EP0483734A1 - Dispositif pour la préparation et l'administration extemporanée d'une solution - Google Patents

Dispositif pour la préparation et l'administration extemporanée d'une solution Download PDF

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Publication number
EP0483734A1
EP0483734A1 EP91118367A EP91118367A EP0483734A1 EP 0483734 A1 EP0483734 A1 EP 0483734A1 EP 91118367 A EP91118367 A EP 91118367A EP 91118367 A EP91118367 A EP 91118367A EP 0483734 A1 EP0483734 A1 EP 0483734A1
Authority
EP
European Patent Office
Prior art keywords
container
administration
capsule
inlet opening
cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP91118367A
Other languages
German (de)
English (en)
Inventor
Girolamo Nocerino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0483734A1 publication Critical patent/EP0483734A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3216—Rigid containers disposed one within the other
    • B65D81/3222—Rigid containers disposed one within the other with additional means facilitating admixture

Definitions

  • the present invention relates to the preparation and administering of extemporaneous solutions of active principles, particularly drugs. More particularly the present invention relates to a device to carry out such a preparation and administering.
  • the solution is sensible to external agents, such as for example the sun light, whereby particular provisions must be adopted (shielded bottles and the like) for the protection of the solution from the said external agents.
  • the main purpose of the present invention is that of providing a device permitting the extemporary preparation and administration of solutions starting from a solid standard pharmaceutical form, such as a tablet or capsule of the solute, and from a dosed amount of liquid solvent.
  • a more specific purpose of the present invention is that of providing a device of the afore mentioned type which is reusable for an undefinite number of times and permits the administration of the solution according to the usual ways, namely not only as a single dose for drinking, but also in form of drops, oral or nasal spray, etc.
  • a device for the extemporary preparation and administration of solutions characterized by comprising a container provided with an administration mouth, susceptible of being coupled with an administration member and an inlet opening of solute in solid form, cutting means internally mounted to the said container for crushing or anyhow reducing to small particles said solid solute and means for supplying a dosed amount of liquid solvent at the bottom of said container.
  • said solid solute is in form of a capsule containing said solid solute in form of particles, whereby said cutting means consist of one or more cutting blades adapted to act onto the outer wall of the capsule, when it is introduced thorugh said inlet opening within a suitable seat formed inside said container, so that the particles of solid solute fall onto the bottom of said container becoming admixed with said liquid solvent, the falling down of said particles being guided by baffle means which preferably also act as retaining and seat means for said capsule.
  • said liquid solvent is supplied to the bottom of said container in form of a cartridge containing a predetermined amount and connectable in a removable manner, for example by screwing, to the lower end of said container of which it becomes said bottom onto which the particles of said solid solute fall.
  • FIG. 1 there is shown a device for the extemporary preparation and the administration of solutions, particularly of drugs in form of solutions, comprising a cylindrical container or shell 10, having at the upper end an administration mouth in form of a screw threaded connection 12, to which the true administration device 14 is coupled, in the specific case being illustrated in form of a spray administration device screwed onto the connection 12.
  • an inlet opening 16 is provided which in this embodiment is closed by a seal tight plug 18 of rubber or like material.
  • the plug 18 is thus of a type such as to permit it to be removed from its seat to give access to the opening 16 and then positioned again thereon with a seal tigh closure for an even very great number of times, for the hereinafter explained reasons.
  • baffle or wall member 20 is formed having a suitable inclination so as to form a funnel like flow channel 22 starting from the inlet opening 16.
  • sharpenend small blades 32 are provided, for example of a plastic material, and positioned with the cutting edge upwardly directed and aligned with a diameter of the inlet opening 16.
  • the bottom of the container 10 is formed by a cartridge 24 which can be fastened for instance by screwing as indicated by the reference 24 to the lower end of the container 10 so as to form the bottom theref.
  • the cartridge 24 is preferably (as shown in fig.2A) a separate piece containing a predetermined amount of liquid solvent and sealed for example by means of a water-proof and tearable cover 28: at the time of the use the said cover is removed, the cartridge containing the liquid is screwed to the container 10, then the rubber plug 18 is removed and a capsule 30 containing the solid solute to be dissolved in the liquid solvent contained in the bottom of the container 10 as completed by the cartridge 24 is introduced within the seat defined by the baffle 20.
  • the capsule 30 Since the capsule 30 is introduced with a slight forcing pressure within the the inlet opening 16 it interferes with the cutting blades 32 and is opened at its lower end whereby the solid solute in powder form contained in the capsule falls downwardly, it being guided in this flow by the funnel shape of the channel formed between the wall 20 and the adjacent internal surface of the container 10. In this manner the solid solute in powder form comes into contact with the liquid in which it is dissolved.
  • the bottom wall of the bottom cartridge 24 has a slight inclination or slope towards the center thereof at which the powdery solid tends to be collected before being completely dissolved.
  • the container 10 is stirred until the dissolution is completed.
  • the adimistration device in the showing of fig.1 consists of a spray atomizer having a small suction tube or pipe 36 permitting the just prepared solution to be taken and administered.
  • the device 14 shall consist of a normal dropper or of a drop delivering pipe of the well known types.
  • the embodiment of fig.3 is differing from that of fig.1 only by the different structure and position of the introduction and cutting seat for the capsule 30.
  • an opening 40 is formed for the introduction of the capsules 30, this opening being closed by a small door 42 hinged so as to rotate around a vertical axis and having a catch closure 44 of standard and well known type.
  • an angle shaped baffle 46 is formed or applied, it serving to retain the capsule 30 in the desired position within the container 10.
  • a vertical slit 48 is provided in which a retractable blade 50 is slidably housed, ending with a point 52 so as to permit the preliminary penetration of the blade within the wall of the capsule 30, the vertical sliding motion of the blade causing thereafter the opening of the capsule 30 along a generatrix thereof up to the complete opening of the capsule at its bottom end.
  • the funnel shaped channel of the embodiment of fig.1 is not necessary, in view of the small distance between the lower end of the capsule 30 and the free surface of the liquid.
  • the device is fully identical to that of fig.1.
  • the embodiment of the figures 4 and 5 it is a variation of that of figure 3, whereby like elements are indicated by the same references, and is different by the fact that, instead of the baffle 46 a small rear wall 56 is provided for the side supporting of the capsule, which is supported at the lower side by an abutting edge 58.
  • the small door 42 is provided with a slit 48 for the vertical sliding motion of the retractable blade 50 having the point 52, so as to carry out in the side wall of the capsule 30 the cutting indicated by the reference number 54.
  • the device according to the present invention permits the same container 10, manufactured from glass or preferably from atoxic and biologically acceptable plastic material, to be used a great number of times, each time a capsule 30 being introduced in the proper seat provided within the container, the capsule being then opened so as to release the powdery or particle solid content thereof, this solid falling by gravity in the liquid solvent, the latter too being introduced in the container 10 by means of the cartridge 10 which remains the only component of the device which is each time substituted for.
  • the device or better to say the container 10 is normally provided with an administration member or element, permanently communicating with the area of the container 10 in which the solution is formed, i.e. the cartridge of liquid solvent 24.
  • an administration member or element permanently communicating with the area of the container 10 in which the solution is formed, i.e. the cartridge of liquid solvent 24.
  • the device of the present invention has no exclusive application in the pharmaceutical field, although the latter is the preferred one.
  • the invention may likewise find application in other fields, in all cases in which a solution of a solid which is otherwise unstable or degradable is to be extemporarily prepared.
  • the choice of the capsule 30 is a preferred but non limiting embodiment, since the invention might be applied also in the case in which the capsule 30 or like element contains for example a liquid to be admixed with another liquid, or in an extreme case when the capsule or vial 30 contains a liquid solvent, whereas the solute, as a powder or a liquid is contained in the bottom cartridge 24.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Steroid Compounds (AREA)
EP91118367A 1990-10-30 1991-10-28 Dispositif pour la préparation et l'administration extemporanée d'une solution Withdrawn EP0483734A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT02192990A IT1243994B (it) 1990-10-30 1990-10-30 Dispositivo per la preparazione estemporanea e l'erogazione di soluzioni
IT2192990 1990-10-30

Publications (1)

Publication Number Publication Date
EP0483734A1 true EP0483734A1 (fr) 1992-05-06

Family

ID=11188962

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91118367A Withdrawn EP0483734A1 (fr) 1990-10-30 1991-10-28 Dispositif pour la préparation et l'administration extemporanée d'une solution

Country Status (2)

Country Link
EP (1) EP0483734A1 (fr)
IT (1) IT1243994B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021155174A1 (fr) * 2020-01-31 2021-08-05 Arizona Board Of Regents On Behalf Of Arizona State University Ensemble de collecte, de stockage et de test d'urine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2102622A6 (fr) * 1970-08-12 1972-04-07 Goupil Jean Jacques
DE3535986A1 (de) * 1985-10-09 1987-04-09 Otto Verpackung Gmbh System zum zubereiten einer wirksubstanz-loesungsmittel-mischung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2102622A6 (fr) * 1970-08-12 1972-04-07 Goupil Jean Jacques
DE3535986A1 (de) * 1985-10-09 1987-04-09 Otto Verpackung Gmbh System zum zubereiten einer wirksubstanz-loesungsmittel-mischung

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021155174A1 (fr) * 2020-01-31 2021-08-05 Arizona Board Of Regents On Behalf Of Arizona State University Ensemble de collecte, de stockage et de test d'urine
US11950769B2 (en) 2020-01-31 2024-04-09 Arizona Board Of Regents On Behalf Of Arizona State University Urine collection, storage, and testing assembly

Also Published As

Publication number Publication date
IT1243994B (it) 1994-06-28
IT9021929A1 (it) 1992-04-30
IT9021929A0 (it) 1990-10-30

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