EP0557900A2 - Blood components separating device - Google Patents

Blood components separating device Download PDF

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Publication number
EP0557900A2
EP0557900A2 EP93102635A EP93102635A EP0557900A2 EP 0557900 A2 EP0557900 A2 EP 0557900A2 EP 93102635 A EP93102635 A EP 93102635A EP 93102635 A EP93102635 A EP 93102635A EP 0557900 A2 EP0557900 A2 EP 0557900A2
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EP
European Patent Office
Prior art keywords
blood bag
separating
blood
bag
holder
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Granted
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EP93102635A
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German (de)
French (fr)
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EP0557900B1 (en
EP0557900A3 (en
Inventor
Heinz Krüssel
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for

Definitions

  • the invention relates to a device for separating various components in blood according to the preamble of claim 1.
  • Such a device is known for example from DE-35 31 430 A1. It is an exclusively motor-operated device in which the blood bags are suspended in the device.
  • the bags usually have several holes in their upper area, with which they can be hung on hooks or similar holding devices.
  • DE-35 31 430 A1 refers to an article in the magazine “Med. Welt", volume 30 (1979), number 43, pages 1597-1601.
  • a device is described which can only be operated manually and which is an in height adjustable Separating frame with horizontally collapsible or separable separating strips and a suspension for the bag contains.
  • the bag is hung directly on hooks or a similar holder, which is part of the device directly and firmly mounted.
  • the secondary separation can take place, for example, in such a device.
  • the two components which are initially separated but are in a common container, such as a blood bag, are finally separated from one another and are accommodated in different containers, for example.
  • the work sequence described above is repeated several times in succession, so that after each new centrifugation the components which are separated further and further are present within the blood bag and one or more components are withdrawn from the bag before the next centrifugation step.
  • the continuously decreasing degree of filling of the blood bags leads to the bag becoming increasingly unstable and no longer standing upright due to its filling volume alone.
  • the invention has for its object to improve a generic device in such a way that a high efficiency and a safe and pure separation of the various components can be achieved even with a poor fill level of the blood bag.
  • the invention proposes to provide a holder for the blood bag on the device which is detachable from the device.
  • the holder should include a plate. In this way, a contact surface is created through the plate, against which the blood bag rests, so that the blood bag is no longer deformed, if the blood bag has a low filling level and does not remain deformation-free due to its own stability.
  • the blood bag can remain on its holder all the time, so that the bag with the holder can be placed in a centrifuge, then transported to the separating device with the holder and clamped in the separating device can.
  • the bag itself must be handled as rarely as possible, since in each case it is not the blood bag itself, but rather the holder that is handled, handled and clamped.
  • multiple removal or hanging of the blood bag on holders is not necessary, since the blood bag can always remain on the same holder during the entire treatment steps.
  • a simplification and structurally and economically favorable design of the separating device can be achieved if the holder is mounted such that it can be adjusted in height but the separating strips always have the same height.
  • the constructional and thus also the financial outlay is considerably reduced, since the separating strips have to absorb certain forces in order to achieve a safe separation of the different components in the bag.
  • To create a height adjustment for separating strips loaded in this way is considerably more complex than the height adjustment for only the holder of the blood bags.
  • the adjustment of the blood bag between the two separating strips can be facilitated in that the separating strip on the user side has a window which exposes the view of the blood bag in the area of the phase boundary.
  • This window can advantageously be created in that the separating strip on the user side consists of a transparent material. This ensures that this separating bar lies securely and sufficiently firmly against the blood bag and, in contrast to windows designed as recesses, a uniform clamping pressure can be exerted over the entire width of the blood bag.
  • the clamping pressure for the two separating strips can be built up and held by hand by means of springs or the like.
  • the arrangement of connecting elements, for example in the form of screws or clamps, at the two outer ends of the separating strips is advantageous.
  • dividing strips 6 and 7 are arranged, which can be made of metal, for example, the dividing strip 7 near the user having a window 8 almost over its entire width, which consists of acrylic glass, glass or a similar transparent material can, so that almost the entire separating strip 7 consists of a transparent material.
  • the separating strips 6 and 7 squeeze a blood bag 9 between them, two different phases being present within the blood bag 9, of which, for example, the lower phase can contain red blood cells, while the upper phase contains blood plasma is formed.
  • the separating strips 6 and 7 ensure that the two phases cannot mix within the blood bag.
  • the clamping effect of the two separating strips 6 and 7 can be improved and ensured by screws 10, which are arranged in the region of the outermost ends of the separating strip 7 and interact with corresponding threaded holes in the outermost ends of the separating strip 6.
  • the blood bag 9 is attached to a holder 11, which essentially consists of a holding plate 12 and a holding fork 14.
  • the blood bag 9 has in its upper region two openings with which it can be hung on the holding fork 14 and a drain opening to which a hose is connected in the illustration, which leads, for example, to a collecting vessel.
  • the holder 11 Since the proportions of the two components to be separated are different for each dispenser, the holder 11 is mounted on the device in an adjustable manner.
  • the holder 11 with the lower region of its holding plate 12 is located in a height-adjustable support 15 which, with its two outer lower regions 16, engages around the vertical arm 2 and is guided in this way, and which is by means of a toothed rack 17 and an adjusting knob 18 its height can be adjusted.
  • a toothed rack 17 and an adjusting knob 18 its height can be adjusted.
  • Fig. 2 the device of Fig. 1 is in section and shown in the open position. It is clear that the lever 5 can be pressed down against the action of a spring 19, so that the arms 2 and 3 are spread approximately V-shaped. In its lowest position, the lever 5 can be fixed with the aid of a locking device 20. In this open position of the two arms 2 and 3, a comfortable hanging of the blood bag into the V-shaped space between the two arms 2 and 3 is possible. A first height adjustment of the blood bag can be made through the height adjustability of the holder 11.
  • the lever 5 can then be moved upwards, overcoming the latching device 7, so that the two arms 2 and 3 are moved relative to one another by the spring 19. Due to the position of the pivot axis 4, the arms 2 and 3 always create a sufficiently large space between them for receiving the blood bag, so that the blood bag is not touched by the arms 2 and 3, as can be seen in particular from FIG. 3.
  • squeeze profiles 21 and 22 which are preferably elastic and can be designed as a rubber profile.
  • the dividing line between the two components may shift within the blood bag 9 the user easily the correct installation of the Check the squeeze profiles, in particular the squeeze profile 22, on the blood bag and, if necessary, make a fine adjustment by adjusting the height.
  • the blood bag 9 can be connected to the holder 11 before the blood bag 9 is placed in the centrifuge for the primary separation of the two components.
  • a mounting surface 23 is formed on the holding plate 12, which enables the holder 11 to be arranged in the centrifuge.
  • the blood bag After centrifugation, the blood bag can be transported over a large area adjacent to the holding plate 12 to the separating device, so that treatment of the blood bag that is as gentle as possible is ensured here and mixing between the two phases within the blood bag 9 can be avoided. Then the holder 11 is inserted into the carrier 15 behind the vertical arm 2, at the same time the blood bag 9 is arranged in front of the arm 2 and in front of the dividing bar 6. The device can now be operated as described above and the two components within the blood bag can be separated immiscibly. The upper component can then be sucked off through the tube connected to the blood bag 9, run off by the action of gravity or the like.
  • the lower component remaining in the blood bag 9 can be centrifuged again and split into sub-components.
  • the blood bag can easily be re-adjusted in height in order to likewise separate the two remaining components.
  • the device according to the invention creates a simple, hand-operated device that does not rely on external energy and ensures safe and trouble-free operation over a long period of time.
  • Careful storage and transport of the blood bag is ensured in the centrifuge, from the centrifuge to the device and in the device, so that the two components, which are primarily separated in the centrifuge, do not mix and contaminate one another in the further course of the treatment. In this way, the two components can be obtained with a very high degree of yield and can be separated from one another with high purity.
  • the two arms 2 and 3 are in their end position almost parallel to each other.
  • the hinge axis 4 could also be closer to the vertical arm 2, as is also known in devices according to the prior art.
  • Undesirable deformation and squeezing of the blood bags can nevertheless be prevented if the dimensions of the dividing strips 6 and 7 are chosen accordingly: in this case, the two arms 2 and 3 are in a still V-shaped spread position when the dividing strips 6 and 7 touch and squeeze the blood bag.
  • the V-shaped space between the two arms 2 and 3 can be dimensioned so large that an undesirable deformation of the blood bag by the arms themselves can be avoided.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

In an auxiliary blood components separating device having two arms which can be moved toward one another and between which a blood bag can be arranged, the invention proposes that separating strips be arranged on the arms, the strips extending over the entire width of a blood bag and being arranged on the arms so as to point toward one another. In this way, the two components can be separated from one another and one of the two components can then be withdrawn from the blood bag. <IMAGE>

Description

Die Erfindung bezieht sich auf eine Vorrichtung zum Trennen verschiedener Komponenten im Blut nach dem Oberbegriff des Anspruches 1.The invention relates to a device for separating various components in blood according to the preamble of claim 1.

Eine derartige Vorrichtung ist beispielsweise aus der DE-35 31 430 A1 bekannt. Es handelt sich dabei um ein ausschließlich motorisch betriebenes Gerät, bei dem die Blutbeutel im Gerät aufgehängt werden. Zu diesem Zweck weisen die Beutel üblicherweise mehrere Löcher in ihrem oberen Bereich auf, mit denen sie auf Haken oder ähnliche Aufnahmevorrichtungen gehängt werden können.Such a device is known for example from DE-35 31 430 A1. It is an exclusively motor-operated device in which the blood bags are suspended in the device. For this purpose, the bags usually have several holes in their upper area, with which they can be hung on hooks or similar holding devices.

Weiterhin verweist die DE-35 31 430 A1 auf einen Artikel in der Zeitschrift "Med. Welt", Band 30 (1979), Heft 43, Seiten 1597 - 1601. Dort wird ein Gerät beschrieben, welches ausschließlich manuell bedienbar ist und welches ein in der Höhe verstellbares Trenngestell mit horizontal zusammen- bzw. auseinanderfahrbaren Trennleisten und eine Aufhängung für den Beutel enthält. Auch in diesem Gerät wird der Beutel direkt auf Haken oder eine ähnliche Halterung aufgehängt, die unmittelbar und fest montiert Teil des Gerätes ist.Furthermore, DE-35 31 430 A1 refers to an article in the magazine "Med. Welt", volume 30 (1979), number 43, pages 1597-1601. There, a device is described which can only be operated manually and which is an in height adjustable Separating frame with horizontally collapsible or separable separating strips and a suspension for the bag contains. In this device, too, the bag is hung directly on hooks or a similar holder, which is part of the device directly and firmly mounted.

Während die primäre Trennung verschieden schwerer Komponenten in einer Flüssigkeit, beispielsweise im Blut von Blutspendern, mittels einer Zentrifuge erfolgt, kann die sekundäre Trennung beispielsweise in einer derartigen Vorrichtung erfolgen. Bei dieser sekundären Trennung werden die beiden Komponenten, die zunächst zwar getrennt, aber in einem gemeinsamen Behälter, wie beispielsweise einem Blutbeutel, vorliegen, endgültig voneinander getrennt und beispielsweise in unterschiedlichen Behältern untergebracht.While the primary separation of components of different weights takes place in a liquid, for example in the blood of blood donors, by means of a centrifuge, the secondary separation can take place, for example, in such a device. In this secondary separation, the two components, which are initially separated but are in a common container, such as a blood bag, are finally separated from one another and are accommodated in different containers, for example.

Häufig wird die oben beschriebene Arbeitsabfolge mehrfach nacheinander wiederholt, so daß nach jedem erneuten Zentrifugieren die immer weiter aufgetrennten Komponenten innerhalb des Blutbeutels vorliegen und jeweils vor dem nächsten Zentrifugierschritt eine oder mehrere Komponenten aus dem Beutel abgezogen werden. Der dabei kontinuierlich abnehmende Füllgrad der Blutbeutel führt dazu, daß der Beutel zunehmend instabiler wird und nicht mehr aufgrund allein seines Füllvolumens aufrecht steht.Frequently, the work sequence described above is repeated several times in succession, so that after each new centrifugation the components which are separated further and further are present within the blood bag and one or more components are withdrawn from the bag before the next centrifugation step. The continuously decreasing degree of filling of the blood bags leads to the bag becoming increasingly unstable and no longer standing upright due to its filling volume alone.

Dies bedeutet, daß bei dem Transport von der Zentrifuge zu der Vorrichtung zum Trennen der Komponenten die Gefahr stark ansteigt, daß eine unbeabsichtigte Verformung des Blutbeutels eine Verletzung der Grenzschicht und eine Vermischung der beiden Komponenten bewirkt. Zudem wird selbst bei erfolgreichem und schonenden Transport der Blutbeutel von der Zentrifuge zur Trennvorrichtung der Beutel anschließend verformt, wenn er in der Trennvorrichtung aufgehängt wird. Die Aufhängungsöffnungen im Beutel sind in geringem Abstand voneinander angeordnet, so daß die beiden oberen Ecken des Blutbeutels, insbesondere bei einem schlechten Füllgrad des Blutbeutels, umklappen und nach vorne oder hinten fallen können, wodurch sich der Beutel verformt und die unerwünschte Störung in der Grenzschicht zwischen den Komponenten auftreten kann.This means that during the transport from the centrifuge to the device for separating the components, there is a great risk that an unintentional deformation of the blood bag will damage the boundary layer and mix the two components causes. In addition, even if the blood bag is successfully and carefully transported from the centrifuge to the separating device, the bag is subsequently deformed when it is suspended in the separating device. The suspension openings in the bag are arranged at a small distance from each other, so that the two upper corners of the blood bag, especially when the blood bag is poorly filled, can fold over and fall forwards or backwards, causing the bag to deform and the undesirable disturbance in the boundary layer between the components can occur.

Die angestrebte Vollständigkeit der Trennung der Komponenten, die durch die Verwendung von Trennleisten erzielt werden soll , kann auf diese Weise in Frage gestellt werden.The desired completeness of the separation of the components, which is to be achieved by using separating strips, can be questioned in this way.

Der Erfindung liegt die Aufgabe zugrunde, eine gattungsgemäße Vorrichtung dahingehend zu verbessern, daß eine hohe Effizienz und eine sichere und reine Trennung der verschiedenen Komponenten auch bei einem schlechten Füllgrad des Blutbeutels erzielbar ist.The invention has for its object to improve a generic device in such a way that a high efficiency and a safe and pure separation of the various components can be achieved even with a poor fill level of the blood bag.

Diese der Erfindung zugrundeliegende Aufgabe wird gelöst durch eine Ausbildung gemäß Anspruch 1.This object on which the invention is based is achieved by an embodiment according to claim 1.

Die Erfindung schlägt mit anderen Worten vor, einen Halter für den Blutbeutel an der Vorrichtung vorzusehen, der von der Vorrichtung lösbar ist. Der Halter soll dabei eine Platte umfassen. Auf diese Weise wird eine Anlagefläche durch die Platte geschaffen, an der der Blutbeutel anliegt, so daß eine Verformung des Blutbeutels auch dann nicht mehr erfolgt, wenn der Blutbeutel einen geringen Füllgrad aufweist und nicht aus eigener Stabilität heraus verformungsfrei bleibt.In other words, the invention proposes to provide a holder for the blood bag on the device which is detachable from the device. The holder should include a plate. In this way, a contact surface is created through the plate, against which the blood bag rests, so that the blood bag is no longer deformed, if the blood bag has a low filling level and does not remain deformation-free due to its own stability.

Insbesondere ist bei der erfindungsgemäßen Ausbildung der Vorrichtung vorteilhaft, daß der Blutbeutel die ganze Zeit über an seinem Halter verbleiben kann, so daß der Beutel mit dem Halter in eine Zentrifuge gegeben werden kann, anschließend mit dem Halter zur Trennvorrichtung transportiert und in die Trennvorrichtung eingespannt werden kann. Auf diese Weise ist eine möglichst seltene Handhabung des Beutels selbst erforderlich, da jeweils nicht der Blutbeutel selbst, sondern der Halter angefaßt, gehandhabt und eingespannt wird. Weiterhin ist kein mehrfaches Abnehmen oder Aufhängen des Blutbeutels an Halterungen erforderlich, da der Blutbeutel während der gesamten Behandlungsschritte stets an demselben Halter verbleiben kann.In particular, in the embodiment of the device according to the invention it is advantageous that the blood bag can remain on its holder all the time, so that the bag with the holder can be placed in a centrifuge, then transported to the separating device with the holder and clamped in the separating device can. In this way, the bag itself must be handled as rarely as possible, since in each case it is not the blood bag itself, but rather the holder that is handled, handled and clamped. Furthermore, multiple removal or hanging of the blood bag on holders is not necessary, since the blood bag can always remain on the same holder during the entire treatment steps.

Insbesondere kann eine Vereinfachung und baulich sowie preislich günstige Ausgestaltung der Trennvorrichtung erzielt werden, wenn der Halter höhenverstellbar gelagert ist, die Trennleisten jedoch stets die gleiche Höhe aufweisen. Gegenüber einer starren Halterung des Beutels und höhenbeweglich verstellbaren Trennleisten wird der konstruktive und damit auch finanzielle Aufwand erheblich verringert, da die Trennleisten gewisse Kräfte aufnehmen müssen, um eine sichere Trennung der verschiedenen Komponenten im Beutel zu erreichen. Eine Höhenverstellbarkeit für derartig belastete Trennleisten zu schaffen, ist gegenüber der Höhenverstellbarkeit für lediglich den Halter der Blutbeutel erheblich aufwendiger.In particular, a simplification and structurally and economically favorable design of the separating device can be achieved if the holder is mounted such that it can be adjusted in height but the separating strips always have the same height. Compared to a rigid holding of the bag and height-adjustable separating strips, the constructional and thus also the financial outlay is considerably reduced, since the separating strips have to absorb certain forces in order to achieve a safe separation of the different components in the bag. To create a height adjustment for separating strips loaded in this way is considerably more complex than the height adjustment for only the holder of the blood bags.

Die Justierung des Blutbeutels zwischen den beiden Trennleisten kann dadurch erleichtert werden, daß die benutzerseitige Trennleiste ein Fenster aufweist, welches den Blick auf den Blutbeutel im Bereich der Phasengrenze freigibt.The adjustment of the blood bag between the two separating strips can be facilitated in that the separating strip on the user side has a window which exposes the view of the blood bag in the area of the phase boundary.

Dieses Fenster kann vorteilhafterweise dadurch geschaffen werden, daß die benutzerseitige Trennleiste aus einem transparenten Werkstoff besteht. So wird sichergestellt, daß diese Trennleiste sicher und ausreichend fest dem Blutbeutel anliegt und im Gegensatz zu als Aussparungen ausgebildeten Fenstern ein gleichmäßiger Klemmdruck über die gesamte Breite des Blutbeutels ausgeübt werden kann.This window can advantageously be created in that the separating strip on the user side consists of a transparent material. This ensures that this separating bar lies securely and sufficiently firmly against the blood bag and, in contrast to windows designed as recesses, a uniform clamping pressure can be exerted over the entire width of the blood bag.

Der Klemmdruck für die beiden Trennleisten kann von Hand durch Federn od. dgl. aufgebaut und gehalten werden. Vorteilhaft ist jedoch die Anordnung von Verbindungselementen, beispielsweise in Form von Schrauben oder Klammern, an den beiden äußeren Enden der Trennleisten. Nach Einspannung und Klemmung des Blutbeutels zwischen den beiden Trennleisten kann auf diese Weise eine sichere Trennung der beiden Komponenten innerhalb des Blutbeutels auch über eine längere Zeit gewährleistet werden.The clamping pressure for the two separating strips can be built up and held by hand by means of springs or the like. However, the arrangement of connecting elements, for example in the form of screws or clamps, at the two outer ends of the separating strips is advantageous. After the blood bag has been clamped and clamped between the two separating strips, a reliable separation of the two components within the blood bag can also be ensured over a long period of time.

Durch Anordnung elastischer Quetschprofile in den Stirnkanten der Trennleisten kann auch bei unregelmäßig dicken Blutbeuteln oder bei auf den Blutbeuteln angebrachten Aufklebern od. dgl. eine gleichmäßig dichte Anlage der beiden Innenflächen des Blutbeutels aneinander durch die Einwirkung der Trennleisten sichergestellt werden.By arranging elastic squeeze profiles in the front edges of the separating strips, even with irregularly thick blood bags or with stickers or the like attached to the blood bags, a uniformly tight contact of the two inner surfaces of the blood bag with one another can be ensured by the action of the separating strips.

Ein Ausführungsbeispiel der Erfindung wird anhand der Zeichnung im folgenden näher erläutert. Dabei zeigt

Fig. 1
eine erfindungsgemäße Vorrichtung in perspektivischer Ansicht,
Fig. 2
einen Schnitt durch die Vorrichtung von Fig. 1 in geöffneter Stellung und
Fig. 3
einen Schnitt ähnlich Fig. 2, jedoch in geschlossener Stellung mit eingespanntem Blutbeutel
In Fig. 1 ist eine erfindungsgemäße Vorrichtung zum Trennen verschiedener Blutkomponenten innerhalb eines Blutbeutels dargestellt. Diese Vorrichtung umfaßt eine Plattform 1 und einen starren, senkrechten Arm 2. Weiterhin umfaßt die Vorrichtung einen schwenkbaren Arm 3, der um eine Schwenkachse 4 schwenkbar gelagert ist und mit Hilfe eines Hebels 5 betätigt, also verschwenkt werden kann.An embodiment of the invention is based on the drawing explained in more detail below. It shows
Fig. 1
a device according to the invention in perspective view,
Fig. 2
a section through the device of Fig. 1 in the open position and
Fig. 3
a section similar to FIG. 2, but in the closed position with a clamped blood bag
1 shows a device according to the invention for separating different blood components within a blood bag. This device comprises a platform 1 and a rigid, vertical arm 2. Furthermore, the device comprises a pivotable arm 3 which is pivotally mounted about a pivot axis 4 and can be actuated, that is to say pivoted, by means of a lever 5.

An den oberen Enden der beiden Arme 2 und 3 sind Trennleisten 6 und 7 angeordnet, die beispielsweise aus Metall bestehen können, wobei die benutzernahe Trennleiste 7 nahezu über ihre gesamte Breite ein Fenster 8 aufweist, welches aus Acrylglas, Glas oder einem ähnlichen transparenten Werkstoff bestehen kann, so daß nahezu die gesamte Trennleiste 7 aus einem transparenten Werkstoff besteht.At the upper ends of the two arms 2 and 3, dividing strips 6 and 7 are arranged, which can be made of metal, for example, the dividing strip 7 near the user having a window 8 almost over its entire width, which consists of acrylic glass, glass or a similar transparent material can, so that almost the entire separating strip 7 consists of a transparent material.

Die Trennleisten 6 und 7 quetschen einen Blutbeutel 9 zwischen sich, wobei innerhalb des Blutbeutels 9 zwei verschiedene Phasen vorliegen, von denen beispielsweise die untere Phase rote Blutkörperchen enthalten kann, während die obere Phase von Blutplasma gebildet wird. Die Trennleisten 6 und 7 stellen sicher, daß sich die beiden Phasen innerhalb des Blutbeutels nicht vermischen können. Zu diesem Zweck kann die Klemmwirkung der beiden Trennleisten 6 und 7 durch Schrauben 10 verbessert und sichergestellt werden, die im Bereich der äußersten Enden der Trennleiste 7 angeordnet sind und mit entsprechenden Gewindebohrungen in den äußersten Enden der Trennleiste 6 zusammenwirken.The separating strips 6 and 7 squeeze a blood bag 9 between them, two different phases being present within the blood bag 9, of which, for example, the lower phase can contain red blood cells, while the upper phase contains blood plasma is formed. The separating strips 6 and 7 ensure that the two phases cannot mix within the blood bag. For this purpose, the clamping effect of the two separating strips 6 and 7 can be improved and ensured by screws 10, which are arranged in the region of the outermost ends of the separating strip 7 and interact with corresponding threaded holes in the outermost ends of the separating strip 6.

Der Blutbeutel 9 ist an einem Halter 11 befestigt, der im wesentlichen aus einer Halteplatte 12 und einer Haltegabel 14 besteht. Der Blutbeutel 9 weist in seinem oberen Bereich zwei Öffnungen auf, mit denen er auf die Haltegabel 14 gehängt werden kann sowie eine Abflußöffnung, an die in der Darstellung ein Schlauch angeschlossen ist, der beispielsweise zu einem Sammelgefäß führt.The blood bag 9 is attached to a holder 11, which essentially consists of a holding plate 12 and a holding fork 14. The blood bag 9 has in its upper region two openings with which it can be hung on the holding fork 14 and a drain opening to which a hose is connected in the illustration, which leads, for example, to a collecting vessel.

Da die Mengenverhältnisse der beiden zu trennenden Komponenten bei jedem Spender unterschiedlich sind, ist der Halter 11 höhenverstellbar an der Vorrichtung gelagert. Zu diesem Zweck befindet sich der Halter 11 mit dem unteren Bereich seiner Halteplatte 12 in einem höhenverstellbaren Träger 15, der mit seinen beiden äußeren unteren Bereichen 16 um den senkrechten Arm 2 greift und so geführt ist, und der mittels einer Zahnstange 17 und eines Einstellknopfes 18 in seiner Höhe verstellt werden kann. Auf diese Weise kann für jeden Blutbeutel unterschiedlich die Stelle einjustiert werden, an der die beiden Phasen voneinander durch die Trennleisten 6 und 7 getrennt werden.Since the proportions of the two components to be separated are different for each dispenser, the holder 11 is mounted on the device in an adjustable manner. For this purpose, the holder 11 with the lower region of its holding plate 12 is located in a height-adjustable support 15 which, with its two outer lower regions 16, engages around the vertical arm 2 and is guided in this way, and which is by means of a toothed rack 17 and an adjusting knob 18 its height can be adjusted. In this way, the location at which the two phases are separated from one another by the separating strips 6 and 7 can be adjusted differently for each blood bag.

In Fig. 2 ist die Vorrichtung von Fig. 1 im Schnitt und in geöffneter Stellung dargestellt. Dabei wird deutlich, daß der Hebel 5 gegen die Wirkung einer Feder 19 heruntergedrückt werden kann, so daß die Arme 2 und 3 etwa V-förmig gespreizt werden. In seiner untersten Stellung kann der Hebel 5 mit Hilfe einer Rastvorrichtung 20 fixiert werden. In dieser geöffneten Stellung der beiden Arme 2 und 3 ist ein bequemes Einhängen des Blutbeutels in den V-förmigen Raum zwischen den beiden Armen 2 und 3 möglich. Eine erste Höhenanpassung des Blutbeutels kann durch die Höhenverstellbarkeit des Halters 11 vorgenommen werden.In Fig. 2 the device of Fig. 1 is in section and shown in the open position. It is clear that the lever 5 can be pressed down against the action of a spring 19, so that the arms 2 and 3 are spread approximately V-shaped. In its lowest position, the lever 5 can be fixed with the aid of a locking device 20. In this open position of the two arms 2 and 3, a comfortable hanging of the blood bag into the V-shaped space between the two arms 2 and 3 is possible. A first height adjustment of the blood bag can be made through the height adjustability of the holder 11.

Anschließend kann der Hebel 5 unter Überwindung der Rastvorrichtung 7 nach oben bewegt werden, so daß die beiden Arme 2 und 3 durch die Feder 19 unterstützt zueinander bewegt werden. Aufgrund der Position der Schwenkachse 4 schaffen die Arme 2 und 3 stets einen ausreichend großen Raum zwischen sich zur Aufnahme des Blutbeutels, so daß der Blutbeutel von den Armen 2 und 3 nicht berührt wird, wie dies insbesondere aus Fig. 3 ersichtlich ist.The lever 5 can then be moved upwards, overcoming the latching device 7, so that the two arms 2 and 3 are moved relative to one another by the spring 19. Due to the position of the pivot axis 4, the arms 2 and 3 always create a sufficiently large space between them for receiving the blood bag, so that the blood bag is not touched by the arms 2 and 3, as can be seen in particular from FIG. 3.

Die sekundäre Trennung der beiden Komponenten innerhalb des Blutbeutels 9 erfolgt durch Quetschprofile 21 und 22, die vorzugsweise elastisch sind und als Gummiprofil ausgebildet sein können.The secondary separation of the two components within the blood bag 9 takes place by means of squeeze profiles 21 and 22, which are preferably elastic and can be designed as a rubber profile.

Während sich die beiden Arme 2 und 3 ihrer in Fig. 3 gezeigten Stellung nähern und den Blutbeutel 9 unter Einwirkung der Feder 19 langsam eindrücken und verformen, verschiebt sich möglicherweise die Trennlinie zwischen den beiden Komponenten innerhalb des Blutbeutels 9. Mit Hilfe des Fensters 8 kann der Benutzer auf einfache Weise die korrekte Anlage der Quetschprofile, insbesondere des Quetschprofils 22, am Blutbeutel kontrollieren und ggf. durch eine Höhenverstellung noch eine Feinjustierung vornehmen.As the two arms 2 and 3 approach their position shown in FIG. 3 and slowly push in and deform the blood bag 9 under the action of the spring 19, the dividing line between the two components may shift within the blood bag 9 the user easily the correct installation of the Check the squeeze profiles, in particular the squeeze profile 22, on the blood bag and, if necessary, make a fine adjustment by adjusting the height.

Dabei erweist sich als vorteilhaft, daß die Verformung des Blutbeutels 9 über seine gesamte Breite erfolgt, so daß sich keine unkontrollierten Strömungen innerhalb des Blutbeutels ausbilden. Trotz der Verformung des Blutbeutels 9 ergibt sich so eine ungestört verlaufende Trennungslinie zwischen den beiden Komponenten, die lediglich durch die Verformung des Blutbeutels 9 eventuell in der Höhe verschoben wird.It proves to be advantageous that the deformation of the blood bag 9 takes place over its entire width, so that no uncontrolled flows form inside the blood bag. Despite the deformation of the blood bag 9, there is an undisturbed dividing line between the two components, which is possibly only shifted in height by the deformation of the blood bag 9.

Dadurch, daß der Halter 11 entfernbar in dem Träger 15 angeordnet ist, kann der Blutbeutel 9 mit dem Halter 11 verbunden werden, bevor der Blutbeutel 9 zur primären Trennung der beiden Komponenten in die Zentrifuge gegeben wird. Hierzu ist an die Halteplatte 12 eine Befestigungsfläche 23 angeformt, die die Anordnung des Halters 11 in der Zentrifuge ermöglicht. Durch die Schaffung der Halteplatte 12 liegt der Blutbeutel 9 großflächig am Halter 11 an, so daß schon in der Zentrifuge unerwünschte Verformungen des Blutbeutels 9 in Form von Falten oder Knicken vermieden werden können.Because the holder 11 is removably arranged in the carrier 15, the blood bag 9 can be connected to the holder 11 before the blood bag 9 is placed in the centrifuge for the primary separation of the two components. For this purpose, a mounting surface 23 is formed on the holding plate 12, which enables the holder 11 to be arranged in the centrifuge. By creating the holding plate 12, the blood bag 9 lies on the holder 11 over a large area, so that undesired deformations of the blood bag 9 in the form of folds or kinks can be avoided even in the centrifuge.

Nach erfolgter Zentrifugierung kann der Blutbeutel großflächig an der Halteplatte 12 anliegend zur Trennvorrichtung transportiert werden, so daß auch hier eine möglichst schonende Behandlung des Blutbeutels sichergestellt ist und Vermischungen zwischen den beiden Phasen innerhalb des Blutbeutels 9 vermieden werden können. Anschließend wird der Halter 11 in den Träger 15 hinter dem senkrechten Arm 2 eingesteckt, wobei gleichzeitig der Blutbeutel 9 vor dem Arm 2 und vor der Trennleiste 6 angeordnet wird. Nun kann die Vorrichtung wie oben beschrieben betätigt werden und die beiden Komponenten innerhalb des Blutbeutels unvermischbar trennen. Die obere Komponente kann anschließend durch den an den Blutbeutel 9 angeschlossenen Schlauch abgesaugt werden, durch die Einwirkung der Schwerkraft ablaufen od. dgl.After centrifugation, the blood bag can be transported over a large area adjacent to the holding plate 12 to the separating device, so that treatment of the blood bag that is as gentle as possible is ensured here and mixing between the two phases within the blood bag 9 can be avoided. Then the holder 11 is inserted into the carrier 15 behind the vertical arm 2, at the same time the blood bag 9 is arranged in front of the arm 2 and in front of the dividing bar 6. The device can now be operated as described above and the two components within the blood bag can be separated immiscibly. The upper component can then be sucked off through the tube connected to the blood bag 9, run off by the action of gravity or the like.

Schließlich kann die untere, im Blutbeutel 9 verbliebene Komponente erneut zentrifugiert und in Unterkomponenten aufgespalten werden. Beim erneuten Einhängen des Blutbeutels in die erfindungsgemäße Vorrichtung kann auf einfache Weise eine erneute Höhenanpassung des Blutbeutels vorgenommen werden, um die nun verbleibenden zwei Komponenten ebenfalls wieder zu trennen.Finally, the lower component remaining in the blood bag 9 can be centrifuged again and split into sub-components. When the blood bag is reinserted into the device according to the invention, the blood bag can easily be re-adjusted in height in order to likewise separate the two remaining components.

Zusammenfassend wird durch die erfindungsgemäße Vorrichtung eine einfache handbetätigte Vorrichtung geschaffen, die nicht auf Fremdenergie angewiesen ist und einen sicheren und störungsfreien Betrieb über eine lange Zeit gewährleistet. Eine schonende Lagerung und ein schonender Transport des Blutbeutels wird in der Zentrifuge, von der Zentrifuge zu der Vorrichtung und in der Vorrichtung gewährleistet, so daß sich die beiden in der Zentrifuge primär getrennten Komponenten auch im weiteren Verlauf der Behandlung nicht vermischen und gegenseitig verunreinigen. Auf diese Weise können die beiden Komponenten mit einem sehr hohen Ausbeutegrad gewonnen und in hoher Reinheit voneinander getrennt werden.In summary, the device according to the invention creates a simple, hand-operated device that does not rely on external energy and ensures safe and trouble-free operation over a long period of time. Careful storage and transport of the blood bag is ensured in the centrifuge, from the centrifuge to the device and in the device, so that the two components, which are primarily separated in the centrifuge, do not mix and contaminate one another in the further course of the treatment. In this way, the two components can be obtained with a very high degree of yield and can be separated from one another with high purity.

Bei dem dargestellten Ausführungsbeispiel befinden sich die beiden Arme 2 und 3 in ihrer Endstellung nahezu parallel zueinander. In Abwandlung des dargestellten Ausführungsbeispiels könnte die Gelenkachse 4 auch näher an dem senkrechten Arm 2 liegen, wie dies auch bei Vorrichtungen nach dem Stand der Technik bekannt ist. Ein unerwünschtes Verformen und Quetschen der Blutbeutel kann dennoch verhindert werden, wenn die Abmessungen bei den Trennleisten 6 und 7 dementsprechend gewählt werden: In diesem Fall befinden sich die beiden Arme 2 und 3 in einer noch V-förmig gespreizten Stellung, wenn die Trennleisten 6 und 7 den Blutbeutel berühren und einquetschen. Bei entsprechender Ausbildung der Trennleisten kann derV-förmige Raum zwischen den beiden Armen 2 und 3 so groß bemessen sein, daß eine unerwünschte Verformung des Blutbeutels durch die Arme selbst vermeidbar ist.In the illustrated embodiment, the two arms 2 and 3 are in their end position almost parallel to each other. In a modification of the illustrated embodiment, the hinge axis 4 could also be closer to the vertical arm 2, as is also known in devices according to the prior art. Undesirable deformation and squeezing of the blood bags can nevertheless be prevented if the dimensions of the dividing strips 6 and 7 are chosen accordingly: in this case, the two arms 2 and 3 are in a still V-shaped spread position when the dividing strips 6 and 7 touch and squeeze the blood bag. With a corresponding design of the dividing strips, the V-shaped space between the two arms 2 and 3 can be dimensioned so large that an undesirable deformation of the blood bag by the arms themselves can be avoided.

Claims (6)

Vorrichtung zum Trennen verschiedener Komponenten im Blut, mit zwei zueinander bewegbaren Armen, zwischen denen ein Beutel mit Blut anordbar ist, und mit Trennleisten (6, 7), die sich über die gesamte Breite eines Blutbeutels (9) erstrecken und an den beiden Armen (2, 3) zueinander gerichtet angeordnet sind, gekennzeichnet durch einen lösbar an der Vorrichtung angeordneten Halter (11) für den Blutbeutel (9), wobei der Halter (11) eine Halteplatte (12) umfaßt.Device for separating various components in the blood, with two arms which can be moved relative to one another, between which a bag of blood can be arranged, and with separating strips (6, 7) which extend over the entire width of a blood bag (9) and on the two arms ( 2, 3) are arranged facing each other, characterized by a holder (11) for the blood bag (9) which is detachably arranged on the device, the holder (11) comprising a holding plate (12). Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß der Halter (11) höhenverstellbar gelagert ist.Apparatus according to claim 1, characterized in that the holder (11) is mounted adjustable in height. Vorrichtung nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß die dem Benutzer nahe Trennleiste (7) ein Fenster (8) aufweist.Device according to claim 1 or 2, characterized in that the separating strip (7) close to the user has a window (8). Vorrichtung nach Anspruch 3, gekennzeichnet durch eine benutzernahe Trennleiste aus transparentem Werkstoff.Device according to claim 3, characterized by a separating strip made of transparent material which is close to the user. Vorrichtung nach einem der vorhergehenden Ansprüche, gekennzeichnet durch Verbindungselemente (Schrauben 10) für die Trennleisten (6, 7) im Bereich der beiden äußeren Enden jeder Trennleiste (6, 7).Device according to one of the preceding claims, characterized by connecting elements (screws 10) for the separating strips (6, 7) in the region of the two outer ends of each separating strip (6, 7). Vorrichtung nach einem der vorhergehenden Ansporüche, gekennzeichnet durch elastische Quetschprofile (21, 22) in den Stirnkanten der Trennleisten (6, 7).Device according to one of the preceding claims, characterized by elastic squeeze profiles (21, 22) in the end edges of the separating strips (6, 7).
EP93102635A 1992-02-25 1993-02-19 Blood components separating device Expired - Lifetime EP0557900B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4205712 1992-02-25
DE4205712A DE4205712C1 (en) 1992-02-25 1992-02-25

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EP0557900A2 true EP0557900A2 (en) 1993-09-01
EP0557900A3 EP0557900A3 (en) 1993-10-13
EP0557900B1 EP0557900B1 (en) 1995-10-11

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AT (1) ATE128875T1 (en)
DE (1) DE4205712C1 (en)

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Publication number Priority date Publication date Assignee Title
WO2012153353A1 (en) * 2011-05-10 2012-11-15 Beniwal Omprakash Plasma expressor manual top and bottom

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
DE4331138C1 (en) * 1993-09-14 1995-01-05 Heinz Kruessel Blood bag holder
DE10316598B4 (en) * 2003-04-11 2008-05-21 Andreas Hettich Gmbh & Co. Kg Process and centrifuge for the recovery of biological fluids
US20070194043A1 (en) * 2003-09-22 2007-08-23 Mank James F Press for removing supernatant from a flexible vessel
FR2968568B1 (en) 2010-12-14 2013-01-18 Maco Pharma Sa DEVICE FOR BREAKING AT LEAST ONE CLOSURE MEMBER WITH A FLEXIBLE TUBE

Citations (2)

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Publication number Priority date Publication date Assignee Title
US4310955A (en) * 1979-12-31 1982-01-19 David Henry B Blood element separation apparatus
EP0213469A2 (en) * 1985-09-03 1987-03-11 Biotest Pharma GmbH Process for extracting fluid constituents by severing volumes from a blood pouch, and device for carrying out the process

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US4310955A (en) * 1979-12-31 1982-01-19 David Henry B Blood element separation apparatus
EP0213469A2 (en) * 1985-09-03 1987-03-11 Biotest Pharma GmbH Process for extracting fluid constituents by severing volumes from a blood pouch, and device for carrying out the process

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012153353A1 (en) * 2011-05-10 2012-11-15 Beniwal Omprakash Plasma expressor manual top and bottom

Also Published As

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ATE128875T1 (en) 1995-10-15
EP0557900B1 (en) 1995-10-11
DE4205712C1 (en) 1993-07-01
EP0557900A3 (en) 1993-10-13

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