EP0499764A1 - Dispositif pour transférer du liquide entre des récipients flexibles et des fioles - Google Patents

Dispositif pour transférer du liquide entre des récipients flexibles et des fioles Download PDF

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Publication number
EP0499764A1
EP0499764A1 EP19910500093 EP91500093A EP0499764A1 EP 0499764 A1 EP0499764 A1 EP 0499764A1 EP 19910500093 EP19910500093 EP 19910500093 EP 91500093 A EP91500093 A EP 91500093A EP 0499764 A1 EP0499764 A1 EP 0499764A1
Authority
EP
European Patent Office
Prior art keywords
canule
piece
vial
thickening
bell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19910500093
Other languages
German (de)
English (en)
Inventor
Francisco Faraco Munoz
Gregorio Frias Garcia
Miguel Angel Moreno De La Guerra
Carlos Manuel Sandoval Balcazar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INSTITUTO DE BIOLOGIA Y SUEROTERAPIA SA
Original Assignee
INSTITUTO DE BIOLOGIA Y SUEROTERAPIA SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INSTITUTO DE BIOLOGIA Y SUEROTERAPIA SA filed Critical INSTITUTO DE BIOLOGIA Y SUEROTERAPIA SA
Publication of EP0499764A1 publication Critical patent/EP0499764A1/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends

Definitions

  • the present invention comprises a plastic device manufactured by injection, provided with a canule sharpened at both ends, adapted to be connected at one end to the appropriate access piece of a flexible container and, at the other end, to the top of a vial containing a liquid or powder which, by piercing of both containers with the canule, allows the transfer of liquids from the flexible container to the vial and from the latter to the flexible container, once its content is dissolved or diluted in the transferred solution, without the need to disconnect the initial connection at any moment of the process.
  • the device is characterized in being manufactured from such materials capable of being chemically or thermically sterilized, being apirogens and compatible with the solutions with which they are brought into contact.
  • the device can be manufactured with various shapes at the ends, in accordance with the kind of vial and flexible container to which it is going to be engaged.
  • vials with a 13 mm, 22 mm or 32 mm diameter mouth
  • flexible containers with 50 ml, 100 ml, 250 ml, 500 ml, 1,000 ml, 21, 31 capacity with threaded coupling which can have different pitches or be engaged under pressure.
  • the essential feature of the device is that it is comprised of a stainless steel canule, firmly held to an injected plastic piece, bell-shaped at one end, with suitable dimensions for attaching to the vial mouth, and of another piece of injected plastic, in which the preceding piece internally slides and integral with the canule, so that in the most extended position the ends of the canule do not protrude beyond the ends of the device and, once slid, pierce the flexible container; this piece has at one end the shape of a chamber with appropriate design to be attached to the coupling of the flexible container.
  • the canule 1 has the shape of a hollow cylinder, with both ends sharpened, and of a suitable length to be able to remain concealed until the time of use, which can be seen in Figure 7.
  • the injected piece is bell-shaped 2 at one end, with an inner diameter slightly larger than the outer diameter of the capsule of the vial with which it is engaged, and of a suitable length, so that on pressing the vial down to the bottom of the bell the canule pierces the cap of the vial and penetrates into the vial sufficiently to issue out of the interior of the cap.
  • the bell has at one end some bulges 3 directed toward the inside to clamp the top of the vial; these bulges likewise hinder insertion of the top of the vial into the bell, whereby said bell has several openings 4, distributed symmetrically in order to facilitate insertion of the top of the vial.
  • the injected piece clamps the canule, along most of its length, with a non-cylindrical section shape 5, whose purpose is to strengthen the canule, preventing it from folding on piercing and, thanks to its shape, engaging with the piece represented in Figures 4 and 6, allowing lengthwise sliding, but not the rotation of one piece with respect to the other.
  • the piece again has a cylindrical shape 6, of greater diameter than the non-cylindrical one 5, this increase having as its purpose to avoid separation of the two pieces once assembled; to facilitate mounting, this cylindrical zone is discontinued with hollow zones 7 by way of longitudinal grooves as can be seen in Figure 3.
  • the injected piece which will serve as guide and protection for the canule, has a zone of internal circular section shape 8, of appropriate length for concealing the canule in the most extended position of the device, as can be seen in Figure 8, and to produce the piercing of the flexible container in the most retracted position of the device, as can be seen in Figure 9; externally it has a grooved shape 9, in order to facilitate handling of the device, preventing slipping on being grasped with the fingers.
  • the piece has internally modified its section, adopting a non-cylindrical section shape 10 like the non-cylindrical section zone 5, with a small clearance to facilitate lengthwise sliding of the pieces; this zone having the narrowing with respect to the circular section zone 8 allows, along with zone 6, avoidance of separation of the two pieces once assembled.
  • the piece comprises a chamber 11, which can have male screw fillets 12 of luer, luer lock, record type or any other suitable kind of screw pitch or shape for attaching to the supplementary coupling of the flexible container.
  • the device is engaged to the flexible container by pressure screwing or equivalent action, in accordance with the kind of coupling 12 involved.
  • This engagement is facilitated through the non-cylindrical section zones 5 and 10 which force the pieces and the canule to turn together.
  • the piece joined to the canule slides internally to the piece engaged to the flexible container, until piercing said container, along the suitable lengths of this piece and of the canule.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP19910500093 1991-02-22 1991-08-08 Dispositif pour transférer du liquide entre des récipients flexibles et des fioles Ceased EP0499764A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9100538U ES1016828Y (es) 1991-02-22 1991-02-22 Dispositivo para la transferencia de liquidos entre recipientes flexibles y viales.
ES9100538U 1991-02-22

Publications (1)

Publication Number Publication Date
EP0499764A1 true EP0499764A1 (fr) 1992-08-26

Family

ID=8271450

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910500093 Ceased EP0499764A1 (fr) 1991-02-22 1991-08-08 Dispositif pour transférer du liquide entre des récipients flexibles et des fioles

Country Status (3)

Country Link
EP (1) EP0499764A1 (fr)
ES (1) ES1016828Y (fr)
FI (1) FI912923A (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19644644C1 (de) * 1996-10-26 1997-12-04 Eltest Ges Fuer Elektrophorese Vorrichtung zur Entnahme einer Flüssigkeitsprobe aus einem Schlauchstück
WO1998002129A1 (fr) * 1996-07-11 1998-01-22 Pharmacia & Upjohn Ab Procede et dispositif permettant de fermer hermetiquement et relier un recipient
FR2780878A1 (fr) * 1998-07-10 2000-01-14 Frederic Senaux Capuchon de transfert encliquetable
WO2000028940A1 (fr) * 1998-11-17 2000-05-25 Novo Nordisk A/S Dispositif de transfert de medicaments
WO2000028941A2 (fr) * 1998-11-17 2000-05-25 Novo Nordisk A/S Dispositif de transfert
WO2000015292A3 (fr) * 1998-09-15 2000-07-20 Baxter Int Dispositif de reconstitution par coulissement pour un recipient a diluant
WO2002053086A1 (fr) * 2001-01-08 2002-07-11 Pierre Frezza Ampoule pour le conditionnement et le transfert d'un liquide ou d'une poudre a usage medical
EP1060730A3 (fr) * 1999-06-16 2002-10-30 Fresenius Kabi Deutschland GmbH Dispositif de connexion avec embout et raccord
US6582415B1 (en) 1998-09-15 2003-06-24 Thomas A. Fowles Sliding reconstitution device for a diluent container
US6610040B1 (en) 1997-12-04 2003-08-26 Baxter International Inc. Sliding reconstitution device with seal
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
FR2998285A1 (fr) * 2012-11-20 2014-05-23 Peugeot Citroen Automobiles Sa Dispositif de remplissage d'un reservoir par un fluide et procede d'utilisation dudit dispositif
DE102006014495B4 (de) * 2006-03-29 2014-06-05 Sartorius Stedim Biotech Gmbh Vorrichtung zum Nehmen von Proben aus Systemen mit flexiblen Wandungen und zum Eintragen von Fluiden in solche

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976073A (en) * 1974-05-01 1976-08-24 Baxter Laboratories, Inc. Vial and syringe connector assembly
EP0126718A2 (fr) * 1983-05-20 1984-11-28 Bengt Gustavsson Dispositif pour transmettre une substance d'un récipient à un autre récipient, ainsi que l'application proposée
WO1986001712A1 (fr) * 1984-09-14 1986-03-27 Baxter Travenol Laboratories, Inc. Dispositif de reconstitution

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976073A (en) * 1974-05-01 1976-08-24 Baxter Laboratories, Inc. Vial and syringe connector assembly
EP0126718A2 (fr) * 1983-05-20 1984-11-28 Bengt Gustavsson Dispositif pour transmettre une substance d'un récipient à un autre récipient, ainsi que l'application proposée
WO1986001712A1 (fr) * 1984-09-14 1986-03-27 Baxter Travenol Laboratories, Inc. Dispositif de reconstitution

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002129A1 (fr) * 1996-07-11 1998-01-22 Pharmacia & Upjohn Ab Procede et dispositif permettant de fermer hermetiquement et relier un recipient
DE19644644C1 (de) * 1996-10-26 1997-12-04 Eltest Ges Fuer Elektrophorese Vorrichtung zur Entnahme einer Flüssigkeitsprobe aus einem Schlauchstück
US6610040B1 (en) 1997-12-04 2003-08-26 Baxter International Inc. Sliding reconstitution device with seal
FR2780878A1 (fr) * 1998-07-10 2000-01-14 Frederic Senaux Capuchon de transfert encliquetable
US6582415B1 (en) 1998-09-15 2003-06-24 Thomas A. Fowles Sliding reconstitution device for a diluent container
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
WO2000015292A3 (fr) * 1998-09-15 2000-07-20 Baxter Int Dispositif de reconstitution par coulissement pour un recipient a diluant
US6755810B1 (en) 1998-11-17 2004-06-29 Novo Nordisk A/S Medicament transferring device
WO2000028941A3 (fr) * 1998-11-17 2000-08-10 Novo Nordisk As Dispositif de transfert
WO2000028941A2 (fr) * 1998-11-17 2000-05-25 Novo Nordisk A/S Dispositif de transfert
WO2000028940A1 (fr) * 1998-11-17 2000-05-25 Novo Nordisk A/S Dispositif de transfert de medicaments
EP1060730A3 (fr) * 1999-06-16 2002-10-30 Fresenius Kabi Deutschland GmbH Dispositif de connexion avec embout et raccord
US6709424B1 (en) 1999-06-16 2004-03-23 Fre{overscore (s)}nius Kabi Deutschland GmbH Connector with a coupling system and a port system
FR2819174A1 (fr) * 2001-01-08 2002-07-12 Pierre Frezza Ampoule pour le conditionnement et le transfert d'un liquide ou d'une poudre a usage medical dans un contenant
US7261707B2 (en) 2001-01-08 2007-08-28 Pierre Frezza Ampule for packaging and transferring a liquid or a powder for medical use
WO2002053086A1 (fr) * 2001-01-08 2002-07-11 Pierre Frezza Ampoule pour le conditionnement et le transfert d'un liquide ou d'une poudre a usage medical
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
DE102006014495B4 (de) * 2006-03-29 2014-06-05 Sartorius Stedim Biotech Gmbh Vorrichtung zum Nehmen von Proben aus Systemen mit flexiblen Wandungen und zum Eintragen von Fluiden in solche
FR2998285A1 (fr) * 2012-11-20 2014-05-23 Peugeot Citroen Automobiles Sa Dispositif de remplissage d'un reservoir par un fluide et procede d'utilisation dudit dispositif
WO2014079815A1 (fr) * 2012-11-20 2014-05-30 Peugeot Citroen Automobiles Sa Dispositif de remplissage d'un reservoir par un fluide et procede d'utilisation dudit dispositif

Also Published As

Publication number Publication date
FI912923A0 (fi) 1991-06-17
ES1016828U (es) 1991-12-01
ES1016828Y (es) 1992-06-01
FI912923A (fi) 1992-08-23

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