EP0562947B1 - Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden - Google Patents

Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden Download PDF

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Publication number
EP0562947B1
EP0562947B1 EP93400744A EP93400744A EP0562947B1 EP 0562947 B1 EP0562947 B1 EP 0562947B1 EP 93400744 A EP93400744 A EP 93400744A EP 93400744 A EP93400744 A EP 93400744A EP 0562947 B1 EP0562947 B1 EP 0562947B1
Authority
EP
European Patent Office
Prior art keywords
length
sheathing
sheath
straw
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP93400744A
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English (en)
French (fr)
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EP0562947A1 (de
Inventor
Robert Cassou
Maurice Cassou
Bertrand Cassou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instruments de Medecine Veterinaire SA IMV
Original Assignee
Instruments de Medecine Veterinaire SA IMV
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Publication date
Application filed by Instruments de Medecine Veterinaire SA IMV filed Critical Instruments de Medecine Veterinaire SA IMV
Publication of EP0562947A1 publication Critical patent/EP0562947A1/de
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Classifications

    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/04—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps to be fastened or secured by the material of the label itself, e.g. by thermo-adhesion
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/0295—Labels or tickets for tubes, pipes and the like

Definitions

  • the invention relates to a device for identifying so-called flake tubes for the cryogenic conservation of biological liquids, in particular viral cultures, and comprising an envelope consisting of a section of tube made of suitable transparent material of regular current diameter with its ends. flattened forming autogenous seal of width greater than the current diameter.
  • document US-A-3 491 472 describes an elliptical identification sleeve, bearing reference marks, which has a plastic memory.
  • the internal dimension along the minor axis is less than the diameter of the article to be identified, while the internal dimension along the major axis is greater than the diameter of the article.
  • Two ribs inside the passage along a part of the internal surface of the passage provide three-point contact on the article contained.
  • Patent document FR-A-2 651 793 describes a so-called flake tube for the cryogenic preservation of biological samples, in particular viral culture, formed of a section of tubular envelope calibrated in substantially transparent polymer material, biologically neutral, provided with '' a seal at each of its two ends and comprising, in the vicinity of a first end, a sliding shutter comprising an aqueous gel between two pads of porous elastic material, which differs from the prior art in that the material polymer is an ionomer resin, and the end seals are formed by autogenous welding of the tube over a determined axial extent.
  • These flakes are, thanks to the physical properties of ionomer resins, in particular their thermoplastic behavior at ambient and higher temperatures, which allows an excellent autogenous welding seal, their resistance to thermal shocks between temperature. ambient and cryogenic temperatures, and their absence of embrittlement at these temperatures, extremely reliable for the cryogenic conservation of rare or dangerous biological liquids, such as genetic engineering products or viruses.
  • ionomer resins and in particular those whose properties at cryogenic temperature are more attractive, are less suitable for printing than the materials used for the manufacture of widely used flakes (for example flakes for artificial insemination of cattle or sheep), components of inks used for printing diffusing less well in ionomer resins, leading to less clear characters and more sensitive to erasure.
  • the invention also proposes a device for identifying so-called flake tubes used for the cryogenic conservation of biological liquids, in particular viral cultures and comprising an envelope made up of a section of tube made of suitable transparent material of regular current diameter with its flattened ends. forming autogenous seals of width greater than the current diameter, device characterized in that it consists of a length of sheath of polymer material forming support for identification signs, threaded on the section of tube between the end seals with an internal diameter sufficient in itself to allow sliding on the tube under its own weight, but less than the width of the seals.
  • the length of sheath is thus trapped between the two end seals of the straw, without the possibility of escaping until a sealed end has not been cut.
  • the sheath is put in place at the same time as the content of the straw is enclosed, and cannot leave the straw until we have undertaken to remove the contents by cutting off one end.
  • the length of sheath can be chosen from a material which accepts printing in an excellent manner and which, moreover, is capable, by its own appearance, of constituting elements of identification. And there is no risk that the printing ink components disposed on the sheath will migrate into the glitter material.
  • the identification signs may include printed characters, a coloring of the sheath material, or even a length ratio between glitter and sheath.
  • the sheath is deformed at one end to resiliently clamp the tube at at least two diametrically opposite points. Threading the sheath thus remains easy, before the end seals, but, once the deformed end has passed, the sheath will remain in a position fixed on the straw. It is understood that the identification of a straw would become difficult if the length of sheath could freely slide along the straw, and thus slide towards the lower end of the straw when it is introduced into the cryogenic vessel. , necessarily by the upper part of the vase.
  • a tube or flake 1 is originally presented, as shown in Figure 1A, in the form of a calibrated section of tube, that is to say of a regular current external diameter, open at its two ends 1 a and 1 b , and consisting of an ionomer resin as described in document FR-A-2 651 793.
  • a sliding shutter such as described in document FR-A-995 878 of September 20, 1948. This shutter consists of a dose of powder capable of gelling on contact with an aqueous liquid, between two porous pads.
  • a length of sheath 3 (FIG. 1B) has been prepared with an internal diameter 30 (see FIG. 4) greater than the external diameter 10 of the straw 1, this length corresponds approximately to one third of that of the straw 1.
  • the sheath 3 is in easily extrudable thermoplastic material, such as poly (vinyl chloride) and mass-colored. As best seen in the Figures 3 and 4, the sheath 3 has been at one end 3a, oval stretch along a major axis 31 so as to have a minor axis 32 which, in the free state ( Figure 1B ), is slightly smaller than the outside diameter 10 of the straw 1.
  • the length of sheath 3 of a chosen color was provided, by printing on its peripheral surface, with identification data of the biological liquid with which the corresponding straw 1 must be filled; the color of the sheath constitutes an identification element, which is added to the printed data, in order to subsequently allow the sample to be taken out of cryogenic storage vessels at first glance, subject to verification of the printed data, of course.
  • the length of sheath 3 is threaded through its end opposite the ovalized end 3 a , leaving the end of the straw 1 b beyond at least 1 cm.
  • the straw 1, provided with its identification sheath, is carried on a filling machine, which are caused to penetrate by suction by the end 1a through the shutter 2, the biological fluid that the straw is intended to contain.
  • the biological liquid reaching the shutter causes the powder to gel and seal the shutter.
  • the ends 1a and 1b are sealed by being clamped between parallel flat heated jaws.
  • the welded ends are formed into spatulas 1 c and 1 d , the width of which, perpendicular to the axis of the glitter exceeds the internal diameter 30, and even the major axis 31 of the ovalized end 3 a of the length of sheath 3. The latter will therefore be trapped between the sealed ends 1 c and 1 d of the straw, until one end has been cut to recover the contents of the straw.
  • the sheath can without disadvantages possess, at cryogenic temperatures, less favorable properties than ionomer resins, since it is not subjected to any mechanical stress, and that it plays no role in reliable preservation. Even a crack in the sheath is without consequences.
  • ovalization 3 a of the length of sheath 3 is intended to avoid the sliding of the sheath 3 along the straw 1, so that this sheath with its identification data remains clearly visible during storage at temperatures cryogenic, without however the establishment of the sheath 3 around the straw 1 is difficult. It is obvious that immobilization of the sheath 3 on the straw 1 could be obtained anyway which causes localized tightening of the sheath, bearing on the straw by at least two diametrically opposite points. In fact, the immobilization of the sheath 3 on the straw is not strictly essential for identification, if the latter is facilitated by the immobilization of the sheath.
  • the sheath length 3 threaded on the straw is not limited necessarily by the need to leave open the ends 1a and 1b of the straw to allow sealing. However, it is useful to provide at least bare lengths of straw in the vicinity of the ends to facilitate the use of transport racks for filling, and allow slicing of the ends for the recovery of the contents. In addition, it will be preferable that at least half of the length of straw 1 remains bare to allow visual inspection of the contents. But a length of sheath 3 less than a quarter of the length of glitter 1 may leave insufficient space for printing identification data.

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Bag Frames (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (6)

  1. Vorrichtung zur Identifizierung von Pailletten genannten Röhrchen, die für die Tiefsttemperaturaufbewahrung von biologischen Flüssigkeiten, insbesondere Viruskulturen, verwendet werden und eine Hülle (1) umfassen, welche aus einem Röhrchenabschnitt aus transparentem, geeigneten Material von regelmäßig verlaufendem Durchmesser (10) gebildet ist, wobei ihre abgeflachten Enden (1c, 1d) autogene Verschmelzungen von einer Breite bilden, die größer als der verlaufende Durchmesser ist, wobei die Vorrichtung dadurch gekennzeichnet ist, daß sie aus einer Hüllenlänge (3) aus Polymermaterial, die einen Träger für Zeichen zur Identifizierung bildet, besteht, welcher auf dem Röhrchenabschnitt (1) zwischen den Endverschmelzungen (1c, 1d) mit einem inneren Durchmesser (30) aufgeschoben ist, der an sich ausreicht, um eine Verschiebung auf dem Röhrchen (1) unter seinem Eigengewicht zu gestatten, welcher jedoch kleiner ist als die Breite der Verschmelzungen (1c, 1d).
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß die Zeichen zur Identifizierung auf die Hülle (3) gedruckte Buchstaben umfassen.
  3. Vorrichtung nach einem der Ansprüche 1 und 2, dadurch gekennzeichnet, daß die Zeichen zur Identifizierung eine Kolorierung des Materiales der Hülle (3) umfassen.
  4. Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß die Hüllenlänge (3) kleiner ist als die Hälfte derjenigen des Röhrchenabschnittes (1).
  5. Vorrichtung nach Anspruch 4, dadurch gekennzeichnet, daß die Hüllenlänge (3) größer ist als das Viertel derjenigen des Röhrchenabschnittes (1).
  6. Vorrichtung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß die Hülle (3) an einem Ende verformt ist, um das Röhrchen (1) an wenigstens zwei sich diametral gegenüberliegenden Punkten elastisch einzuspannen.
EP93400744A 1992-03-26 1993-03-23 Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden Expired - Lifetime EP0562947B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9203637A FR2689283B1 (fr) 1992-03-26 1992-03-26 Dispositif d'identification de paillettes pour la conservation cryogenique de liquides biologiques.
FR9203637 1992-03-26

Publications (2)

Publication Number Publication Date
EP0562947A1 EP0562947A1 (de) 1993-09-29
EP0562947B1 true EP0562947B1 (de) 1997-01-02

Family

ID=9428090

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93400744A Expired - Lifetime EP0562947B1 (de) 1992-03-26 1993-03-23 Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden

Country Status (4)

Country Link
EP (1) EP0562947B1 (de)
DE (2) DE69306993T2 (de)
ES (1) ES2044810T1 (de)
FR (1) FR2689283B1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101272861B (zh) * 2005-09-28 2012-05-30 Cryo生物系统股份有限公司 低温玻璃化保存预定体积物质的包装装置

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707875B1 (fr) * 1993-07-22 1995-10-06 Gestion Engineering Et Dispositif en forme de paillette pour la conservation d'un produit liquide ou pulvérulent.
FR2846128B1 (fr) * 2002-10-16 2004-12-24 Eurl Cryo Vet Paillette munie d'un tube exterieur de protection et d'identification
FR2891166B1 (fr) * 2005-09-28 2007-11-23 Cryo Bio System Sa Enveloppe de conditionnement d'un volume predetermine de substance biologique destinee a etre plongee dans un agent cryogenique liquide
WO2014191501A1 (en) 2013-05-30 2014-12-04 Cryogenetics As Cryopreservation device for biological material
US10531657B2 (en) 2015-12-07 2020-01-14 Coopersurgical, Inc. Low temperature specimen carriers and related methods
FR3046715B1 (fr) * 2016-01-19 2018-02-16 Imv Technologies Dispositif pour la conservation d'une dose predeterminee de substance a base liquide et gamme de tels dispositifs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491472A (en) * 1968-05-01 1970-01-27 Thomas & Betts Corp Article identification sleeve
US4019272A (en) * 1975-12-01 1977-04-26 Kerz Phillip D Identification marker
FR2651793B1 (fr) * 1989-09-14 1991-12-06 Cassou Robert Tubes ou paillettes pour la conservation cryogenique d'echantillons biologiques tels que virus, et procede de remplissage.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101272861B (zh) * 2005-09-28 2012-05-30 Cryo生物系统股份有限公司 低温玻璃化保存预定体积物质的包装装置

Also Published As

Publication number Publication date
FR2689283A1 (fr) 1993-10-01
DE69306993D1 (de) 1997-02-13
DE562947T1 (de) 1994-02-03
DE69306993T2 (de) 1997-05-07
ES2044810T1 (es) 1994-01-16
FR2689283B1 (fr) 1996-12-20
EP0562947A1 (de) 1993-09-29

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