EP0471323A1 - Atomizer for liquid medicaments - Google Patents

Atomizer for liquid medicaments Download PDF

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Publication number
EP0471323A1
EP0471323A1 EP91113500A EP91113500A EP0471323A1 EP 0471323 A1 EP0471323 A1 EP 0471323A1 EP 91113500 A EP91113500 A EP 91113500A EP 91113500 A EP91113500 A EP 91113500A EP 0471323 A1 EP0471323 A1 EP 0471323A1
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EP
European Patent Office
Prior art keywords
nozzle
nebulizer
tip
gap
cylinder
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Granted
Application number
EP91113500A
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German (de)
French (fr)
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EP0471323B1 (en
Inventor
Waltraud Hecker
Ludwig Hallmannseder
Rudolf Schinagl
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PARI GmbH Spezialisten fuer Effektive Inhalation
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PAUL RITZAU PARI-WERK GmbH
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus

Definitions

  • the invention relates to a liquid nebulizer for nebulizing aqueous or oily medications during inhalation therapy with an atomizing nozzle for the discharge of compressed air, this nebuliser being intended for installation in a two-part nebulizing device, the lower part of which has a storage container for the liquid through the bottom thereof sealed the liquid nebulizer working on the Venturi principle is guided.
  • the invention has for its object to improve a liquid nebulizer so that optimal particle sizes are achieved in the sense of a fine atomization.
  • a nozzle body at the upper end has a nozzle opening which is surrounded by a concentric, annular gap which is connected to the storage container via channels, and that is at a distance from the nozzle opening a baffle plate is arranged, which carries a pin directed against the nozzle opening with a conical tip.
  • Negative pressure is generated by the compressed air flowing out of the nozzle opening.
  • liquid emerges from the annular gap, which is carried away by the rapidly flowing air and broken down into the finest drops rotating around its center, which burst further due to their high speed and form even smaller droplets.
  • This effect is further increased by the arrangement of the pin with the conical tip and by the baffle plate, because this creates a swirling of the stream consisting of compressed air and atomized liquid which is important for the atomization.
  • a defined amount of a medication must be inhaled for the treatment of respiratory diseases.
  • a maximum of medication is atomized by the invention, so that the inhalation time is minimized.
  • Another advantage of the invention is that the liquid is supplied to the gap through channels and thus in a controlled manner.
  • the liquid nebulizer shown in Figures 1 and 2 is part of a hand-held device for inhalations.
  • the liquid nebulizer is located within a two-part housing, of which the reservoir 20 for the liquid is shown in FIG. 2.
  • the housing (not shown in the rest) has a hose for the supply of compressed air (not shown) and a mouthpiece (not shown) at the top and is also equipped with a known nebulizer button (not shown), at the pressure of which the compressed air is operated becomes.
  • the liquid nebulizer consists of three parts, namely the nozzle body A, the cylinder sleeve B and the attachment C. These parts are connected to one another by simple plug connections.
  • the nozzle body A which is shown in FIG. 4, has a downwardly directed nozzle body extension 21 to which a compressed air line is connected. In the area of the nozzle body extension 21, the nozzle body A is guided through the bottom of the storage container 20 in a sealed manner.
  • the nozzle body A has a central nozzle channel 1 which runs in the longitudinal direction through the entire nozzle body.
  • the upper section of the nozzle body A is designed in the form of a nozzle cone 4 with a nozzle tip 3.
  • the nozzle opening 2 sits in the center of the nozzle tip 3, which is cylindrical on the outside.
  • the nozzle body A has ribs 5 on the outside, which together with the inner wall of the cylinder sleeve B form channels 7 in which the Liquid is sucked from the reservoir to the gap 2a.
  • the cylinder sleeve B shown in FIGS. 5 and 6 has an outer cylinder surface 9.
  • the cylinder formed in this way passes over a shoulder into the nozzle jacket 8 of smaller diameter.
  • the top of the nozzle jacket is designed as a depression 14.
  • the cylinder ring 12 forms together with the nozzle tip 3 an annular gap 2a which concentrically surrounds the nozzle opening 2 at a distance.
  • the cylinder sleeve B ends at the bottom somewhat above the bottom of the storage container 20, so that an annular gap 6 is formed.
  • the attachment C has a cylinder 15 at the bottom, the wall thickness of which corresponds to the dimension of the shoulder formed between the cylinder outer surface 9 and the nozzle jacket 8.
  • the cylinder 15 is connected to a baffle plate 16 via webs 19.
  • the baffle plate 16 has a pin 17, which is directed towards the nozzle opening 2 and has a conical tip 18.
  • the height of the cylinder 15 is dimensioned such that, in the installed state, its top is higher than the top of the nozzle jacket 8.
  • the top of the cylinder 15 is approximately at the height of the tip 18, a maximum distance of 0.2 mm should be provided.
  • the device described works as follows: If compressed air is passed through the nozzle channel 1, a negative pressure is created at the nozzle opening 2. The air is also swirled by deflecting the emerging air at the tip 18 of the pin 17 and at the baffle plate 16.
  • the effect of the Venturi principle is optimally used. This effect is further increased by the fact that the top of the nozzle jacket 8 is designed as a depression 14 and that the tip 18 has a tip angle of 140-160.

Abstract

A device for atomising medicines for inhalation therapy is described, in which a nozzle body (A) is provided at the upper end with a nozzle opening (2) which is surrounded by a cylindrical envelope (B) in order to produce a gap. In this arrangement, the gap connects with a reservoir via channels (7). A baffle which bears a pin with a conical tip (18) which is directed towards the nozzle opening is arranged opposite the nozzle opening at a distance therefrom. <IMAGE>

Description

Die Erfindung betrifft einen Flüssigkeitsvernebler für die Verneblung wäßriger oder öliger Medikamente bei der Inhalationstherapie mit einer Zerstäuberdüse für den Austritt von Druckluft, wobei dieser Vernebler für den Einbau in ein zweiteiliges Verneblungsgerät bestimmt ist, dessen unterer Teil einen Vorratsbehälter für die Flüssigkeit aufweist, durch dessen Boden abgedichtet der nach dem Venturi-Prinzip arbeitende Flüssigkeitsvernebler geführt ist.The invention relates to a liquid nebulizer for nebulizing aqueous or oily medications during inhalation therapy with an atomizing nozzle for the discharge of compressed air, this nebuliser being intended for installation in a two-part nebulizing device, the lower part of which has a storage container for the liquid through the bottom thereof sealed the liquid nebulizer working on the Venturi principle is guided.

Bei bekannten Vorrichtungen dieser Art werden flüssige pharmazeutische Substanzen unter der Wirkung der aus einer Düse austretenden Druckluft, wobei Unterdruck erzeugt wird, aus dem Vorratsbehälter angesaugt und in kleine Teilchen zerstäubt. Allerdings wird mit den bisher bekannten Vorrichtungen zwar eine Zerstäubung in Teilchen unterschiedlicher Größe erreicht, was für die Therapie wichtig ist, doch sind die kleinsten Teilchen noch zu groß, als daß sie bis in die letzten Verästelungen der Bronchien eindringen könnten.In known devices of this type, liquid pharmaceutical substances are sucked out of the storage container and atomized into small particles under the action of the compressed air emerging from a nozzle, whereby negative pressure is generated. However, with the previously known devices, atomization in particles of different sizes is achieved, which is important for therapy, but the smallest particles are still too large to penetrate into the last branches of the bronchi.

Der Erfindung liegt die Aufgabe zugrunde, einen Flüssigkeitsvernebler so zu verbessern, daß im Sinne einer Feinstvernebelung optimale Teilchengrößen erreicht werden.The invention has for its object to improve a liquid nebulizer so that optimal particle sizes are achieved in the sense of a fine atomization.

Die Lösung dieser Aufgabe besteht nach dem Anspruch 1 darin, daß ein Düsenkörper am oberen Ende eine Düsenöffnung aufweist, die von einem konzentrischen, ringförmigen Spalt umgeben ist, der über Kanäle mit dem Vorratsbehälter in Verbindung steht, und daß gegenüber der Düsenöffnung mit Abstand zu dieser eine Prallplatte angeordnet ist, die einen gegen die Düsenöffnung gerichteten Stift mit kegelförmiger Spitze trägt.This object is achieved according to claim 1 in that a nozzle body at the upper end has a nozzle opening which is surrounded by a concentric, annular gap which is connected to the storage container via channels, and that is at a distance from the nozzle opening a baffle plate is arranged, which carries a pin directed against the nozzle opening with a conical tip.

Durch das Ausströmen der Druckluft aus der Düsenöffnung wird Unterdruck erzeugt. Infolge dieses Unterdrucks tritt aus dem ringförmigen Spalt Flüssigkeit aus, die durch die schnell strömende Luft mitgerissen und in feinste, um ihren Mittelpunkt rotierende Tropfen zerlegt wird, die aufgrund ihrer hohen Drehzahl weiter zerplatzen und noch kleinere Tröpfchen bilden. Diese Wirkung wird noch gesteigert durch die Anordnung des Stiftes mit der kegelförmigen Spitze und durch die Prallplatte, weil dadurch eine für die Zerstäubung wichtige Verwirbelung des aus Druckluft und zerstäubter Flüssigkeit bestehenden Stroms entsteht.Negative pressure is generated by the compressed air flowing out of the nozzle opening. As a result of this negative pressure, liquid emerges from the annular gap, which is carried away by the rapidly flowing air and broken down into the finest drops rotating around its center, which burst further due to their high speed and form even smaller droplets. This effect is further increased by the arrangement of the pin with the conical tip and by the baffle plate, because this creates a swirling of the stream consisting of compressed air and atomized liquid which is important for the atomization.

Für die Behandlung von Atemwegserkrankungen ist eine definierte Menge eines Medikaments zu inhalieren. Durch die Erfindung wird ein Maximum an Medikament vernebelt, so daß die Inhalationszeit minimiert wird. Ein weiterer Vorteil der Erfindung besteht darin, daß die Flüssigkeit durch Kanäle und damit geregelt dem Spalt zugeführt wird.A defined amount of a medication must be inhaled for the treatment of respiratory diseases. A maximum of medication is atomized by the invention, so that the inhalation time is minimized. Another advantage of the invention is that the liquid is supplied to the gap through channels and thus in a controlled manner.

Vorteilhafte weitere Ausgestaltungen des Flüssigkeitsvernebler sind Gegenstand der Unteransprüche.Advantageous further developments of the liquid nebulizer are the subject of the subclaims.

Aus den Unteransprüchen ergibt sich, daß der aus drei Teilen bestehende Flüssigkeitsvernebler durch einfaches Zusammenstecken dieser einfach herstellbaren Teile gebildet wird.From the subclaims it follows that the three-part liquid nebulizer is formed by simply plugging these easily manufactured parts together.

Im folgenden wird die Erfindung anhand eines in der Zeichnung dargestellten Ausführungsbeispiels eines Verneblers für therapeutische Zwecke näher erläutert:

  • Es zeigt:
    • Fig. 1 einen Längsschnitt durch Vernebler mit in Ansicht dargestelltem Düsenkörper,
    • Fig. 2 den Vernebler im Längsschnitt in eingebautem Zustand;
    • Fig. 3 einen Schnitt durch die Zylinderhülse gemäß Linie A-A in Fig. 1 mit Draufsicht auf den Düsenkörper;
    • Fig. 4 den Düsenkörper in Seitenansicht, teilweise geschnitten;
    • Flg. 5 die Zylinderhülse in Seitenansicht, teilweise geschnitten;
    • Fig. 6 eine Unteransicht auf den in Fig. 5 dargestellten Gegenstand;
    • Fig. 7 den Aufsatz in Seitenansicht;
    • Fig. 8 den Aufsatz in der Draufsicht.
The invention is explained in more detail below on the basis of an exemplary embodiment of a nebulizer for therapeutic purposes shown in the drawing:
  • It shows:
    • 1 is a longitudinal section through the nebulizer with the nozzle body shown in view,
    • Figure 2 shows the nebulizer in longitudinal section in the installed state.
    • 3 shows a section through the cylinder sleeve along line AA in FIG. 1 with a plan view of the nozzle body;
    • 4 shows the nozzle body in a side view, partially in section;
    • Flg. 5 the cylinder sleeve in a side view, partially cut;
    • Fig. 6 is a bottom view of the object shown in Fig. 5;
    • 7 shows the attachment in a side view;
    • Fig. 8 shows the top view.

Der in den Figuren 1 und 2 dargestellte Flüssigkeitsvernebler ist Bestandteil eines Handgeräts für Inhalationen. Der Flüssigkeitsvernebler befindet sich innerhalb eines zweiteiligen Gehäuses, von dem in Fig. 2 der Vorratsbehälter 20 für die Flüssigkeit dargestellt ist. Das Gehäuse (im übrigen nicht dargestellt) weist unten einen Schlauch für die Zufuhr von Druckluft (nicht dargestellt) und oben ein Mundstück (nicht dargestellt) auf und ist auch mit einer bekannten Verneblertaste (nicht dargestellt) ausgerüstet, bei deren Drücken der Druckluft strom betätigt wird.The liquid nebulizer shown in Figures 1 and 2 is part of a hand-held device for inhalations. The liquid nebulizer is located within a two-part housing, of which the reservoir 20 for the liquid is shown in FIG. 2. The housing (not shown in the rest) has a hose for the supply of compressed air (not shown) and a mouthpiece (not shown) at the top and is also equipped with a known nebulizer button (not shown), at the pressure of which the compressed air is operated becomes.

Der Flüssigkeitsvernebler besteht aus drei Teilen, nämlich dem Düsenkörper A, der Zylinderhülse B und dem Aufsatz C. Diese Teile sind durch einfache Steckverbindungen miteinander verbunden.The liquid nebulizer consists of three parts, namely the nozzle body A, the cylinder sleeve B and the attachment C. These parts are connected to one another by simple plug connections.

Der Düsenkörper A, der für sich in Fig. 4 dargestellt ist, weist einen nach unten gerichteten Düsenkörperfortsatz 21 auf, an den eine Druckluftleitung angeschlossen wird. Im Bereich des Düserkörperfortsatzes 21 ist der Düsenkörper A abgedichtet durch den Boden des Vorratsbehälter 20 geführt.The nozzle body A, which is shown in FIG. 4, has a downwardly directed nozzle body extension 21 to which a compressed air line is connected. In the area of the nozzle body extension 21, the nozzle body A is guided through the bottom of the storage container 20 in a sealed manner.

Der Düsenkörper A weist einen zentrischen, durch den gesamten Düsenkörper in Längsrichtung verlaufenden Düsenkanal 1 auf. Der obere Abschnitt des Düsenkörpers A ist in Form eines Düsenkegels 4 mit einer Düsenspitze 3 ausgeführt. Mittig in der Düsenspitze 3, die außen zylindrisch ist, sitzt die Düsenöffnung 2.The nozzle body A has a central nozzle channel 1 which runs in the longitudinal direction through the entire nozzle body. The upper section of the nozzle body A is designed in the form of a nozzle cone 4 with a nozzle tip 3. The nozzle opening 2 sits in the center of the nozzle tip 3, which is cylindrical on the outside.

Im mittleren Abschnitt hat der Düsenkörper A außen Rippen 5, die zusammen mit der Innenwand der Zylinderhülse B Kanäle 7 bilden, in denen die Flüssigkeit aus dem Vorratsbehälter zum Spalt 2a angesaugt wird.In the middle section, the nozzle body A has ribs 5 on the outside, which together with the inner wall of the cylinder sleeve B form channels 7 in which the Liquid is sucked from the reservoir to the gap 2a.

Die in den Figuren 5 und 6 dargestellte Zylinderhülse B hat eine Zylinderaußenfläche 9. Der so gebildete Zylinder geht über einen Absatz in den Düsenmantel 8 kleineren Durchmessers über. Innen folgt - von unten nach oben - auf einen Innenzylinder, der gemäß Figuren 1 und 2 auch leicht kegelstumpfförmig sein kann, nach einem Absatz 11 in Form einer Ringschulter einen Innenkegelstumpf 13, der sich aus dem Bereich der Zylinderaußenfläche 9 bis in den Düsenmantel 4 erstreckt und oben in einem Zylinderring 12 endet. Die Oberseite des Düsenmantels ist als Senke 14 ausgebildet. Der Zylinderring 12 bildet zusammen mit der Düsenspitze 3 einen ringförmigen Spalt 2a, der die Düsenöffnung 2 mit Abstand konzentrisch umgibt.The cylinder sleeve B shown in FIGS. 5 and 6 has an outer cylinder surface 9. The cylinder formed in this way passes over a shoulder into the nozzle jacket 8 of smaller diameter. Inside follows - from bottom to top - an inner cylinder, which can also have a slightly frustoconical shape according to FIGS and ends up in a cylinder ring 12. The top of the nozzle jacket is designed as a depression 14. The cylinder ring 12 forms together with the nozzle tip 3 an annular gap 2a which concentrically surrounds the nozzle opening 2 at a distance.

Die Zylinderhülse B endet unten etwas oberhalb des Bodens des Vorratsbehälters 20, so daß ein Ringspalt 6 gebildet wird.The cylinder sleeve B ends at the bottom somewhat above the bottom of the storage container 20, so that an annular gap 6 is formed.

Der Aufsatz C weist unten einen Zylinder 15 auf, dessen Wandungsdicke der Abmessung des zwischen Zylinderaußenfläche 9 und Düsenmantel 8 gebildeten Absatzes entspricht. Über Stege 19 ist der Zylinder 15 mit einer Prallplatte 16 verbunden. Die Prallplatte 16 weist zentrisch einen gegen die Düsenöffnung 2 gerichteten Stift 17 auf, der eine kegelförmige Spitze 18 hat.The attachment C has a cylinder 15 at the bottom, the wall thickness of which corresponds to the dimension of the shoulder formed between the cylinder outer surface 9 and the nozzle jacket 8. The cylinder 15 is connected to a baffle plate 16 via webs 19. The baffle plate 16 has a pin 17, which is directed towards the nozzle opening 2 and has a conical tip 18.

Die Höhe des Zy linders 15 ist so bemessen, daß in eingebautem Zustand seine Oberseite höher liegt als die Oberseite des Düsenmantels 8. Die Oberseite des Zylinders 15 liegt etwa auf der Höhe des Spitze 18, maximal ist ein Abstand von 0,2 mm vorzusehen.The height of the cylinder 15 is dimensioned such that, in the installed state, its top is higher than the top of the nozzle jacket 8. The top of the cylinder 15 is approximately at the height of the tip 18, a maximum distance of 0.2 mm should be provided.

Die beschriebene Vorrichtung arbeitet wie folgt: Wird Druckluft durch den Düsenkanal 1 geleitet, dann entsteht an der Düsenöffnung 2 ein Unterdruck. Durch das Ablenken der austretenden Luft an der Spitze 18 des Stiftes 17 und an der Prallplatte 16 wird die Luft außerdem verwirbelt.The device described works as follows: If compressed air is passed through the nozzle channel 1, a negative pressure is created at the nozzle opening 2. The air is also swirled by deflecting the emerging air at the tip 18 of the pin 17 and at the baffle plate 16.

Infolge des Unterdrucks wird über die Kanäle 7 aus dem Vorratsbehälter 20 Flüssigkeit angesaugt, die dann durch den ringförmigen Spalt 6 austritt. Durch die Verengung des Strömungsquerschnitts bis auf den Querschnitt des düsenartig wirkenden Spalts 6 wird die Bewegung der Flüssigkeit beschleunigt, so daß die Flüssigkeit beim Austritt durch den Spalt 6 in einzelne Teilchen zerstäubt wird. Die rotierenden Teilchen, die schon durch ihre Rotation weiter zerkleinert werden, treffen dann noch auf die Spitze 18 des Stiftes 17 und auf die Prallplatte 16, so daß eine weitere Verwirbelung und damit ganz geringe Teilchengrößen erreicht werden.As a result of the negative pressure, liquid is sucked in from the storage container 20 via the channels 7 and then exits through the annular gap 6. By narrowing the flow cross section to the cross section of the nozzle-like gap 6, the movement of the liquid is accelerated so that the liquid is atomized into individual particles as it exits through the gap 6. The rotating particles, which are further crushed by their rotation, then still hit the tip 18 of the pin 17 and the baffle plate 16, so that a further swirling and thus very small particle sizes are achieved.

Durch die konzentrische Anordnung des ringförmigen Spalts 6 in Verbindung mit der kegelförmigen Spitze 18 des Stiftes 17 wird die Wirkung des Venturi-Prinzips optimal genutzt. Diese Wirkung wird noch dadurch gesteigert, daß die Oberseite des Düsenmantels 8 als Senke 14 ausgebildet ist und daß die Spitze 18 einen Spitzenwinkel von 140 - 160 hat.Due to the concentric arrangement of the annular gap 6 in connection with the conical tip 18 of the pin 17, the effect of the Venturi principle is optimally used. This effect is further increased by the fact that the top of the nozzle jacket 8 is designed as a depression 14 and that the tip 18 has a tip angle of 140-160.

Bei Versuchen mit einem erfindungsgemäß ausgebildeten Flüssigkeitsvernebler hat sich gezeigt, daß ca. 420 mg/min zerstäubt werden können und dabei die Teilchengröße des Nebels mit 50% unter 3um Teilchendurchmesser und mit 72% unter 5um beträgt, was eine optimale Vernebelung darstellt.Experiments with a liquid nebulizer designed according to the invention have shown that about 420 mg / min can be atomized and the particle size of the mist is 50% less than 3 µm particle diameter and 72% less than 5 µm, which is an optimal nebulization.

Zu große Teilchen setzen sich an der Innenwand des an den Flüssigkeitsvernebler anschließenden Mundrohres größeren Durchmessers ab und tropfen von dort in den Vorratsbehälter 20.Particles that are too large settle on the inner wall of the larger diameter connecting pipe connected to the nebuliser and drip from there into the storage container 20.

Claims (10)

1. Vorrichtung für die Verneblung wäßriger oder öliger Medikamente bei der Inhalationstherapie mit einer Zerstäuberdüse für den Austritt von Druckluft, wobei dieser Vernebler für den Einbau in ein zweiteiliges Verneblungsgerät bestimmt ist, dessen unterer Teil einen Vorratsbehälter für die Flüssigkeit aufweist, durch dessen Boden abgedichtet der nach dem Venturi-Prinzip arbeitende Flüssigkeitsvernebler geführt ist.
dadurch gekennzeichnet,
daß ein Düsenkörper (A) am oberen Ende eine Düsenöffnung (2) aufweist, die von einem konzentrischen, ringförmigen Spalt (6) umgeben ist, der über Kanäle (7) mit dem Vorratsbehälter (20) in Verbindung steht, und daß gegenüber der Düsenöffnung (2) mit Abstand zu dieser eine Prallplatte (16) angeordnet ist, die einen gegen die Düsenöffnung (2) gerichteten Stift (17) mit kegelförmiger Spitze (18) trägt.1. Device for the nebulization of aqueous or oily medications during inhalation therapy with an atomizing nozzle for the discharge of compressed air, this nebulizer being intended for installation in a two-part nebulizing device, the lower part of which has a reservoir for the liquid, the bottom of which seals liquid nebulizer operating on the Venturi principle.
characterized,
that a nozzle body (A) has at the upper end a nozzle opening (2) which is surrounded by a concentric, annular gap (6) which is connected to the reservoir (20) via channels (7), and that opposite the nozzle opening (2) a baffle plate (16) is arranged at a distance from it, which carries a pin (17) with a conical tip (18) directed towards the nozzle opening (2). 2. Vernebler nach Anspruch 1, dadurch gekennzeichnet, daß der Spalt (6) von der Düsenspitze (3) und einem Düsenmantel (8) gebildet ist und daß der Düsenmantel (8) den oberen Teil einer den Düsenkörper (A) umgebende Zylinderhülse (B) bildet.2. Nebuliser according to claim 1, characterized in that the gap (6) from the nozzle tip (3) and a nozzle jacket (8) is formed and that the nozzle jacket (8) the upper part of a nozzle sleeve (A) surrounding the cylinder sleeve (B ) forms. 3. Vernebler nach Anspruch 2, dadurch gekennzeichnet, daß die Zylinderhülse (B) unter Bildung eines unteren, als Zugangsöffnung zum Vorratsbehälter (20) dienenden Ringspalts (6) auf äußeren Rippen (5) des Düsenkörpers (A) sitzt und daß durch die Rippen (5) und die Innenwand der Zylinderhülse (B) die zum Spalt (2a) führenden Kanäle (7) gebildet sind.3. Nebulizer according to claim 2, characterized in that the cylinder sleeve (B) is seated on the outer ribs (5) of the nozzle body (A) and that through the ribs to form a lower annular gap (6) serving as an access opening to the reservoir (20) (5) and the inner wall of the cylinder sleeve (B) the channels (7) leading to the gap (2a) are formed. 4. Vernebler nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß der Durchmesser des Stiftes (17) dem Außendurchmesser des Spalts (2a) entspricht.4. Nebulizer according to one of claims 1 to 3, characterized in that the diameter of the pin (17) corresponds to the outer diameter of the gap (2a). 5. Vernebler nach einem der Ansprüche 2 bis 4, dadurch gekennzeichnet, daß die Oberseite des Düsenmantels (8) als Senke (14) ausgebildet ist, deren tiefster Punkt in der Ebene der Düsenöffnung (2) oder darüber liegt.5. Nebulizer according to one of claims 2 to 4, characterized in that the top of the nozzle jacket (8) is designed as a depression (14), the lowest point of which is in the plane of the nozzle opening (2) or above. 6. Vernebler nach einem der Ansprüche 2 bis 5, dadurch gekennzeichnet, daß auf der Zylinderhülse (B) ein Zylinder (15) sitzt, der über Stege (19) mit der Prallplatte (16) verbunden ist und mit dieser eine Einheit (Aufsatz C) bildet.6. Nebulizer according to one of claims 2 to 5, characterized in that on the cylinder sleeve (B) sits a cylinder (15) which is connected via webs (19) to the baffle plate (16) and with this a unit (attachment C ) forms. 7. Vernebler nach Anspruch 6, dadurch gekennzeichnet, daß die Oberkante des Zylinders (15) in einem maximalen Abstand von 0,2 mm von der Spitze (18) des Stiftes (17) angeordnet ist.7. Nebulizer according to claim 6, characterized in that the upper edge of the cylinder (15) is arranged at a maximum distance of 0.2 mm from the tip (18) of the pin (17). 8. Vernebler nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß der die Spitze (18) bildende Kegel einen Spitzenwinkel von 140-160° hat.8. Nebuliser according to one of claims 1 to 7, characterized in that the cone forming the tip (18) has a tip angle of 140-160 °. 9. Vernebler nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, daß der Boden des Flüssigkeitsbehälters (20) zur Mitte hin abfällt.9. Nebulizer according to one of claims 1 to 8, characterized in that the bottom of the liquid container (20) drops towards the center. 10. Vernebler nach einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, daß er aus Kunststoffteilen zusammengesteckt ist.10. Nebulizer according to one of claims 1 to 9, characterized in that it is put together from plastic parts.
EP91113500A 1990-08-13 1991-08-12 Atomizer for liquid medicaments Expired - Lifetime EP0471323B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE9011768U DE9011768U1 (en) 1990-08-13 1990-08-13
DE9011768U 1990-08-13

Publications (2)

Publication Number Publication Date
EP0471323A1 true EP0471323A1 (en) 1992-02-19
EP0471323B1 EP0471323B1 (en) 1999-12-01

Family

ID=6856490

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91113500A Expired - Lifetime EP0471323B1 (en) 1990-08-13 1991-08-12 Atomizer for liquid medicaments

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EP (1) EP0471323B1 (en)
JP (1) JPH04244168A (en)
AT (1) ATE187084T1 (en)
DE (2) DE9011768U1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5370318A (en) * 1991-06-28 1994-12-06 Glaxo Group Limited Atomizing nozzle for producing a spray from a liquid under pressure
EP0627266A2 (en) * 1993-06-04 1994-12-07 Medic-Aid Limited Nebuliser
US5875774A (en) * 1996-01-05 1999-03-02 Sunrise Medical Hhg Inc. Nebulizer
WO2007000330A2 (en) 2005-06-29 2007-01-04 Boehringer Ingelheim International Gmbh Method and device for atomising liquid
US9757528B2 (en) 2010-08-23 2017-09-12 Darren Rubin Nebulizer having different negative pressure threshold settings
CN109172965A (en) * 2018-10-24 2019-01-11 威海盛洁医疗科技有限公司 A kind of atomizing cup of the adjustable section of atomizing particle
EP3950028A1 (en) 2010-08-23 2022-02-09 Darren Rubin Systems and methods of aerosol delivery with airflow regulation

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9113446U1 (en) * 1991-10-29 1992-01-16 Kendall Medizinische Erzeugnisse Gmbh, 8425 Neustadt, De
GB0100756D0 (en) 2001-01-11 2001-02-21 Powderject Res Ltd Needleless syringe
GB0708758D0 (en) 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE100333C (en) *
DE1006354B (en) * 1954-03-19 1957-04-11 Paul Tegtmeier Liquid shower
US3762409A (en) * 1970-11-03 1973-10-02 V Lester Nebulizer
AU483193B2 (en) * 1975-12-03 1976-02-26 Hudson Oxygen Therapy Sales Company A nebulizer
EP0170715A1 (en) * 1984-08-09 1986-02-12 Inge Brugger Nebulizer
EP0261649A2 (en) * 1986-09-22 1988-03-30 Omron Tateisi Electronics Co. Nebulizer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE100333C (en) *
DE1006354B (en) * 1954-03-19 1957-04-11 Paul Tegtmeier Liquid shower
US3762409A (en) * 1970-11-03 1973-10-02 V Lester Nebulizer
AU483193B2 (en) * 1975-12-03 1976-02-26 Hudson Oxygen Therapy Sales Company A nebulizer
EP0170715A1 (en) * 1984-08-09 1986-02-12 Inge Brugger Nebulizer
EP0261649A2 (en) * 1986-09-22 1988-03-30 Omron Tateisi Electronics Co. Nebulizer

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5370318A (en) * 1991-06-28 1994-12-06 Glaxo Group Limited Atomizing nozzle for producing a spray from a liquid under pressure
US5370317A (en) * 1991-06-28 1994-12-06 Glaxo Group Limited Atomizing device for producing a spray from a liquid under pressure
EP0627266A2 (en) * 1993-06-04 1994-12-07 Medic-Aid Limited Nebuliser
EP0627266A3 (en) * 1993-06-04 1995-09-13 Aid Medic Ltd Nebuliser.
US5875774A (en) * 1996-01-05 1999-03-02 Sunrise Medical Hhg Inc. Nebulizer
WO2007000330A2 (en) 2005-06-29 2007-01-04 Boehringer Ingelheim International Gmbh Method and device for atomising liquid
US7611072B2 (en) 2005-06-29 2009-11-03 Boehringer Ingelheim International Gmbh Method and device for atomizing liquid
US9757528B2 (en) 2010-08-23 2017-09-12 Darren Rubin Nebulizer having different negative pressure threshold settings
EP3950028A1 (en) 2010-08-23 2022-02-09 Darren Rubin Systems and methods of aerosol delivery with airflow regulation
CN109172965A (en) * 2018-10-24 2019-01-11 威海盛洁医疗科技有限公司 A kind of atomizing cup of the adjustable section of atomizing particle

Also Published As

Publication number Publication date
DE9011768U1 (en) 1990-11-08
ATE187084T1 (en) 1999-12-15
DE59109170D1 (en) 2000-01-05
JPH04244168A (en) 1992-09-01
EP0471323B1 (en) 1999-12-01

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