EP0562947A1 - Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden - Google Patents

Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden Download PDF

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Publication number
EP0562947A1
EP0562947A1 EP93400744A EP93400744A EP0562947A1 EP 0562947 A1 EP0562947 A1 EP 0562947A1 EP 93400744 A EP93400744 A EP 93400744A EP 93400744 A EP93400744 A EP 93400744A EP 0562947 A1 EP0562947 A1 EP 0562947A1
Authority
EP
European Patent Office
Prior art keywords
sheath
straw
tube
length
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP93400744A
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English (en)
French (fr)
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EP0562947B1 (de
Inventor
Robert Cassou
Maurice Cassou
Bertrand Cassou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instruments de Medecine Veterinaire SA IMV
Original Assignee
Instruments de Medecine Veterinaire SA IMV
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Filing date
Publication date
Application filed by Instruments de Medecine Veterinaire SA IMV filed Critical Instruments de Medecine Veterinaire SA IMV
Publication of EP0562947A1 publication Critical patent/EP0562947A1/de
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Publication of EP0562947B1 publication Critical patent/EP0562947B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/04—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps to be fastened or secured by the material of the label itself, e.g. by thermo-adhesion
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/0295—Labels or tickets for tubes, pipes and the like

Definitions

  • the invention relates to a device for identifying so-called flake tubes for the cryogenic conservation of biological liquids, in particular viral cultures, and comprising an envelope consisting of a section of tube made of suitable transparent material of regular current diameter with its ends. flattened forming autogenous seal of width greater than the current diameter.
  • Patent document FR-A-2 651 793 describes a so-called flake tube for the cryogenic preservation of biological samples, in particular viral culture, formed of a section of tubular envelope calibrated in substantially transparent polymer material, biologically neutral, provided with '' a seal at each of its two ends and comprising, in the vicinity of a first end, a sliding shutter comprising an aqueous gel between two pads of porous elastic material, which differs from the prior art in that the material polymer is an ionomer resin, and the end seals are formed by autogenous welding of the tube over a determined axial extent.
  • These flakes are, thanks to the physical properties of ionomer resins, in particular their thermoplastic behavior at ambient and higher temperatures, which allows an excellent autogenous sealing, their resistance to thermal shocks between ambient temperature and cryogenic temperatures, and their absence of embrittlement. at these temperatures, extremely reliable for the cryogenic conservation of rare or dangerous biological liquids, such as genetic engineering products or viruses.
  • ionomer resins and in particular those whose properties at cryogenic temperature are more attractive, are less suitable for printing than the materials used for the manufacture of widely used flakes (for example flakes for artificial insemination of cattle or sheep), components of the inks used for printing diffusing less well in ionomer resins, leading to less sharp characters and more sensitive to erasure.
  • the invention also proposes a device for identifying so-called flake tubes used for the cryogenic preservation of biological liquids, in particular viral cultures and comprising an envelope made up of a section of tube made of suitable transparent material of regular current diameter with its flattened ends. forming autogenous seals of width greater than the current diameter, device characterized in that it consists of a length of sheath of polymer material forming support for identification signs, threaded on the section of tube between the end seals with an internal diameter less than the width of the seals.
  • the length of sheath is thus trapped between the two end seals of the straw, without the possibility of escaping until a sealed end has not been cut.
  • the sheath is put in place at the same time as the content of the straw is enclosed, and cannot leave the straw until one has undertaken to remove the contents by cutting off one end.
  • the sheath length can be chosen from a material which accepts printing in an excellent manner and which, moreover, is capable, by its own appearance, of constituting identification elements. And there is no risk that the printing ink components disposed on the sheath will migrate into the glitter material.
  • the identification signs may include printed characters, a coloring of the sheath material, or even a length ratio between glitter and sheath.
  • the sheath diameter being sufficient in itself to allow sliding under its own weight, the sheath is deformed at one end to elastically clamp the tube at at least two diametrically opposite points. Threading the sheath thus remains easy, before the end seals, but, once the deformed end has passed, the sheath will remain in a position fixed on the straw. It is understandable that the identification of a straw would become difficult if the length of sheath could freely slide along the straw, and thus slide towards the lower end of the straw when it is introduced into the cryogenic vessel. , necessarily by the upper part of the vase.
  • a tube or flake 1 is originally presented, as shown in Figure 1A, in the form of a calibrated tube section, that is to say of a regular current outside diameter, open at its two ends 1 a and 1 b , and consisting of an ionomer resin as described in document FR-A-2 651 793.
  • a sliding shutter such as described in document FR-A-995 878 of September 20, 1948. This shutter consists of a dose of powder capable of gelling on contact with an aqueous liquid, between two porous pads.
  • a length of sheath 3 (FIG. 1B) was prepared with an internal diameter 30 (see FIG. 4) greater than the external diameter 10 of the straw 1, this length corresponds approximately to one third of that of the straw 1.
  • the sheath 3 is in easily extrudable thermoplastic material, such as poly (vinyl chloride) and mass-colored. As best seen in the Figures 3 and 4, the sheath 3 has been at one end 3a, oval stretch along a major axis 31 so as to have a minor axis 32 which, in the free state ( Figure 1B ), is slightly smaller than the outside diameter 10 of the straw 1.
  • the length of sheath 3 of a chosen color was provided, by printing on its peripheral surface, with identification data of the biological liquid with which the corresponding straw 1 must be filled; the color of the sheath constitutes an identification element, which is added to the printed data, in order to subsequently allow the sample to be taken out of cryogenic storage vessels at first look, subject to verification of the printed data, of course.
  • the length of sheath 3 is threaded through its end opposite the ovalized end 3 a , leaving the end of the straw 1 b protruding by at least 1 cm.
  • the straw 1, provided with its identification sheath, is carried on a filling machine, which are caused to penetrate by suction by the end 1a through the shutter 2, the biological fluid that the straw is intended to contain.
  • the biological liquid reaching the shutter causes the powder to gel and seal the shutter.
  • the ends 1a and 1b are sealed by being clamped between parallel flat heated jaws.
  • the welded ends are formed into spatulas 1 c and 1 d , the width of which, perpendicular to the axis of the glitter exceeds the internal diameter 30, and even the major axis 31 of the ovalized end 3 a of the length of sheath 3. The latter will therefore be trapped between the sealed ends 1 c and 1 d of the straw, until one end has been cut to recover the contents of the straw.
  • the sheath can, without drawbacks, possess less favorable properties at cryogenic temperatures than ionomer resins, since it is not subjected to any mechanical stress, and that it plays no role in reliable preservation. Even a crack in the sheath is without consequences.
  • ovalization 3 a of the length of the sheath 3 is intended to avoid the sliding of the sheath 3 along the straw 1, so that this sheath with its identification data remains clearly visible during storage at temperatures cryogenic, without however the establishment of the sheath 3 around the straw 1 is difficult. It is obvious that immobilization of the sheath 3 on the straw 1 could be obtained anyway which causes localized tightening of the sheath, bearing on the straw by at least two diametrically opposite points. In fact, the immobilization of the sheath 3 on the straw is not strictly essential for identification, if the latter is facilitated by the immobilization of the sheath.
  • the sheath length 3 threaded on the straw is not limited necessarily by the need to leave open the ends 1a and 1b of the straw to allow sealing. However, it is useful to provide at least bare lengths of straw in the vicinity of the ends to facilitate the use of transport racks for filling, and allow slicing of the ends for the recovery of the contents. In addition, it will be preferable that at least half of the length of straw 1 remains bare to allow visual inspection of the contents. But a length of sheath 3 less than a quarter of the length of glitter 1 may leave insufficient space for printing identification data.

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Bag Frames (AREA)
  • Sampling And Sample Adjustment (AREA)
EP93400744A 1992-03-26 1993-03-23 Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden Expired - Lifetime EP0562947B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9203637 1992-03-26
FR9203637A FR2689283B1 (fr) 1992-03-26 1992-03-26 Dispositif d'identification de paillettes pour la conservation cryogenique de liquides biologiques.

Publications (2)

Publication Number Publication Date
EP0562947A1 true EP0562947A1 (de) 1993-09-29
EP0562947B1 EP0562947B1 (de) 1997-01-02

Family

ID=9428090

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93400744A Expired - Lifetime EP0562947B1 (de) 1992-03-26 1993-03-23 Vorrichtung zum Kennzeichnen von Röhrchen, die für die kryogenische Bewahrung von biologischen Flüssigkeiten verwendet werden

Country Status (4)

Country Link
EP (1) EP0562947B1 (de)
DE (2) DE562947T1 (de)
ES (1) ES2044810T1 (de)
FR (1) FR2689283B1 (de)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0635305A1 (de) * 1993-07-22 1995-01-25 Societe D'etudes, De Gestion, D'engineering Plättchenförmige Einrichtung zur Konservierung eines flüssigen oder pulverförmigen Produktes
FR2846128A1 (fr) * 2002-10-16 2004-04-23 Eurl Cryo Vet Paillette munie d'un tube exterieur de protection et d'identification
FR2891166A1 (fr) * 2005-09-28 2007-03-30 Cryo Bio System Sa Enveloppe de conditionnement d'un volume predetermine de substance biologique destinee a etre plongee dans un agent cryogenique liquide
FR2891165A1 (fr) * 2005-09-28 2007-03-30 Cryo Bio System Sa Ensemble de conditionnement d'un volume predetermine de substance a conserver par vitrification cryogenique.
WO2014191501A1 (en) 2013-05-30 2014-12-04 Cryogenetics As Cryopreservation device for biological material
CN110349492A (zh) * 2019-07-22 2019-10-18 杭州沃朴物联科技有限公司 一种防伪标签及防伪标签的制备方法
US10531657B2 (en) 2015-12-07 2020-01-14 Coopersurgical, Inc. Low temperature specimen carriers and related methods
US11406101B2 (en) * 2016-01-19 2022-08-09 Imv Technologies Device for preserving a predetermined dose of liquid-based substance, and range of such devices

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491472A (en) * 1968-05-01 1970-01-27 Thomas & Betts Corp Article identification sleeve
US4019272A (en) * 1975-12-01 1977-04-26 Kerz Phillip D Identification marker
FR2651793A1 (fr) * 1989-09-14 1991-03-15 Cassou Robert Tubes ou paillettes pour la conservation cryogenique d'echantillons biologiques tels que virus, et procede de remplissage.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491472A (en) * 1968-05-01 1970-01-27 Thomas & Betts Corp Article identification sleeve
US4019272A (en) * 1975-12-01 1977-04-26 Kerz Phillip D Identification marker
FR2651793A1 (fr) * 1989-09-14 1991-03-15 Cassou Robert Tubes ou paillettes pour la conservation cryogenique d'echantillons biologiques tels que virus, et procede de remplissage.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent Publications Ltd., London, GB; AN 68-89786P & AU-A-53 635 (SIMALEX LTD.) 13 Juillet 1967 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0635305A1 (de) * 1993-07-22 1995-01-25 Societe D'etudes, De Gestion, D'engineering Plättchenförmige Einrichtung zur Konservierung eines flüssigen oder pulverförmigen Produktes
FR2707875A1 (fr) * 1993-07-22 1995-01-27 Gestion Engineering Et Dispositif en forme de paillette pour la conservation d'un produit liquide ou pulvérulent.
FR2846128A1 (fr) * 2002-10-16 2004-04-23 Eurl Cryo Vet Paillette munie d'un tube exterieur de protection et d'identification
KR101025485B1 (ko) * 2005-09-28 2011-04-04 크리오 바이오 시스템 액체 극저온처리제에 침지되도록 설계된 정해진 부피의생물학적 물질을 포장하기 위한 외피 집
FR2891165A1 (fr) * 2005-09-28 2007-03-30 Cryo Bio System Sa Ensemble de conditionnement d'un volume predetermine de substance a conserver par vitrification cryogenique.
WO2007036628A1 (fr) * 2005-09-28 2007-04-05 Cryo Bio System Enveloppe de conditionnement d'un volume predetermine de substance biologique destinee a etre plongee dans un agent cryogenique liquide
WO2007036627A1 (fr) * 2005-09-28 2007-04-05 Cryo Bio System Ensemble de conditionnement d'un volume predetermine de substance a conserver par vitrification cryogenique
KR101013402B1 (ko) * 2005-09-28 2011-02-14 크리오 바이오 시스템 극저온처리 유리화에 의해 정해진 부피의 보존할 물질을포장하기 위한 키트
FR2891166A1 (fr) * 2005-09-28 2007-03-30 Cryo Bio System Sa Enveloppe de conditionnement d'un volume predetermine de substance biologique destinee a etre plongee dans un agent cryogenique liquide
US8372633B2 (en) 2005-09-28 2013-02-12 Cryo Bio System Kit for packaging predetermined volume of substance to be preserved by cryogenic vitrification
US10149748B2 (en) 2005-09-28 2018-12-11 Cryo Bio System Sheathing for packaging a predetermined volume of a biological substance designed to be immersed in a liquid cryogenic agent
WO2014191501A1 (en) 2013-05-30 2014-12-04 Cryogenetics As Cryopreservation device for biological material
US10531657B2 (en) 2015-12-07 2020-01-14 Coopersurgical, Inc. Low temperature specimen carriers and related methods
US11406101B2 (en) * 2016-01-19 2022-08-09 Imv Technologies Device for preserving a predetermined dose of liquid-based substance, and range of such devices
CN110349492A (zh) * 2019-07-22 2019-10-18 杭州沃朴物联科技有限公司 一种防伪标签及防伪标签的制备方法
CN110349492B (zh) * 2019-07-22 2024-06-07 杭州沃朴物联科技有限公司 一种防伪标签及防伪标签的制备方法

Also Published As

Publication number Publication date
DE69306993T2 (de) 1997-05-07
DE562947T1 (de) 1994-02-03
EP0562947B1 (de) 1997-01-02
FR2689283B1 (fr) 1996-12-20
DE69306993D1 (de) 1997-02-13
ES2044810T1 (es) 1994-01-16
FR2689283A1 (fr) 1993-10-01

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