EP0570446B1 - Method of coating a substrate with a liquid - Google Patents
Method of coating a substrate with a liquid Download PDFInfo
- Publication number
- EP0570446B1 EP0570446B1 EP92904219A EP92904219A EP0570446B1 EP 0570446 B1 EP0570446 B1 EP 0570446B1 EP 92904219 A EP92904219 A EP 92904219A EP 92904219 A EP92904219 A EP 92904219A EP 0570446 B1 EP0570446 B1 EP 0570446B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- nozzle
- process according
- internal nozzle
- gas inlet
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011248 coating agent Substances 0.000 title claims abstract description 14
- 238000000576 coating method Methods 0.000 title claims abstract description 14
- 239000000758 substrate Substances 0.000 title claims abstract description 9
- 238000000034 method Methods 0.000 title claims description 48
- 239000007788 liquid Substances 0.000 title description 25
- 239000000314 lubricant Substances 0.000 claims abstract description 35
- 239000000126 substance Substances 0.000 claims abstract description 7
- 239000012530 fluid Substances 0.000 claims abstract 12
- 239000000725 suspension Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 230000002093 peripheral effect Effects 0.000 claims description 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000007789 gas Substances 0.000 description 29
- 238000013461 design Methods 0.000 description 4
- 239000000976 ink Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000005499 meniscus Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 238000007142 ring opening reaction Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/10—Spray pistols; Apparatus for discharge producing a swirling discharge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
- B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
- B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
Definitions
- the invention relates to a method for applying a liquid to a substrate, using a device with a two-substance nozzle, according to the preamble of patent claim 1.
- Methods of this type can also be used for microdosing and in particular for introducing an active ingredient into a carrier, such as a tablet.
- Another important application of such methods is the coating of a press chamber with a lubricant: for example in the manufacture of tablets for human and / or veterinary medicine, catalysts and various foodstuffs, it is necessary to use the upper punch or the male and the lower punch or coat the die with a lubricant to facilitate both the pressing process and the ejection of the tablet after the pressing process is complete.
- a press chamber coating device is shown in Fig. 1 of this article.
- a nozzle system is used which has a two-substance nozzle from which lubricant mixed with air emerges intermittently.
- lubricant medium and air are alternately metered into the nozzle prechamber.
- the lubricant is applied essentially to the bottom surfaces of the male and female dies or the lower die; According to the invention, however, it has been recognized that lubricant is required, in particular, on the peripheral edge of the tablet, ie the die, that is to say at the locations to which only comparatively little lubricant is used in the known device is applied. With this device, more lubricant than required is thus applied to the floor surfaces if the amount of lubricant on the press chamber peripheral wall (ie die) is optimally metered.
- EP-A-0 244 204 discloses a method and a device for applying a liquid to a substrate; this method was used in the formulation of the preamble of claim 1.
- the device has a two-substance nozzle which has an inner nozzle with an outlet opening and an annular space coaxially surrounding this inner nozzle.
- the annular space has an outlet opening surrounding the outlet opening of the inner nozzle.
- At least one gas inlet nozzle opens into the lateral surface of the annular space, the longitudinal axis of which does not intersect the longitudinal axis of the inner nozzle.
- a device is also provided which supplies the liquid to the inner nozzle and a gas to the annular space.
- EP-A-0 244 204 does not specify any operating parameters which would allow the liquid to be discharged on a hollow cone, as would be optimal according to the above statements, for example for coating press chambers with a lubricant.
- the invention has for its object to develop a method for applying a liquid to a substrate according to the preamble of claim 1 such that it is possible, inter alia. to obtain annular application images on the substrate, so that, for example, when using the method according to the invention for coating a press chamber, the lubricant is primarily applied to the press chamber peripheral wall.
- the gas entering the annular space which can be in particular air, but also an inert gas, such as nitrogen or a noble gas, is placed in a "turbulent ring flow" in the process according to the invention, which due to the metering of the liquid at the Exit opening of the inner nozzle formed convex meniscus "entrains".
- the liquid is transported to the substrate essentially in a rotating path, which lies approximately on a conical surface.
- the conical path results in a significantly thicker coating of the peripheral surface than the bottom surface, and in particular an excellent lubricant application to the between the lower stamp and the die formed gap.
- a nozzle system is provided for each of the upper and lower tools, which is arranged such that the outlet openings lie opposite the respective bottom surface of the tool.
- the “cone angle” depends on the distance (in the direction of the longitudinal axis) of the inner nozzle from the surrounding outlet opening and the dimensions of the individual elements:
- the ring or point diameter is reduced. Conversely, the ring diameter increases when the distance is reduced:
- a cone angle of approximately 90 ° is obtained with the usual viscosities of lubricants used in the pharmaceutical sector if the inner nozzle protrudes 0.1 mm beyond the ring opening with the specified dimensions.
- the “inner diameter of the ring" can be made so small by appropriate design of the nozzle that in practice there is a point with a particularly preferred almost rectangular distribution of the coating material over the "area of the point".
- suspensions which can be used in the process according to the invention have the advantage that practically all of the alcohol (e.g. ethanol) "evaporates” between the outlet opening and the tool surface or substrate, so that the lubricant is applied “dry”.
- the permanent gas flow prevents the lubricant from “falling back” into the nozzle and other causes of contamination.
- the method according to the invention enables the smallest amounts of liquid to be metered, so that it can be used in particular for microdosing.
- the gas inlet nozzle has a cross-sectional constriction to increase the gas velocity, which in particular can at least reach the value 2.
- a turbulent gas flow to provide at least two gas inlet nozzles in the annular space.
- the gas inlet nozzles can be spaced in the direction of the longitudinal axis of the inner nozzle or they can be in the same plane, which is preferably as close as possible to the annular outlet opening.
- the liquid is conveyed from a storage container via a pump and a valve system and corresponding connecting lines back into the storage container, and the amount of liquid required for the discharge in the almost unpressurized part of the circuit is removed via a bypass line, the cross section of which preferably smaller by at least a factor of 3 than the cross section of the Delivery line is a particularly pulsation-free, yet intermittently operable variable delivery of the small amounts of liquid required in the inventive method is achieved.
- the method according to the invention is described below as an example for the coating of a press chamber.
- the nozzle system designed according to the invention can be used in the same way for microdosing or for a printer and in particular a so-called large-character printer.
- the device for coating a press chamber 1 with a lubricant such as is used in particular for the production of tablets, has an inner nozzle 2 with a longitudinal axis 2 ', to which the lubricant is fed intermittently.
- a body 3 forms, together with the inner nozzle, an annular space 4 surrounding it.
- two gas inlet nozzles 51 and 52 with longitudinal axes 51 'and 52' are provided, which are diametrically opposed to one another with respect to the axis of the inner nozzle and - at the embodiment shown - have a distance in the direction of the axis of the inner nozzle 2.
- the axis of the gas inlet nozzles do not intersect the axis of the inner nozzle 2.
- the axes of the gas inlet nozzle lie approximately in the tangent to the outer boundary wall of the annular space.
- a gas for example air
- the gas inlet nozzles 51 and 52 have a cross-sectional constriction, which typically reduces the cross-sectional area by at least a factor of 2. This makes it possible to supply small gas flows with low overpressures, typically in the range from 100 to 500 mbar. Nevertheless, there is good swirling of the gas in the annular space 4.
- An outlet opening 33 for the gas surrounding the inner nozzle 2 is provided in the end face 32 of the body 3.
- the front boundary surface of the inner nozzle 2 projects approximately 0.1 mm above the ring opening 33.
- the boundary surface of the inner nozzle is preferably ground conically at a 30 ° to 45 ° angle.
- the lubricant container can be a diffusion-proof bag with inlet and outlet and visual inspection.
- the liquid is preferably metered intermittently into the rotating gas stream with a high-speed microvalve.
- the dosing and dispensing process takes about 0.5 to 1 msec.
- An almost unpressurized liquid is applied to the valve, so that it can be controlled at frequencies of 100 to approximately 300 Hz or more. Nevertheless, the gas consumption is only about 2 l / min.
- the inventive lubricant is conveyed on a rotating path that runs obliquely to the nozzle axis.
Abstract
Description
Die Erfindung bezieht sich auf ein Verfahren zum Auftragen einer Flüssigkeit auf ein Substrat, unter Verwendung einer Vorrichtung mit einer Zweistoffdüse, gemäß dem Oberbegriff des Patentanspruchs 1.The invention relates to a method for applying a liquid to a substrate, using a device with a two-substance nozzle, according to the preamble of
Gattungsgemäße Verfahren werden beispielsweise in sogenannten Tintenstrahl-Druckern insbesondere für das "Large Character Printing" eingesetzt.Generic methods are used, for example, in so-called inkjet printers, in particular for "large character printing".
Weiterhin können derartige Verfahren zur Mikrodosierung und insbesondere zum Einbringen eines Wirkstoffs in einen Träger, wie beispielsweise eine Tablette, benutzt werden.Methods of this type can also be used for microdosing and in particular for introducing an active ingredient into a carrier, such as a tablet.
Eine weitere wichtige Anwendung derartiger Verfahren ist das Beschichten einer Preßkammer mit einem Schmiermittel: Beispielsweise bei der Herstellung von Tabletten für die Human- und/oder Tiermedizin, von Katalysatoren und verschiedenen Lebensmittels ist es erforderlich, den Oberstempel bzw. die Patrize und den Unterstempel bzw. die Matrize mit einem Schmiermittel zu beschichten, um sowohl den Preßvorgang als auch den Ausstoß der Tablette nach Beendigung des Preßvorgangs zu erleichtern.Another important application of such methods is the coating of a press chamber with a lubricant: for example in the manufacture of tablets for human and / or veterinary medicine, catalysts and various foodstuffs, it is necessary to use the upper punch or the male and the lower punch or coat the die with a lubricant to facilitate both the pressing process and the ejection of the tablet after the pressing process is complete.
In der DE-A-27 17 438 ist vorgeschlagen worden, das Schmiermittel auf die Verdichtungswerkzeuge aufzusprühen. Weitere Einzelheiten zu dem in dieser Druckschrift beschriebenen Verfahren sind dem Artikel "Preßkammerbeschichtung, ein Beitrag zur Optimierung der Tablettenherstellung", erschienen in Pharm. Ind. 50, 7, 839-845 (1988) oder der DE-A-39 02 293 zu entnehmen.In DE-A-27 17 438 it has been proposed to spray the lubricant onto the compression tools. Further details on the process described in this publication can be found in the article "Press chamber coating, a contribution to optimizing tablet production", published in Pharm. Ind. 50 , 7, 839-845 (1988) or DE-A-39 02 293 .
In Abb.1 dieses Artikel ist eine Preßkammer-Beschichtungsvorrichtung dargestellt. Bei dieser Vorrichtung wird ein Düsensystem verwendet, das eine Zweistoffdüse aufweist, aus der mit Luft gemischtes Schmiermittel intermittierend austritt. Hierzu werden nacheinander im Wechsel Schmiermittel-Medium und Luft in die Düsenvorkammer dosiert.A press chamber coating device is shown in Fig. 1 of this article. In this device, a nozzle system is used which has a two-substance nozzle from which lubricant mixed with air emerges intermittently. For this purpose, lubricant medium and air are alternately metered into the nozzle prechamber.
Diese bekannte Vorrichtung ermöglicht zwar eine drastische Verringerung des pro Preßlings benötigten Schmiermittels auf Größenordnungen von 0,01 bis 0,01 mg pro Preßling, erfindungsgemäß ist aber erkannt worden, daß auch diese bekannte Vorrichtung noch einen wesentlichen Nachteil aufweist, der einen weiteren Verringerung der pro Preßling eingesetzten Schmiermittelmenge entgegen steht:Although this known device allows a drastic reduction in the lubricant required per compact to orders of magnitude of 0.01 to 0.01 mg per compact, but it has been recognized according to the invention that this known device also has a significant disadvantage, which further reduces the pro The amount of lubricant used is opposed to:
Bei dieser Vorrichtung erfolgt der Schmiermittel-Auftrag im wesentlichen auf die Bodenflächen der Patrize und der Matrize bzw. des Unterstempels; erfindungsgemäß ist aber erkannt worden, daß Schmiermittel insbesondere am Umfangsrand der Tablette, d.h. der Matrize benötigt wird, also an den Stellen, auf die bei der bekannten Vorrichtung nur vergleichsweise wenig Schmiermittel aufgetragen wird. Damit wird bei dieser Vorrichtung auf die Bodenflächen mehr Schmiermittel als benötigt aufgetragen, wenn die Schmiermittelmenge an der Preßkammer-Umfangswand (i.e. Matrize) optimal dosiert ist.In this device, the lubricant is applied essentially to the bottom surfaces of the male and female dies or the lower die; According to the invention, however, it has been recognized that lubricant is required, in particular, on the peripheral edge of the tablet, ie the die, that is to say at the locations to which only comparatively little lubricant is used in the known device is applied. With this device, more lubricant than required is thus applied to the floor surfaces if the amount of lubricant on the press chamber peripheral wall (ie die) is optimally metered.
Hierzu wäre es erforderlich, das Schmiermittel auf einem Hohlkegel auszutragen; dies ist aber mit dem aus der DE-A-27 17 438 bekannten Verfahren bzw. der aus dieser Druckschrift bekannten Vorrichtung nicht möglich.For this it would be necessary to discharge the lubricant on a hollow cone; however, this is not possible with the method known from DE-A-27 17 438 or the device known from this document.
Aus der EP-A-0 244 204 ist ein Verfahren und eine Vorrichtung zum Auftragen einer Flüssigkeit auf ein Substrat bekannt; von diesem Verfahren ist bei der Formulierung des Oberbegriffs des Anspruchs 1 ausgegangen worden. Die Vorrichtung weist eine Zweistoffdüse auf, die eine innere Düse mit einer Austrittsöffnung und einen diese innere Düse koaxial umgebenden Ringraum aufweist. Der Ringraum besitzt eine die Austrittsöffnung der inneren Düse umgebende Austrittsöffnung. In die Mantelfläche des Ringraumes mündet wenigstens eine Gaseintrittsdüse, deren Längsachse die Längsache der inneren Düse nicht schneidet. Ferner ist eine Einrichtung vorgesehen, die der inneren Düse die Flüssigkeit und dem Ringraum ein Gas zuführt. In der EP-A-0 244 204 sind keine Betriebsparameter angegeben, die das Austragen der Flüssigkeit auf einem Hohlkegel erlauben würden, wie es entsprechend des vorstehenden Darlegungen beispielsweise für die Beschichtung von Preßkammern mit einem Schmiermittel optimal wäre.EP-A-0 244 204 discloses a method and a device for applying a liquid to a substrate; this method was used in the formulation of the preamble of
Der Erfindung liegt die Aufgabe zugrunde, ein Verfahren zum Auftragen einer Flüssigkeit auf ein Substrat gemäß dem Oberbegriff des Patentanspruchs 1 derart weiterzubilden, daß es möglich ist, u.a. ringförmige Auftragbilder auf dem Substrat zu erhalten, so daß beispielsweise bei einer Verwendung des erfindungsgemäßen Verfahrens zur Beschichtung einer Preßkammer das Schmiermittel primär auf die Preßkammer-Umfangswand aufgetragen wird.The invention has for its object to develop a method for applying a liquid to a substrate according to the preamble of
Eine erfindungsgemäße Lösung dieser Aufgabe ist im kennzeichnenden Teil des Patentanspruchs 1 angegeben. Weiterbildungen der Erfindung sind Gegenstand der abhängigen Ansprüche.An inventive solution to this problem is specified in the characterizing part of
Bei dem erfindungsgemäßen Verfahren ist die Flüssigkeit eine Lösung, eine Dispersion oder eine Suspension eines Beschichtungsstoffes in einer verdampfbaren Trägerflüssigkeit. Die Einrichtung führt der inneren Düse die Flüssigkeit inermittierend und dem Ringraum das Gas kontinuierlich zu. Weiterhin sind der Abstand zwischen dem vorderen Ende der inneren Düse und der die innere Düse umgebenden Austrittsöffnung des Ringraums sowie der Innen- und Außendurchmesser und der Kegelwinkel der innneren Düse in Abhängigkeit von der Viskosität und der Oberflächenspannung der verwendeten Flüssigkeit derart gewählt, daß bei der inneren Düse nur ein geringer Venturieffekt auftritt, so daß die Flüssigkeit auf einem Hohlkegel ausgetragen wird, wobei
- der Abstand zwischen dem vorderen Ende der innern Düse und der die innere Düse umgebenden Austrittsöffnung des Ringraums insbesondere 0,1 mm,
- der Innendurchmesser der inneren Düse insbesondere 0,4 bis 0,6 mm,
- der Außendurchmesser der inneren Düse insbesondere 0,7 mm, und
- der Kegelwinkel der inneren Düse insbesondere 30° bis 45° beträgt.
- the distance between the front end of the inner nozzle and the outlet opening of the annular space surrounding the inner nozzle, in particular 0.1 mm,
- the inner diameter of the inner nozzle in particular 0.4 to 0.6 mm,
- the outer diameter of the inner nozzle in particular 0.7 mm, and
- the cone angle of the inner nozzle is in particular 30 ° to 45 °.
Aufgrund dieser Ausbildung wird bei dem erfindungsgemäßen Verfahren das in den Ringraum eintretende Gas, das insbesondere Luft, aber auch ein inertes Gas, wie Stickstoff oder ein Edelgas sein kann, in eine "turbulente Ringströmung" versetzt, die den aufgrund der Dosierung der Flüssigkeit an der Austrittsöffnung der inneren Düse gebildeten konvexen Meniskus "mitreißt". Die Flüssigkeit wird im wesentlichen auf einem rotierenden Weg, der in etwa auf einer Kegelfläche liegt, zu dem Substrat transportiert.Because of this design, the gas entering the annular space, which can be in particular air, but also an inert gas, such as nitrogen or a noble gas, is placed in a "turbulent ring flow" in the process according to the invention, which due to the metering of the liquid at the Exit opening of the inner nozzle formed convex meniscus "entrains". The liquid is transported to the substrate essentially in a rotating path, which lies approximately on a conical surface.
So ergibt sich beispielsweise bei der Verwendung eines erfindungsgemäßen Verfahrens zur Beschichtung einer Preßkammer bei geeignetem Abstand der Zweistoffdüse von der Bodenfläche des Stempels aufgrund der kegelförmigen Bahn eine deutlich stärkere Beschichtung der Umfangsfläche als der Bodenfläche, und insbesondere eine hervorragende Schmiermittel-Beaufschlagung des zwischen Unterstempels und Matrize gebildeten Spalts.For example, when using a method according to the invention for coating a press chamber with a suitable distance of the two-component nozzle from the bottom surface of the stamp, the conical path results in a significantly thicker coating of the peripheral surface than the bottom surface, and in particular an excellent lubricant application to the between the lower stamp and the die formed gap.
In diesem Anwendungsfall eines erfindungsgemäßen Verfahrens ist es bevorzugt, wenn für das Ober- und das Unterwerkzeug jeweils ein Düsensystem vorgesehen ist, das so angeordnet ist, daß die Austrittsöffnungen der jeweiligen Bodenfläche des Werkzeugs gegenüberliegen.In this application of a method according to the invention, it is preferred if a nozzle system is provided for each of the upper and lower tools, which is arranged such that the outlet openings lie opposite the respective bottom surface of the tool.
Dabei ist der "Kegelwinkel" von dem Abstand (in Richtung der Längsachse) der inneren Düse von der umgebenden Austrittsöffnung sowie den Abmessungen der einzelnen Elemente abhängig:The "cone angle" depends on the distance (in the direction of the longitudinal axis) of the inner nozzle from the surrounding outlet opening and the dimensions of the individual elements:
Vergrößert man den Abstand, so reduziert sich der Ring- bzw. Punktdurchmesser. Umgekehrt vergrößert sich der Ringdurchmesser bei einer Verkleinerung des Abstandes:If you increase the distance, the ring or point diameter is reduced. Conversely, the ring diameter increases when the distance is reduced:
Beispielsweise erhält man einen Kegelwinkel von ca 90° bei üblichen Viskositäten von im pharmazeutischen Bereich eingesetzten Schmiermitteln, wenn bei den angegebenen Abmessungen die innere Düse um 0,1 mm über die Ringöffnung vorsteht.For example, a cone angle of approximately 90 ° is obtained with the usual viscosities of lubricants used in the pharmaceutical sector if the inner nozzle protrudes 0.1 mm beyond the ring opening with the specified dimensions.
Durch geeignete Wahl des Abstandes zwischen dem vorderen Ende der inneren Düse und der die innere Düse umgebenden Austrittsöffnung sowie der Ausbildung und insbesondere des Innendurchmessers der inneren Düse sowie in Abhängigkeit von der Viskosität und der Oberflächenspannung der Flüssigkeit kann erreicht werden, daß konvexe Flüssigkeit-Meniskus im wesentlichen durch den durch das rotierend ausströmende Gas erzeugten Unterdruck "mitgerissen" wird, daß also bei der inneren Düse nur ein geringer Venturieffekt auftritt. Damit ergibt sich der besonders vorteilhafter "ringförmiger Auftrag" der Flüssigkeit.By a suitable choice of the distance between the front end of the inner nozzle and the outlet opening surrounding the inner nozzle and the design and in particular the inner diameter of the inner nozzle and depending on the viscosity and the surface tension of the liquid, it can be achieved that convex liquid meniscus in the is essentially "carried away" by the negative pressure generated by the rotatingly flowing gas, so that only a slight Venturi effect occurs in the inner nozzle. This results in the particularly advantageous "annular application" of the liquid.
Durch entsprechende Ausbildung der Düse kann der "innere Durchmesser des Rings" so klein gemacht werden, daß sich in der Praxis ein Punkt mit einer besonders bevorzugten nahezu rechteckförmigen Verteilung des Beschichtungs-Stoffes über die "Fläche des Punktes" ergibt.The "inner diameter of the ring" can be made so small by appropriate design of the nozzle that in practice there is a point with a particularly preferred almost rectangular distribution of the coating material over the "area of the point".
Abmessungen, mit denen dies für handelsübliche Tinten oder Schmiermittel bzw. übliche Schmiermittel-Suspensionen erreicht werden kann, sind beispielhaft im Anspruch 1 angegeben:
- Außendurchmesser der inneren Düse ca 0,7 mm,
- Innendurchmesser ca 0,4 - 0,6 mm
- Durchmesser der die innere Düse umgebenden Austrittsöffnung ca 1 bis 1,5 mm.
- Outer diameter of the inner nozzle approx. 0.7 mm,
- Inner diameter approx. 0.4 - 0.6 mm
- Diameter of the outlet opening surrounding the inner nozzle approx. 1 to 1.5 mm.
Selbstverständlich können aber auch andere Abmessungen gewählt werden: So erhält man besonders kleine Punkte, wenn man den Außendurchmesser der inneren Düse auf (beispielsweise) 0,2 mm und den Innendurchmesser auf 0,1 mm verkleinert.Of course, other dimensions can also be selected: This gives particularly small dots if the outer diameter of the inner nozzle is reduced to (for example) 0.2 mm and the inner diameter to 0.1 mm.
Vor allem aber tritt aufgrund der erfindungsgemäßen Ausbildung und insbesondere durch die permanente Umflutung der inneren Düse sowie durch das drucklose Zuführen der Suspension zum Filter, zum Ventil und zur Düse keine Scherung der Tinte oder der Schmiermittel-Suspension, d.h. keine Flüssigkeits-Zersetzung auf.Above all, however, due to the design according to the invention and in particular due to the permanent flooding of the inner nozzle and the pressure-free supply of the suspension to the filter, the valve and the nozzle, there is no shearing of the ink or the lubricant suspension, i.e. no liquid decomposition.
Damit können bei dem erfindungsgemäßen Verfahren nicht nur alle herkömmlichen Tinten und Schmiermittel eingesetzt werden, wie sie für die Tablettenherstellung typisch sind, beispielsweise eine Stearinsäure-Lösung, sondern es ist auch möglich, Tinten, Wirkstoffe oder Schmiermittel zu verarbeiten, die mit herkömmlichen Vorrichtungen nicht verarbeitbar sind, beispielsweise eine bis zu 50%-Suspension von Magnesiumstearat in Alkohol.This means that not only all conventional inks and lubricants such as are typical for tablet production, for example a stearic acid solution, can be used in the process according to the invention, but it is also possible to process inks, active ingredients or lubricants which cannot be processed with conventional devices are, for example an up to 50% suspension of magnesium stearate in alcohol.
Derartig hochprozentige Suspensionen können mit herkömmlichen Verfahren und Vorrichtungen nicht so präzise wie mit dem erfindungsgemäßen Verfahren dosiert werden. Die bei dem erfindungsgemäßen Verfahren verwendbaren Suspensionen haben den Vorteil, daß zwischen Austrittsöffnung und Werkzeug-Oberfläche, bzw. Substrat praktisch der gesamte Alkohol (z.B. Ethanol) "verdampft", so daß das Schmiermittel "trocken" aufgetragen wird. Darüberhinaus werden durch den permanenten Gasstrom ein "Zurückfallen" des Schmiermittels in die Düse sowie sonstige Verschmutzungsursachen verhindert.Such high percentage suspensions cannot be dosed with conventional methods and devices as precisely as with the method according to the invention. The suspensions which can be used in the process according to the invention have the advantage that practically all of the alcohol (e.g. ethanol) "evaporates" between the outlet opening and the tool surface or substrate, so that the lubricant is applied "dry". In addition, the permanent gas flow prevents the lubricant from “falling back” into the nozzle and other causes of contamination.
In jedem Falle ermöglicht es das erfindungsgemäße Verfahren, kleinste Flüssigkeitsmengen zu dosieren, so daß es insbesondere für die Mikrodosierung verwendbar ist.In any case, the method according to the invention enables the smallest amounts of liquid to be metered, so that it can be used in particular for microdosing.
Weiterhin ist es möglich, mit Schmiermittelmengen in der Größenordnung von vorzugsweise 0,1-20 µg Schmiermittel pro Preßling zu arbeiten, d.h. die erfindungsgemäß benötigten Schmiermittelmengen liegen um mehrere Größenordnungen unter den beim Stand der Technik benötigten Mengen.It is also possible to work with amounts of lubricant on the order of preferably 0.1-20 µg of lubricant per compact, i.e. the amounts of lubricant required according to the invention are several orders of magnitude lower than the amounts required in the prior art.
Gemäß Anspruch 2 weist die Gaseintrittsdüse zur Erhöhung der Gasgeschwindigkeit eine Querschnittsverengung auf, die insbesondere wenigstens den Wert 2 erreichen kann.According to
Durch die im Anspruch 4 angegebenen Druckverhältnisse, gemäß denen das Gas mit einem Überdruck von bevorzugt 100 bis 500 mbar zugeführt wird, ergibt sich ein minimaler Luftstrom, der dennoch einen guten Flüssigkeitsauftrag bewirkt.The pressure conditions specified in claim 4, according to which the gas is supplied at an excess pressure of preferably 100 to 500 mbar, result in a minimal air flow, which nevertheless causes good liquid application.
Die Weiterbildung, bei der die Achse der Gaseintrittsdüse in etwa in der Tangente an die äußere Begrenzungswand des Ringraums liegt, hat den Vorteil, daß sich eine besonders günstige turbulente Strömung ergibt.The development in which the axis of the gas inlet nozzle lies approximately in the tangent to the outer boundary wall of the annular space has the advantage that a particularly favorable turbulent flow results.
Besonders vorteilhaft für eine turbulente Gas-Strömung ist es, im Ringraum wenigstens zwei Gaseintrittsdüsen vorzusehen.It is particularly advantageous for a turbulent gas flow to provide at least two gas inlet nozzles in the annular space.
Bei der Verwendung zweier Gaseintrittsdüsen liegen sich diese bezogen auf die Achse der inneren Düse diametral gegenüber, während bei der Verwendung von drei oder mehr Gaseintrittsdüsen deren Längsachsen bei einer Projektion auf eine zur Längsachse der inneren Düse senkrechte Ebene gleichen Winkelabstand haben. Durch die Verwendung von drei oder mehr, bevorzugt vier Gaseintrittsdüsen wird die "ringförmige Ausströmung" am Gasauslaß weiter begünstigt.When using two gas inlet nozzles, these are diametrically opposed with respect to the axis of the inner nozzle, while when using three or more gas inlet nozzles, their longitudinal axes have the same angular distance when projected onto a plane perpendicular to the longitudinal axis of the inner nozzle. The use of three or more, preferably four, gas inlet nozzles further promotes the "annular outflow" at the gas outlet.
Die Gaseintrittsdüsen können in Richtung der Längsachse der inneren Düse einen Abstand aufweisen oder in der gleichen Ebene liegen, die bevorzugt möglichst nahe an der ringförmigen Austrittsöffnung liegt.The gas inlet nozzles can be spaced in the direction of the longitudinal axis of the inner nozzle or they can be in the same plane, which is preferably as close as possible to the annular outlet opening.
Durch die Weiterbildung, bei der die Flüssigkeit aus einem Vorratsbehälter über eine Pumpe und ein Ventilsystem sowie entsprechende Verbindungsleitungen zurück in den Vorratsbehälter gefördert wird, und die für den Austrag benötigte Flüssigkeitsmenge im nahezu drucklosen Teil des Kreislaufes über eine Bypass-Leitung entnommen wird, deren Querschnitt vorzugsweise um mindestens den Faktor 3 kleiner als der Querschnitt der Förderleitung ist, wird eine besonders pulsationsfreie und dennoch intermittierend betreibbare variable Förderung der bei dem erfindungsgemäßen Verfahren benötigten kleinen Flüssigkeitsmengen erreicht.Through the further development, in which the liquid is conveyed from a storage container via a pump and a valve system and corresponding connecting lines back into the storage container, and the amount of liquid required for the discharge in the almost unpressurized part of the circuit is removed via a bypass line, the cross section of which preferably smaller by at least a factor of 3 than the cross section of the Delivery line is a particularly pulsation-free, yet intermittently operable variable delivery of the small amounts of liquid required in the inventive method is achieved.
Die Erfindung wird nachstehend ohne Beschränkung des allgemeinen Erfindungsgedankens anhand von Ausführungsbeispielen unter Bezugnahme auf die Zeichnung exemplarisch beschrieben, auf die im übrigen bezüglich der Offenbarung aller im Text nicht näher erläuterten erfindungsgemäßen Einzelheiten ausdrücklich verwiesen wird. Es zeigen:
- Fig. 1
- einen Längsschnitt durch eine bei dem erfindungsgemäßen Verfahren verwendete Vorrichtung,
- Fig. 2
- einen Querschnitt bei I-I in Fig. 1.
- Fig. 1
- 2 shows a longitudinal section through a device used in the method according to the invention,
- Fig. 2
- a cross section at II in Fig. 1st
Im folgenden wird das erfindungsgemäße Verfahren exemplarisch für die Beschichtung einer Preßkammer beschrieben. Es versteht sich jedoch von selbst, daß das erfindungsgemäß ausgebildete Düsensystem in gleicher Weise für die Mikrodosierung oder für einen Drucker und insbesondere einen sogenannten Large-Character-Printer verwendet werden kann.The method according to the invention is described below as an example for the coating of a press chamber. However, it goes without saying that the nozzle system designed according to the invention can be used in the same way for microdosing or for a printer and in particular a so-called large-character printer.
Die Vorrichtung zur Beschichtung einer Preßkammer 1 mit einem Schmiermittel, wie sie insbesondere für die Herstellung von Tabletten verwendet wird, weist eine innere Düse 2 mit einer Längsachse 2' auf, der das Schmiermittel intermittierend zugeführt wird.The device for coating a
Ein Körper 3 bildet zusammen mit der inneren Düse einen diese umgebenden Ringraum 4. In der Mantelfläche 31 des Ringraums sind zwei Gaseintrittsdüse 51 und 52 mit Längsachsen 51' und 52' vorgesehen, die sich bezogen auf die Achse der inneren Düse diametral gegenüberliegen und - bei dem gezeigten Ausführungsbeispiel - in Richtung der Achse der inneren Düse 2 einen Abstand aufweisen. Die Achse der Gaseintrittsdüsen schneiden die Achse der inneren Düse 2 nicht. Bei dem gezeigten Ausführungsbeispiel liegen die Achsen der Gaseintrittsdüse in etwa in der Tangente an die äußere Begrenzungswand des Ringraums.A
Durch die Gaseintrittsdüsen 51 und 52 wird ein Gas, beispielsweise Luft kontinuierlich zugeführt. Die Gaseintrittsdüsen 51 und 52 weisen zur Erhöhung der Gasgeschwindigkeit eine Querschnittsverengung auf, durch die sich die Querschnittsfläche typischerweise wenigstens um den Faktor 2 verringert. Damit ist es möglich, kleine Gasströme mit geringen Überdrücken, typischerweise im Bereich von 100 bis 500 mbar zuzuführen. Dennoch ergibt sich eine gute Verwirbelung des Gases im Ringraum 4.A gas, for example air, is fed continuously through the
In der Stirnfläche 32 des Körpers 3 ist eine die innere Düse 2 umgebende Austrittsöffnung 33 für das Gas vorgesehen.An outlet opening 33 for the gas surrounding the
Bei dem gezeigten Ausführungsbeispiel haben die einzelnen Teile folgenden Abmessungen:
- Außendurchmesser der inneren Düse: ca 0,7 mm,
- Innendurchmesser der inneren Düse: ca 0,4 mm
- Durchmesser der die innere Düse umgebenden Austrittsöffnung: ca 1 mm
- Outer diameter of the inner nozzle: approx. 0.7 mm,
- Inner diameter of the inner nozzle: approx. 0.4 mm
- Diameter of the outlet opening surrounding the inner nozzle: approx. 1 mm
Ferner steht die vordere Begrenzungsfläche der inneren Düse 2 ca 0,1mm über die Ringöffnung 33 vor.Furthermore, the front boundary surface of the
Die Begrenzungsfläche der inneren Düse ist bevorzugt unter einem 30° bis 45°-Winkel konisch angeschliffen.The boundary surface of the inner nozzle is preferably ground conically at a 30 ° to 45 ° angle.
Der Schmiermittel-Behälter kann ein diffusionsfester Beutel mit Zu- und Ablauf und Sichtkontrolle sein. Die Flüssigkeit wird vorzugsweise mit einem High-Speed-Mikroventil dem rotierenden permant anliegenden Gasstrom intermittierend zudosiert. Der Dosier- und Abgabevorgang dauert etwa 0,5 bis 1 msec. Das Ventil wird mit einer nahezu drucklosen Flüssigkeit beaufschlagt, so daß es mit Frequenzen von 100 bis ca 300 Hz oder mehr angesteuert werden kann. Dennoch beträgt der Gasverbrauch nur ca 2 l/min.The lubricant container can be a diffusion-proof bag with inlet and outlet and visual inspection. The liquid is preferably metered intermittently into the rotating gas stream with a high-speed microvalve. The dosing and dispensing process takes about 0.5 to 1 msec. An almost unpressurized liquid is applied to the valve, so that it can be controlled at frequencies of 100 to approximately 300 Hz or more. Nevertheless, the gas consumption is only about 2 l / min.
In jedem Falle wird durch die erfindungsgemäße Ausbildung das Schmiermittel auf einer rotierenden Bahn, die schräg zur Düsenachse verläuft, gefördert.In any case, the inventive lubricant is conveyed on a rotating path that runs obliquely to the nozzle axis.
Vorstehend ist die Erfindung anhand eines Ausführungsbeispiels beschrieben worden, innerhalb des allgemeinen Erfindungsgedankens, wie er in den Ansprüchen zum Ausdruck kommt, sind selbstverständlich die verschiedensten Abwandlungen möglich.The invention has been described above using an exemplary embodiment, and within the general inventive concept as expressed in the claims, a wide variety of modifications are of course possible.
In jedem Falle wird, da die fluidisierte Flüssigkeit rotierend geführt wird, die Bildung sog. Satelliten weitgehend vermieden.In any case, since the fluidized liquid is rotated, the formation of so-called satellites is largely avoided.
Claims (19)
- A process for applying a fluid onto a substrate using a a device having- a two-substance nozzle provided with- an internal nozzle (2) having an outlet opening and- a ring chamber (4) which coaxially surrounds said internal nozzle and which possesses an outlet opening (33) which surrounds said outlet opening of said internal nozzle (2), and at least one gas inlet nozzle (51, 52) which runs into the lateral surface (31) of said ring chamber (4) and the longitudinal axis (51', 52') of said gas inlet nozzle does not intersect the longitudinal axis (2') of said internal nozzle (2), and- a device which supplies said fluid to said internal nozzle (2) and a gas to said ring chamber (4)characterized by said fluid being a solution, a dispersion or a suspension of a coating substance in a vaporable carrier fluid, by said device supplying said fluid intermittently to said internal nozzle (2) and supplying said gas continuously to said ring chamber (4), and by the distance between the front end of said internal nozzle and said outlet opening (33) of said ring chamber (4) surrounding said internal nozzle (2) as well as the internal diameter and the external diameter and the conic angle of said internal nozzle (2) being selected dependent on the viscosity and the surface tension of the employed fluid in such a manner that only a small Venturi effect occurs in said internal nozzle (2) so that said fluid is discharged on a hollow cone, with- the distance between the front end of said internal nozzle (2) and said outlet opening (33) of said ring chamber (4) surrounding said internal nozzle (2) being in particular 0.1mm,- the internal diameter of said internal nozzle (2) being, in particular, 0.4 to 0.6 mm,- the exterior diameter of said internal nozzle (2) being, in particular, 0.7 mm, and- the cone angle of said internal nozzle (2) being, in particular, 30° to 45°.
- A process according to claim 1,
characterized by the cross-section of said gas inlet nozzle (51, 52) being contracted in order to increase the velocity of said gas. - A process according to claim 2,
characterized by said cross-section of said gas inlet nozzle (51, 52) being reduced by at least a factor 2 between said inlet and outlet. - A process according to claim 3,
characterized by said gas being conveyed with an overpressure of 100 to 500 mbar compared to the ambient pressure. - A process according to one of the claims 1 to 4,
characterized by the axis of said gas inlet nozzle (51, 52) lying in the tangent to the outer peripheral wall (31) of said ring chamber (4). - A process according to one of the claims 1 to 5,
characterized by said ring chamber (4) having two said gas inlet nozzles (51, 52) the longitudinal axes of which are diametrically opposite each other upon projection onto a plane running perpendicular to the longitudinal axis of said internal nozzle (2). - A process according to one of the claims 1 to 6,
characterized by said ring chamber (4) having three or more gas inlet nozzles the longitudinal axes of which have the same angular spacing upon projection onto a plane running perpendicular to the longitudinal axis of said internal nozzle (2). - A process according to claim 6 or 7,
characterized by the longitudinal axes of said gas inlet nozzles (51, 52) being spaced apart in the direction of said longitudinal axis of said internal nozzle (2). - A process according to claim 6 or 7,
characterized by the longitudinal axes of said gas inlet nozzles (51, 52) lying in the same plane which runs perpendicular to the longitudinal axis of said internal nozzle (2). - A process according to one of the claims 1 to 9,
characterized by the front periphery of said internal nozzle (2) being moveable relative to the ring chamber opening (33) in the direction of the longitudinal axis of said internal nozzle (2). - A process according to one of the claims 1 to 10,
characterized by air being said gas. - A process according to claim 11,
characterized by for one application, 0.1-20 µg of fluid being transported by setting the open time of a valve in the lubricant supply line dependent on the applied pressure. - A process according to one of the claims 1 to 12,
characterized by said fluid being transported from a supply tank via a pump and a valve system as well as corresponding connecting conduits back into said supply tank and the amount of lubricant required for the application being drawn from the pressureless part of the cycle via a bypass conduit the cross-section of which is at least smaller by a factor 3 than the cross-section of the transporting conduit. - A process according to claim 13,
characterized by said pump running briefly in suction operation after switching off the transport operation, and the valves of the lubricant supply device being opened. - A process according to one of the claims 1 to 14,
characterized by said process being utilized in an ink-jet printer. - A process according to one of the claims 1 to 15,
characterized by said process being utilized for microdosing and, in particular, for introducing the active substance of a medicine into a tablet. - A process according to one of the claims 1 to 16,
characterized by said process being utilized for microdosing and, in particular, for introducing the active substance of a medicine into a tablet. - A process according to claim 17,
characterized by said fluid being an up to 50% suspension of magnesium stearate in alcohol. - A process according to claim 17 or 18,
characterized by a nozzle system being provided for the top and the bottom tool respectively of said compression chamber with the outlet opening of said nozzle systems being arranged in such a manner that they are opposite the respective bottom surface of said tool.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4103413 | 1991-02-05 | ||
| DE4103413A DE4103413C1 (en) | 1991-02-05 | 1991-02-05 | |
| PCT/DE1992/000075 WO1992013643A1 (en) | 1991-02-05 | 1992-02-05 | Device for coating a pressing chamber with a lubricant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0570446A1 EP0570446A1 (en) | 1993-11-24 |
| EP0570446B1 true EP0570446B1 (en) | 1997-05-07 |
Family
ID=6424405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP92904219A Expired - Lifetime EP0570446B1 (en) | 1991-02-05 | 1992-02-05 | Method of coating a substrate with a liquid |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5609908A (en) |
| EP (1) | EP0570446B1 (en) |
| AT (1) | ATE152641T1 (en) |
| DE (2) | DE4103413C1 (en) |
| WO (1) | WO1992013643A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005037773B3 (en) * | 2005-08-10 | 2007-01-18 | Voss, Gunter M. | Solvent film application process for surface mold involves applying hollow-cone gas flow, applying medium, and applying hollow-cone gas flow at different gas pressure |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4400112A1 (en) * | 1994-01-04 | 1995-07-06 | Gunter M Voss | Process for making tablets |
| DE4400111C2 (en) * | 1994-01-04 | 2003-06-18 | Gunter M Voss | Process for making tablets |
| ES2130005B1 (en) * | 1995-06-05 | 2000-05-01 | Mangra S A | LIQUID ENZYME DISPENSER. |
| US6620358B2 (en) * | 1996-07-03 | 2003-09-16 | Gunter Voss | Process for manufacturing tablets |
| DE19647089A1 (en) * | 1996-11-14 | 1998-05-28 | Bayer Ag | Device for the controlled spraying of powdered lubricants onto punches and dies of tablet presses |
| US6461812B2 (en) | 1998-09-09 | 2002-10-08 | Agilent Technologies, Inc. | Method and multiple reservoir apparatus for fabrication of biomolecular arrays |
| US6702894B2 (en) | 2001-10-24 | 2004-03-09 | Hewlett-Packard Development Company, L.P. | Fluid ejection cartridge and system for dispensing a bioactive substance |
| US6623785B2 (en) * | 2001-06-07 | 2003-09-23 | Hewlett-Packard Development Company, L.P. | Pharmaceutical dispensing apparatus and method |
| US6962715B2 (en) * | 2001-10-24 | 2005-11-08 | Hewlett-Packard Development Company, L.P. | Method and dosage form for dispensing a bioactive substance |
| US6786591B2 (en) | 2002-10-24 | 2004-09-07 | Hewlett-Packard Development Company, L.P. | Fluid ejector apparatus and methods |
| US20040081689A1 (en) * | 2002-10-24 | 2004-04-29 | Dunfield John Stephen | Pharmaceutical dosage form and method of making |
| JP2004298891A (en) * | 2003-03-28 | 2004-10-28 | Mitsubishi Materials Corp | Powder molding die apparatus and powder compact molding method |
| US8609198B2 (en) * | 2004-07-21 | 2013-12-17 | Hewlett-Packard Development Company, L.P. | Pharmaceutical dose form with a patterned coating and method of making the same |
| US20070231432A1 (en) | 2006-03-29 | 2007-10-04 | Wm Wrigley Jr. Company | Sales methods for a printed comestible product |
| US8733274B2 (en) * | 2006-10-20 | 2014-05-27 | Hewlett-Packard Development Company, L.P. | Tube mounted inkjet printhead die |
| US7867548B2 (en) * | 2006-10-27 | 2011-01-11 | Hewlett-Packard Development Company, L.P. | Thermal ejection of solution having solute onto device medium |
| US20100021540A1 (en) * | 2008-02-28 | 2010-01-28 | Abbott Laboratories | Tablets and Preparation Thereof |
| DE102016123279B4 (en) * | 2016-12-01 | 2019-02-21 | Fette Compacting Gmbh | Method and system for feeding a lubricant or release agent to press tools of a tablet press |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3857363A (en) * | 1972-08-14 | 1974-12-31 | Olivetti & Co Spa | Device for the mist lubrication of dies for sintering |
| CH571365A5 (en) * | 1974-07-22 | 1976-01-15 | Fischer Ag Georg | |
| DE2717438A1 (en) * | 1977-04-20 | 1978-10-26 | Gunter M Voss | Moulding tool coating system - sprays lubricant onto working surfaces intermittently and briefly before each compression operation |
| DE2808342A1 (en) * | 1978-02-27 | 1979-09-06 | Gerd W Dr Ing Seifert | Swirl nozzle for lawn sprinkler or windscreen washer - has second fluid jet injected into spray jet to form conical jacket jet |
| ES485764A1 (en) * | 1978-11-15 | 1980-10-01 | Thomae Gmbh Dr K | Method and apparatus for dotting moulding devices by means of discrete droplets of a liquid or suspended lubricant during the manufacture of moulded objects in the pharmaceutical, food or catalytic field. |
| IT1134153B (en) * | 1979-11-21 | 1986-07-31 | Siv Soc Italiana Vetro | NOZZLE FOR STORING CONTINUOUSLY ON A SUBSTRATE A LAYER OF A SOLID MATERIAL |
| DE3020764C2 (en) * | 1980-05-31 | 1984-05-17 | Kollross, Günter, 6080 Groß-Gerau | Method and device for the inside oiling of tubular packaging material |
| DE3312634A1 (en) * | 1983-04-08 | 1984-10-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | IMPROVED METHOD AND DEVICES FOR POINTING MOLDING TOOLS WITH DROPLETS OF LIQUID OR SUSPENDED LUBRICANTS IN THE PRODUCTION OF FORMS IN THE PHARMACEUTICAL, FOOD OR CATALYST AREA |
| US4619597A (en) * | 1984-02-29 | 1986-10-28 | General Electric Company | Apparatus for melt atomization with a concave melt nozzle for gas deflection |
| CN87104313A (en) * | 1986-04-28 | 1988-07-20 | 西方包装系统有限公司 | Low pressure atomization nozzle |
| DE3902293A1 (en) * | 1989-01-26 | 1990-08-02 | Gunther M Voss | NEW METHOD FOR PRESS CHAMBER COATING BY LUBRICANT RING FORMING ON THE TABLET WALL OF TABLET PRESSES |
| JPH02274559A (en) * | 1989-04-18 | 1990-11-08 | Komori Corp | Head of image printer |
-
1991
- 1991-02-05 DE DE4103413A patent/DE4103413C1/de not_active Expired - Lifetime
-
1992
- 1992-02-05 DE DE59208462T patent/DE59208462D1/en not_active Expired - Fee Related
- 1992-02-05 WO PCT/DE1992/000075 patent/WO1992013643A1/en active IP Right Grant
- 1992-02-05 US US08/122,486 patent/US5609908A/en not_active Expired - Lifetime
- 1992-02-05 EP EP92904219A patent/EP0570446B1/en not_active Expired - Lifetime
- 1992-02-05 AT AT92904219T patent/ATE152641T1/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005037773B3 (en) * | 2005-08-10 | 2007-01-18 | Voss, Gunter M. | Solvent film application process for surface mold involves applying hollow-cone gas flow, applying medium, and applying hollow-cone gas flow at different gas pressure |
Also Published As
| Publication number | Publication date |
|---|---|
| DE59208462D1 (en) | 1997-06-12 |
| US5609908A (en) | 1997-03-11 |
| ATE152641T1 (en) | 1997-05-15 |
| DE4103413C1 (en) | 1992-11-12 |
| EP0570446A1 (en) | 1993-11-24 |
| WO1992013643A1 (en) | 1992-08-20 |
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