EP0489879A1 - Procede et dispositif pour le traitement de l'epilepsie - Google Patents
Procede et dispositif pour le traitement de l'epilepsieInfo
- Publication number
- EP0489879A1 EP0489879A1 EP91910970A EP91910970A EP0489879A1 EP 0489879 A1 EP0489879 A1 EP 0489879A1 EP 91910970 A EP91910970 A EP 91910970A EP 91910970 A EP91910970 A EP 91910970A EP 0489879 A1 EP0489879 A1 EP 0489879A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pulses
- electrodes
- positive
- frequency
- duration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36064—Epilepsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/3615—Intensity
- A61N1/36153—Voltage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
Definitions
- the present invention relates to a method and a device for the treatment of epilepsy by using electrodes producing electrical pulses applied to the patient's head.
- the impulses can be positive or negative. According to a particular embodiment of the invention, the pulses will preferably be positive.
- the pulses can also be multiple pulses made up of different frequencies, used either sequentially or alternately, or even using a carrier frequency or a frequency modulated by another frequency.
- an essential rectangular, negative wave is superimposed on a generally positive pulse, so that the energy of the negative part is essentially equivalent to the energy of the positive part. Any phenomenon of electrolysis can be controlled.
- electrodes are applied which produce electrical pulses of low frequency between the above-mentioned values and of power which can vary from 1 to 170 V (peak voltage).
- the duration of a pulse can vary from 2.5 ms to 0.025 ms, preferably from 0.2 to 0.30 ms. A value of 0.25 ms (+/- 0.1) was advantageously applied.
- the patients Preferably use three electrodes, for example a positive front electrode and 2 negative electrodes at the base of the neck. It is also possible to use more than three electrodes.
- the patients are treated in two successive phases of approximately 10 minutes, the frequencies being 1.5 Hz or approximately 1.5 Hz for the first phase which may last 10 minutes and 28 Hz or approximately 28 Hz for the second phase of the same duration.
- the powers must be adapted to each particular case and can vary from 1 to 170 Volts.
- the generator used for implementing the invention can be easily designed by those skilled in the art.
- the apparatus for implementing the invention can operate on a single protected 6-volt battery.
- This battery is rechargeable on the mains, with protection preventing any use on the mains.
- the device comprises two mono Jack inputs, 2 potentiometers, one of which is provided with a -4-
- the device can be fitted with a charge indicator. It switches off when the battery voltage drops to 4.5 volts, to prevent premature deterioration of the battery.
- the voltmeter and the ammeter indicate: the peak values.
- the device is preferably compact and transportable.
- FIG. 1 illustrates the shape of the empty and loaded pulse.
- FIG. 2 illustrates the invention by way of example. References in the figure refer to the following:
Landscapes
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE9000660 | 1990-06-28 | ||
BE9000660 | 1990-06-28 | ||
BE9100054 | 1991-01-23 | ||
BE9100054 | 1991-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0489879A1 true EP0489879A1 (fr) | 1992-06-17 |
Family
ID=25662538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91910970A Withdrawn EP0489879A1 (fr) | 1990-06-28 | 1991-06-27 | Procede et dispositif pour le traitement de l'epilepsie |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0489879A1 (es) |
JP (1) | JPH05502608A (es) |
AU (1) | AU8095491A (es) |
CA (1) | CA2065388A1 (es) |
IE (1) | IE912227A1 (es) |
IL (1) | IL98656A0 (es) |
MX (1) | MX9100005A (es) |
NO (1) | NO920780L (es) |
PT (1) | PT98122A (es) |
WO (1) | WO1992000119A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5752979A (en) * | 1996-11-01 | 1998-05-19 | Medtronic, Inc. | Method of controlling epilepsy by brain stimulation |
US9375573B2 (en) | 1998-08-05 | 2016-06-28 | Cyberonics, Inc. | Systems and methods for monitoring a patient's neurological disease state |
US8762065B2 (en) | 1998-08-05 | 2014-06-24 | Cyberonics, Inc. | Closed-loop feedback-driven neuromodulation |
US9042988B2 (en) | 1998-08-05 | 2015-05-26 | Cyberonics, Inc. | Closed-loop vagus nerve stimulation |
US7209787B2 (en) | 1998-08-05 | 2007-04-24 | Bioneuronics Corporation | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US9415222B2 (en) | 1998-08-05 | 2016-08-16 | Cyberonics, Inc. | Monitoring an epilepsy disease state with a supervisory module |
US7853329B2 (en) | 1998-08-05 | 2010-12-14 | Neurovista Corporation | Monitoring efficacy of neural modulation therapy |
US7747325B2 (en) | 1998-08-05 | 2010-06-29 | Neurovista Corporation | Systems and methods for monitoring a patient's neurological disease state |
DE10300069A1 (de) * | 2003-01-03 | 2004-07-22 | Grönemeyer, Dietrich H. W., Prof. Dr.med. | Elektrotrainer |
US8868172B2 (en) | 2005-12-28 | 2014-10-21 | Cyberonics, Inc. | Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders |
US8725243B2 (en) | 2005-12-28 | 2014-05-13 | Cyberonics, Inc. | Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders |
WO2007150003A2 (en) | 2006-06-23 | 2007-12-27 | Neurovista Corporation | Minimally invasive monitoring systems and methods |
US8295934B2 (en) | 2006-11-14 | 2012-10-23 | Neurovista Corporation | Systems and methods of reducing artifact in neurological stimulation systems |
WO2008092119A2 (en) | 2007-01-25 | 2008-07-31 | Neurovista Corporation | Systems and methods for identifying a contra-ictal condition in a subject |
EP2124734A2 (en) | 2007-01-25 | 2009-12-02 | NeuroVista Corporation | Methods and systems for measuring a subject's susceptibility to a seizure |
US8036736B2 (en) | 2007-03-21 | 2011-10-11 | Neuro Vista Corporation | Implantable systems and methods for identifying a contra-ictal condition in a subject |
US9788744B2 (en) | 2007-07-27 | 2017-10-17 | Cyberonics, Inc. | Systems for monitoring brain activity and patient advisory device |
US9259591B2 (en) | 2007-12-28 | 2016-02-16 | Cyberonics, Inc. | Housing for an implantable medical device |
US20090171168A1 (en) | 2007-12-28 | 2009-07-02 | Leyde Kent W | Systems and Method for Recording Clinical Manifestations of a Seizure |
US8849390B2 (en) | 2008-12-29 | 2014-09-30 | Cyberonics, Inc. | Processing for multi-channel signals |
US8588933B2 (en) | 2009-01-09 | 2013-11-19 | Cyberonics, Inc. | Medical lead termination sleeve for implantable medical devices |
US8786624B2 (en) | 2009-06-02 | 2014-07-22 | Cyberonics, Inc. | Processing for multi-channel signals |
US9643019B2 (en) | 2010-02-12 | 2017-05-09 | Cyberonics, Inc. | Neurological monitoring and alerts |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3918461A (en) * | 1974-01-31 | 1975-11-11 | Irving S Cooper | Method for electrically stimulating the human brain |
WO1985001213A1 (en) * | 1983-09-14 | 1985-03-28 | Jacob Zabara | Neurocybernetic prosthesis |
US4646744A (en) * | 1984-06-29 | 1987-03-03 | Zion Foundation | Method and treatment with transcranially applied electrical signals |
WO1987007511A2 (en) * | 1986-06-16 | 1987-12-17 | Zion Educational Foundation | Method and apparatus for delivering a prescriptive electrical signal |
GB8904998D0 (en) * | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
-
1991
- 1991-06-26 IE IE222791A patent/IE912227A1/en unknown
- 1991-06-27 IL IL98656A patent/IL98656A0/xx unknown
- 1991-06-27 WO PCT/BE1991/000043 patent/WO1992000119A1/fr not_active Application Discontinuation
- 1991-06-27 AU AU80954/91A patent/AU8095491A/en not_active Abandoned
- 1991-06-27 EP EP91910970A patent/EP0489879A1/fr not_active Withdrawn
- 1991-06-27 PT PT98122A patent/PT98122A/pt not_active Application Discontinuation
- 1991-06-27 JP JP3510685A patent/JPH05502608A/ja active Pending
- 1991-06-27 CA CA002065388A patent/CA2065388A1/fr not_active Abandoned
- 1991-07-04 MX MX919100005A patent/MX9100005A/es unknown
-
1992
- 1992-02-27 NO NO92920780A patent/NO920780L/no unknown
Non-Patent Citations (1)
Title |
---|
See references of WO9200119A1 * |
Also Published As
Publication number | Publication date |
---|---|
IE912227A1 (en) | 1992-01-01 |
JPH05502608A (ja) | 1993-05-13 |
CA2065388A1 (fr) | 1991-12-29 |
NO920780D0 (no) | 1992-02-27 |
PT98122A (pt) | 1993-09-30 |
MX9100005A (es) | 1992-02-03 |
NO920780L (no) | 1992-02-27 |
WO1992000119A1 (fr) | 1992-01-09 |
AU8095491A (en) | 1992-01-23 |
IL98656A0 (en) | 1992-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19920709 |
|
17Q | First examination report despatched |
Effective date: 19940428 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19940909 |