EP0569532A1 - Compositions elastiques ameliorees de collodion - Google Patents

Compositions elastiques ameliorees de collodion

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Publication number
EP0569532A1
EP0569532A1 EP19920906146 EP92906146A EP0569532A1 EP 0569532 A1 EP0569532 A1 EP 0569532A1 EP 19920906146 EP19920906146 EP 19920906146 EP 92906146 A EP92906146 A EP 92906146A EP 0569532 A1 EP0569532 A1 EP 0569532A1
Authority
EP
European Patent Office
Prior art keywords
composition
composition according
acid
amount
salicylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920906146
Other languages
German (de)
English (en)
Inventor
Karl F. Popp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stiefel Research Australia Pty Ltd
Stiefel Laboratories Inc
Original Assignee
Stiefel Research Australia Pty Ltd
Stiefel Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stiefel Research Australia Pty Ltd, Stiefel Laboratories Inc filed Critical Stiefel Research Australia Pty Ltd
Publication of EP0569532A1 publication Critical patent/EP0569532A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Definitions

  • the present invention pertains to improved film-forming flexible collodion compositions intended for topical appli ⁇ cation and related methods.
  • USP United States Pharmacopoeia
  • BP British Pharmacopoeia
  • Collodion is a solution, typically 4 parts by weight of nitrocellulose dissolved in 75 parts by volume of ethyl ether and 25 parts by volume of ethanol.
  • Flexible collodion compositions are widely employed in human and veterinary applications.
  • Flexible collodion is generally a pale yellow, syrupy liquid which, when applied to the skin and thus exposed to air, dries forming a color ⁇ less or nearly colorless flexible, adherent film.
  • USP and BP flexible collodions can be used.
  • a useful flexible collodion composition typically consists of collodion with 2% by weight of camphor and 3% by weight of castor oil.
  • flexible collodion itself can be used as a skin protectant
  • various therapeutic agents often are added, as for example, salicylic acid, tannic acid, cantharides, camphor, and the like.
  • the present invention relates to improved flexible collodion compositions.
  • One or more topically acceptable polymers can be added to increase the resilience of the film formed by flexible collodion compositions.
  • a local anesthetic can be added to flexible collodion compositions containing a keratolytic agent to alleviate the localized discomfort and irritation often associated with the application of keratolytic agents to the skin.
  • a topically acceptable crystallization inhibitor can be added to flexible collodion compositions containing salicylic acid.
  • combinations of the above can be incorporated into flexible collodion compositions.
  • the film formed by the flexible collodion composition should be resilient.
  • the film formed by the flexible collodion composition should be durable and resistant to "rub off" or abrasion, tenacious, flexible (that is, plastic) , and occlusive.
  • the present invention is based upon the discovery that the addition of one or more topically acceptable polymers increases the resilience of the film formed by the flexible collodion composition.
  • Typical topically acceptable polymers which can be used are polyalkylenes and (meth)acrylate homo- or copolymers.
  • the use of "meth" as a prefix in parenthesis indicates that the polymer molecule is derived from one or both of acrylic and methacrylic species.
  • Suitable polyalkylenes include homopoly ers and copolymers of butenes, isobutene, isobuty- lene, butadienes, and isoprenes (e.g. Indopol L-50, Indopol H-100) .
  • isobutylene- butene copolymer is preferred.
  • suitable (meth)acrylate homo- or copolymers include polymethyl methacrylate (e.g.
  • Lucite 4F Lucite 4F
  • polyacrylamide e.g. Gelamide 250
  • polyacrylic acid e.g. Acrysol A-l
  • polyethylacry- late e.g. ethyl methacrylate
  • ethylene/acrylate copolymer e.g. A-C Copolymer 540
  • ethyl-2-cyano-3,3-diphenyl acrylate e.g.
  • acrylate/acrylamide copolymer e.g. Ultrahold 8
  • acrylates copolymer e.g. Rhoplex K-3
  • acrylate/ammonium meth ⁇ acrylate copolymer Polymethyl methacrylate is a preferred (meth)acrylate polymer.
  • the amount of topically acceptable polymer added to the flexible collodion composition is at least the minimum amount which is sufficient to increase the resilience of the film formed.
  • the amount of polymer sufficient to increase the resilience of the film formed is from about 0.05% to about 10.0% by weight of the total composition. While it is recognized that the addition of polymer in amounts greater than 10.0% will still achieve the desired result of increased resilience, a point is reached at which the addition of further amounts of polymer is economically unadvantageous due to the minimal benefit afforded.
  • the amount of polyalkylene added is from 0.05 to 5.0% by weight of the total composition, preferably from 0.1 to 1.0%.
  • the amount of (meth)acrylate homo- or copolymer typically added is from 0.05 to 10.0% by weight of the total composition, preferably from 0.1 to 1.0%.
  • the resulting flexible collodion composition exhibits an increased resilience in the film formed.
  • the film formed by the resulting composition thus shows increased durability and resistance to "rub-off" or abrasion, increased tenacity, increased flexibility (that is, increased plasticity) , and increased occlusivity.
  • the above attributes imparted by the polymer to the film formed lead to (1) improved compliance, since the film formed is less “sloppy” than the film formed by conventional flexible collodion compositions, and (2) improved therapeutic efficacy, as the film formed will remain intact where applied for an increased duration and the improved occlusivity will enhance the penetration of any therapeutic agent present in the composition.
  • Hyperkeratosis is characterized by an overgrowth of the horny layer of the skin. Hyperkera- totic conditions include corns, calluses and warts.
  • Keratolytic agents are used topically in the treatment of hyperkeratosis and act by softening and destroying the stratum corneum layer of the skin, thereby enhancing desqua- mation at the site of application.
  • Salicylic acid is a commonly used keratolytic agent.
  • Other keratolytic agents include ascorbic acid, calcium pantothenate, glacial acetic acid, lactic acid, podophyllum resin, zinc chloride, and mono-, di-, or trichloroacetic acid.
  • Salicylic acid is keratolytic at about 5% by weight of the total composition. While higher concentrations of salicylic acid can be used, generally no more than 40% by weight of salicylic acid is desirable as higher concentra ⁇ tions are excessively corrosive or caustic.
  • lactic acid is not traditionally considered to be a keratolytic agent, its use in combination with sali ⁇ cylic acid or chloroacetic acid softens the skin thereby improving the keratolysis seen with either agent alone.
  • the amount of lactic acid present will be from about 1% to about 20% and preferably, from 5% to 16.5% by weight of composition.
  • Keratolytic agents are typically applied topically to the hyperkeratotic lesion in a film forming fluid composi ⁇ tion including flexible collodion. "Fluid" means capable of flowing and thus includes both liquid and gel compositions.
  • Keratolytic agents generally are formulated in flexible collodion compositions because the film-forming property of the flexible collodion provides two important advantages.
  • the occlusive film formed by the flexible collodion prevents the evaporation of moisture from the area. The increased reten ⁇ tion of moisture by the tissues enhances permeation of the keratolytic agent, maceration and sloughing.
  • the present invention is useful in the treatment of hyperkeratosis.
  • a film-forming fluid com ⁇ position including a keratolytic agent such as salicylic acid, flexible collodion and a topically acceptable polymer according to the present invention in an amount sufficient to increase the resilience of the film formed will exhibit the improved compliance and improved therapeutic efficacy discussed above.
  • the present invention alleviates the localized dis ⁇ comfort and irritation often associated with the application of keratolytics to the skin.
  • Local anesthetics appropriate for use in the present invention include, but are not limited to, esters of benzoic acid such as benzocaine, procaine, tetracaine, and chlorop- rocaine, and amides such as bupivacaine, dibucaine, lido- caine, epivacaine, prilocaine, and etidocaine.
  • the amount of local anesthetic present will be that which is effective in achieving localized anesthesia in the area to which the agent is applied. This is generally from about 0.5% to about 15% or more and preferably is from 1% to 10% by weight of composition.
  • the effective range is from about 0.5% to about 4%.
  • the effective range is from about 5% to about 25%.
  • the present invention comprises a salt, the anion of which is the salicylic acid, lactic acid or chloroacetic acid anion and the cation of which is the protonated form of benzocaine, procaine, tetracaine, chloro- procaine, bupivacaine, dibucaine, lidocaine, mepivacaine, prilocaine, or etidocaine.
  • the salt can be formed either in situ, i.e. by the contemporaneous application to the skin of an acidic kera- tolytic agent and a basic local anesthetic, or prior to application when these two elements are brought together in a pharmaceutical preparation.
  • the present invention also includes the method of treating hyperkeratosis which comprises applying to the hyperkeratotic lesions a composition comprising flexible collodion, a therapeutically effective amount of at least one topical keratolytic agent such as salicylic acid, lactic acid, or chloroacetic acid and an anesthetically effective amount of a local anesthetic such as benzocaine, procaine, tetracaine, chloroprocaine, bupivacaine, dibucaine, lido ⁇ caine, mepivacaine, prilocaine, or etidocaine.
  • a topical keratolytic agent such as salicylic acid, lactic acid, or chloroacetic acid
  • an anesthetically effective amount of a local anesthetic such as benzocaine, procaine, tetracaine, chloroprocaine, bupivacaine, dibucaine, lido ⁇ caine, mepivacaine, prilocaine, or eti
  • the salicylic acid tends to crystallize out of solution both on the applicator and the mouth of the container.
  • crystallize or “crystallization” refer to the separation of solid from the solution which, for the purposes of this application, is synonymous with precipitation.
  • the crystallization of the salicylic acid from solution decreases the concentration of salicylic acid in solution which correspondingly decreases the keratolytic activity of the composition.
  • lactic acid to formulations of salicylic acid in flexible collodion has been found to retard the formation of crystals, thereby yielding formulations acceptable for com- ercialization. Such formulations are marketed under the product names Duofilm®, Wart-Off®, and Tinamed®.
  • a film- forming composition including salicylic acid dissolved in flexible collodion can be improved by the inclusion of a topically acceptable crystallization inhibitor.
  • the crys ⁇ tallization inhibitor is at least one mono- or polyester and/or ether.
  • Esters are conventionally defined in terms of an acid portion and an alcohol portion.
  • Typical acids from which the acid portion of the ester-type crystallization inhibitor can be derived include alkanoic acids, hydroxyalkanoic acids, alkenoic acids, or hydroxyalkenoic acids having from two to twenty carbon atoms (straight chain or branched) , and benzoic acids.
  • suitable alkanoic acids are acetic acid, isobutyric acid, pelargonic acid, isononanoic acid and isostearic acid.
  • Suitable hydroxyalkanoic acids are lactic acid, hydroxybutyric acid, hydroxypentanoic acid, and the like.
  • Suitable alkenoic acids are acrylic acid, crotonic acid, oleic acid, and the like.
  • An example of a suitable hydrox alkenoic acid is ricinoleic acid.
  • Typical alcohols from which the alcohol portion of the ester-type crystallization inhibitor can be derived include monohydroxyalkanes, polyhydroxyalkanes, poly(alkanediol)s, and saccharides.
  • suitable monohydroxyalkanes include ethanol, propanol, butanol, isobutanol, octanol, isostearol and the like.
  • suitable polyhydrox ⁇ yalkanes include ethylene glycol, propylene glycol, glycerol, and the like.
  • Suitable pol (alkanediol)s include the polyethylene glycols.
  • suitable saccharides include the disaccharides, i.e. sucrose, maltose, and lactose.
  • Suitable mono- or polyester crystallization inhibitors thus include ethyl acetate, ethyl acrylate, ethyl pelargonate, ethyl lactate, propyl acetate, octyl isononanoate, isostearyl isostearate, isobutyl benzoate, isostearyl benzoate, propylene glycol isostearate, propylene glycol dipelargonate, polyethylene glycol dilaurate, castor oil, and sucrose acetate isobutyrate.
  • the crystallization inhibitor also can include one or more ethers.
  • Ethers can be defined as consisting of a first- group and a second group, the groups being linked through an ethereal oxygen atom.
  • Suitable first groups are alkyl groups or phenyl groups.
  • Suitable alkyl groups are typically from one to twenty carbon atoms, such as methyl, ethyl, propyl, stearyl, and the like, and can be straight chain or branched.
  • the phenyl groups can be unsubstituted or substituted with alkyl groups, typically of one to ten carbon atoms, which can be straight chain or branched.
  • Suitable second groups are hydroxyalkyl, polyhy- droxyalkyl, or pol (alkanediol) groups.
  • Typical hydrox ⁇ yalkyl groups include hydroxyethyl, hydroxypropyl, hydroxy- butyl, and the like.
  • Suitable polyhydroxyalkyl groups include dihydroxyalkyls of one to ten carbon atoms such as dihydroxypropyl, dihydroxybutyl, and the like.
  • Suitable poly(alkanediol)s include the poly
  • Suitable ether-type crystallization inhibitors thus include ethoxyethanol, polyethylene glycol stearyl ether, octoxynol, and nonoxynol.
  • Preferred topically acceptable crystallization inhibitors include propylene glycol dipelargonate, ethyl lactate, and castor oil, either alone or in combination.
  • the amount of topically acceptable crystallization inhibitor utilized is an amount sufficient to suppress the crystallization of dissolved salicylic acid from the flexi ⁇ ble collodion solution.
  • the amount of crystal- lization inhibitor sufficient to suppress the crystalliza ⁇ tion of dissolved salicylic acid from the flexible collodion composition is from about 1.0 to about 60.0% by weight of the total composition. Amounts of crystallization inhibitor greater than 60% will still suppress crystallization. Economic factors, however, outweigh the minimal benefit gained by the addition of further amounts of crystallization inhibitor.
  • compositions of the present invention can also include topically acceptable pharmaceutical excipients, such as solvents, diluents, thickeners, etc.
  • Typical liquid compositions for the topical treatment of hyperkeratosis embodied by the present invention include from 5 to 40% by weight of the total composition of salicylic acid, not less than 50% by weight of the total composition of flexible collodion, and from 15 to 45% by weight of the total composition of ethyl lactate.
  • the amount of salicylic acid is preferably from 15 to 30%, and most preferably about 17% or about 27% by weight of the total composition.
  • such liquid compositions typically can include from 1 to 15%, preferably about 3% by weight of the total composition of castor oil.
  • the compositions also will contain an effective amount, for example from about 0.5% to about 25% by weight of the total composition of a local anesthetic.
  • Typical gel compositions for the topical treatment of hyperkeratosis embodied by the present invention include from 5 to 40% by weight of the total composition of salicylic acid, from 20 to 60% by weight of the total compo ⁇ sition of flexible collodion, and from 5 to 25% by weight of the total composition of ethyl lactate. Similar to the liquid compositions, the amount of salicylic acid is prefer ⁇ ably from 15 to 30%, and most preferably about 17% or about 27% by weight of the total composition. Preferably the compositions also will contain an effective amount, for example from about 0.5% to about 25% by weight of the total composition of a local anesthetic.
  • a flexible collodion composition is prepared by first adding 15.0 g of ethyl lactate to 64.9 g of flexible collo ⁇ dion while stirring. Stirring is continued until the mixture is uniform. Next, 3.0 g of castor oil is added, followed by 0.1 g of isobutylene-butene copolymer. Finally, 17.0 g of salicylic acid is slowly dissolved in the mixture while stirring. About 100.0 g of clear pale-yellow liquid is produced.
  • a flexible collodion composition is produced by taking 21.8 g of flexible collodion and adding to it 45.0 g of ethyl alcohol, followed by 5.0 g of ethyl lactate, while stirring. To this mixture, 0.1 g of isobutylene-butene copolymer is added and the mixture is stirred until uniform. Next, 27.0 g of salicylic acid is slowly added while stirring. Once the salicylic acid is completely dissolved, 1.0 g of hydroxyethyl cellulose and 0.1 g of polymethyl methacrylate are added with rapid agitation. After sitting overnight, the mixture yields 100.0 g of a clear gel product.
  • Example 2 The procedure in Example 2 is followed, except the following amounts are used: 32.0 g of ethyl alcohol, 44.9 g of flexible collodion, 5.0 g of ethyl lactate, 0.1 g of isobutylene-butene copolymer, 17.0 g of salicylic acid, and 1.0 g of hydroxyethyl cellulose. The procedure yields 100.0 g of a clear gel composition.
  • EXAMPLE 7 The procedure yields 100.0 g of a clear gel composition.
  • Example 2 The procedure in Example 2 is followed, except the following amounts are used: 51.4 g of ethyl alcohol, 25.0 g of flexible collodion, 5.0 g ethyl lactate, 0.1 g of isobutylene-butene copolymer, 17.0 g of salicylic acid, and 1.5 g of hydroxyethyl cellulose.
  • the procedure yields 100.0 g of a clear gel composition.
  • a flexible collodion composition is prepared by adding 45.1 g of ethyl alcohol and 5.0 g of ethyl lactate, one at a time, to 21.9 g of flexible collodion while stirring. To this mixture is slowly added 27.0 g of salicylic acid, and the mixture is stirred until the salicylic acid is completely dissolved. Hydroxyethyl cellulose in the amount of 1.0 g is added with rapid agitation and the product is allowed to sit overnight, yielding 100.0 g of a clear gel.
  • Example 8 The procedure of Example 8 is followed, except the following amounts were used: 51.7 g of ethyl alcohol, 5.0 g of ethyl lactate, 25.0 g of flexible collodion, 17.0 g of salicylic acid, and 1.3 g of hydroxyethyl cellulose. About
  • 100.0 g of a liquid composition is produced by mixing 16.5 g of ethyl lactate with 66.5 g of flexible collodion, and subsequently dissolving 17.0 g of salicylic acid in this mixture.
  • the final product is clear and pale-yellow in color.
  • a flexible collodion composition is prepared by first adding 15.0 g of ethyl lactate to 54.9 g of flexible collo- dion while stirring. Stirring is continued until the mixture is uniform. Next, 3.0 g of castor oil is added, followed by 0.1 g of isobutylene-butene copolymer. Finally, 17.0 g of salicylic acid and 10.0 g of benzocaine are slowly dissolved in the mixture while stirring. About 100.0 g of clear pale-yellow liquid is produced.
  • the foregoing ingredients are combined in a suitable container and thoroughly mixed to form a uniform prepara ⁇ tion.
  • a small amount of the preparation is applied directly to the wart loci.
  • the preparation dries to form a film.
  • the foregoing ingredients are combined in a suitable container and thoroughly mixed to form a uniform prepara ⁇ tion.
  • a small amount of the preparation is applied directly to the wart loci.
  • the preparation dries to form a film.
  • Lactic Acid 16.500 Tetracaine 1.000 The foregoing ingredients are combined in a suitable container and thoroughly mixed to form a uniform prepara ⁇ tion. A small amount of the preparation is applied directly to the wart loci. The preparation dries to form a film.

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  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des compositions élastiques filmogènes de collodion peuvent être améliorées par l'inclusion d'un ou de plusieurs polymères topiquement tolérables, dans une quantité suffisante pour augmenter l'élasticité du film formé. Des polymères appropriés incluent les polyalkylènes et les homo- ou copolymères de (méth)acrylate. Des modes préférés de réalisation incluent le copolymère d'isobutylène-butène et/ou le méthacrylate de polyméthyle. Ces compositions peuvent en outre renfermer de l'acide salicylique et un inhibiteur de cristallisation topiquement tolérable, dans une quantité suffisante pour supprimer dans la composition la cristallisation de l'acide salicylique dissous. Les inhibiteurs de cristallisation appropriés comportent au moins un mono- ou polyester et/ou éther. Des formes d'exécution préférées renferment un mélange de lactate d'éthyle et d'huile de ricin, et de lactate d'éthyle seul. Ces compositions renferment de préférence un anesthésique local.
EP19920906146 1991-02-01 1992-01-31 Compositions elastiques ameliorees de collodion Withdrawn EP0569532A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64969291A 1991-02-01 1991-02-01
US649692 1991-02-01
US72482491A 1991-07-02 1991-07-02
US724824 1991-07-02

Publications (1)

Publication Number Publication Date
EP0569532A1 true EP0569532A1 (fr) 1993-11-18

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ID=27095681

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920906146 Withdrawn EP0569532A1 (fr) 1991-02-01 1992-01-31 Compositions elastiques ameliorees de collodion

Country Status (3)

Country Link
EP (1) EP0569532A1 (fr)
CA (1) CA2101083C (fr)
WO (1) WO1992013529A1 (fr)

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US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
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CA2101083C (fr) 2004-09-14
CA2101083A1 (fr) 1992-08-02

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