EP0584262A1 - Spectrometre de masse a temps de vol tandem. - Google Patents

Spectrometre de masse a temps de vol tandem.

Info

Publication number
EP0584262A1
EP0584262A1 EP92913066A EP92913066A EP0584262A1 EP 0584262 A1 EP0584262 A1 EP 0584262A1 EP 92913066 A EP92913066 A EP 92913066A EP 92913066 A EP92913066 A EP 92913066A EP 0584262 A1 EP0584262 A1 EP 0584262A1
Authority
EP
European Patent Office
Prior art keywords
reflecting
flight
opening
mass analyzer
type mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP92913066A
Other languages
German (de)
English (en)
Other versions
EP0584262B1 (fr
EP0584262A4 (fr
Inventor
Robert J Cotter
Timothy J Cornish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of EP0584262A1 publication Critical patent/EP0584262A1/fr
Publication of EP0584262A4 publication Critical patent/EP0584262A4/en
Application granted granted Critical
Publication of EP0584262B1 publication Critical patent/EP0584262B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/406—Time-of-flight spectrometers with multiple reflections

Abstract

Spectromètre de masse à temps de vol tandem comprenant une enceinte à vide mise à la terre (7), deux analyseurs de masse de type réfléchissant (1, 2) couplée par l'intermédiaire d'une chambre de collision (15) et des canaux de vol (3, 4) isolés électriquement par rapport à l'enceinte à vide mise à la terre (7). Le premier analyseur de masse de type réfléchissant (1) reçoit des molécules ionisées (ions). Ces ions traversent le canal de vol (3) du premier analyseur de masse de type réfléchissant (1) et sont fragmentée dans la chambre de collision (15). Les ions fragmentés traversent le canal de vol (4) du deuxième analyseur de masse de type réfléchissant (2). Des détecteurs (03, 04) situés dans la chambre de collision (15) et dans le deuxième analyseur de masse de type réfléchissant (2) détectant le spectre du premier analyseur de masse de type réfléchissant (1), ainsi que les spectres de l'analyseur de masse à temps de vol tandem (100) respectivement.
EP92913066A 1991-05-16 1992-05-15 Spectrometre de masse a temps de vol tandem Expired - Lifetime EP0584262B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US700697 1991-05-16
US07/700,697 US5202563A (en) 1991-05-16 1991-05-16 Tandem time-of-flight mass spectrometer
PCT/US1992/003884 WO1992021140A1 (fr) 1991-05-16 1992-05-15 Spectrometre de masse a temps de vol tandem

Publications (3)

Publication Number Publication Date
EP0584262A1 true EP0584262A1 (fr) 1994-03-02
EP0584262A4 EP0584262A4 (fr) 1994-08-31
EP0584262B1 EP0584262B1 (fr) 1997-07-16

Family

ID=24814545

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92913066A Expired - Lifetime EP0584262B1 (fr) 1991-05-16 1992-05-15 Spectrometre de masse a temps de vol tandem

Country Status (6)

Country Link
US (1) US5202563A (fr)
EP (1) EP0584262B1 (fr)
JP (1) JPH07500449A (fr)
CA (1) CA2103038C (fr)
DE (1) DE69220943T2 (fr)
WO (1) WO1992021140A1 (fr)

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DE19631161A1 (de) * 1996-08-01 1998-02-12 Bergmann Thorald Flugzeit-Flugzeit-Massenspektrometer mit differentiell gepumpter Kollisionszelle
DE19631162A1 (de) * 1996-08-01 1998-02-12 Bergmann Thorald Kollisionszelle mit integriertem Ionenselektor für Flugzeit-Flugzeit-Massenspektrometer
US6469295B1 (en) * 1997-05-30 2002-10-22 Bruker Daltonics Inc. Multiple reflection time-of-flight mass spectrometer
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AU8274798A (en) * 1997-07-02 1999-01-25 Merck & Co., Inc. Novel mass spectrometer
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US6348688B1 (en) 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
CA2275140C (fr) * 1998-06-18 2008-04-29 Micromass Limited Spectrometre de masse a admission multiple
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US6858839B1 (en) * 2000-02-08 2005-02-22 Agilent Technologies, Inc. Ion optics for mass spectrometers
US6570152B1 (en) 2000-03-03 2003-05-27 Micromass Limited Time of flight mass spectrometer with selectable drift length
GB2406436B (en) * 2000-03-13 2005-06-08 Univ Warwick Time of flight mass spectrometry apparatus
US6545268B1 (en) 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
US20020195555A1 (en) * 2000-10-11 2002-12-26 Weinberger Scot R. Apparatus and methods for affinity capture tandem mass spectrometry
CA2425434A1 (fr) * 2000-10-11 2002-04-18 Tina Morris Procedes de caracterisation d'interactions moleculaires au moyen de la spectrometrie de masse en tandem pour capture par affinite
US6570153B1 (en) 2000-10-18 2003-05-27 Agilent Technologies, Inc. Tandem mass spectrometry using a single quadrupole mass analyzer
US6441369B1 (en) 2000-11-15 2002-08-27 Perseptive Biosystems, Inc. Tandem time-of-flight mass spectrometer with improved mass resolution
AU2002255502A1 (en) * 2001-02-01 2002-10-03 The Johns Hopkins University Diagnosis of pathogen infections using mass spectral analysis of immune system modulators in post-exposure biological samples.
US20040234971A1 (en) * 2001-02-01 2004-11-25 Joany Jackman Diagnosis of pathogen infections using mass spectral analysis of immune system modulators in post-exposure biological samples
US6777671B2 (en) * 2001-04-10 2004-08-17 Science & Engineering Services, Inc. Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same
US6781117B1 (en) 2002-05-30 2004-08-24 Ross C Willoughby Efficient direct current collision and reaction cell
EP1597749A2 (fr) * 2003-02-21 2005-11-23 The Johns Hopkins University School Of Medicine Spectrometre de masse de temps de vol en tandem
US7385187B2 (en) * 2003-06-21 2008-06-10 Leco Corporation Multi-reflecting time-of-flight mass spectrometer and method of use
GB2403063A (en) * 2003-06-21 2004-12-22 Anatoli Nicolai Verentchikov Time of flight mass spectrometer employing a plurality of lenses focussing an ion beam in shift direction
US7199363B2 (en) * 2003-10-14 2007-04-03 Micromass Uk Limited Mass spectrometer
US7297960B2 (en) * 2003-11-17 2007-11-20 Micromass Uk Limited Mass spectrometer
CA2546645A1 (fr) * 2003-11-25 2005-06-09 Syft Technologies Limited Ameliorations portant sur des instruments sift-ms
JP4214925B2 (ja) * 2004-02-26 2009-01-28 株式会社島津製作所 質量分析装置
JP4980583B2 (ja) * 2004-05-21 2012-07-18 日本電子株式会社 飛行時間型質量分析方法及び装置
WO2006037059A2 (fr) 2004-09-27 2006-04-06 The Johns Hopkins Universtiy Systeme de spectrometrie de masse de point d'intervention
US7351958B2 (en) * 2005-01-24 2008-04-01 Applera Corporation Ion optics systems
US7439520B2 (en) * 2005-01-24 2008-10-21 Applied Biosystems Inc. Ion optics systems
JP4581958B2 (ja) * 2005-10-18 2010-11-17 株式会社島津製作所 質量分析装置
US8626449B2 (en) * 2006-10-17 2014-01-07 The Regents Of The University Of California Biological cell sorting and characterization using aerosol mass spectrometry
GB0620963D0 (en) * 2006-10-20 2006-11-29 Thermo Finnigan Llc Multi-channel detection
GB0624677D0 (en) * 2006-12-11 2007-01-17 Shimadzu Corp A co-axial time-of-flight mass spectrometer
US7663100B2 (en) * 2007-05-01 2010-02-16 Virgin Instruments Corporation Reversed geometry MALDI TOF
DE102007048618B4 (de) * 2007-10-10 2011-12-22 Bruker Daltonik Gmbh Gereinigte Tochterionenspektren aus MALDI-Ionisierung
US8138472B2 (en) * 2009-04-29 2012-03-20 Academia Sinica Molecular ion accelerator
CN104508792B (zh) 2012-06-18 2017-01-18 莱克公司 使用非均匀采样的串联式飞行时间质谱法
GB201613988D0 (en) 2016-08-16 2016-09-28 Micromass Uk Ltd And Leco Corp Mass analyser having extended flight path
GB2567794B (en) 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
GB2563571B (en) 2017-05-26 2023-05-24 Micromass Ltd Time of flight mass analyser with spatial focussing
WO2019030477A1 (fr) 2017-08-06 2019-02-14 Anatoly Verenchikov Accélérateur pour spectromètres de masse à passages multiples
US11239067B2 (en) 2017-08-06 2022-02-01 Micromass Uk Limited Ion mirror for multi-reflecting mass spectrometers
US11295944B2 (en) 2017-08-06 2022-04-05 Micromass Uk Limited Printed circuit ion mirror with compensation
EP3662503A1 (fr) 2017-08-06 2020-06-10 Micromass UK Limited Injection d'ions dans des spectromètres de masse à passages multiples
US11049712B2 (en) 2017-08-06 2021-06-29 Micromass Uk Limited Fields for multi-reflecting TOF MS
WO2019030475A1 (fr) 2017-08-06 2019-02-14 Anatoly Verenchikov Spectromètre de masse à multipassage
US11081332B2 (en) 2017-08-06 2021-08-03 Micromass Uk Limited Ion guide within pulsed converters
GB201806507D0 (en) 2018-04-20 2018-06-06 Verenchikov Anatoly Gridless ion mirrors with smooth fields
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201807605D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
GB201901411D0 (en) 2019-02-01 2019-03-20 Micromass Ltd Electrode assembly for mass spectrometer

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DE4106796A1 (de) * 1991-03-04 1991-11-07 Wollnik Hermann Ein flugzeit-massenspektrometer als sekundaerstufe eines ms-ms systems

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PATENT ABSTRACTS OF JAPAN vol. 10, no. 255 (E-433) (2311) 2 September 1986 & JP-A-61 082 652 (SHIMADZU CO.) 26 April 1986 *
See also references of WO9221140A1 *

Also Published As

Publication number Publication date
EP0584262B1 (fr) 1997-07-16
EP0584262A4 (fr) 1994-08-31
DE69220943D1 (de) 1997-08-21
DE69220943T2 (de) 1997-12-04
US5202563A (en) 1993-04-13
CA2103038C (fr) 2002-08-13
WO1992021140A1 (fr) 1992-11-26
JPH07500449A (ja) 1995-01-12
CA2103038A1 (fr) 1992-11-17

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