EP0489879A1 - Procede et dispositif pour le traitement de l'epilepsie - Google Patents

Procede et dispositif pour le traitement de l'epilepsie

Info

Publication number
EP0489879A1
EP0489879A1 EP91910970A EP91910970A EP0489879A1 EP 0489879 A1 EP0489879 A1 EP 0489879A1 EP 91910970 A EP91910970 A EP 91910970A EP 91910970 A EP91910970 A EP 91910970A EP 0489879 A1 EP0489879 A1 EP 0489879A1
Authority
EP
European Patent Office
Prior art keywords
pulses
electrodes
positive
frequency
duration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP91910970A
Other languages
German (de)
English (en)
French (fr)
Inventor
Jean-Marie Verhoeven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VERHOEVEN JEAN MARIE
Original Assignee
VERHOEVEN JEAN MARIE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VERHOEVEN JEAN MARIE filed Critical VERHOEVEN JEAN MARIE
Publication of EP0489879A1 publication Critical patent/EP0489879A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064—Epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Definitions

  • the present invention relates to a method and a device for the treatment of epilepsy by using electrodes producing electrical pulses applied to the patient's head.
  • the impulses can be positive or negative. According to a particular embodiment of the invention, the pulses will preferably be positive.
  • the pulses can also be multiple pulses made up of different frequencies, used either sequentially or alternately, or even using a carrier frequency or a frequency modulated by another frequency.
  • an essential rectangular, negative wave is superimposed on a generally positive pulse, so that the energy of the negative part is essentially equivalent to the energy of the positive part. Any phenomenon of electrolysis can be controlled.
  • electrodes are applied which produce electrical pulses of low frequency between the above-mentioned values and of power which can vary from 1 to 170 V (peak voltage).
  • the duration of a pulse can vary from 2.5 ms to 0.025 ms, preferably from 0.2 to 0.30 ms. A value of 0.25 ms (+/- 0.1) was advantageously applied.
  • the patients Preferably use three electrodes, for example a positive front electrode and 2 negative electrodes at the base of the neck. It is also possible to use more than three electrodes.
  • the patients are treated in two successive phases of approximately 10 minutes, the frequencies being 1.5 Hz or approximately 1.5 Hz for the first phase which may last 10 minutes and 28 Hz or approximately 28 Hz for the second phase of the same duration.
  • the powers must be adapted to each particular case and can vary from 1 to 170 Volts.
  • the generator used for implementing the invention can be easily designed by those skilled in the art.
  • the apparatus for implementing the invention can operate on a single protected 6-volt battery.
  • This battery is rechargeable on the mains, with protection preventing any use on the mains.
  • the device comprises two mono Jack inputs, 2 potentiometers, one of which is provided with a -4-
  • the device can be fitted with a charge indicator. It switches off when the battery voltage drops to 4.5 volts, to prevent premature deterioration of the battery.
  • the voltmeter and the ammeter indicate: the peak values.
  • the device is preferably compact and transportable.
  • FIG. 1 illustrates the shape of the empty and loaded pulse.
  • FIG. 2 illustrates the invention by way of example. References in the figure refer to the following:

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
EP91910970A 1990-06-28 1991-06-27 Procede et dispositif pour le traitement de l'epilepsie Withdrawn EP0489879A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
BE9000660 1990-06-28
BE9000660 1990-06-28
BE9100054 1991-01-23
BE9100054 1991-01-23

Publications (1)

Publication Number Publication Date
EP0489879A1 true EP0489879A1 (fr) 1992-06-17

Family

ID=25662538

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91910970A Withdrawn EP0489879A1 (fr) 1990-06-28 1991-06-27 Procede et dispositif pour le traitement de l'epilepsie

Country Status (10)

Country Link
EP (1) EP0489879A1 (no)
JP (1) JPH05502608A (no)
AU (1) AU8095491A (no)
CA (1) CA2065388A1 (no)
IE (1) IE912227A1 (no)
IL (1) IL98656A0 (no)
MX (1) MX9100005A (no)
NO (1) NO920780D0 (no)
PT (1) PT98122A (no)
WO (1) WO1992000119A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5752979A (en) * 1996-11-01 1998-05-19 Medtronic, Inc. Method of controlling epilepsy by brain stimulation
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US9320900B2 (en) 1998-08-05 2016-04-26 Cyberonics, Inc. Methods and systems for determining subject-specific parameters for a neuromodulation therapy
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
DE10300069A1 (de) * 2003-01-03 2004-07-22 Grönemeyer, Dietrich H. W., Prof. Dr.med. Elektrotrainer
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US20080027348A1 (en) 2006-06-23 2008-01-31 Neuro Vista Corporation Minimally Invasive Monitoring Systems for Monitoring a Patient's Propensity for a Neurological Event
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
EP2124734A2 (en) 2007-01-25 2009-12-02 NeuroVista Corporation Methods and systems for measuring a subject's susceptibility to a seizure
WO2008092119A2 (en) 2007-01-25 2008-07-31 Neurovista Corporation Systems and methods for identifying a contra-ictal condition in a subject
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3918461A (en) * 1974-01-31 1975-11-11 Irving S Cooper Method for electrically stimulating the human brain
WO1985001213A1 (en) * 1983-09-14 1985-03-28 Jacob Zabara Neurocybernetic prosthesis
US4646744A (en) * 1984-06-29 1987-03-03 Zion Foundation Method and treatment with transcranially applied electrical signals
AU601203B2 (en) * 1986-06-16 1990-09-06 Zion Educational Foundation Method and apparatus for delivering a prescriptive electrical signal
GB8904998D0 (en) * 1989-03-04 1989-04-19 Matthews Tony Anaesthetising apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9200119A1 *

Also Published As

Publication number Publication date
CA2065388A1 (fr) 1991-12-29
WO1992000119A1 (fr) 1992-01-09
JPH05502608A (ja) 1993-05-13
IL98656A0 (en) 1992-07-15
MX9100005A (es) 1992-02-03
AU8095491A (en) 1992-01-23
IE912227A1 (en) 1992-01-01
NO920780L (no) 1992-02-27
PT98122A (pt) 1993-09-30
NO920780D0 (no) 1992-02-27

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