AU3947293A - Method of obtaining antiallergic components from the hotbed field agaric body with exclusion of pathogenic organism - Google Patents
Method of obtaining antiallergic components from the hotbed field agaric body with exclusion of pathogenic organismInfo
- Publication number
- AU3947293A AU3947293A AU39472/93A AU3947293A AU3947293A AU 3947293 A AU3947293 A AU 3947293A AU 39472/93 A AU39472/93 A AU 39472/93A AU 3947293 A AU3947293 A AU 3947293A AU 3947293 A AU3947293 A AU 3947293A
- Authority
- AU
- Australia
- Prior art keywords
- disinfection
- concentration
- solution
- agaric
- champignon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/26—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating
- A23L3/263—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating with corpuscular or ionising radiation, i.e. X, alpha, beta or omega radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/206—Ethylene oxide
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Plasma & Fusion (AREA)
- Optics & Photonics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Storage Of Fruits Or Vegetables (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Fruits And Vegetables (AREA)
Description
METH0D OF OBTAINING ANTIALLERGIC COMPOIJEIJTS PROM THE HOT-BED FIELD AGARIC BODY WITH EXCLUSION OP PATHOGENIC ORGANISM
The Field of Invention
The present invention relates to a method of treating the hot-bed field agaric body belonging to genus Agaricus hortensis capable of obtaining components providing for an antiallergic effect and being free of a contamination by pathogenic organises
Description of the Prior Art
The hot-bed field agaric known also as champignon includes, according to a research made by French physician Daguin, a substance effective against the allergic diseases and especially, against the dermatic ones. The same physician has published in 1944 at that time a surprising finding based on the statistical data collected from 36 clinical cases that the dry extract from said champignon fungi includes a very effective substance bringing about the healing of various allergic diseases. After consumption of a greater quantity of champignons an outstanding decline in clinic&l symptoms of dermatic diseases and of bronchial allergies has accured.
In ČSPR this particular problem has been studied by a medical team of Marie Apetauer, MD and Jaroslav Vesely, MD. The results of that study were published in Čs. Dermatology, 1975 No . 6, page 373-377 and later repeatedly in 1961, No. 5, page 329-334. In the period between 1957 and 1961 both physicians were occupied with testing the new therapy on some allergic diseases with use of a dry champignon substance of genus Agaricus campester hortensis Cooke and in result, they confirmed an outstanding antiallergic effect in cases of dermatic allergies both acute and chronic ones. The named authors recommended, with respect to the applied therapy using dry substance obtained from the champignon fungi, and on the ground of the clinically verified cases resisting, so far, to any
usual antiallergetic therapy, to introducd the new drug into production. This idea, however, has not been accepted because the drug obtained by the method known at that could not comply with the proper hygienical regulationso
Even at present, it is still not known which principle brings about the effect based on use of the champignon fungi. It is considered that the curative effect related to the allergic diseases may be dependent of some ferments included in the champignon substance and which, so far, could not be separated therefrom. However, according to present knowledge there exists relation between the way of fungus preparation and the healing effect and especially, it is known that a tretment at high temperatures could destroy or at least degrade the influence of the effective ferments. At present, there exists obvious increase in number of allergical disseases and especially among the infantile population.
These disseanses are characterized by various clinical symp» toms, however, they are mostly of a dermatic origin. The medicaments applied in such cases are neither indifferent nor without secondary effects. In addition, such medicaments are to be applied chronically and often for whole life which could influence the complete state of health. In comparision with the conventional medicaments the present drug obtained from champignon fungi provides for a reliable antiallergic effect without secondary indications.
From reasons stated above said drug is occasionally being introduced on market by the popular healers. It is a pity that this happens with a product which resulted from an unsatisfactory treatment and could cause the risks of a secondary infection for the patients. This is because of the presence of pathogenetic microorganisms which occure in intreated champignon fungi as in great quantities as in many genera. The champignon bodies, similarly as the bodies of other fungi of higher geni remain, in spite of the drying routine, strongly contaminated with microorganisms. In case of fungus plan-
ting in monocultures that contamination is far greater than at natural champignon cultures because the artificial planting requires application of a substrate fertilizer including the horse manure. Therefore, the powder made from industrially cultivated champignon fungi is contaminated with large quantities of microbe cultures as for the instance Escherichia coli, Enterobacteria aerogenes, Staphylococcus epidermis, Staphylococcus aureus, Proteus, microbes of the genus Clostridium, Bacillus and a number of moulds. Therefore, the drug prepared and applied under above described conditions could not comply with regulations concerning the hygienical, food productive and medical requirements.
Summary of the Invention
The main problem is seen in disinfecting and sterilizing the dry champignon mass in such a wav and by such means which would retain the effectiveness thereof. With respect to the fact that the effective substance itself, included obviously in the champignon fungus, is yet not known and that the present knowledge of the proper therapy capable of effective healing of the allergical symptoms is considerably uncomplete, there is the way in devoloping an utmost treatment and preparation of the fungus body mass belonging to the genus Agaricus and to the hybrides thereof.
Consequently, the object of the present invention comprises a specific method of champignon body treatment in order to preserve the same as an usual and harmless eatable component and to retain its effective substances bringing about an outstanding antiallergic effect. According to this method of said champignon body treatment the dry champignon mass being obtained, for example, by drying it at temperatures not exceeding 60 ºC or by lyophilization and by pulverization thereof is, subsequently, being disinfected by means of the solutions of chloramine, sorbic acid, ethanol, peracetic acid, benzole acid and by soluble salts thereof, respectively. Before the next step the fungus mass is being
rinsed with a drinking water and thereafter, sterilized by gas, as for the instance, by ethylen-oxid or glutaraldehyd within a closed environment. Subsequently, the fungus mass is cleaned with a stream of sterile air and.
thereafter sterilized with ionization dose od 0,1 to 15 kGy. As a radiation source a cobalt charge of 60Co-radiator is usedo
As a result, there is obtained a substance being completely harmless both from the hygienical and the medical point of view. At the production and the treatment of
food, eatables and pharmaceutical goods it is necessary to respect regulations and norms issued by the Miniεtry ot health and Ministry of agriculture and alimentation, namely the Provision of the MZd ČSSR No, 18 from 1 955 concerning the hygienical and antiepidemical conditions at the production of eatables, Provision No. 46 concerning the hygienical conditions of working environment, Norm No
86 2000 relating to the industrially produced pharmaceutical goods, State Norm No. 86 6002 concerning the medical drugs and State Norm No. 56 01100 concerning microbiological testing of eatables, articles of a common use and of the food production environment.
Examples of Elaboration of the Invention
Example 1
The gathered champignon fungi were purified by a mechanical way and before the cutting thereof they have been disinfected in order to prevent leaching and subsequent loss of the substances providing for an antiallergic effect. Said disinfection was performed with 1,5 % solution of chloramide for the period of 15 minutes. Thereafter, the fungi were removed from said chloramine solution and rinsed with a drink water in order to wash off any residua of chlorine. After the dripping has taken place the fungi were cut and dried in a drier by steadily streaming air at temperature of 40 °C. Finally, the dry mass was pulverized an formed
for the purpose of application per os. In addition, it fellowed the sterilization of the product by ionization from a cobalt charge emitting the dose of 10 kGy.
Example 2
The mechanically purifie champignon fungi were disinfected by 1 % solution of sorbic for the period of 10 minutes o Subsequently, the fungi were rinsed with a drink water and thereafter cut, drie and pulverized. For purpose of inal sterilization by ionization a cobalt charge emitting dose of 8 kGy has been used.
Example 3
In this case it wad used a different way of disinfeciton. The purified fungi were treated with 40 % solution of ethanol for the period of 10 minutes. Further steps which followed corresponded with previous example.
Industrial Utilization of the Invention
By the steps of disinfection and sterilization of the fungus mass the pathogenic substances therein are neutralized, and in addition, a leaching of antiallergic substances is prevented whereby an effective, hygienically and sanitary harmless substance is obtained being suitable for treatment of allergic difficulties. The same substance would be applicable also externally for dermatological purposes as a cosmetic preparation with antiallergic affect.
Claims (9)
1. A method of hot-bed field agaric mass treatment c h ar a c t ee r i z e d i n that the fungus bodies are mechanically purified, disinfected at least for the period of 3 minutes, rinsed with drink water or cleaned by a stream of sterile air, subsequently cut and dried by a sterile medium at temperatures not exceeding 60ºC, said mass thereafter being pulverized and formed into a final product suitable for use by a patient, and in addition, sterilized by ionizeition with use of 8 gamma Co-radiator emitting a dose not exceeding 15 kGy.
2. A method according to claim 1, c h a r a c t e r i z e d i n that said step of disinfection is performed by a solution of chloramine with, concentration thereof of 0,5 to 1,5 %.
3. A method according to claim 1, c h a r a c t e r i z e d i n that said step of disinfection is performed by & solution of sorbic acid with concentration thereof of 1 %.
4. A method according to claim 1, c h a r a c t e r i z e d i n that said step of disinfection is performed by a solution of ethenol with concentration thereof of 30 to 90 %.
5. A method according to claim 1, c h a r a c t e r i z e d i n that said atep of disinfection is performed by a solution of perβcetie ecid with concentration thereof of 0,05 to 0,2 %.
6. A method according to claim 1, c h e r a c t e r i z e d i n that said disinfection is performed by the derivatives of para-hydroxybenzoic acid.
7. A method sccording to claim 1, c h a r a c t e r i z e d i n that said disinfection step is performed by benzoic acid and by the soluble salts thereof with concentration of 1 to 3 % .
8. A method sccording to claim 1, c h a r a c t e r i z e d i n that said disinfection step is performed by ethylen oxide .
9. A method according to claim 1, c h a r a c t e r i z e d i n that said disinfection step is performed by glutaraldehyde.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS921051A CZ282268B6 (en) | 1992-04-07 | 1992-04-07 | Process of obtaining anti-allergic components from mushroom bodies which do not contain pathogenic organisms |
PCT/CZ1993/000008 WO1993020793A2 (en) | 1992-04-07 | 1993-04-02 | Method of obtaining antiallergic components from the hot-bed field agaric body with exclusion of pathogenic organism |
Publications (3)
Publication Number | Publication Date |
---|---|
AU3947293A true AU3947293A (en) | 1993-11-18 |
AU673669B2 AU673669B2 (en) | 1996-11-21 |
AU673669C AU673669C (en) | 1997-08-14 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
CZ282268B6 (en) | 1997-06-11 |
AU673669B2 (en) | 1996-11-21 |
CZ105192A3 (en) | 1994-02-16 |
WO1993020793A3 (en) | 1993-11-25 |
EP0607366A1 (en) | 1994-07-27 |
PL170917B1 (en) | 1997-02-28 |
PL308303A1 (en) | 1995-07-24 |
CA2115431A1 (en) | 1993-10-28 |
WO1993020793A2 (en) | 1993-10-28 |
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