EP0607366A1 - Method of obtaining antiallergic components from the hot-bed field agaric body with exclusion of pathogenic organism - Google Patents

Method of obtaining antiallergic components from the hot-bed field agaric body with exclusion of pathogenic organism

Info

Publication number
EP0607366A1
EP0607366A1 EP93908794A EP93908794A EP0607366A1 EP 0607366 A1 EP0607366 A1 EP 0607366A1 EP 93908794 A EP93908794 A EP 93908794A EP 93908794 A EP93908794 A EP 93908794A EP 0607366 A1 EP0607366 A1 EP 0607366A1
Authority
EP
European Patent Office
Prior art keywords
disinfection
concentration
solution
agaric
hot
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93908794A
Other languages
German (de)
English (en)
French (fr)
Inventor
Josef Radosta
Hana Radostov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FELIS Co Ltd
Original Assignee
FELIS Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FELIS Co Ltd filed Critical FELIS Co Ltd
Publication of EP0607366A1 publication Critical patent/EP0607366A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/26—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating
    • A23L3/263—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating with corpuscular or ionising radiation, i.e. X, alpha, beta or omega radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/206—Ethylene oxide

Definitions

  • the hot-bed field agaric known also as champignon includes, according to a research made by French physician Daguin, a substance effective against the allergic diseases and especially, against the dermatic ones. The same physician has published in 1944 at that time a surprising finding based on the statistical data collected from 36 clinical cases that the dry extract from said champignon fungi includes a very effective substance bringing about the healing of various allergic diseases. After consumption of a greater quantity of champignons an outstanding decline in clinic&l symptoms of dermatic diseases and of bronchial allergies has accured.
  • the powder made from industrially cultivated champignon fungi is contaminated with large quantities of microbe cultures as for the instance Escherichia coli, Enterobacteria aerogenes, Staphylococcus epidermis, Staphylococcus aureus, Proteus, microbes of the genus Clostridium, Bacillus and a number of moulds. Therefore, the drug prepared and applied under above described conditions could not comply with regulations concerning the hygienical, food productive and medical requirements.
  • the object of the present invention comprises a specific method of champignon body treatment in order to preserve the same as an usual and harmless eatable component and to retain its effective substances bringing about an outstanding antiallergic effect.
  • this method of said champignon body treatment the dry champignon mass being obtained, for example, by drying it at temperatures not exceeding 60 oC or by lyophilization and by pulverization thereof is, subsequently, being disinfected by means of the solutions of chloramine, sorbic acid, ethanol, peracetic acid, benzole acid and by soluble salts thereof, respectively.
  • the fungus mass Before the next step the fungus mass is being rinsed with a drinking water and thereafter, sterilized by gas, as for the instance, by ethylen-oxid or glutaraldehyd within a closed environment. Subsequently, the fungus mass is cleaned with a stream of sterile air and.
  • ionization dose od 0,1 to 15 kGy.
  • a radiation source a cobalt charge of 60 Co-radiator is usedo
  • State Norm No. 86 6002 concerning the medical drugs
  • State Norm No. 56 01100 concerning microbiological testing of eatables, articles of a common use and of the food production environment.
  • the gathered champignon fungi were purified by a mechanical way and before the cutting thereof they have been disinfected in order to prevent leaching and subsequent loss of the substances providing for an antiallergic effect. Said disinfection was performed with 1,5 % solution of chloramide for the period of 15 minutes. Thereafter, the fungi were removed from said chloramine solution and rinsed with a drink water in order to wash off any residua of chlorine. After the dripping has taken place the fungi were cut and dried in a drier by steadily streaming air at temperature of 40 °C. Finally, the dry mass was pulverized an formed for the purpose of application per os. In addition, it fellowed the sterilization of the product by ionization from a cobalt charge emitting the dose of 10 kGy.
  • the mechanically purifie champignon fungi were disinfected by 1 % solution of sorbic for the period of 10 minutes o Subsequently, the fungi were rinsed with a drink water and thereafter cut, drie and pulverized. For purpose of inal sterilization by ionization a cobalt charge emitting dose of 8 kGy has been used.
  • the pathogenic substances therein are neutralized, and in addition, a leaching of antiallergic substances is prevented whereby an effective, hygienically and sanitary harmless substance is obtained being suitable for treatment of allergic difficulties.
  • the same substance would be applicable also externally for dermatological purposes as a cosmetic preparation with antiallergic affect.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Plasma & Fusion (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Storage Of Fruits Or Vegetables (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
EP93908794A 1992-04-07 1993-04-02 Method of obtaining antiallergic components from the hot-bed field agaric body with exclusion of pathogenic organism Withdrawn EP0607366A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CS1051/92 1992-04-07
CS921051A CZ282268B6 (cs) 1992-04-07 1992-04-07 Způsob získávání antialergických komponent z plodnic pečárky neobsahujících patogenní orga nismy
PCT/CZ1993/000008 WO1993020793A2 (en) 1992-04-07 1993-04-02 Method of obtaining antiallergic components from the hot-bed field agaric body with exclusion of pathogenic organism

Publications (1)

Publication Number Publication Date
EP0607366A1 true EP0607366A1 (en) 1994-07-27

Family

ID=5343897

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93908794A Withdrawn EP0607366A1 (en) 1992-04-07 1993-04-02 Method of obtaining antiallergic components from the hot-bed field agaric body with exclusion of pathogenic organism

Country Status (5)

Country Link
EP (1) EP0607366A1 (cs)
CA (1) CA2115431A1 (cs)
CZ (1) CZ282268B6 (cs)
PL (1) PL170917B1 (cs)
WO (1) WO1993020793A2 (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6575084B2 (en) * 2001-06-01 2003-06-10 Surebeam Corporation, Inc. System for, and method of, irradiating food products

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1592602A (cs) * 1967-11-03 1970-05-19
FR2512675B1 (fr) * 1981-09-17 1987-07-17 Viaud Henri Hydrolat d'agaricus biosporus et campester
EP0255814A3 (fr) * 1986-06-27 1989-08-16 Raymond Honnay Procédé pour améliorer la conservation de légumes et de fruit frais
US4810512A (en) * 1987-10-22 1989-03-07 Nestec S.A. Stabilization of color of green vegetables
GB9012790D0 (en) * 1990-06-08 1990-08-01 Interox Chemicals Ltd Food storage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9320793A2 *

Also Published As

Publication number Publication date
PL170917B1 (pl) 1997-02-28
CZ282268B6 (cs) 1997-06-11
AU673669B2 (en) 1996-11-21
PL308303A1 (en) 1995-07-24
WO1993020793A3 (en) 1993-11-25
CA2115431A1 (en) 1993-10-28
WO1993020793A2 (en) 1993-10-28
CZ105192A3 (en) 1994-02-16
AU3947293A (en) 1993-11-18

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