ⁇ 5 l / min, ie compressor operation possible, home therapy).
  • the air throughput of the atomizer nozzles examined with the pressure difference and the bore of the nozzle holder i.e. the diameter of the mixing chamber 23 increases.
  • a nozzle insert 1 with an outlet opening 14 of 0.30 mm (d 0.30) combined with a nozzle holder 2 with a mixing chamber 23 with a diameter of 0.40 mm (D 0.40)
  • the mean drop diameter increases with increasing mixing chamber diameter at constant pressure, initially goes through a minimum and then increases slightly again.
  • the duct dimensions are the same for all three nozzle holders.
  • the liquid is conveyed into the mixing chamber 23 with a constant volume flow through a bore of 0.30 mm in diameter.
  • a mixing chamber diameter D With a mixing chamber diameter D of 0.40 mm, its free cross section is smaller than the sum of the free cross sections of the channels 22 at the inlet of the mixing chamber.
  • the compressed air in the mixing chamber 23 is jammed.
  • a larger diameter of the mixing chamber 23 approximately 0.50 mm, the distance between the channel mouth and the liquid bore 14 is greater than with a smaller mixing chamber diameter.
  • the compressed air can relax too early. In both cases, if the mixing chamber diameter D is too small or too large, the release of the kinetic energy of the compressed air to the liquid is negatively influenced and the dispersion efficiency is worse.
  • both nozzle bodies, d 0.30 / D 0.45 and d 0.30 / D 0.40, have approximately that same performance efficiency.
  • the primary droplet spectrum requires a defined amount of dispersing air to dry.
  • the nozzle body 0.30 / DK 0.45 is therefore more suitable, because with it a constant liquid flow into a spray with a certain medium Droplet diameter is dispersed with more air flow and lower pressure difference.
  • the dispersion efficiency of the nozzle body d 0.30 / D 0.45 is independent of liquid flows up to 250 ⁇ l / min. Due to the air jet deflection and the acceleration of the air jet, certain shear forces corresponding to an operating point prevail in the mixing chamber. These shear forces counteract the surfaces on the liquid droplets. The surface force depends on the drop diameter. A certain shear force corresponds to a certain drop diameter, below which the drop cannot be further crushed. To disperse the liquid, a certain amount of energy corresponding to the amount of liquid is taken from the compressed air. The rest is used for transportation or dissipation. With larger liquid flows, the compressed air can release more dispersing energy. However, due to the required drying, only smaller liquid flows that are dependent on the air flow rate are useful.
  • the selection of the operating point of a nozzle can be made on the basis of the application of the product from the mean drop diameter and the air flow rate over the pressure difference. This criterion is also used to select a suitable compressor for home therapy.
  • the optimal operating point corresponds to the minimum in the course of this function.
  • the liquid flow and the drug concentration must then be adapted to the air throughput at the operating point. For short inhalation times, high fluid flows with a high drug concentration are required, which require high air throughputs and finer primary droplet distributions.
  • the nozzle is operated at pressures higher than the determined optimum energy.

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  • Fuel-Injection Apparatus (AREA)
  • Percussion Or Vibration Massage (AREA)
EP93120417A 1993-12-17 1993-12-17 Buse de pulverisation Expired - Lifetime EP0663241B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES93120417T ES2120471T3 (es) 1993-12-17 1993-12-17 Boquilla de pulverizacion.
AT93120417T ATE168289T1 (de) 1993-12-17 1993-12-17 Zerstäuberdüse
DK93120417T DK0663241T3 (da) 1993-12-17 1993-12-17 Forstøverdyse
EP93120417A EP0663241B1 (fr) 1993-12-17 1993-12-17 Buse de pulverisation
DE59308788T DE59308788D1 (de) 1993-12-17 1993-12-17 Zerstäuberdüse
CA002138234A CA2138234A1 (fr) 1993-12-17 1994-12-15 Tuyere pour nebuliseur
US08/760,911 US5740966A (en) 1993-12-17 1996-12-06 Nebulizer nozzle

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93120417A EP0663241B1 (fr) 1993-12-17 1993-12-17 Buse de pulverisation

Publications (2)

Publication Number Publication Date
EP0663241A1 true EP0663241A1 (fr) 1995-07-19
EP0663241B1 EP0663241B1 (fr) 1998-07-15

Family

ID=8213506

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93120417A Expired - Lifetime EP0663241B1 (fr) 1993-12-17 1993-12-17 Buse de pulverisation

Country Status (7)

Country Link
US (1) US5740966A (fr)
EP (1) EP0663241B1 (fr)
AT (1) ATE168289T1 (fr)
CA (1) CA2138234A1 (fr)
DE (1) DE59308788D1 (fr)
DK (1) DK0663241T3 (fr)
ES (1) ES2120471T3 (fr)

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EP1047560A1 (fr) * 1996-10-21 2000-11-02 Jemtex Ink Jet Printing Ltd Appareil et procede pour produire de multiples jets d'un fluide haute viscosite
WO2012010337A1 (fr) * 2010-07-20 2012-01-26 Sulzer Mixpac Ag Mélangeur à pulvérisation statique
WO2012010338A1 (fr) * 2010-07-20 2012-01-26 Sulzer Mixpac Ag Mélangeur à pulvérisation statique

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EP1272243B1 (fr) 2000-04-11 2005-10-26 Trudell Medical International Appareil aerosol avec une capacite de pression expiratoire positive
DE10163102A1 (de) * 2001-12-20 2003-07-10 Alto Deutschland Gmbh Hochdruckdüse, insbesondere für ein Hochdruckreinigungsgerät
US20030205226A1 (en) 2002-05-02 2003-11-06 Pre Holding, Inc. Aerosol medication inhalation system
US6904908B2 (en) 2002-05-21 2005-06-14 Trudell Medical International Visual indicator for an aerosol medication delivery apparatus and system
US7267120B2 (en) * 2002-08-19 2007-09-11 Allegiance Corporation Small volume nebulizer
JP4808970B2 (ja) * 2002-12-30 2011-11-02 ネクター セラピューティクス 噴霧乾燥システム
US7360537B2 (en) * 2003-04-16 2008-04-22 Trudell Medical International Antistatic medication delivery apparatus
EP3718532A1 (fr) 2005-12-08 2020-10-07 Insmed Incorporated Compositions a base de lipide d'anti-infectieux pour traiter des infections pulmonaires
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US20090215734A1 (en) * 2008-02-26 2009-08-27 Elevation Pharmaceuticals, Inc. Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
US20100055045A1 (en) * 2008-02-26 2010-03-04 William Gerhart Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
EP2852391B1 (fr) 2012-05-21 2021-11-17 Insmed Incorporated Systèmes de traitement d'infections pulmonaires
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
SI3104853T1 (sl) 2014-02-10 2020-03-31 Respivant Sciences Gmbh Zdravljenje s stabilizatorji mastocitov za sistemske motnje
US20160367520A1 (en) 2014-02-10 2016-12-22 Patara Pharma, LLC Mast cell stabilizers for lung disease treatment
ES2755941T3 (es) 2014-05-15 2020-04-24 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas
WO2017011729A1 (fr) 2015-07-16 2017-01-19 Patara Pharma, LLC Polythérapies pour le traitement de maladies pulmonaires
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
EP3331522A1 (fr) 2015-08-07 2018-06-13 Patara Pharma LLC Méthodes de traitement de troubles liés aux mastocytes par des stabilisateurs de mastocytes
WO2017034961A1 (fr) 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Procédés de traitement d'une infection pulmonaire avec la caspofungine
KR20180080189A (ko) 2015-09-01 2018-07-11 퍼스트 웨이브 바이오, 인코포레이티드 이상 염증 반응과 연관된 질환을 치료하기 위한 방법 및 조성물
GB2542142A (en) * 2015-09-08 2017-03-15 De Beers Uk Ltd Vacuum nozzle
AU2017321495A1 (en) 2016-08-31 2019-03-21 Respivant Sciences Gmbh Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
JP2019531308A (ja) 2016-10-07 2019-10-31 レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングＲｅｓｐｉｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ 肺線維症の治療のためのクロモリン組成物
WO2019040790A1 (fr) 2017-08-23 2019-02-28 Merakris Therapeutics, Llc Compositions contenant des composants amniotiques et leurs procédés de préparation et d'utilisation
WO2019157453A1 (fr) 2018-02-12 2019-08-15 Trilogy Therapeutics, Inc. Compositions de caspofongine pour inhalation
WO2019191627A1 (fr) 2018-03-30 2019-10-03 Insmed Incorporated Procédés pour la fabrication continue de produits médicamenteux liposomaux
WO2021142238A1 (fr) 2020-01-10 2021-07-15 First Wave Bio, Inc. Niclosamide deutéré
US10980756B1 (en) 2020-03-16 2021-04-20 First Wave Bio, Inc. Methods of treatment
US20230190684A1 (en) 2020-03-16 2023-06-22 First Wave Bio, Inc. Methods of treating covid-19 with a niclosamide compound
CN112934513B (zh) * 2021-01-29 2022-08-05 重庆重交再生资源开发股份有限公司 一种可拆卸式喷涂设备及其方法
WO2022212365A1 (fr) 2021-03-29 2022-10-06 Chimerix, Inc. Nucléosides de pyrrolopyrimidine pour le traitement ou la prévention d'une infection par sras-cov-2

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1047560A1 (fr) * 1996-10-21 2000-11-02 Jemtex Ink Jet Printing Ltd Appareil et procede pour produire de multiples jets d'un fluide haute viscosite
EP1047560A4 (fr) * 1996-10-21 2001-02-07 Jemtex Ink Jet Printing Ltd Appareil et procede pour produire de multiples jets d'un fluide haute viscosite
WO2012010337A1 (fr) * 2010-07-20 2012-01-26 Sulzer Mixpac Ag Mélangeur à pulvérisation statique
WO2012010338A1 (fr) * 2010-07-20 2012-01-26 Sulzer Mixpac Ag Mélangeur à pulvérisation statique
RU2567638C2 (ru) * 2010-07-20 2015-11-10 Зульцер Микспэк Аг Статический распылительный смеситель
US9770728B2 (en) 2010-07-20 2017-09-26 Sulzer Mixpac Ag Static spray mixer
US10265713B2 (en) 2010-07-20 2019-04-23 Sulzer Mixpac Ag Static spray mixer
US10625282B2 (en) 2010-07-20 2020-04-21 Sulzer Mixpac Ag Static spray mixer

Also Published As

Publication number Publication date
US5740966A (en) 1998-04-21
ATE168289T1 (de) 1998-08-15
CA2138234A1 (fr) 1995-06-18
DK0663241T3 (da) 1999-04-19
ES2120471T3 (es) 1998-11-01
EP0663241B1 (fr) 1998-07-15
DE59308788D1 (de) 1998-08-20

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