EP0509754A2 - Dispositif de distribution - Google Patents

Dispositif de distribution Download PDF

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Publication number
EP0509754A2
EP0509754A2 EP92303332A EP92303332A EP0509754A2 EP 0509754 A2 EP0509754 A2 EP 0509754A2 EP 92303332 A EP92303332 A EP 92303332A EP 92303332 A EP92303332 A EP 92303332A EP 0509754 A2 EP0509754 A2 EP 0509754A2
Authority
EP
European Patent Office
Prior art keywords
bottle
bottle according
medicament
receiving
frustoconical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92303332A
Other languages
German (de)
English (en)
Other versions
EP0509754A3 (en
Inventor
Leo Bunin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0509754A2 publication Critical patent/EP0509754A2/fr
Publication of EP0509754A3 publication Critical patent/EP0509754A3/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3216—Rigid containers disposed one within the other
    • B65D81/3222—Rigid containers disposed one within the other with additional means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2031—Separating means having openings brought into alignment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2037—Separating means having valve means

Definitions

  • Dispenser devices having multiple compartments for separately enclosed materials to be mixed prior to use are disclosed in U.S. patents 3,340,873, 3,354,883, 3,397,694, 3,411,503, 4,331,146, 4,412,836, 4,330,531 and 4,950,237. These systems are complex, contain many parts, and are expensive to manufacture.
  • This invention relates to fluid dispensing devices in which constituents of the fluid mixture can be maintained in isolation from one another and in which the separated constituents can be mixed in vitro , when desired, by placing the constituents in communication with one another.
  • a dislodgeable holder serves to maintain separation of the mixture components but can be dislodged by a plunger which is activated by the depression of the flexible bottom of the device.
  • a plunger which is activated by the depression of the flexible bottom of the device.
  • the body of the dispenser which may be provided with a removable cap, can thereafter be squeezed thereby causing droplet, flow or jet of mixed fluid to be emitted from an outlet nozzle of the dispenser.
  • the dispenser includes a septum to permit withdrawal of the mixed substances using a hypodermic needle or the like.
  • Figure 1 is a cross-sectional side elevation of the dispenser device of this invention before mixing the components.
  • Figure 2 is a cross-sectional side elevation of the dispenser device of this invention after mixing the components.
  • the dispenser device of the present invention preferably is made of a plastic material, for example, low density polyethylene, by a conventional blow molding technique to produce the bottom and mid body section, inserting the tablet containing means, and subsequently molding the body section to produce the upper section of the dispenser device. If, however, the neck is sufficiently wide to permit insertion of the holder device, the entire bottle can be made in one step. It is to be understood that the present invention is not limited to the specific material from which the dispenser device of the present invention is made, or the particular process by which it is made as it will be understood by those skilled in the art that many different materials and various manufacturing techniques may be employed.
  • the dispensing device of the present invention has a bellows bottom to permit in situ mixing of the contents at time of use, and a dropper dispenser tip calibrated to deliver predetermined amount of solution. Both bellows bottom vials and dropper dispenser tips are known in the art.
  • the dispensing device of the present invention comprises a bottle means 10 having bellows bottom 11 and dispenser means 12, for example, a dropper tip.
  • Bottle 10 is filled with a liquid 13, such as, for example, a physiologically acceptable ophthalmic liquid.
  • Tablet holding means 14 is an enlongated member having a cut-out section 15 for holding a solid medicament 16.
  • the holding means 14 may have a constant, or tapered cross section and the circumference or outer wall of holding means 14 may be circular or non-circular, e.g., cylindrical or oval.
  • the holding 14 means 14 preferably has a tapered cross section, such as, for example, a frustoconical member, to facilitate both seating and unseating against seating means 19.
  • a push member 17 extends from the bottom of member 15 to or near to the bottom of bottle 10.
  • Seating means 19 has inner wall 20 that is complementary in shape to the outer wall of member 14 and is thereby adapted to form a seal preventing liquid 13 from contacting medicament 16.
  • Seating means 19 is held by one or more support means 21 extending from shoulder 22 of bottle 10 to the member 15.
  • the bottom of support 21 is provided with flange means 23 to prevent seating means 19 from movement. In this position cut-out section 15 is surrounded by inner walls 20 of seating means 21 and is not in contact with liquid 13.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP19920303332 1991-04-18 1992-04-14 Dispenser device Withdrawn EP0509754A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68735191A 1991-04-18 1991-04-18
US687351 1991-04-18

Publications (2)

Publication Number Publication Date
EP0509754A2 true EP0509754A2 (fr) 1992-10-21
EP0509754A3 EP0509754A3 (en) 1993-04-07

Family

ID=24760114

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920303332 Withdrawn EP0509754A3 (en) 1991-04-18 1992-04-14 Dispenser device

Country Status (4)

Country Link
EP (1) EP0509754A3 (fr)
JP (1) JPH0611285B2 (fr)
CA (1) CA2065814A1 (fr)
IE (1) IE921238A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0702968A1 (fr) * 1994-04-12 1996-03-27 Tsukada Medical Research Co., Ltd. Recipient en forme de soufflet pour substance chimique
US5697919A (en) * 1994-04-11 1997-12-16 Tsukada Medical Research Co., Ltd. Portable analgesic system
WO2010081174A2 (fr) * 2009-01-12 2010-07-15 Aktivpak, Inc. Produits emballés, inserts et compartiments pour le mélange aseptique de substances, ainsi que procédés pour l'utilisation avec ceux-ci
WO2021186485A1 (fr) * 2020-03-18 2021-09-23 Brevetti Angela S.R.L. Récipient pré-rempli, méthode d'utilisation et méthode de production associée

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4608301B2 (ja) * 2004-12-14 2011-01-12 大成化工株式会社 用時溶解型点眼容器キット
KR20160071287A (ko) 2014-12-11 2016-06-21 이상희 환자용 약 보관 장치

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354883A (en) * 1965-03-08 1967-11-28 Southerland Elizabeth Lee Disposable syringe having frangible means for mixing plural medicaments
DE3152033A1 (de) * 1981-12-31 1983-07-07 Alfred Von 4178 Kevelaer Schuckmann Behaelter zur sterilen uebergabe von medikamenten
EP0417998A1 (fr) * 1989-09-15 1991-03-20 Merck & Co. Inc. Dispositif de distribution de fluide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354883A (en) * 1965-03-08 1967-11-28 Southerland Elizabeth Lee Disposable syringe having frangible means for mixing plural medicaments
DE3152033A1 (de) * 1981-12-31 1983-07-07 Alfred Von 4178 Kevelaer Schuckmann Behaelter zur sterilen uebergabe von medikamenten
EP0417998A1 (fr) * 1989-09-15 1991-03-20 Merck & Co. Inc. Dispositif de distribution de fluide

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5697919A (en) * 1994-04-11 1997-12-16 Tsukada Medical Research Co., Ltd. Portable analgesic system
EP0702968A1 (fr) * 1994-04-12 1996-03-27 Tsukada Medical Research Co., Ltd. Recipient en forme de soufflet pour substance chimique
EP0702968A4 (fr) * 1994-04-12 1997-04-02 Tsukada Medical Research Co Lt Recipient en forme de soufflet pour substance chimique
US5683369A (en) * 1994-04-12 1997-11-04 Tsukada Medical Research Co., Ltd. Bellows type container charged with liquid medicine
WO2010081174A2 (fr) * 2009-01-12 2010-07-15 Aktivpak, Inc. Produits emballés, inserts et compartiments pour le mélange aseptique de substances, ainsi que procédés pour l'utilisation avec ceux-ci
WO2010081174A3 (fr) * 2009-01-12 2010-10-14 Aktivpak, Inc. Produits emballés, inserts et compartiments pour le mélange aseptique de substances, ainsi que procédés pour l'utilisation avec ceux-ci
CN102482023A (zh) * 2009-01-12 2012-05-30 阿克蒂弗派克股份有限公司 用于无菌混合物质的包装产品、插入件和隔室及其使用方法
WO2021186485A1 (fr) * 2020-03-18 2021-09-23 Brevetti Angela S.R.L. Récipient pré-rempli, méthode d'utilisation et méthode de production associée

Also Published As

Publication number Publication date
IE921238A1 (en) 1992-10-21
EP0509754A3 (en) 1993-04-07
JPH05111523A (ja) 1993-05-07
CA2065814A1 (fr) 1992-10-19
JPH0611285B2 (ja) 1994-02-16

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